FR2549082B2 - Vecteurs perfectionnes d'expression d'une proteine ayant l'activite de l'antitrypsine-a1 humaine - Google Patents

Vecteurs perfectionnes d'expression d'une proteine ayant l'activite de l'antitrypsine-a1 humaine

Info

Publication number
FR2549082B2
FR2549082B2 FR8311594A FR8311594A FR2549082B2 FR 2549082 B2 FR2549082 B2 FR 2549082B2 FR 8311594 A FR8311594 A FR 8311594A FR 8311594 A FR8311594 A FR 8311594A FR 2549082 B2 FR2549082 B2 FR 2549082B2
Authority
FR
France
Prior art keywords
activity
expression vectors
protein expression
improved protein
human antitrypsin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR8311594A
Other languages
English (en)
Other versions
FR2549082A2 (fr
Inventor
Michael Courtney
Anne Buchwalder
Luc Henri Tessier
Michael Jaye
Richard Lathe
Paul Tolstoshev
Jean Pierre Lecocq
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transgene SA
Original Assignee
Transgene SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transgene SA filed Critical Transgene SA
Priority to FR8311594A priority Critical patent/FR2549082B2/fr
Priority to CA000445727A priority patent/CA1303530C/fr
Priority to AT84400126T priority patent/ATE55150T1/de
Priority to DE8484400126T priority patent/DE3482840D1/de
Priority to EP84400126A priority patent/EP0114777B1/fr
Priority to PCT/FR1984/000014 priority patent/WO1984002918A1/fr
Priority to DK450584A priority patent/DK450584D0/da
Publication of FR2549082A2 publication Critical patent/FR2549082A2/fr
Application granted granted Critical
Publication of FR2549082B2 publication Critical patent/FR2549082B2/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR8311594A 1983-01-21 1983-07-12 Vecteurs perfectionnes d'expression d'une proteine ayant l'activite de l'antitrypsine-a1 humaine Expired FR2549082B2 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
FR8311594A FR2549082B2 (fr) 1983-07-12 1983-07-12 Vecteurs perfectionnes d'expression d'une proteine ayant l'activite de l'antitrypsine-a1 humaine
CA000445727A CA1303530C (fr) 1983-01-21 1984-01-20 VECTEURS D'EXPRESSION ET LEUR UTILISATION POUR LA PREPARATION D'UNE PROTEINE AYANT UNE ACTIVITE .alpha. -ANTITRYPSINE HUMAINE
AT84400126T ATE55150T1 (de) 1983-01-21 1984-01-20 Expressionsvektoren und deren verwendung zur herstellung eines proteins mit menschlicher alpha-antitrypsin-aktivitaet.
DE8484400126T DE3482840D1 (de) 1983-01-21 1984-01-20 Expressionsvektoren und deren verwendung zur herstellung eines proteins mit menschlicher alpha-antitrypsin-aktivitaet.
EP84400126A EP0114777B1 (fr) 1983-01-21 1984-01-20 Nouveaux vecteurs d'expression et leur application à la préparation d'une protéine ayant l'activité de l'antitrypsine-alpha 1 humaine
PCT/FR1984/000014 WO1984002918A1 (fr) 1983-01-21 1984-01-20 NOUVEAUX VECTEURS D'EXPRESSION ET LEUR APPLICATION A LA PREPARATION D'UNE PROTEINE AYANT L'ACTIVITE DE L'ANTITRYPSINE-alpha1 HUMAINE
DK450584A DK450584D0 (da) 1983-01-21 1984-09-20 Ekspressionsvektorer og anvendelse deraf til fremstilling af et protein med aktiviteten af humant antitrypsin-alfa1

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8311594A FR2549082B2 (fr) 1983-07-12 1983-07-12 Vecteurs perfectionnes d'expression d'une proteine ayant l'activite de l'antitrypsine-a1 humaine

Publications (2)

Publication Number Publication Date
FR2549082A2 FR2549082A2 (fr) 1985-01-18
FR2549082B2 true FR2549082B2 (fr) 1986-05-16

Family

ID=9290756

Family Applications (1)

Application Number Title Priority Date Filing Date
FR8311594A Expired FR2549082B2 (fr) 1983-01-21 1983-07-12 Vecteurs perfectionnes d'expression d'une proteine ayant l'activite de l'antitrypsine-a1 humaine

Country Status (1)

Country Link
FR (1) FR2549082B2 (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE895961A (fr) * 1983-02-21 1983-06-16 Wallone Region Procede de preparation d'un clone bacterien produisant de 1'alpha 1-antitrypsine humaine

Also Published As

Publication number Publication date
FR2549082A2 (fr) 1985-01-18

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