FR2562088B1 - Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine - Google Patents

Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine

Info

Publication number: FR2562088B1
Authority: FR; France
Prior art keywords: hirudin; expression vectors; transformed cells; preparing; hirudin expression
Prior art date: 1984-03-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired

Application number

FR8404755A

Other languages

English (en)

Other versions

FR2562088A1 (fr

Inventor

Paul Tolstoshev

Richard Harvey

Michael Courtney

Jean-Pierre Lecocq

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Transgene SA

Original Assignee

Transgene SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-03-27

Filing date

1984-03-27

Publication date

1987-11-13

1984-03-27 Priority to FR8404755A priority Critical patent/FR2562088B1/fr

1984-03-27 Application filed by Transgene SA filed Critical Transgene SA

1985-03-27 Priority to CA000477676A priority patent/CA1341414C/fr

1985-03-27 Priority to AT85400598T priority patent/ATE78294T1/de

1985-03-27 Priority to EP85400598A priority patent/EP0158564B1/fr

1985-03-27 Priority to JP60501396A priority patent/JP2696316B2/ja

1985-03-27 Priority to CA000615690A priority patent/CA1341417C/fr

1985-03-27 Priority to PCT/FR1985/000062 priority patent/WO1985004418A1/fr

1985-03-27 Priority to DE8585400598T priority patent/DE3586333T2/de

1985-10-04 Publication of FR2562088A1 publication Critical patent/FR2562088A1/fr

1985-11-26 Priority to DK198505471A priority patent/DK175217B1/da

1987-11-13 Application granted granted Critical

1987-11-13 Publication of FR2562088B1 publication Critical patent/FR2562088B1/fr

1995-06-07 Priority to US08/481,867 priority patent/US5705355A/en

1995-07-10 Priority to US08/500,111 priority patent/US5824505A/en

Status Expired legal-status Critical Current

Links

102000007625 Hirudins Human genes 0.000 title 2
108010007267 Hirudins Proteins 0.000 title 2
WQPDUTSPKFMPDP-OUMQNGNKSA-N hirudin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC(OS(O)(=O)=O)=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]1NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)CC)NC(=O)[C@@H]2CSSC[C@@H](C(=O)N[C@@H](CCC(O)=O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)N[C@H](C(NCC(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N2)=O)CSSC1)C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)[C@@H](C)O)CSSC1)C(C)C)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 WQPDUTSPKFMPDP-OUMQNGNKSA-N 0.000 title 2
229940006607 hirudin Drugs 0.000 title 2
239000013604 expression vector Substances 0.000 title 1
238000004519 manufacturing process Methods 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Genetics & Genomics (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Wood Science & Technology (AREA)
Biotechnology (AREA)
General Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Physics & Mathematics (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

FR8404755A 1984-03-27 1984-03-27 Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine Expired FR2562088B1 (fr)

Priority Applications (11)

Application Number	Priority Date	Filing Date	Title
FR8404755A FR2562088B1 (fr)	1984-03-27	1984-03-27	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
DE8585400598T DE3586333T2 (de)	1984-03-27	1985-03-27	Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin.
EP85400598A EP0158564B1 (fr)	1984-03-27	1985-03-27	Vecteurs d'expression de l'hirudine, cellules transformées et procédé de préparation de l'hirudine
JP60501396A JP2696316B2 (ja)	1984-03-27	1985-03-27	ヒルジンの発現のためのベクター、形質転換細胞及びヒルジンの製造方法
CA000615690A CA1341417C (fr)	1984-03-27	1985-03-27	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
PCT/FR1985/000062 WO1985004418A1 (fr)	1984-03-27	1985-03-27	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
CA000477676A CA1341414C (fr)	1984-03-27	1985-03-27	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine
AT85400598T ATE78294T1 (de)	1984-03-27	1985-03-27	Expressionsvektoren fuer hirudin, transformierte zellen und verfahren zur herstellung von hirudin.
DK198505471A DK175217B1 (da)	1984-03-27	1985-11-26	Hirudinanalog, vektorer til ekspression af hirudinanalog, transformerede celler og fremgangsmåde til fremstilling af hirudinanalog
US08/481,867 US5705355A (en)	1984-03-27	1995-06-07	Hirudin, pharmaceutical compositions comprising it and their use
US08/500,111 US5824505A (en)	1984-03-27	1995-07-10	Vectors, transformed cells and process for the preparation of hirudin

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8404755A FR2562088B1 (fr)	1984-03-27	1984-03-27	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine

Publications (2)

Publication Number	Publication Date
FR2562088A1 FR2562088A1 (fr)	1985-10-04
FR2562088B1 true FR2562088B1 (fr)	1987-11-13

Family

ID=9302516

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR8404755A Expired FR2562088B1 (fr)	1984-03-27	1984-03-27	Vecteurs d'expression de l'hirudine, cellules transformees et procede de preparation de l'hirudine

Country Status (2)

Country	Link
JP (1)	JP2696316B2 (fr)
FR (1)	FR2562088B1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE64956T1 (de) *	1984-06-14	1991-07-15	Ciba Geigy Ag	Verfahren zur herstellung von thrombininhibitoren.
ES2129749T3 (es) *	1990-11-08	1999-06-16	Japan Energy Corp	Vector de secrecion, microorganismos transformados que contienen el indicado vector y produccion de un producto a partir de dicho microorganismo.
JP2573114B2 (ja) *	1991-09-09	1997-01-22	株式会社ジャパンエナジー	ヒルジン類分泌生産培養液の処理法
CN117866949A (zh) *	2024-01-15	2024-04-12	南京翌科仪器有限公司	一种基于基因编辑的昆虫生物物质提取方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3342139A1 (de) *	1983-11-22	1985-05-30	Ciba-Geigy Ag, Basel	Desulfatohirudine, verfahren zu ihrer herstellung und pharmazeutische mittel

1984
- 1984-03-27 FR FR8404755A patent/FR2562088B1/fr not_active Expired
1985
- 1985-03-27 JP JP60501396A patent/JP2696316B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JP2696316B2 (ja)	1998-01-14
JPS61501609A (ja)	1986-08-07
FR2562088A1 (fr)	1985-10-04

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Legal Events

Date	Code	Title	Description
2003-09-26	TP	Transmission of property