FR2663M - Phénylacétonitriles substitués par des groupes basiques. - Google Patents

Phénylacétonitriles substitués par des groupes basiques.

Info

Publication number
FR2663M
FR2663M FR893083A FR893083A FR2663M FR 2663 M FR2663 M FR 2663M FR 893083 A FR893083 A FR 893083A FR 893083 A FR893083 A FR 893083A FR 2663 M FR2663 M FR 2663M
Authority
FR
France
Prior art keywords
phenylacetonitriles
substituted
basic groups
basic
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR893083A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Application granted granted Critical
Publication of FR2663M publication Critical patent/FR2663M/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FR893083A 1961-04-01 1962-04-02 Phénylacétonitriles substitués par des groupes basiques. Expired FR2663M (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEK0043374 1961-04-01
DEK43596A DE1154810B (de) 1961-04-01 1961-04-28 Verfahren zur Herstellung basisch substituierter Phenylacetonitrile

Publications (1)

Publication Number Publication Date
FR2663M true FR2663M (fr) 1964-07-20

Family

ID=25983389

Family Applications (1)

Application Number Title Priority Date Filing Date
FR893083A Expired FR2663M (fr) 1961-04-01 1962-04-02 Phénylacétonitriles substitués par des groupes basiques.

Country Status (6)

Country Link
US (1) US3261859A (fr)
BE (1) BE615861A (fr)
CH (1) CH418346A (fr)
DE (1) DE1154810B (fr)
FR (1) FR2663M (fr)
GB (1) GB999612A (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0180810A1 (fr) * 1984-10-17 1986-05-14 Hokuriku Pharmaceutical Co.,Ltd Alpha-aminoalcoyl-alpha-alcoylphénylacétonitriles
FR2588258A1 (fr) * 1985-10-04 1987-04-10 Adir Nouveaux derives d'amino-5 valeronitrile, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
EP0175249A3 (fr) * 1984-09-12 1987-08-19 Roche Diagnostics GmbH Dérivés de phénylacétonitrile
EP0257768A1 (fr) * 1986-07-18 1988-03-02 SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu Dérivés de 2-isopropyl-2-phényl-5-(N-méthyl-2-phényl-éthylamino)valéronitrile et des procédés pour leur préparation

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957845A (en) * 1962-04-27 1976-05-18 Knoll A.G. Chemische Fabriken Trifluoromethyl-substituted phenyl acetonitriles
DE1518545A1 (de) * 1965-04-01 1970-01-15 Boehringer Mannheim Gmbh Verfahren zur Herstellung neuer Phenylcyclohexylalkylamine und ihrer Salze
US3485873A (en) * 1966-12-21 1969-12-23 Sterling Drug Inc N-benzyl-n-methyl-omega-phenyl-omega-cycloalkyl-lower-alkylamines
DE1793383C3 (de) * 1968-09-10 1979-03-01 Knoll Ag, 6700 Ludwigshafen 4-Cyan-4-phenyl-aminocyclohexane und deren wasserlösliche Salze, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
US3998965A (en) * 1973-12-15 1976-12-21 Aspro-Nicholas Limited 4-Aminoalkyl-4-cyano-4-phenyl-butanoic acid esters
DE2631222C3 (de) * 1976-07-12 1979-01-04 Knoll Ag, 6700 Ludwigshafen Verfahren zur Herstellung basisch substituierter Phenylacetonitrile
DE2658500C2 (de) * 1976-12-23 1986-10-09 Knoll Ag, 6700 Ludwigshafen Pharmazeutische Präparate mit kardioprotektiver Wirkung
DE2816190A1 (de) 1978-04-14 1979-10-25 Bayer Ag Neue benzodioxolderivate
DE2946545A1 (de) 1979-11-17 1981-05-27 Basf Ag, 6700 Ludwigshafen Verfahren zur gewinnung der enantiomeren formen von 4-cyan-1-(n-methyl-n-(2'-((3'',4'',-dimethoxyphenyl))-aethyl)-amino)-5-methyl-4-(3',4',5'-trimethoxyphenyl)-hexan und dessen salzen
DE3034221A1 (de) 1980-09-11 1982-04-22 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung basisch substituierter phenylacetonitrile
DE3113901A1 (de) * 1981-04-07 1982-10-28 Basf Ag, 6700 Ludwigshafen Wirkstoffzubereitung zur oralen applikation
DE3144150A1 (de) 1981-04-10 1982-12-09 Basf Ag, 6700 Ludwigshafen (omega)-cyan-1,(omega)-diphenyl-azaalkan-derivate, ihre herstellung und diese enthaltende arzneimittel
DE3121766A1 (de) * 1981-06-02 1982-12-16 Basf Ag, 6700 Ludwigshafen Verfahren zur herstellung basisch substituierter phenylacetonitrile
DE3344755A1 (de) * 1983-12-10 1985-06-20 Basf Ag, 6700 Ludwigshafen 1,7-diphenyl-3-methylaza-7-cyan-8-methyl-nonan zur verwendung bei der bekaempfung von krankheiten
ATE32061T1 (de) * 1984-06-15 1988-02-15 Heumann Ludwig & Co Gmbh Verfahren zur herstellung basisch substituierter phenylacetonitrile.
DE3440881A1 (de) * 1984-11-06 1986-05-15 Schering AG, Berlin und Bergkamen, 1000 Berlin Pharmazeutische zusammensetzung, ihre herstellung und verwendung
DE3635930A1 (de) * 1986-10-22 1988-04-28 Basf Ag Wirkstoffe zur anwendung bei der behandlung von tumoren
DE3535949A1 (de) * 1985-10-09 1987-04-09 Basf Ag Kombinationspraeparat
PH23152A (en) * 1985-10-18 1989-05-19 Searle & Co Bicyclo-substituted phenylacetonitrile derivatives
US4593042A (en) * 1985-10-18 1986-06-03 G. D. Searle & Co. Bicyclo-substituted phenylacetonitrile derivatives
US4667038A (en) * 1985-12-02 1987-05-19 Syntex (U.S.A.) Inc. Tetrahydroisoquinoline derivatives
DE3542994A1 (de) * 1985-12-05 1987-06-11 Basf Ag Basisch substituierte phenylacetaldehyde, ihre herstellung und diese enthaltende arzneimittel
DE3603032A1 (de) * 1986-01-31 1987-08-06 Basf Ag Basisch substituierte phenylacetonitrile, ihre herstellung und diese enthaltende arzneimittel
DE3634389A1 (de) * 1986-10-09 1988-04-21 Knoll Ag Verwendung von anipamil
IT1215409B (it) * 1987-04-08 1990-02-08 Alfa Chem Ital Processo per la sintesi dell'alfa-(1-metiletil)-3,4-dimetossibenzeneacetonitrile.
DE3741415C1 (en) * 1987-12-07 1989-07-06 Luitpold Werk Chem Pharm Use of 5-[N-(3,4-dimethoxyphenylethyl)-N-methylamino]-2-(3,4-dimethoxyphenyl) -2-isopropylvaleronitril ("verapamil") or its pharmaceutically suitable salts for the percutaneous treatment of chronic venous insufficiency
US4833162A (en) * 1988-02-03 1989-05-23 American Cyanamid Company Substituted benzeneacetonitriles and their use as calcium channel blockers
US5886012A (en) * 1989-03-22 1999-03-23 Peter K. T. Pang Method of treatment for disease associated with excessive PHF using combination therapy involving exogenous calcium and calcium channel blockers
ATE144419T1 (de) * 1989-03-22 1996-11-15 Peter K T Pang Hypertensiver faktor des parathyroids
US5350771A (en) * 1989-03-22 1994-09-27 Peter K. T. Pang Method and treatment for hypertension using combination therapy involving exogenous calcium and calcium channel blockers
DE3921006A1 (de) * 1989-06-27 1991-01-03 Knoll Ag Verwendung von nor-verapamil und nor-gallopamil als antiarteriosklerotica
US5486539A (en) * 1989-12-21 1996-01-23 G. D. Searle & Co. Method of using phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5162569A (en) * 1989-12-21 1992-11-10 G. D. Searle & Co. Phenylacetonitrilealkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
US5247119A (en) * 1990-12-12 1993-09-21 G. D. Searle & Co. Phenylacetonitrilehydroxyalkylaminoalkyl-ortho-substituted aryl compounds as immunosuppressives
DE4203547A1 (de) * 1992-02-07 1993-08-12 Knoll Ag Verfahren zur racemattrennung von verapamil
US5451604A (en) * 1993-07-26 1995-09-19 G. D. Searle & Co. Halogenated phenylacetonitrile alkylaminoalkylphenyl compounds as immunosuppressives
US5695781A (en) * 1995-03-01 1997-12-09 Hallmark Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers
US6083532A (en) * 1995-03-01 2000-07-04 Duramed Pharmaceuticals, Inc. Sustained release formulation containing three different types of polymers and tablet formed therefrom
EP1545519B1 (fr) 2002-08-19 2011-03-23 Pfizer Inc. Therapie de combinaison pour maladies hyperproliferatives
US20060135506A1 (en) * 2003-04-22 2006-06-22 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
US20050159403A1 (en) * 2003-04-22 2005-07-21 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of central nervous system damage
US20050037063A1 (en) * 2003-07-21 2005-02-17 Bolton Anthony E. Combined therapies
EP1796653A2 (fr) * 2004-07-26 2007-06-20 Actelion Pharmaceuticals Ltd. Traitement de l'hypertension pulmonaire au moyen d'iloprost inhale avec une formulation de microparticules
US20060063803A1 (en) * 2004-09-23 2006-03-23 Pfizer Inc 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds
AU2005308575A1 (en) * 2004-11-23 2006-06-01 Warner-Lambert Company Llc 7-(2h-pyrazol-3-yl)-3, 5-dihyroxy-heptanoic acid derivatives as HMG Co-A reductase inhibitors for the treatment of lipidemia
JP2008528626A (ja) * 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク． ヒドロキシル化されたネビボロールを含む薬学的組成物
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
EP2351569B1 (fr) 2005-10-26 2012-08-22 Asahi Kasei Pharma Corporation Fasudil dans des thérapies combinées pour le traitement de l'hypertension artérielle pulmonaire
US7893050B2 (en) * 2005-10-26 2011-02-22 Asahi Kasei Pharma Corporation Fasudil in combination therapies for the treatment of pulmonary arterial hypertension
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
US7919506B2 (en) 2006-03-10 2011-04-05 Pfizer Inc. Dibenzyl amine compounds and derivatives
JP5498168B2 (ja) 2006-12-01 2014-05-21 ブリストル−マイヤーズ スクイブ カンパニー アテローム性動脈硬化および循環器疾患の治療のためのｃｅｔｐ阻害剤としてのｎ−（（３−ベンジル）−２，２−（ビス−フェニル）−プロパン−１−アミン誘導体
JP5421908B2 (ja) 2007-06-20 2014-02-19 マイルストーン ファーマシューティカルズ インコーポレーテッド 短時間作用型フェニルアルキルアミンカルシウムチャネルブロッカーおよびその使用
WO2009032286A2 (fr) 2007-09-06 2009-03-12 Nektar Therapeutics Al, Corporation Conjugués oligomère - bloqueur de canaux calciques
WO2009086464A1 (fr) 2007-12-26 2009-07-09 Sicor Inc. Procédé de préparation de n-méthyl-3,4-diméthoxyphényléthylamine
US8883844B2 (en) 2010-09-24 2014-11-11 Nitrogenix Inc. Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions
SG11201507496UA (en) 2013-04-17 2015-11-27 Pfizer N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases
WO2016055901A1 (fr) 2014-10-08 2016-04-14 Pfizer Inc. Composés d'amide substitué
EP3294703A4 (fr) 2015-05-12 2019-01-02 Piramal Enterprises Limited Procédé de préparation de chlorhydrate de vérapamil
US11248001B2 (en) 2019-01-18 2022-02-15 Astrazeneca Ab PCSK9 inhibitors and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2268108A (en) * 1938-03-11 1941-12-30 Ici Ltd Insecticidal composition
US2446804A (en) * 1943-03-09 1948-08-10 Hoffmann La Roche 3-aryl-3-carbalkoxy piperidines and pyrrolidines and synthesis thereof
US2486794A (en) * 1943-06-25 1949-11-01 Ciba Pharm Prod Inc 1-alkyl-4-(meta-hydroxyphenyl)-piperidyl-(4)-alkylketones and their production
US2527527A (en) * 1948-10-14 1950-10-31 Sterling Drug Inc Methylenedioxy tertiary amines
US3116311A (en) * 1959-09-24 1963-12-31 Delmar Chem Aminonitriles and process for their preparation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0175249A3 (fr) * 1984-09-12 1987-08-19 Roche Diagnostics GmbH Dérivés de phénylacétonitrile
EP0180810A1 (fr) * 1984-10-17 1986-05-14 Hokuriku Pharmaceutical Co.,Ltd Alpha-aminoalcoyl-alpha-alcoylphénylacétonitriles
FR2588258A1 (fr) * 1985-10-04 1987-04-10 Adir Nouveaux derives d'amino-5 valeronitrile, leurs procedes de preparation et les compositions pharmaceutiques les renfermant
US4792559A (en) * 1985-10-04 1988-12-20 Adir Et Compagnie 1,2,3,4-tetrahydroquinoline substituted 5-aminopentanenitrile compounds and their use as calcium modulators
EP0220104A3 (en) * 1985-10-04 1989-04-05 Adir Et Compagnie 5-amino-pentanenitrile derivatives, processes for their preparation and pharmaceutical compositions containing them
EP0257768A1 (fr) * 1986-07-18 1988-03-02 SPOFA Spojené Podniky Pro Zdravotnickou Vyrobu Dérivés de 2-isopropyl-2-phényl-5-(N-méthyl-2-phényl-éthylamino)valéronitrile et des procédés pour leur préparation

Also Published As

Publication number Publication date
GB999612A (en) 1965-07-28
BE615861A (fr) 1962-10-01
US3261859A (en) 1966-07-19
CH418346A (de) 1966-08-15
DE1154810B (de) 1963-09-26

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