FR2684994B1 - Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments. - Google Patents

Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments.

Info

Publication number
FR2684994B1
FR2684994B1 FR9115416A FR9115416A FR2684994B1 FR 2684994 B1 FR2684994 B1 FR 2684994B1 FR 9115416 A FR9115416 A FR 9115416A FR 9115416 A FR9115416 A FR 9115416A FR 2684994 B1 FR2684994 B1 FR 2684994B1
Authority
FR
France
Prior art keywords
benzyloxyimino
medicaments
application
preparation process
substituted radical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR9115416A
Other languages
English (en)
Other versions
FR2684994A1 (fr
Inventor
Jozsef Aszodi
Jean-Francois Chantot
Patrick Fauveau
Ambrieres Solange Gouin D
Daniel Humbert
Christophe Dini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR9115416A priority Critical patent/FR2684994B1/fr
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Priority to US07/989,235 priority patent/US5455238A/en
Priority to CA002085137A priority patent/CA2085137A1/fr
Priority to HU9203929A priority patent/HU221478B/hu
Priority to KR1019920023908A priority patent/KR0143092B1/ko
Priority to HU0104737A priority patent/HU0104737D0/hu
Priority to EP00200918A priority patent/EP1016646A1/fr
Priority to PT92403361T priority patent/PT551034E/pt
Priority to DK92403361T priority patent/DK0551034T3/da
Priority to RU92004562A priority patent/RU2114852C1/ru
Priority to EP92403361A priority patent/EP0551034B1/fr
Priority to MX9207198A priority patent/MX9207198A/es
Priority to DE69231464T priority patent/DE69231464T2/de
Priority to ES92403361T priority patent/ES2149770T3/es
Priority to AT92403361T priority patent/ATE196472T1/de
Priority to SG1996007288A priority patent/SG45426A1/en
Priority to ZA929626A priority patent/ZA929626B/xx
Priority to CN92114376A priority patent/CN1061045C/zh
Priority to JP4352801A priority patent/JP2670954B2/ja
Priority to AU30113/92A priority patent/AU664058C/en
Publication of FR2684994A1 publication Critical patent/FR2684994A1/fr
Priority to US08/167,192 priority patent/US5587372A/en
Application granted granted Critical
Publication of FR2684994B1 publication Critical patent/FR2684994B1/fr
Priority to US08/453,923 priority patent/US5712266A/en
Priority to US08/453,990 priority patent/US5728828A/en
Priority to AU34475/95A priority patent/AU693932B2/en
Priority to US08/769,488 priority patent/US5763617A/en
Priority to JP08241497A priority patent/JP3288951B2/ja
Priority to US08/900,366 priority patent/US6313305B1/en
Priority to US08/903,460 priority patent/US5883248A/en
Priority to GR20000402644T priority patent/GR3034937T3/el
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C239/00—Compounds containing nitrogen-to-halogen bonds; Hydroxylamino compounds or ethers or esters thereof
    • C07C239/08—Hydroxylamino compounds or their ethers or esters
    • C07C239/20—Hydroxylamino compounds or their ethers or esters having oxygen atoms of hydroxylamino groups etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/565—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cephalosporin Compounds (AREA)
FR9115416A 1991-12-12 1991-12-12 Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments. Expired - Fee Related FR2684994B1 (fr)

Priority Applications (29)

Application Number Priority Date Filing Date Title
FR9115416A FR2684994B1 (fr) 1991-12-12 1991-12-12 Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments.
CA002085137A CA2085137A1 (fr) 1991-12-12 1992-12-11 Nouvelles cephalosporines comportant en position 7 un radical benzyloxyimino substitue, leur procede de preparation, leur application comme medicaments
HU9203929A HU221478B (en) 1991-12-12 1992-12-11 Cephalosporine derivatives substituted in 7th position by benzyl-oxi-imino group, pharmaceutical compositions containing the same, method for producing them and intermediates
KR1019920023908A KR0143092B1 (ko) 1991-12-12 1992-12-11 7 위치에 치환된 벤질옥시이미노 라디칼을 함유하는 신규 세팔로스포린, 그의 제조 방법 및 의약으로서의 그의 용도
HU0104737A HU0104737D0 (en) 1991-12-12 1992-12-11 Intermediates for the preparation of cephalosporin derivatives substituted at 7-position by benzyloxyimino group, process for the preparation thereof
EP00200918A EP1016646A1 (fr) 1991-12-12 1992-12-11 Nouveaux produits intermédiaires pour la préparation de céphalosporines comportant en position 7 un radical benzyloxyimino substitué
PT92403361T PT551034E (pt) 1991-12-12 1992-12-11 Antibioticos cefalosporinas com um radical benziloxiimino substituido na posicao 7
DK92403361T DK0551034T3 (da) 1991-12-12 1992-12-11 Antibiotiske cephalosporiner med en i stilling 7 substitueret benzyloxyiminogruppe
RU92004562A RU2114852C1 (ru) 1991-12-12 1992-12-11 Производные син-изомера цефема, способ их получения и фармацевтический состав на их основе
EP92403361A EP0551034B1 (fr) 1991-12-12 1992-12-11 Céphalosporines antibiotiques comportant en position 7 un radical benzyloxyimino substitué
MX9207198A MX9207198A (es) 1991-12-12 1992-12-11 Nuevas cefalosporinas, procedimiento para su preparacion y composiciones farmaceuticas que las contienen
DE69231464T DE69231464T2 (de) 1991-12-12 1992-12-11 Antibiotische Cephalosporine einen substituierten Benzyloxyimino-Radikal in Position 7 tragend
ES92403361T ES2149770T3 (es) 1991-12-12 1992-12-11 Cefalosporinas antibioticos que comprenden en posicion 7 un radical benzoiloxiimino sustituido.
AT92403361T ATE196472T1 (de) 1991-12-12 1992-12-11 Antibiotische cephalosporine einen substituierten benzyloxyimino-radikal in position 7 tragend
US07/989,235 US5455238A (en) 1991-12-12 1992-12-11 Cephalosporins
ZA929626A ZA929626B (en) 1991-12-12 1992-12-11 Cephalosporins containing in position 7 a substituted benzyloxyimino radical, their preparation process and their use as medicaments
SG1996007288A SG45426A1 (en) 1991-12-12 1992-12-11 Novel cephalosporins substituted in the 7-position by a benzylamino radical processes for their preparation and their use as medicaments
CN92114376A CN1061045C (zh) 1991-12-12 1992-12-12 在7位上含有取代的苄氧亚氨基基团的新头孢菌素的制备方法
AU30113/92A AU664058C (en) 1991-12-12 1992-12-14 New cephalosporins containing in position 7 a substituted benzyloxyimino radical, their preparation process and their use as medicaments
JP4352801A JP2670954B2 (ja) 1991-12-12 1992-12-14 ７位に置換ベンジルオキシイミノ基を含有する新規なセファロスポリン、それらの製造法及びそれらの薬剤としての用途
US08/167,192 US5587372A (en) 1991-12-12 1993-12-13 Cephalosporins
US08/453,923 US5712266A (en) 1991-12-12 1995-05-30 Cephalosporins
US08/453,990 US5728828A (en) 1991-12-12 1995-05-30 Cephalosporins
AU34475/95A AU693932B2 (en) 1991-12-12 1995-10-26 7 substituted benzyloxyimino cephalosporins as precursors orintermediates
US08/769,488 US5763617A (en) 1991-12-12 1996-12-18 Cephalosporins
JP08241497A JP3288951B2 (ja) 1991-12-12 1997-03-17 ７位に置換ベンジルオキシイミノ基を含有する新規なセファロスポリンの製造用中間体
US08/900,366 US6313305B1 (en) 1991-12-12 1997-07-21 Cephalosporins
US08/903,460 US5883248A (en) 1991-12-12 1997-07-30 Cephalosporins
GR20000402644T GR3034937T3 (en) 1991-12-12 2000-11-29 Cephalosporins having in position 7 a benzyloxyimino radical substitute, process for their preparation and their use as medicaments.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9115416A FR2684994B1 (fr) 1991-12-12 1991-12-12 Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments.

Publications (2)

Publication Number Publication Date
FR2684994A1 FR2684994A1 (fr) 1993-06-18
FR2684994B1 true FR2684994B1 (fr) 1995-03-03

Family

ID=9419956

Family Applications (1)

Application Number Title Priority Date Filing Date
FR9115416A Expired - Fee Related FR2684994B1 (fr) 1991-12-12 1991-12-12 Nouvelles cephalosporines comportant en position 7, un radical benzyloxyimino substitue, leur procede de preparation et leur application comme medicaments.

Country Status (2)

Country Link
FR (1) FR2684994B1 (fr)
ZA (1) ZA929626B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0723966A4 (fr) * 1994-08-16 1997-01-29 Meiji Seika Co Nouveau derive de cepheme
FR2948660B1 (fr) 2009-07-30 2011-08-19 Oroxcell Derives de 2-amino-2-phenyl-alkanol, leur preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4486586A (en) * 1983-02-10 1984-12-04 Bristol-Myers Company Cephalosporin derivatives
GB8623211D0 (en) * 1986-09-26 1986-10-29 Glaxo Group Ltd Chemical compounds
FR2622585B1 (fr) * 1987-11-03 1991-04-19 Roussel Uclaf Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus

Also Published As

Publication number Publication date
ZA929626B (en) 1993-12-13
FR2684994A1 (fr) 1993-06-18

Similar Documents

Publication Publication Date Title
MA22668A1 (fr) Procede de preparation d'oxamides .
ZA917528B (en) Nasal pharmaceutical composition.
FI915826L (fi) Farmaceutiska aemnen.
AU2211183A (en) Pharmaceutical 1,4-benzodiazepine-2-ones
DE59001400D1 (de) Mittenfreie rollendrehverbindung.
DE69002267D1 (de) Nass-kaltwalzverfahren.
FR2678104B1 (fr) Procede d'extraction combinee transuraniens-strontium.
PH31073A (en) Pharmaceutical composition and process for the preparation thereof.
DE69005622D1 (de) Motorisierte gehhilfe.
FR2695396B1 (fr) Composition formatrice d'elastomere et procede pour sa production.
FR2656309B1 (fr) Nouveaux produits sterouides comportant en position 10, un radical ethyle substitue, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant.
CS265391A3 (en) Novel thienodiazepines, process for their preparation and pharmaceutical comprising them
IL99294A0 (en) Indolonaphthyridines,their production and pharmaceutical compositions containing them
RU92004562A (ru) Новые цефалоспорины, имеющие в положении 7 замещенный оксииминный радикал, метод их получения и их использование в качестве медикаментов, фармацевтический состав на их основе
AU8131091A (en) Tier sheets and method for producing the same
MX9200469A (es) Proceso de dos etapas para la preparacion de 2,2,6,6-tetrametil-4-piperidilaminas
FR2668031B1 (fr) Bouillies bordelaises et leur procede de preparation.
ZA918381B (en) Pharmaceutical compositions.
FR2722790B1 (fr) Nouvelles cephalosporines comportant en position 7 un radical benzyloxymino subtitue, leur procede de preparation leur application comme medicaments
EP0421216A3 (en) Process for the preparation of 2,4, resp. 2,6 dihalo-aniline
FR2678273B1 (fr) Nouvelles cephalosporines comportant un noyau 2-thia cepheme, leur procede de preparation, leur application comme medicaments, et les nouveaux intermediaires obtenus.
FR2674247B1 (fr) Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
FR2692577B1 (fr) Nouvelles quinolones fluorees, leur procede de preparation et les compositions pharmaceutiques en renfermant.
FR2674854B1 (fr) Nouvelles quinolones leur procede de preparation et les compositions pharmaceutiques en refermant.
ZA917789B (en) Pharmaceutical preparation.

Legal Events

Date Code Title Description
CA Change of address
CD Change of name or company name
TP Transmission of property
TP Transmission of property
ST Notification of lapse

Effective date: 20110923