FR2805265B1 - Oligonucleotides immunostimulants - Google Patents

Oligonucleotides immunostimulants

Info

Publication number: FR2805265B1
Authority: FR; France
Prior art keywords: immunostimulating oligonucleotides; immunostimulating; oligonucleotides
Prior art date: 2000-02-18
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

FR0002057A

Other languages

English (en)

Other versions

FR2805265A1 (fr

Inventor

Monique Bachy

Emmanuelle Trannoy

Regis Sodoyer

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Sanofi Pasteur SA

Original Assignee

Aventis Pasteur SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-18

Filing date

2000-02-18

Publication date

2002-04-12

2000-02-18 Application filed by Aventis Pasteur SA filed Critical Aventis Pasteur SA

2000-02-18 Priority to FR0002057A priority Critical patent/FR2805265B1/fr

2001-02-07 Priority to AU2001235616A priority patent/AU2001235616A1/en

2001-02-07 Priority to PCT/FR2001/000349 priority patent/WO2001062909A1/fr

2001-08-24 Publication of FR2805265A1 publication Critical patent/FR2805265A1/fr

2002-04-12 Application granted granted Critical

2002-04-12 Publication of FR2805265B1 publication Critical patent/FR2805265B1/fr

2020-02-18 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

108091034117 Oligonucleotide Proteins 0.000 title 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 title 1
230000003308 immunostimulating effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/18—Type of nucleic acid acting by a non-sequence specific mechanism

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Physics & Mathematics (AREA)
Microbiology (AREA)
Biochemistry (AREA)
Plant Pathology (AREA)
Biophysics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

FR0002057A 2000-02-18 2000-02-18 Oligonucleotides immunostimulants Expired - Fee Related FR2805265B1 (fr)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
FR0002057A FR2805265B1 (fr)	2000-02-18	2000-02-18	Oligonucleotides immunostimulants
AU2001235616A AU2001235616A1 (en)	2000-02-18	2001-02-07	Immunostimulatory oligonucleotides
PCT/FR2001/000349 WO2001062909A1 (fr)	2000-02-18	2001-02-07	Oligonucleotides immunostimulants

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0002057A FR2805265B1 (fr)	2000-02-18	2000-02-18	Oligonucleotides immunostimulants

Publications (2)

Publication Number	Publication Date
FR2805265A1 FR2805265A1 (fr)	2001-08-24
FR2805265B1 true FR2805265B1 (fr)	2002-04-12

Family

ID=8847156

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR0002057A Expired - Fee Related FR2805265B1 (fr)	2000-02-18	2000-02-18	Oligonucleotides immunostimulants

Country Status (3)

Country	Link
AU (1)	AU2001235616A1 (fr)
FR (1)	FR2805265B1 (fr)
WO (1)	WO2001062909A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6207646B1 (en)	1994-07-15	2001-03-27	University Of Iowa Research Foundation	Immunostimulatory nucleic acid molecules
DK1733735T3 (en)	1998-05-22	2017-06-19	Ottawa Hospital Res Inst	Methods and products for the induction of mucosal immunity
ES2572834T3 (es)	1999-02-17	2016-06-02	Csl Limited	Complejos inmunogénicos y métodos relacionados con los mismos
IL148843A0 (en)	1999-09-25	2002-09-12	Univ Iowa Res Found	Immunostimulatory nucleic acids
ES2314099T3 (es)	2001-08-17	2009-03-16	Coley Pharmaceutical Gmbh	Oligonucleotidos inmunoestimulantes con motivos combinados con actividad mejorada.
CA2388049A1 (fr)	2002-05-30	2003-11-30	Immunotech S.A.	Oligonucleotides immunostimulateurs et utilisations connexes
JP2006512927A (ja)	2002-12-11	2006-04-20	コーリーファーマシューティカルグループ，インコーポレイテッド	５’ｃｐｇ核酸およびその使用方法
JP2013521002A (ja)	2010-03-05	2013-06-10	プレジデントアンドフェロウズオブハーバードカレッジ	誘導樹状細胞組成物及びその使用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1996002555A1 (fr) *	1994-07-15	1996-02-01	The University Of Iowa Research Foundation	Oligonucleotides immunomodulateurs
JP2001526688A (ja) *	1997-05-19	2001-12-18	メルクエンドカンパニーインコーポレーテッド	オリゴヌクレオチドアジュバント

2000
- 2000-02-18 FR FR0002057A patent/FR2805265B1/fr not_active Expired - Fee Related
2001
- 2001-02-07 AU AU2001235616A patent/AU2001235616A1/en not_active Abandoned
- 2001-02-07 WO PCT/FR2001/000349 patent/WO2001062909A1/fr not_active Ceased

Also Published As

Publication number	Publication date
FR2805265A1 (fr)	2001-08-24
AU2001235616A1 (en)	2001-09-03
WO2001062909A1 (fr)	2001-08-30

Legal Events

Date	Code	Title	Description
2003-11-28	ST	Notification of lapse

Publication	Publication Date	Title
DE60125312D1 (de)	2007-02-01	Mikroarray
DE60134243D1 (de)	2008-07-10	Biegevorrichtung
DE60140351D1 (de)	2009-12-17	Biegevorrichtung
DE60114185D1 (de)	2006-03-02	Viszerales fettmessgerät
NO20032512L (no)	2003-07-29	Polymerisasjonsprosess
DE60133189D1 (de)	2008-04-24	Aufblasvorrichtung
NO20013129L (no)	2001-12-24	Brönnpakning
NO20030276L (no)	2003-03-18	Fremgangsmåte
DE60110137D1 (de)	2005-05-25	Biochip
DE10196082T1 (de)	2003-03-13	FLIP-CHIP-Montageverfahren
DE60113294D1 (de)	2005-10-13	Aufblasvorrichtung
AR028061A1 (es)	2003-04-23	2-enamino-cetonitrilos fenil-substituidos
AR027931A1 (es)	2003-04-16	Antitranspirantes
FR2805264B1 (fr)	2002-04-12	Oligonucleotides immunostimulants
FR2805883B1 (fr)	2002-10-25	Profile
AT500246B8 (de)	2007-02-15	Chokerring
ATA11602000A (de)	2005-10-15	Sonnenstandsnachführungssystem
UA4607S (uk)	2001-02-15	Профіль
UA4349S (uk)	2000-12-15	Профіль
UA4587S (uk)	2001-02-15	Профіль
UA4727S (uk)	2001-04-16	Профіль
UA4342S (uk)	2000-12-15	Профіль
UA3797S (uk)	2000-10-16	Профіль
UA3799S (uk)	2000-10-16	Профіль
UA4588S (uk)	2001-02-15	Профіль