FR2806418B1 - Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations - Google Patents

Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations

Info

Publication number
FR2806418B1
FR2806418B1 FR0003262A FR0003262A FR2806418B1 FR 2806418 B1 FR2806418 B1 FR 2806418B1 FR 0003262 A FR0003262 A FR 0003262A FR 0003262 A FR0003262 A FR 0003262A FR 2806418 B1 FR2806418 B1 FR 2806418B1
Authority
FR
France
Prior art keywords
hybrid
vectors containing
inducible promoters
inflammation
inflammation inducible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR0003262A
Other languages
English (en)
Other versions
FR2806418A1 (fr
Inventor
Charbel Massaad
Francis Berenbaum
Jean Luc Olivier
Colette Salvat
Gilbert Bereziat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharma SA
Original Assignee
Aventis Pharma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0003262A priority Critical patent/FR2806418B1/fr
Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA
Priority to AT01914000T priority patent/ATE312187T1/de
Priority to CA002403189A priority patent/CA2403189A1/fr
Priority to EP01914000A priority patent/EP1263978B1/fr
Priority to US09/808,388 priority patent/US6870044B2/en
Priority to DK01914000T priority patent/DK1263978T3/da
Priority to ES01914000T priority patent/ES2254378T3/es
Priority to PCT/FR2001/000759 priority patent/WO2001068845A2/fr
Priority to DE60115610T priority patent/DE60115610T2/de
Priority to JP2001567329A priority patent/JP2003526368A/ja
Priority to AU2001239392A priority patent/AU2001239392A1/en
Publication of FR2806418A1 publication Critical patent/FR2806418A1/fr
Application granted granted Critical
Publication of FR2806418B1 publication Critical patent/FR2806418B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C12N9/20—Triglyceride splitting, e.g. by means of lipase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/15—Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/30—Vector systems having a special element relevant for transcription being an enhancer not forming part of the promoter region
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
    • C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Rheumatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
FR0003262A 2000-03-14 2000-03-14 Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations Expired - Fee Related FR2806418B1 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
FR0003262A FR2806418B1 (fr) 2000-03-14 2000-03-14 Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations
DE60115610T DE60115610T2 (de) 2000-03-14 2001-03-14 Durch Entzündungsvermittler induzierbare hybride Promotoren, diese enthaltende Vektoren und Verwendungen davon
EP01914000A EP1263978B1 (fr) 2000-03-14 2001-03-14 Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations
US09/808,388 US6870044B2 (en) 2000-03-14 2001-03-14 Inflammation inducible hybrid promoters, vectors comprising them and uses thereof
DK01914000T DK1263978T3 (da) 2000-03-14 2001-03-14 Hybridpromotorer som kan induceres af inflammation, vektorer indeholdende disse og anvendelse deraf
ES01914000T ES2254378T3 (es) 2000-03-14 2001-03-14 Promotores hibridos inducibles por la inflamacion, vectores que los contienen y utilizaciones.
AT01914000T ATE312187T1 (de) 2000-03-14 2001-03-14 Durch entzündungsvermittler induzierbare hybridpromotoren, diese enthaltende vektoren und verwendungen davon
CA002403189A CA2403189A1 (fr) 2000-03-14 2001-03-14 Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations
JP2001567329A JP2003526368A (ja) 2000-03-14 2001-03-14 炎症により誘導可能なハイブリッドプロモーター、それらを含有するベクター、及びそれらの使用
AU2001239392A AU2001239392A1 (en) 2000-03-14 2001-03-14 Inflammation-inducible hybrid promoters, vectors containing same and uses thereof
PCT/FR2001/000759 WO2001068845A2 (fr) 2000-03-14 2001-03-14 Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0003262A FR2806418B1 (fr) 2000-03-14 2000-03-14 Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations

Publications (2)

Publication Number Publication Date
FR2806418A1 FR2806418A1 (fr) 2001-09-21
FR2806418B1 true FR2806418B1 (fr) 2004-07-16

Family

ID=8848073

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0003262A Expired - Fee Related FR2806418B1 (fr) 2000-03-14 2000-03-14 Promoteurs hybrides inductibles par l'inflammation, vecteurs les contenant et utilisations

Country Status (2)

Country Link
US (1) US6870044B2 (fr)
FR (1) FR2806418B1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1288303A1 (fr) * 2001-08-23 2003-03-05 Aventis Pharma S.A. Systèmes d'expression inductibles utilisant PPAR comme activateurs transcriptionnels
AU2002333682A1 (en) * 2001-08-02 2003-02-17 Gencell S.A. Inducible expression systems employing ppar transcriptional activators
US8697139B2 (en) 2004-09-21 2014-04-15 Frank M. Phillips Method of intervertebral disc treatment using articular chondrocyte cells
MX2010003371A (es) * 2007-09-28 2010-05-05 Intrexon Corp Constructos interruptores genicos terapeuticos y biorreactores para la expresion de moleculas bioterapeuticas y usos de los mismos.
DK2623604T3 (da) * 2012-02-02 2015-06-01 Baylor College Medicine Adenovirusbaseret biologisk afgivelses- og ekspressionssystem til anvendelse ved behandling af osteoartrose

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2269897A (en) * 1992-08-13 1994-02-23 Merck Frosst Canada Inc Assay to detect peroxisome proliferator activity
US6413994B1 (en) * 1999-02-22 2002-07-02 The Salk Institute For Biological Studies Modulators of peroxisome proliferator activated receptor-gamma, and methods for the use thereof
FR2755699B1 (fr) * 1996-11-08 1998-12-18 Rhone Poulenc Rorer Sa Nouvelles constructions et vecteurs pour l'expression ciblee et inductible des genes

Also Published As

Publication number Publication date
US6870044B2 (en) 2005-03-22
FR2806418A1 (fr) 2001-09-21
US20020081719A1 (en) 2002-06-27

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Effective date: 20111130