FR2825092A1 - Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent - Google Patents

Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Info

Publication number
FR2825092A1
FR2825092A1 FR0106791A FR0106791A FR2825092A1 FR 2825092 A1 FR2825092 A1 FR 2825092A1 FR 0106791 A FR0106791 A FR 0106791A FR 0106791 A FR0106791 A FR 0106791A FR 2825092 A1 FR2825092 A1 FR 2825092A1
Authority
FR
France
Prior art keywords
bopi
optionally substituted
heteroaryl
aryl
tryciclic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
FR0106791A
Other languages
English (en)
Other versions
FR2825092B1 (fr
Inventor
Henri Philippe Husson
Renault Sylviane Giorgi
Stephanie Desbene
John Hickman
Alain Pierre
Berthier Laurence Kraus
Bruno Pfeiffer
Pierre Renard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR0106791A priority Critical patent/FR2825092B1/fr
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Priority to BR0209963-2A priority patent/BR0209963A/pt
Priority to PCT/FR2002/001716 priority patent/WO2002094840A2/fr
Priority to EP02735551A priority patent/EP1399455A2/fr
Priority to MXPA03010597A priority patent/MXPA03010597A/es
Priority to CZ20033496A priority patent/CZ20033496A3/cs
Priority to HU0401345A priority patent/HUP0401345A3/hu
Priority to CA002448197A priority patent/CA2448197A1/fr
Priority to PL02364083A priority patent/PL364083A1/xx
Priority to KR10-2003-7015307A priority patent/KR20040008190A/ko
Priority to EA200301172A priority patent/EA200301172A1/ru
Priority to US10/477,244 priority patent/US20040180917A1/en
Priority to JP2002591513A priority patent/JP2004529191A/ja
Priority to CNA028103483A priority patent/CN1511161A/zh
Priority to SK1601-2003A priority patent/SK16012003A3/sk
Priority to ARP020101905A priority patent/AR033914A1/es
Publication of FR2825092A1 publication Critical patent/FR2825092A1/fr
Priority to ZA200308628A priority patent/ZA200308628B/en
Priority to NO20035214A priority patent/NO20035214L/no
Application granted granted Critical
Publication of FR2825092B1 publication Critical patent/FR2825092B1/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

Composé de formuls (I) : (CF DESSIN DANS BOPI) dans laquelle :* (CF DESSIN DANS BOPI) représente une liaison simple ou double, * (CF DESSIN DANS BOPI) représente un cycle tel que défini dans la description, * R1 représente un groupement choisi parmi hydrogène, aryle, hétéroaryle, cycloalkyle, alkyle éventuellement substitué, et COR11 , dans lequel R11 est tel que défini dans la description, * R2 à R3 sont tels que définis dans la description,* (CF DESSIN DANS BOPI) représente un groupement aryle, hétéroaryle ou arylalkyle, ses isomères optiques, ses sels d'addition à un acide pharmaceutiquement acceptable ainsi que ses hydrates et solvates. Médicaments. * R2 , à R8 représentent chacun un groupement choisi parmi hydrogène, halogène, hydroxy, polyhalogénoalkyle, nitro, alkyle éventuellement substitué, amino éventuellement substitué, alkoxy éventuellement substitué, -OPO (OH) 2 et (CF DESSIN DANS BOPI) dans laquelle m représente un entier tel que 1 <= m <= 4, ou R2 avec R3 , ou R3 avec R4 , ou R4 avec R5 , forment ensemble avec les atomes de carbone qui les portent un groupement mono- oubicyclique contenant éventuellement 1 ou 2 hétéroatomes et éventuellement substitué,* (CF DESSIN DANS BOPI) représente un groupement aryle, hétéroaryle ou arylalkyle,ses isomères optiques, ses sels d'addition à un acide pharmaceutiquement acceptable ainsi que ses hydrates et solvates. Médicaments.
FR0106791A 2001-05-23 2001-05-23 Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent Expired - Fee Related FR2825092B1 (fr)

Priority Applications (18)

Application Number Priority Date Filing Date Title
FR0106791A FR2825092B1 (fr) 2001-05-23 2001-05-23 Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US10/477,244 US20040180917A1 (en) 2001-05-23 2002-05-22 Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing the same
EP02735551A EP1399455A2 (fr) 2001-05-23 2002-05-22 Derives tricycliques de dihydroquinoleines,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
MXPA03010597A MXPA03010597A (es) 2001-05-23 2002-05-22 Derivados de triciclicos de dihidroquinolinas proceso para prepararlos y composiciones farmaceuticas que los contienen.
CZ20033496A CZ20033496A3 (cs) 2001-05-23 2002-05-22 Tricyklické dihydrochinolinové sloučeniny, způsob jejich přípravy a farmaceutické kompozice které je obsahují
HU0401345A HUP0401345A3 (en) 2001-05-23 2002-05-22 Novel tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing same
CA002448197A CA2448197A1 (fr) 2001-05-23 2002-05-22 Derives tricycliques de dihydroquinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
PL02364083A PL364083A1 (en) 2001-05-23 2002-05-22 Tricyclic dihydro-quinoline derivatives, method for preparing same and pharmaceutical compositions containing same
KR10-2003-7015307A KR20040008190A (ko) 2001-05-23 2002-05-22 트리시클릭 디히드로퀴놀린 유도체, 이의 제조 방법 및이를 함유하는 약제조성물
CNA028103483A CN1511161A (zh) 2001-05-23 2002-05-22 三环类二氢喹啉衍生物、其制备方法以及包含它们的药物组合物
BR0209963-2A BR0209963A (pt) 2001-05-23 2002-05-22 Derivados tricìclicos de dihidro-quinoleìnas, o respectivo processo de preparação e as composições farmacêuticas que os contêm
PCT/FR2002/001716 WO2002094840A2 (fr) 2001-05-23 2002-05-22 Derives tricycliques de dihydroquinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EA200301172A EA200301172A1 (ru) 2001-05-23 2002-05-22 Новые соединения трициклических дигидрохинолинов, способ их получения и фармацевтические композиции, содержащие их
SK1601-2003A SK16012003A3 (sk) 2001-05-23 2002-05-22 Tricyklické dihydrochinolínové zlúčeniny, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú
JP2002591513A JP2004529191A (ja) 2001-05-23 2002-05-22 新しい三環式ジヒドロキノリン化合物、これらの製造方法及びこれらを含む医薬組成物
ARP020101905A AR033914A1 (es) 2001-05-23 2002-05-23 Compuestos triciclicos dihidroquinolina, un procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ZA200308628A ZA200308628B (en) 2001-05-23 2003-11-05 Tricyclic dihydroquinoline compounds, a process for their preparation and pharmaceutical compositions containing them.
NO20035214A NO20035214L (no) 2001-05-23 2003-11-24 Tricykliske dihydrokinolinforbindelser, fremgangsmåte for deres fremstilling og farmasöytiske sammensetninger inneholdende dem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0106791A FR2825092B1 (fr) 2001-05-23 2001-05-23 Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
FR2825092A1 true FR2825092A1 (fr) 2002-11-29
FR2825092B1 FR2825092B1 (fr) 2005-01-14

Family

ID=8863588

Family Applications (1)

Application Number Title Priority Date Filing Date
FR0106791A Expired - Fee Related FR2825092B1 (fr) 2001-05-23 2001-05-23 Nouveau derives trycicliques de dihydro-quinoleines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Country Status (18)

Country Link
US (1) US20040180917A1 (fr)
EP (1) EP1399455A2 (fr)
JP (1) JP2004529191A (fr)
KR (1) KR20040008190A (fr)
CN (1) CN1511161A (fr)
AR (1) AR033914A1 (fr)
BR (1) BR0209963A (fr)
CA (1) CA2448197A1 (fr)
CZ (1) CZ20033496A3 (fr)
EA (1) EA200301172A1 (fr)
FR (1) FR2825092B1 (fr)
HU (1) HUP0401345A3 (fr)
MX (1) MXPA03010597A (fr)
NO (1) NO20035214L (fr)
PL (1) PL364083A1 (fr)
SK (1) SK16012003A3 (fr)
WO (1) WO2002094840A2 (fr)
ZA (1) ZA200308628B (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12013502619A1 (en) 2011-06-17 2014-02-17 Merck Sharp & Dohme Cycloalkyl-fused tetrahydroquinolines as crth2 receptor modulators
CA2936874A1 (fr) 2014-01-15 2015-07-23 Guy Chabot Analogues de 4-azapodophyllotoxine solubles dans l'eau
US11731980B1 (en) 2023-03-22 2023-08-22 King Faisal University Furo[3,4-b]quinolone compounds as antibacterial agents

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1103554A1 (fr) * 1999-11-24 2001-05-30 Adir Et Compagnie Dérivés de dihydrofuro-(3,4-b) quinoléin-1-ones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1103554A1 (fr) * 1999-11-24 2001-05-30 Adir Et Compagnie Dérivés de dihydrofuro-(3,4-b) quinoléin-1-ones, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HITOTSUYANAGI Y Y ET AL: "4-Aza-2,3-dehydro-4-deoxypodophyllotoxins: simple aza-podophyllotoxin analogues possessing potent cytotoxicity", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 10, no. 4, February 2000 (2000-02-01), pages 315 - 317, XP004189922, ISSN: 0960-894X *
MATSUO, K.; KOBAYASHI, M.: "Synthesis and reaction of 9-aryl-1H,3H-thieno[3,4-b]-quinolin-1-ones", CHEM. EXPRESS, vol. 8, no. 6, 1993, pages 389 - 92, XP001053563 *

Also Published As

Publication number Publication date
CN1511161A (zh) 2004-07-07
NO20035214D0 (no) 2003-11-24
KR20040008190A (ko) 2004-01-28
MXPA03010597A (es) 2004-03-09
EA200301172A1 (ru) 2004-04-29
HUP0401345A3 (en) 2006-11-28
WO2002094840A3 (fr) 2003-05-01
NO20035214L (no) 2003-11-24
CA2448197A1 (fr) 2002-11-28
HUP0401345A2 (hu) 2004-11-29
FR2825092B1 (fr) 2005-01-14
WO2002094840A2 (fr) 2002-11-28
EP1399455A2 (fr) 2004-03-24
SK16012003A3 (sk) 2004-06-08
CZ20033496A3 (cs) 2004-04-14
ZA200308628B (en) 2004-11-05
JP2004529191A (ja) 2004-09-24
BR0209963A (pt) 2004-04-13
PL364083A1 (en) 2004-12-13
US20040180917A1 (en) 2004-09-16
AR033914A1 (es) 2004-01-07

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Effective date: 20070131