FR2853663B1 - Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine - Google Patents

Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine

Info

Publication number: FR2853663B1
Authority: FR; France
Prior art keywords: mastocyte; obtaining; lines; type molecules; producing heparin
Prior art date: 2003-04-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

FR0304671A

Other languages

English (en)

Other versions

FR2853663A1 (fr

Inventor

Jean Marc Guillaume

Sandrine Perez

Werner Dittrich

Christine Michele Pie Andreoni

Romain Paillot

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Aventis Pharma SA

Original Assignee

Aventis Pharma SA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-04-14

Filing date

2003-04-14

Publication date

2007-08-31

2003-04-14 Priority to FR0304671A priority Critical patent/FR2853663B1/fr

2003-04-14 Application filed by Aventis Pharma SA filed Critical Aventis Pharma SA

2004-04-13 Priority to PCT/FR2004/000902 priority patent/WO2004092356A2/fr

2004-04-13 Priority to US10/823,142 priority patent/US20050181484A1/en

2004-04-13 Priority to ARP040101235A priority patent/AR043862A1/es

2004-04-13 Priority to EP04742485A priority patent/EP1616002A2/fr

2004-04-13 Priority to TW093110163A priority patent/TW200506059A/zh

2004-04-13 Priority to JP2006505794A priority patent/JP2006522597A/ja

2004-10-15 Publication of FR2853663A1 publication Critical patent/FR2853663A1/fr

2007-08-31 Application granted granted Critical

2007-08-31 Publication of FR2853663B1 publication Critical patent/FR2853663B1/fr

2007-11-12 Priority to US11/938,422 priority patent/US20080064095A1/en

2023-04-14 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title 1
229960002897 heparin Drugs 0.000 title 1
229920000669 heparin Polymers 0.000 title 1
210000003630 histaminocyte Anatomy 0.000 title 1
235000015277 pork Nutrition 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0642—Granulocytes, e.g. basopils, eosinophils, neutrophils, mast cells
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
- C12P19/28—N-glycosides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/125—Stem cell factor [SCF], c-kit ligand [KL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/22—Colony stimulating factors (G-CSF, GM-CSF)
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/04—Immortalised cells

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Genetics & Genomics (AREA)
Bioinformatics & Cheminformatics (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biomedical Technology (AREA)
Molecular Biology (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Immunology (AREA)
Cell Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Hematology (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)
Peptides Or Proteins (AREA)

FR0304671A 2003-04-14 2003-04-14 Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine Expired - Fee Related FR2853663B1 (fr)

Priority Applications (8)

Application Number	Priority Date	Filing Date	Title
FR0304671A FR2853663B1 (fr)	2003-04-14	2003-04-14	Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine
US10/823,142 US20050181484A1 (en)	2003-04-14	2004-04-13	Method for obtaining mastocyte lines from pig tissues and for producing heparin-type molecules
ARP040101235A AR043862A1 (es)	2003-04-14	2004-04-13	Procedimiento para la obtencion de estirpes celulares de mastocitos a partir de tejidos de cerdo y procedimiento para la produccion de moleculas de tipo de la heparina
EP04742485A EP1616002A2 (fr)	2003-04-14	2004-04-13	Procede d obtention de lignees de mastocytes a partir de tis sus de porcs et procede de production de molecules de type heparine
PCT/FR2004/000902 WO2004092356A2 (fr)	2003-04-14	2004-04-13	Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine
TW093110163A TW200506059A (en)	2003-04-14	2004-04-13	Method for obtaining mastocyte lines from pig tissues and for producing heparin-type molecules
JP2006505794A JP2006522597A (ja)	2003-04-14	2004-04-13	ブタ組織から肥満細胞系統を得る方法およびヘパリンタイプの分子を製造する方法
US11/938,422 US20080064095A1 (en)	2003-04-14	2007-11-12	Method for obtaining mastocyte lines from pig tissues and for producing heparin-type modules

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR0304671A FR2853663B1 (fr)	2003-04-14	2003-04-14	Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine

Publications (2)

Publication Number	Publication Date
FR2853663A1 FR2853663A1 (fr)	2004-10-15
FR2853663B1 true FR2853663B1 (fr)	2007-08-31

Family

ID=33041865

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FR0304671A Expired - Fee Related FR2853663B1 (fr)	2003-04-14	2003-04-14	Procede d'obtention de lignees de mastocytes a partir de tissus de porcs et procede de production de molecules de type heparine

Country Status (7)

Country	Link
US (2)	US20050181484A1 (fr)
EP (1)	EP1616002A2 (fr)
JP (1)	JP2006522597A (fr)
AR (1)	AR043862A1 (fr)
FR (1)	FR2853663B1 (fr)
TW (1)	TW200506059A (fr)
WO (1)	WO2004092356A2 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2876386B1 (fr) *	2004-10-12	2007-04-06	Aventis Pharma Sa	Lignees de mastocytes porcins produisant des molecules de type heparine
WO2008116889A1 (fr) *	2007-03-26	2008-10-02	Institut Pasteur	Nouveau modèle in vitro de mastocytes de type séreux matures servant à l'analyse de maladies autoimmunes et d'inflammations allergiques
JP2009171895A (ja) *	2008-01-24	2009-08-06	Hitachi Software Eng Co Ltd	核内ノンコーディングｒｎａの機能解析方法
HK1200484A1 (zh)	2011-09-14	2015-08-07	Translate Bio Ma, Inc.	多聚寡核苷酸化合物
CN104583398A (zh) *	2012-05-16	2015-04-29	Rana医疗有限公司	用于调节基因表达的组合物和方法
CN104583402A (zh)	2012-05-16	2015-04-29	Rana医疗有限公司	用于调节mecp2表达的组合物和方法
US10174315B2 (en)	2012-05-16	2019-01-08	The General Hospital Corporation	Compositions and methods for modulating hemoglobin gene family expression
CN104540946A (zh)	2012-05-16	2015-04-22	Rana医疗有限公司	用于调节utrn表达的组合物和方法
JP2015523854A (ja)	2012-05-16	2015-08-20	ラナセラピューティクスインコーポレイテッド	Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
EA201492120A1 (ru) *	2012-05-16	2015-10-30	Рана Терапьютикс, Инк.	Композиции и способы для модулирования экспрессии atp2a2
US10837014B2 (en)	2012-05-16	2020-11-17	Translate Bio Ma, Inc.	Compositions and methods for modulating SMN gene family expression
US20150247141A1 (en)	2012-09-14	2015-09-03	Rana Therapeutics, Inc.	Multimeric oligonucleotide compounds
CN111094550A (zh) *	2017-09-08	2020-05-01	株式会社大塚制药工厂	来源于幼猪的干细胞及其制备方法
NL2035425B1 (en) *	2023-07-19	2024-05-30	Univ China Agricultural	Method for isolating and culturing bone marrow-derived mast cells of newborn piglets

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1990014418A1 (fr) *	1989-05-19	1990-11-29	The Uab Research Foundation	Lignees cellulaires de mastocytome murine produisant l'heparine
US20030125519A1 (en) *	1990-08-27	2003-07-03	Peter Besmer	Ligand for the c-kit receptor and methods of use thereof
ATE299030T1 (de) *	1996-07-10	2005-07-15	Meiji Dairies Corp	Verwendung von proteinen aus der mk familie als hämatopoietischer faktor
JP2002504814A (ja) *	1997-05-30	2002-02-12	ピッグインプルーブメントカンパニーユーケイリミティッド	動物生産物を分析する方法
FI974321A0 (fi) *	1997-11-25	1997-11-25	Jenny Ja Antti Wihurin Rahasto	Multipel heparinglykosaminoglykan och en proteoglykan innehaollande dessa
FR2831184B1 (fr) *	2001-10-22	2004-01-02	Agronomique Inst Nat Rech	Cultures de mastocytes de porc et leurs utilisations
FR2831186B1 (fr) *	2001-10-22	2004-06-18	Aventis Pharma Sa	Production d'heparine a partir de cultures de mastocytes

2003
- 2003-04-14 FR FR0304671A patent/FR2853663B1/fr not_active Expired - Fee Related
2004
- 2004-04-13 WO PCT/FR2004/000902 patent/WO2004092356A2/fr not_active Ceased
- 2004-04-13 JP JP2006505794A patent/JP2006522597A/ja not_active Withdrawn
- 2004-04-13 EP EP04742485A patent/EP1616002A2/fr not_active Withdrawn
- 2004-04-13 TW TW093110163A patent/TW200506059A/zh unknown
- 2004-04-13 AR ARP040101235A patent/AR043862A1/es not_active Application Discontinuation
- 2004-04-13 US US10/823,142 patent/US20050181484A1/en not_active Abandoned
2007
- 2007-11-12 US US11/938,422 patent/US20080064095A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20080064095A1 (en)	2008-03-13
JP2006522597A (ja)	2006-10-05
EP1616002A2 (fr)	2006-01-18
AR043862A1 (es)	2005-08-17
WO2004092356A3 (fr)	2005-05-26
WO2004092356A2 (fr)	2004-10-28
US20050181484A1 (en)	2005-08-18
TW200506059A (en)	2005-02-16
FR2853663A1 (fr)	2004-10-15

Legal Events

Date	Code	Title	Description
2010-01-22	ST	Notification of lapse	Effective date: 20091231

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