FR2859633A1 - Immunogene synthetique pour le traitement et la prevention des abus de produits narcotiques et psychoactifs - Google Patents
Immunogene synthetique pour le traitement et la prevention des abus de produits narcotiques et psychoactifs Download PDFInfo
- Publication number
- FR2859633A1 FR2859633A1 FR0409762A FR0409762A FR2859633A1 FR 2859633 A1 FR2859633 A1 FR 2859633A1 FR 0409762 A FR0409762 A FR 0409762A FR 0409762 A FR0409762 A FR 0409762A FR 2859633 A1 FR2859633 A1 FR 2859633A1
- Authority
- FR
- France
- Prior art keywords
- conjugate
- narcotic
- synthetic
- polyoxydonium
- immunogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000002163 immunogen Effects 0.000 title claims abstract description 38
- 230000003533 narcotic effect Effects 0.000 title claims abstract description 17
- 239000000126 substance Substances 0.000 title description 14
- 206010012335 Dependence Diseases 0.000 title description 2
- 238000011321 prophylaxis Methods 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 108010074605 gamma-Globulins Proteins 0.000 claims abstract description 19
- -1 aromatic propaneamines Chemical class 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims abstract description 11
- 108010058846 Ovalbumin Proteins 0.000 claims abstract description 7
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 7
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 7
- 125000006840 diphenylmethane group Chemical class 0.000 claims abstract description 6
- 230000000506 psychotropic effect Effects 0.000 claims abstract description 6
- IHWDSEPNZDYMNF-UHFFFAOYSA-N 1H-indol-2-amine Chemical class C1=CC=C2NC(N)=CC2=C1 IHWDSEPNZDYMNF-UHFFFAOYSA-N 0.000 claims abstract description 5
- 150000003053 piperidines Chemical class 0.000 claims abstract description 5
- 229920000867 polyelectrolyte Polymers 0.000 claims abstract description 5
- 150000007656 barbituric acids Chemical class 0.000 claims abstract description 4
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical class C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims description 7
- 229940092253 ovalbumin Drugs 0.000 claims description 6
- 231100000757 Microbial toxin Toxicity 0.000 claims description 4
- 230000002265 prevention Effects 0.000 claims description 4
- 150000003384 small molecules Chemical class 0.000 claims 1
- 229920005617 polyoxidonium Polymers 0.000 abstract description 6
- 231100000614 poison Toxicity 0.000 abstract description 4
- 239000002574 poison Substances 0.000 abstract description 3
- 231100000566 intoxication Toxicity 0.000 abstract description 2
- 230000035987 intoxication Effects 0.000 abstract description 2
- 231100000699 Bacterial toxin Toxicity 0.000 abstract 1
- 239000000688 bacterial toxin Substances 0.000 abstract 1
- 150000002537 isoquinolines Chemical class 0.000 abstract 1
- 229960002069 diamorphine Drugs 0.000 description 24
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 24
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 22
- 230000015572 biosynthetic process Effects 0.000 description 22
- 238000003127 radioimmunoassay Methods 0.000 description 21
- 238000003786 synthesis reaction Methods 0.000 description 19
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 16
- 238000012360 testing method Methods 0.000 description 14
- 238000000034 method Methods 0.000 description 12
- 229960005181 morphine Drugs 0.000 description 12
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 description 12
- 229960003086 naltrexone Drugs 0.000 description 12
- 241000283973 Oryctolagus cuniculus Species 0.000 description 10
- 229960001797 methadone Drugs 0.000 description 10
- 210000002966 serum Anatomy 0.000 description 10
- 239000000203 mixture Substances 0.000 description 9
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 description 8
- 229960004126 codeine Drugs 0.000 description 8
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 8
- 229940127240 opiate Drugs 0.000 description 8
- 231100000636 lethal dose Toxicity 0.000 description 7
- 241001465754 Metazoa Species 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 230000006870 function Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 206010020751 Hypersensitivity Diseases 0.000 description 5
- 108010008038 Synthetic Vaccines Proteins 0.000 description 5
- 206010013023 diphtheria Diseases 0.000 description 5
- 230000003053 immunization Effects 0.000 description 5
- 238000002649 immunization Methods 0.000 description 5
- 229920001184 polypeptide Polymers 0.000 description 5
- 238000002360 preparation method Methods 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- 229940125717 barbiturate Drugs 0.000 description 4
- 229940079593 drug Drugs 0.000 description 4
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 230000004727 humoral immunity Effects 0.000 description 4
- 229960002715 nicotine Drugs 0.000 description 4
- 230000000144 pharmacologic effect Effects 0.000 description 4
- 238000001179 sorption measurement Methods 0.000 description 4
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 3
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 description 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- VAYOSLLFUXYJDT-RDTXWAMCSA-N Lysergic acid diethylamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N(CC)CC)C2)=C3C2=CNC3=C1 VAYOSLLFUXYJDT-RDTXWAMCSA-N 0.000 description 3
- 229940025084 amphetamine Drugs 0.000 description 3
- HNYOPLTXPVRDBG-UHFFFAOYSA-N barbituric acid Chemical compound O=C1CC(=O)NC(=O)N1 HNYOPLTXPVRDBG-UHFFFAOYSA-N 0.000 description 3
- 230000007969 cellular immunity Effects 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 229960003920 cocaine Drugs 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000004081 narcotic agent Substances 0.000 description 3
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 3
- 201000009032 substance abuse Diseases 0.000 description 3
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 2
- 206010002199 Anaphylactic shock Diseases 0.000 description 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical class CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
- 208000026251 Opioid-Related disease Diseases 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- VOXIUXZAOFEFBL-UHFFFAOYSA-N Voacangin Natural products CCC1CC2CN3CC1C(C2)(OC(=O)C)c4[nH]c5ccc(OC)cc5c4C3 VOXIUXZAOFEFBL-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 208000003455 anaphylaxis Diseases 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 230000001580 bacterial effect Effects 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 206010013663 drug dependence Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000035931 haemagglutination Effects 0.000 description 2
- OLOCMRXSJQJJPL-UHFFFAOYSA-N ibogaine Natural products CCC1CC2CC3C1N(C2)C=Cc4c3[nH]c5ccc(OC)cc45 OLOCMRXSJQJJPL-UHFFFAOYSA-N 0.000 description 2
- AREITJMUSRHSBK-UHFFFAOYSA-N ibogamine Natural products CCC1CC2C3CC1CN2CCc4c3[nH]c5ccccc45 AREITJMUSRHSBK-UHFFFAOYSA-N 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 230000003308 immunostimulating effect Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000010253 intravenous injection Methods 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- RHCSKNNOAZULRK-UHFFFAOYSA-N mescaline Chemical compound COC1=CC(CCN)=CC(OC)=C1OC RHCSKNNOAZULRK-UHFFFAOYSA-N 0.000 description 2
- 239000002207 metabolite Substances 0.000 description 2
- TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 2
- 150000002987 phenanthrenes Chemical class 0.000 description 2
- JTJMJGYZQZDUJJ-UHFFFAOYSA-N phencyclidine Chemical compound C1CCCCN1C1(C=2C=CC=CC=2)CCCCC1 JTJMJGYZQZDUJJ-UHFFFAOYSA-N 0.000 description 2
- 229950010883 phencyclidine Drugs 0.000 description 2
- DDBREPKUVSBGFI-UHFFFAOYSA-N phenobarbital Chemical compound C=1C=CC=CC=1C1(CC)C(=O)NC(=O)NC1=O DDBREPKUVSBGFI-UHFFFAOYSA-N 0.000 description 2
- 229960002695 phenobarbital Drugs 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 150000003254 radicals Chemical class 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000010254 subcutaneous injection Methods 0.000 description 2
- 239000007929 subcutaneous injection Substances 0.000 description 2
- 208000011117 substance-related disease Diseases 0.000 description 2
- 230000009466 transformation Effects 0.000 description 2
- 238000000844 transformation Methods 0.000 description 2
- 239000002676 xenobiotic agent Substances 0.000 description 2
- DQJCDTNMLBYVAY-ZXXIYAEKSA-N (2S,5R,10R,13R)-16-{[(2R,3S,4R,5R)-3-{[(2S,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}-5-(ethylamino)-6-hydroxy-2-(hydroxymethyl)oxan-4-yl]oxy}-5-(4-aminobutyl)-10-carbamoyl-2,13-dimethyl-4,7,12,15-tetraoxo-3,6,11,14-tetraazaheptadecan-1-oic acid Chemical compound NCCCC[C@H](C(=O)N[C@@H](C)C(O)=O)NC(=O)CC[C@H](C(N)=O)NC(=O)[C@@H](C)NC(=O)C(C)O[C@@H]1[C@@H](NCC)C(O)O[C@H](CO)[C@H]1O[C@H]1[C@H](NC(C)=O)[C@@H](O)[C@H](O)[C@@H](CO)O1 DQJCDTNMLBYVAY-ZXXIYAEKSA-N 0.000 description 1
- TXQAZWIBPGKHOX-UHFFFAOYSA-N 1H-indol-3-amine Chemical compound C1=CC=C2C(N)=CNC2=C1 TXQAZWIBPGKHOX-UHFFFAOYSA-N 0.000 description 1
- JDTUPLBMGDDPJS-UHFFFAOYSA-N 2-methoxy-2-phenylethanol Chemical compound COC(CO)C1=CC=CC=C1 JDTUPLBMGDDPJS-UHFFFAOYSA-N 0.000 description 1
- SHXWCVYOXRDMCX-UHFFFAOYSA-N 3,4-methylenedioxymethamphetamine Chemical compound CNC(C)CC1=CC=C2OCOC2=C1 SHXWCVYOXRDMCX-UHFFFAOYSA-N 0.000 description 1
- RBTBFTRPCNLSDE-UHFFFAOYSA-N 3,7-bis(dimethylamino)phenothiazin-5-ium Chemical compound C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 RBTBFTRPCNLSDE-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 102000009027 Albumins Human genes 0.000 description 1
- 101001023095 Anemonia sulcata Delta-actitoxin-Avd1a Proteins 0.000 description 1
- 101000641989 Araneus ventricosus Kunitz-type U1-aranetoxin-Av1a Proteins 0.000 description 1
- 108030001720 Bontoxilysin Proteins 0.000 description 1
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 101001028691 Carybdea rastonii Toxin CrTX-A Proteins 0.000 description 1
- 101000685083 Centruroides infamatus Beta-toxin Cii1 Proteins 0.000 description 1
- 101000685085 Centruroides noxius Toxin Cn1 Proteins 0.000 description 1
- 101001028688 Chironex fleckeri Toxin CfTX-1 Proteins 0.000 description 1
- 102000009016 Cholera Toxin Human genes 0.000 description 1
- 108010049048 Cholera Toxin Proteins 0.000 description 1
- 235000015655 Crocus sativus Nutrition 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- 101000644407 Cyriopagopus schmidti U6-theraphotoxin-Hs1a Proteins 0.000 description 1
- 150000008574 D-amino acids Chemical class 0.000 description 1
- 206010013654 Drug abuse Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- WVVSZNPYNCNODU-CJBNDPTMSA-N Ergometrine Natural products C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@@H](CO)C)C2)=C3C2=CNC3=C1 WVVSZNPYNCNODU-CJBNDPTMSA-N 0.000 description 1
- 108010044091 Globulins Proteins 0.000 description 1
- 102000006395 Globulins Human genes 0.000 description 1
- 102000002068 Glycopeptides Human genes 0.000 description 1
- 108010015899 Glycopeptides Proteins 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108010003272 Hyaluronate lyase Proteins 0.000 description 1
- 108060003951 Immunoglobulin Proteins 0.000 description 1
- WVVSZNPYNCNODU-XTQGRXLLSA-N Lysergic acid propanolamide Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@H](CO)C)C2)=C3C2=CNC3=C1 WVVSZNPYNCNODU-XTQGRXLLSA-N 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000018526 Narcotic-Related disease Diseases 0.000 description 1
- 241000208125 Nicotiana Species 0.000 description 1
- 235000002637 Nicotiana tabacum Nutrition 0.000 description 1
- 102000003840 Opioid Receptors Human genes 0.000 description 1
- 108090000137 Opioid Receptors Proteins 0.000 description 1
- 208000004224 Opium Dependence Diseases 0.000 description 1
- 101000679608 Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) Cysteine rich necrotrophic effector Tox1 Proteins 0.000 description 1
- 108010071390 Serum Albumin Proteins 0.000 description 1
- 102000007562 Serum Albumin Human genes 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- 108010055044 Tetanus Toxin Proteins 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000000172 allergic effect Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 238000013475 authorization Methods 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- HFACYLZERDEVSX-UHFFFAOYSA-N benzidine Chemical compound C1=CC(N)=CC=C1C1=CC=C(N)C=C1 HFACYLZERDEVSX-UHFFFAOYSA-N 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 229940053031 botulinum toxin Drugs 0.000 description 1
- 239000012888 bovine serum Substances 0.000 description 1
- 229940098773 bovine serum albumin Drugs 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- IRXBNHGNHKNOJI-UHFFFAOYSA-N butanedioyl dichloride Chemical compound ClC(=O)CCC(Cl)=O IRXBNHGNHKNOJI-UHFFFAOYSA-N 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229960002179 ephedrine Drugs 0.000 description 1
- 229960001405 ergometrine Drugs 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
- HSIBGVUMFOSJPD-CFDPKNGZSA-N ibogaine Chemical compound N1([C@@H]2[C@H]3C[C@H](C1)C[C@@H]2CC)CCC1=C3NC2=CC=C(OC)C=C12 HSIBGVUMFOSJPD-CFDPKNGZSA-N 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 230000008105 immune reaction Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 102000018358 immunoglobulin Human genes 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 229940072221 immunoglobulins Drugs 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 239000007927 intramuscular injection Substances 0.000 description 1
- 238000010255 intramuscular injection Methods 0.000 description 1
- 231100000518 lethal Toxicity 0.000 description 1
- 230000001665 lethal effect Effects 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 229950002454 lysergide Drugs 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- RMCDUNHIVVEEDD-UHFFFAOYSA-N methylcyclopropane Chemical compound [CH2]C1CC1 RMCDUNHIVVEEDD-UHFFFAOYSA-N 0.000 description 1
- 229960000907 methylthioninium chloride Drugs 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 201000005040 opiate dependence Diseases 0.000 description 1
- 229940005483 opioid analgesics Drugs 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 125000001792 phenanthrenyl group Chemical group C1(=CC=CC=2C3=CC=CC=C3C=CC12)* 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- WGYKZJWCGVVSQN-UHFFFAOYSA-N propylamine Chemical compound CCCN WGYKZJWCGVVSQN-UHFFFAOYSA-N 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 239000002516 radical scavenger Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 235000013974 saffron Nutrition 0.000 description 1
- 239000004248 saffron Substances 0.000 description 1
- 210000004989 spleen cell Anatomy 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000001256 steam distillation Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 231100000736 substance abuse Toxicity 0.000 description 1
- 229940118376 tetanus toxin Drugs 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 239000013598 vector Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0013—Therapeutic immunisation against small organic molecules, e.g. cocaine, nicotine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39583—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials not provided for elsewhere, e.g. haptens, coenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2003127705/15A RU2236257C1 (ru) | 2003-09-15 | 2003-09-15 | Синтетический иммуноген для терапии и профилактики злоупотреблений наркотическими и психоактивными веществами |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| FR2859633A1 true FR2859633A1 (fr) | 2005-03-18 |
Family
ID=33434130
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FR0409762A Pending FR2859633A1 (fr) | 2003-09-15 | 2004-09-15 | Immunogene synthetique pour le traitement et la prevention des abus de produits narcotiques et psychoactifs |
Country Status (5)
| Country | Link |
|---|---|
| DE (1) | DE102004044666A1 (it) |
| EA (1) | EA006248B1 (it) |
| FR (1) | FR2859633A1 (it) |
| IT (1) | ITTO20040621A1 (it) |
| RU (1) | RU2236257C1 (it) |
Cited By (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010100632A2 (en) | 2009-03-06 | 2010-09-10 | Novartis Ag | Chlamydia antigens |
| WO2011004263A2 (en) | 2009-07-07 | 2011-01-13 | Novartis Ag | Conserved escherichia coli immunogens |
| WO2011007257A1 (en) | 2009-07-16 | 2011-01-20 | Novartis Ag | Detoxified escherichia coli immunogens |
| WO2011008974A2 (en) | 2009-07-15 | 2011-01-20 | Novartis Ag | Rsv f protein compositions and methods for making same |
| WO2011048561A1 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Diagnostic and therapeutic methods for rheumatic heart disease based upon group a streptococcus markers |
| WO2011058302A1 (en) | 2009-11-10 | 2011-05-19 | Guy's And St Thomas's Nhs Foundation Trust | Bacteremia-associated antigen from staphylococcus aureus |
| WO2011080595A2 (en) | 2009-12-30 | 2011-07-07 | Novartis Ag | Polysaccharide immunogens conjugated to e. coli carrier proteins |
| EP2368573A2 (en) | 2005-11-04 | 2011-09-28 | Novartis Vaccines and Diagnostics S.r.l. | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| EP2368572A2 (en) | 2005-11-04 | 2011-09-28 | Novartis Vaccines and Diagnostics S.r.l. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| EP2377551A2 (en) | 2005-11-04 | 2011-10-19 | Novartis Vaccines and Diagnostics S.r.l. | Adjuvanted influenza vaccines including cytokine-inducing agents |
| EP2382987A1 (en) | 2006-03-24 | 2011-11-02 | Novartis Vaccines and Diagnostics GmbH | Storage of influenza vaccines without refrigeration |
| WO2011161551A2 (en) | 2010-06-11 | 2011-12-29 | Novartis Ag | Omv vaccines |
| EP2478916A1 (en) | 2006-01-27 | 2012-07-25 | Novartis Vaccines and Diagnostics GmbH | Influenza vaccines containing hemagglutinin and matrix proteins |
| WO2012103361A1 (en) | 2011-01-26 | 2012-08-02 | Novartis Ag | Rsv immunization regimen |
| EP2484377A1 (en) | 2007-06-27 | 2012-08-08 | Novartis AG | Low-additive influenza vaccines |
| EP2497495A2 (en) | 2006-09-11 | 2012-09-12 | Novartis AG | Making influenza virus vaccines without using eggs |
| EP2510947A1 (en) | 2009-04-14 | 2012-10-17 | Novartis AG | Compositions for immunising against Staphylococcus aureus |
| EP2514437A1 (en) | 2006-07-20 | 2012-10-24 | Novartis AG | Frozen stockpiling of influenza vaccines |
| WO2012158613A1 (en) | 2011-05-13 | 2012-11-22 | Novartis Ag | Pre-fusion rsv f antigens |
| EP2532362A1 (en) | 2006-12-06 | 2012-12-12 | Novartis AG | Vaccines including antigen from four strains of influenza virus |
| EP2572726A1 (en) | 2007-08-01 | 2013-03-27 | Novartis AG | Compositions comprising pneumococcal antigens |
| WO2013068949A1 (en) | 2011-11-07 | 2013-05-16 | Novartis Ag | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| EP2614835A1 (en) | 2007-11-26 | 2013-07-17 | Novartis AG | Vaccination with multiple clades of H5 influenza A virus |
| USH2283H1 (en) | 2009-04-27 | 2013-09-03 | Novartis Ag | Vaccines for protecting against influenza |
| WO2014053521A2 (en) | 2012-10-02 | 2014-04-10 | Novartis Ag | Nonlinear saccharide conjugates |
| EP2889042A2 (en) | 2008-03-18 | 2015-07-01 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
| WO2020160199A1 (en) * | 2019-01-31 | 2020-08-06 | Siemens Healthcare Diagnostics Inc. | Anti-naloxone and anti-naltrexone monoclonal antibodies and methods of production and use thereof |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2290947C1 (ru) * | 2005-10-27 | 2007-01-10 | Александр Иванович Воронов | Способ лечения опийной наркомании |
| RU2526807C2 (ru) * | 2012-11-28 | 2014-08-27 | Общество с ограниченной ответственностью "ДИАМЕДИКА" ООО "ДИАМЕДИКА" | Синтетический иммуноген для защиты от токсического действия наркотических и психоактивных веществ |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997021451A1 (en) * | 1995-12-14 | 1997-06-19 | The Scripps Research Institute | Anti-cocaine vaccine |
| RU2112543C1 (ru) * | 1996-09-26 | 1998-06-10 | Александр Григорьевич Хоменко | Иммуномодулирующее лекарственное средство |
| RU2148412C1 (ru) * | 1999-08-06 | 2000-05-10 | Москаленко Екатерина Петровна | Способ получения протективного коклюшного антигена |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2073031C1 (ru) * | 1990-08-06 | 1997-02-10 | Некрасов Аркадий Васильевич | Производные поли-1,4-этиленпиперазина, обладающие иммуномодулирующей, противовирусной и антибактериальной активностями |
| RU2164148C1 (ru) * | 2000-08-09 | 2001-03-20 | Петров Рэм Викторович | Вакцина против вируса гриппа и способ ее получения |
-
2003
- 2003-09-15 RU RU2003127705/15A patent/RU2236257C1/ru not_active IP Right Cessation
-
2004
- 2004-09-14 EA EA200401080A patent/EA006248B1/ru not_active IP Right Cessation
- 2004-09-15 FR FR0409762A patent/FR2859633A1/fr active Pending
- 2004-09-15 DE DE102004044666A patent/DE102004044666A1/de not_active Withdrawn
- 2004-09-15 IT IT000621A patent/ITTO20040621A1/it unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997021451A1 (en) * | 1995-12-14 | 1997-06-19 | The Scripps Research Institute | Anti-cocaine vaccine |
| RU2112543C1 (ru) * | 1996-09-26 | 1998-06-10 | Александр Григорьевич Хоменко | Иммуномодулирующее лекарственное средство |
| RU2148412C1 (ru) * | 1999-08-06 | 2000-05-10 | Москаленко Екатерина Петровна | Способ получения протективного коклюшного антигена |
Non-Patent Citations (7)
| Title |
|---|
| CARRERA M R A ET AL: "SUPPRESSION OF PSYCHOACTIVE EFFECTS OF COCAINE BY ACTIVE IMMUNIZATION", NATURE, MACMILLAN JOURNALS LTD. LONDON, GB, vol. 378, no. 6558, 14 December 1995 (1995-12-14), pages 727 - 730, XP000946580, ISSN: 0028-0836 * |
| DAMBAEVA S V ET AL: "The effect of polyoxidonium on the phagocytic activity of human peripheral blood leukocytes", CENTRAL-EUROPEAN JOURNAL OF IMMUNOLOGY 2003 POLAND, vol. 28, no. 2, 2003, pages 47 - 53, XP009054190, ISSN: 1426-3912 * |
| DATABASE WPI Section Ch Week 199738, Derwent World Patents Index; Class A96, AN 1997-413822, XP002346311 * |
| DATABASE WPI Section Ch Week 199954, Derwent World Patents Index; Class A96, AN 1999-631937, XP002346312 * |
| DATABASE WPI Section Ch Week 200061, Derwent World Patents Index; Class B04, AN 2000-636607, XP002346310 * |
| DYAKONOVA V A ET AL: "Study of interaction between the polyoxidonium immunomodulator and the human immune system cells", INTERNATIONAL IMMUNOPHARMACOLOGY 2004 NETHERLANDS, vol. 4, no. 13, 2004, pages 1615 - 1623, XP002346306, ISSN: 1567-5769 * |
| KOSTEN T R ET AL: "Human therapeutic cocaine vaccine: safety and immunogenicity", VACCINE, BUTTERWORTH SCIENTIFIC. GUILDFORD, GB, vol. 20, no. 7-8, 15 January 2002 (2002-01-15), pages 1196 - 1204, XP004332992, ISSN: 0264-410X * |
Cited By (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3714900A1 (en) | 2005-11-04 | 2020-09-30 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| EP2368573A2 (en) | 2005-11-04 | 2011-09-28 | Novartis Vaccines and Diagnostics S.r.l. | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
| EP2368572A2 (en) | 2005-11-04 | 2011-09-28 | Novartis Vaccines and Diagnostics S.r.l. | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
| EP2377551A2 (en) | 2005-11-04 | 2011-10-19 | Novartis Vaccines and Diagnostics S.r.l. | Adjuvanted influenza vaccines including cytokine-inducing agents |
| EP2478916A1 (en) | 2006-01-27 | 2012-07-25 | Novartis Vaccines and Diagnostics GmbH | Influenza vaccines containing hemagglutinin and matrix proteins |
| EP3753574A1 (en) | 2006-01-27 | 2020-12-23 | Seqirus UK Limited | Influenza vaccines containing hemagglutinin and matrix proteins |
| EP2382987A1 (en) | 2006-03-24 | 2011-11-02 | Novartis Vaccines and Diagnostics GmbH | Storage of influenza vaccines without refrigeration |
| EP2514437A1 (en) | 2006-07-20 | 2012-10-24 | Novartis AG | Frozen stockpiling of influenza vaccines |
| EP3456348A1 (en) | 2006-09-11 | 2019-03-20 | Seqirus UK Limited | Making influenza virus vaccines without using eggs |
| EP2497495A2 (en) | 2006-09-11 | 2012-09-12 | Novartis AG | Making influenza virus vaccines without using eggs |
| EP2679240A1 (en) | 2006-12-06 | 2014-01-01 | Novartis AG | Vaccines including antigen from four strains of influenza virus |
| EP2532362A1 (en) | 2006-12-06 | 2012-12-12 | Novartis AG | Vaccines including antigen from four strains of influenza virus |
| EP2484377A1 (en) | 2007-06-27 | 2012-08-08 | Novartis AG | Low-additive influenza vaccines |
| EP2572726A1 (en) | 2007-08-01 | 2013-03-27 | Novartis AG | Compositions comprising pneumococcal antigens |
| EP2614835A1 (en) | 2007-11-26 | 2013-07-17 | Novartis AG | Vaccination with multiple clades of H5 influenza A virus |
| EP3459563A1 (en) | 2008-03-18 | 2019-03-27 | Seqirus UK Limited | Improvements in preparation of influenza virus vaccine antigens |
| EP2889042A2 (en) | 2008-03-18 | 2015-07-01 | Novartis AG | Improvements in preparation of influenza virus vaccine antigens |
| EP3549602A1 (en) | 2009-03-06 | 2019-10-09 | GlaxoSmithKline Biologicals S.A. | Chlamydia antigens |
| WO2010100632A2 (en) | 2009-03-06 | 2010-09-10 | Novartis Ag | Chlamydia antigens |
| EP3263128A2 (en) | 2009-04-14 | 2018-01-03 | GlaxoSmithKline Biologicals S.A. | Compositions for immunising against staphylococcus aureus |
| EP2510947A1 (en) | 2009-04-14 | 2012-10-17 | Novartis AG | Compositions for immunising against Staphylococcus aureus |
| USH2284H1 (en) | 2009-04-27 | 2013-09-03 | Novartis Ag | Vaccines for protecting against influenza |
| USH2283H1 (en) | 2009-04-27 | 2013-09-03 | Novartis Ag | Vaccines for protecting against influenza |
| WO2011004263A2 (en) | 2009-07-07 | 2011-01-13 | Novartis Ag | Conserved escherichia coli immunogens |
| EP3988115A2 (en) | 2009-07-15 | 2022-04-27 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| EP3178490A2 (en) | 2009-07-15 | 2017-06-14 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| EP4183412A1 (en) | 2009-07-15 | 2023-05-24 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| EP4218800A1 (en) | 2009-07-15 | 2023-08-02 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| EP4218799A1 (en) | 2009-07-15 | 2023-08-02 | GlaxoSmithKline Biologicals S.A. | Rsv f protein compositions and methods for making same |
| WO2011008974A2 (en) | 2009-07-15 | 2011-01-20 | Novartis Ag | Rsv f protein compositions and methods for making same |
| EP2837386A1 (en) | 2009-07-16 | 2015-02-18 | Novartis AG | Detoxified Escherichia coli immunogens |
| WO2011007257A1 (en) | 2009-07-16 | 2011-01-20 | Novartis Ag | Detoxified escherichia coli immunogens |
| WO2011048561A1 (en) | 2009-10-20 | 2011-04-28 | Novartis Ag | Diagnostic and therapeutic methods for rheumatic heart disease based upon group a streptococcus markers |
| WO2011058302A1 (en) | 2009-11-10 | 2011-05-19 | Guy's And St Thomas's Nhs Foundation Trust | Bacteremia-associated antigen from staphylococcus aureus |
| WO2011080595A2 (en) | 2009-12-30 | 2011-07-07 | Novartis Ag | Polysaccharide immunogens conjugated to e. coli carrier proteins |
| WO2011161551A2 (en) | 2010-06-11 | 2011-12-29 | Novartis Ag | Omv vaccines |
| EP3399021A1 (en) | 2010-06-11 | 2018-11-07 | GlaxoSmithKline Biologicals S.A. | Omv vaccines |
| WO2012103361A1 (en) | 2011-01-26 | 2012-08-02 | Novartis Ag | Rsv immunization regimen |
| EP3527224A1 (en) | 2011-01-26 | 2019-08-21 | GlaxoSmithKline Biologicals S.A. | Rsv immunization regimen |
| EP4159232A1 (en) | 2011-01-26 | 2023-04-05 | GlaxoSmithKline Biologicals S.A. | Rsv immunization regimen |
| EP4144368A1 (en) | 2011-01-26 | 2023-03-08 | GlaxoSmithKline Biologicals S.A. | Rsv immunization regimen |
| EP3275892A2 (en) | 2011-05-13 | 2018-01-31 | GlaxoSmithKline Biologicals S.A. | Pre-fusion rsv f antigens |
| WO2012158613A1 (en) | 2011-05-13 | 2012-11-22 | Novartis Ag | Pre-fusion rsv f antigens |
| WO2013068949A1 (en) | 2011-11-07 | 2013-05-16 | Novartis Ag | Carrier molecule comprising a spr0096 and a spr2021 antigen |
| WO2014053521A2 (en) | 2012-10-02 | 2014-04-10 | Novartis Ag | Nonlinear saccharide conjugates |
| JP2022519534A (ja) * | 2019-01-31 | 2022-03-24 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 抗ナロキソンおよび抗ナルトレキソンモノクローナル抗体ならびにその作製方法および使用方法 |
| US20220049018A1 (en) * | 2019-01-31 | 2022-02-17 | Siemens Healthcare Diagnostics Inc. | Anti-naloxone and anti-naltrexone monoclonal antibodies and methods of production and use thereof |
| CN113424060A (zh) * | 2019-01-31 | 2021-09-21 | 美国西门子医学诊断股份有限公司 | 抗纳洛酮和抗纳曲酮单克隆抗体及其生产和使用方法 |
| WO2020160199A1 (en) * | 2019-01-31 | 2020-08-06 | Siemens Healthcare Diagnostics Inc. | Anti-naloxone and anti-naltrexone monoclonal antibodies and methods of production and use thereof |
| JP2024045330A (ja) * | 2019-01-31 | 2024-04-02 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 抗ナロキソンおよび抗ナルトレキソンモノクローナル抗体ならびにその作製方法および使用方法 |
| US12404346B2 (en) | 2019-01-31 | 2025-09-02 | Siemens Healthcare Diagnostics Inc. | Anti-naloxone and anti-naltrexone monoclonal antibodies and methods of production and use thereof |
| JP2025139595A (ja) * | 2019-01-31 | 2025-09-26 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | 抗ナロキソンおよび抗ナルトレキソンモノクローナル抗体ならびにその作製方法および使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| ITTO20040621A1 (it) | 2004-12-15 |
| RU2236257C1 (ru) | 2004-09-20 |
| EA200401080A1 (ru) | 2005-04-28 |
| EA006248B1 (ru) | 2005-10-27 |
| DE102004044666A1 (de) | 2005-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FR2859633A1 (fr) | Immunogene synthetique pour le traitement et la prevention des abus de produits narcotiques et psychoactifs | |
| US6699474B1 (en) | Vaccine and immunserum against drugs of abuse | |
| DE69931377T2 (de) | Verfahren zur behandlung von ig-e assozierten krankheiten und zusammensetzungen zur verwendung in diesen verfahren | |
| Schwartz | Chemical aspects of penicillin allergy | |
| FR2598622A1 (fr) | Adjuvants immunologiques pour vaccins polysaccharidiques | |
| US8357375B2 (en) | Process for the preparation and use of a bivalent vaccine against morphine-heroine addiction | |
| RU2532911C2 (ru) | Способы и композиции, относящиеся к синтетическим бета-1,6-глюкозаминолигосахаридам | |
| HUP0104365A2 (hu) | Nikotinfüggőség kezelésére és megelőzésére alkalmas haptén-hordozó konjugátumok, azokat tartalmazó vakcinák és gyógyászati készítmények a kojugátumokra válaszként termelődő antitest és alkalmazásuk | |
| FR2513125A1 (fr) | Medicament curatif du deficit immunitaire | |
| CA2067205C (en) | Vaccine and immune serum against drugs of abuse | |
| US20100015172A1 (en) | Method to reduce the physiologic effects of drugs on mammals | |
| DE69630682T2 (de) | Synthetische peptide und diese enthaltende arzneimittel zur behandlung des systemischen lupus erythematodes | |
| EP0001197B1 (fr) | Produits de couplage de la cytidine-diphosphocholine et de composés aminés, procédé d'obtention et application pharmaceutique et analytique | |
| CN102002049B (zh) | 一种抗原及其制备方法与应用 | |
| RU2526807C2 (ru) | Синтетический иммуноген для защиты от токсического действия наркотических и психоактивных веществ | |
| JPS62228023A (ja) | 免疫学的増幅因子と関連組成物 | |
| RU2635517C1 (ru) | Синтетический иммуноген для защиты и лечения от зависимости от психоактивных веществ | |
| RU2643329C1 (ru) | Синтетический иммуноген для защиты и лечения от зависимости от психоактивных веществ | |
| JPH09505563A (ja) | 抗アレルギー治療に有効な化合物 | |
| JP2001506994A (ja) | 免疫グロブリン受容体相互作用の阻害剤を含んでいる医薬組成物 | |
| RU2548802C1 (ru) | Иммуноген для лечения и профилактики зависимости от опиатов | |
| RU2259847C1 (ru) | Вакцина против гипертонии | |
| De Weck | Drug Allergy [Abridged] The Formation of Penicillin Antigens | |
| EP0316212B1 (fr) | Application de nitrophényles ou d'anticorps anti-nitrophényles à la modification de l'interaction entre des cellules sensibles d'un hôte et un agent pathogene | |
| EP0215081A1 (fr) | Preparations d'immunoglobulines presentant des titres eleves en anticorps bloquants |