FR2976287B1 - Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique - Google Patents

Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique

Info

Publication number
FR2976287B1
FR2976287B1 FR1155028A FR1155028A FR2976287B1 FR 2976287 B1 FR2976287 B1 FR 2976287B1 FR 1155028 A FR1155028 A FR 1155028A FR 1155028 A FR1155028 A FR 1155028A FR 2976287 B1 FR2976287 B1 FR 2976287B1
Authority
FR
France
Prior art keywords
benzoquinolizidine
derivatives
preparation
therapeutic applications
therapeutic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1155028A
Other languages
English (en)
Other versions
FR2976287A1 (fr
Inventor
Yves Guminski
Patrice Mayer
Philippe Chopin
Thierry Imbert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre Medicament SA
Original Assignee
Pierre Fabre Medicament SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre Medicament SA filed Critical Pierre Fabre Medicament SA
Priority to FR1155028A priority Critical patent/FR2976287B1/fr
Priority to EP12729076.5A priority patent/EP2718291A1/fr
Priority to PCT/EP2012/060805 priority patent/WO2012168368A1/fr
Publication of FR2976287A1 publication Critical patent/FR2976287A1/fr
Application granted granted Critical
Publication of FR2976287B1 publication Critical patent/FR2976287B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
    • C07D455/06—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine containing benzo [a] quinolizine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
FR1155028A 2011-06-09 2011-06-09 Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique Expired - Fee Related FR2976287B1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
FR1155028A FR2976287B1 (fr) 2011-06-09 2011-06-09 Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique
EP12729076.5A EP2718291A1 (fr) 2011-06-09 2012-06-07 Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique
PCT/EP2012/060805 WO2012168368A1 (fr) 2011-06-09 2012-06-07 Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1155028A FR2976287B1 (fr) 2011-06-09 2011-06-09 Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique

Publications (2)

Publication Number Publication Date
FR2976287A1 FR2976287A1 (fr) 2012-12-14
FR2976287B1 true FR2976287B1 (fr) 2013-07-05

Family

ID=46331276

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1155028A Expired - Fee Related FR2976287B1 (fr) 2011-06-09 2011-06-09 Derives benzoquinolizidines, leur procede de preparation et leurs applications en therapeutique

Country Status (3)

Country Link
EP (1) EP2718291A1 (fr)
FR (1) FR2976287B1 (fr)
WO (1) WO2012168368A1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686226A (en) * 1985-09-03 1987-08-11 Merck & Co., Inc. Substituted benzo[b]furo- and benzo[b]thieno quinolizines
FR2770215B1 (fr) * 1997-10-28 2000-01-14 Pf Medicament Derives d'aminomethyl-benzo[a]quinolizidine, leur preparation et leur application en therapeutique pour les maladies neurodegeneratives
EP1430898A4 (fr) * 2001-09-28 2005-11-02 Kyowa Hakko Kogyo Kk Antagoniste de recepteur
AR052342A1 (es) 2004-12-21 2007-03-14 Janssen Pharmaceutica Nv Derivados sustituidos de triazolona,tetrazolona e imidazolona con actividad selectiva antagonista de alfa2c-adenoreceptores
EP2029553A1 (fr) 2006-05-22 2009-03-04 Janssen Pharmaceutica, N.V. Dérivés de pyrazinone substitués à utiliser comme médicament
CA2659923A1 (fr) 2006-10-12 2008-04-17 Janssen Pharmaceutica Nv Derives de pyrazinone substitues pour une utilisation en tant que medicament

Also Published As

Publication number Publication date
EP2718291A1 (fr) 2014-04-16
WO2012168368A1 (fr) 2012-12-13
FR2976287A1 (fr) 2012-12-14

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Legal Events

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Year of fee payment: 6

ST Notification of lapse

Effective date: 20180228