FR3009497B1 - Nouvelle association entre le 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolein-4-yl}oxy)-n-methylnaphtalene-1-carboxamide et un anti-oestrogene dans le cancer du sein - Google Patents

Nouvelle association entre le 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolein-4-yl}oxy)-n-methylnaphtalene-1-carboxamide et un anti-oestrogene dans le cancer du sein

Info

Publication number
FR3009497B1
FR3009497B1 FR1357936A FR1357936A FR3009497B1 FR 3009497 B1 FR3009497 B1 FR 3009497B1 FR 1357936 A FR1357936 A FR 1357936A FR 1357936 A FR1357936 A FR 1357936A FR 3009497 B1 FR3009497 B1 FR 3009497B1
Authority
FR
France
Prior art keywords
methylnaphtalene
aminocyclopropyl
methoxyquinolin
oestrogen
carboxamide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
FR1357936A
Other languages
English (en)
Other versions
FR3009497A1 (fr
Inventor
Valerie Agrapart
Marie-Jeanne Pierrat
Stephane Depil
Michael Burbridge
Anne Jacquet-Bescond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Les Laboratoires Servier SAS
Original Assignee
Les Laboratoires Servier SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Les Laboratoires Servier SAS filed Critical Les Laboratoires Servier SAS
Priority to FR1357936A priority Critical patent/FR3009497B1/fr
Priority to PCT/FR2014/052065 priority patent/WO2015019030A1/fr
Publication of FR3009497A1 publication Critical patent/FR3009497A1/fr
Application granted granted Critical
Publication of FR3009497B1 publication Critical patent/FR3009497B1/fr
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
FR1357936A 2013-08-09 2013-08-09 Nouvelle association entre le 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolein-4-yl}oxy)-n-methylnaphtalene-1-carboxamide et un anti-oestrogene dans le cancer du sein Expired - Fee Related FR3009497B1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
FR1357936A FR3009497B1 (fr) 2013-08-09 2013-08-09 Nouvelle association entre le 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolein-4-yl}oxy)-n-methylnaphtalene-1-carboxamide et un anti-oestrogene dans le cancer du sein
PCT/FR2014/052065 WO2015019030A1 (fr) 2013-08-09 2014-08-08 Nouvelle association entre le 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolein-4-yl}oxy)-n-methylnaphtalene-1-carboxamide et un anti-œstrogene dans le cancer du sein

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR1357936A FR3009497B1 (fr) 2013-08-09 2013-08-09 Nouvelle association entre le 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolein-4-yl}oxy)-n-methylnaphtalene-1-carboxamide et un anti-oestrogene dans le cancer du sein

Publications (2)

Publication Number Publication Date
FR3009497A1 FR3009497A1 (fr) 2015-02-13
FR3009497B1 true FR3009497B1 (fr) 2015-08-07

Family

ID=49237487

Family Applications (1)

Application Number Title Priority Date Filing Date
FR1357936A Expired - Fee Related FR3009497B1 (fr) 2013-08-09 2013-08-09 Nouvelle association entre le 6-({7-[(1-aminocyclopropyl)methoxy]-6-methoxyquinolein-4-yl}oxy)-n-methylnaphtalene-1-carboxamide et un anti-oestrogene dans le cancer du sein

Country Status (2)

Country Link
FR (1) FR3009497B1 (fr)
WO (1) WO2015019030A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110483393A (zh) * 2018-05-14 2019-11-22 上海海和药物研究开发有限公司 德立替尼的晶型

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8163923B2 (en) * 2007-03-14 2012-04-24 Advenchen Laboratories, Llc Spiro substituted compounds as angiogenesis inhibitors
WO2009039700A1 (fr) * 2007-09-24 2009-04-02 Xi'an Libang Pharmaceutical Co., Ltd. Procédé de fabrication de 7-alpha-[9-(4,4,5,5,5-pentafluoropentylsulfinyl)nonyl]estra-1,3,5-(10)-trièn-3,17-bêta-diol
WO2011072244A1 (fr) * 2009-12-10 2011-06-16 Mount Sinai School Of Medicine Of New York University Méthode de traitement du cancer du sein utilisant le tamoxifène

Also Published As

Publication number Publication date
FR3009497A1 (fr) 2015-02-13
WO2015019030A1 (fr) 2015-02-12

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Legal Events

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Year of fee payment: 3

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Effective date: 20170428