FR3120127B1 - Procede et dispositif d’analyse d’un liquide susceptible de contenir un analyte - Google Patents

Procede et dispositif d’analyse d’un liquide susceptible de contenir un analyte Download PDF

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Publication number
FR3120127B1
FR3120127B1 FR2101771A FR2101771A FR3120127B1 FR 3120127 B1 FR3120127 B1 FR 3120127B1 FR 2101771 A FR2101771 A FR 2101771A FR 2101771 A FR2101771 A FR 2101771A FR 3120127 B1 FR3120127 B1 FR 3120127B1
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FR
France
Prior art keywords
analysis
analyte
digital image
analyzing
magnetic
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Active
Application number
FR2101771A
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English (en)
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FR3120127A1 (fr
Inventor
Paul Kauffmann
Damien Kirk
Mario Fratzl
Roman Gorbenkov
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Magia Diagnostics SAS
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Magia Diagnostics SAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to FR2101771A priority Critical patent/FR3120127B1/fr
Application filed by Magia Diagnostics SAS filed Critical Magia Diagnostics SAS
Priority to PCT/FR2022/050308 priority patent/WO2022180334A1/fr
Priority to US18/546,812 priority patent/US20240125685A1/en
Priority to CN202280016437.7A priority patent/CN117043577A/zh
Priority to BR112023017068A priority patent/BR112023017068A2/pt
Priority to JP2023551107A priority patent/JP2024509775A/ja
Priority to CA3205139A priority patent/CA3205139A1/fr
Priority to KR1020237031018A priority patent/KR20230156346A/ko
Priority to EP22710670.5A priority patent/EP4298425A1/fr
Publication of FR3120127A1 publication Critical patent/FR3120127A1/fr
Application granted granted Critical
Publication of FR3120127B1 publication Critical patent/FR3120127B1/fr
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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1429—Signal processing
    • G01N15/1433—Signal processing using image recognition
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G01N15/0606—Investigating concentration of particle suspensions by collecting particles on a support
    • G01N15/0612—Optical scan of the deposits
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54346—Nanoparticles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H01F1/0045—Zero dimensional, e.g. nanoparticles, soft nanoparticles for medical/biological use
    • H01F1/0054—Coated nanoparticles, e.g. nanoparticles coated with organic surfactant
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N2015/0023—Investigating dispersion of liquids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Dispersion Chemistry (AREA)
  • Nanotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Inorganic Chemistry (AREA)
  • Power Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Signal Processing (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Computer Vision & Pattern Recognition (AREA)

Abstract

L’invention porte sur un procédé et un dispositif d’analyse d’un liquide susceptible de contenir un analyte. Le procédé d’analyse comprend une étape d’acquisition d’une image numérique d’une surface d’analyse pendant une période d’exposition, à l’aide d’un dispositif de prise de vue présentant un axe optique dirigé vers la surface d’analyse, l’image numérique présentant une variation spatiale d’intensité conforme à un motif de détection lorsque l’analyte est présent dans l’échantillon. Il comprend également une étape de traitement de l’image numérique pour y repérer la variation spatiale d’intensité. Selon l’invention, pendant une partie au moins de la période d’exposition, le support d’analyse est disposé dans un champ magnétique dit « d’illumination » produit par une source magnétique d’illumination. Le champ magnétique d’illumination est parallèle à l’axe optique du dispositif de prise de vue sur une partie au moins de la surface d’analyse. Figure à publier avec l’abrégé : 11
FR2101771A 2021-02-24 2021-02-24 Procede et dispositif d’analyse d’un liquide susceptible de contenir un analyte Active FR3120127B1 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
FR2101771A FR3120127B1 (fr) 2021-02-24 2021-02-24 Procede et dispositif d’analyse d’un liquide susceptible de contenir un analyte
US18/546,812 US20240125685A1 (en) 2021-02-24 2022-02-21 Method and device for analyzing a liquid liable to contain an analyte
CN202280016437.7A CN117043577A (zh) 2021-02-24 2022-02-21 对可能含有分析物的液体进行分析的方法和装置
BR112023017068A BR112023017068A2 (pt) 2021-02-24 2022-02-21 Método e dispositivo de análise de um líquido suscetível de conter um analito
PCT/FR2022/050308 WO2022180334A1 (fr) 2021-02-24 2022-02-21 Procede et dispositif d'analyse d'un liquide susceptible de contenir un analyte
JP2023551107A JP2024509775A (ja) 2021-02-24 2022-02-21 検体を含む可能性のある液体を分析するための方法及び装置
CA3205139A CA3205139A1 (fr) 2021-02-24 2022-02-21 Procede et dispositif d'analyse d'un liquide susceptible de contenir un analyte
KR1020237031018A KR20230156346A (ko) 2021-02-24 2022-02-21 분석물에 포함할 수 있는 액체를 분석하기 위한 방법 및 장치
EP22710670.5A EP4298425A1 (fr) 2021-02-24 2022-02-21 Procede et dispositif d'analyse d'un liquide susceptible de contenir un analyte

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR2101771A FR3120127B1 (fr) 2021-02-24 2021-02-24 Procede et dispositif d’analyse d’un liquide susceptible de contenir un analyte
FR2101771 2021-02-24

Publications (2)

Publication Number Publication Date
FR3120127A1 FR3120127A1 (fr) 2022-08-26
FR3120127B1 true FR3120127B1 (fr) 2023-09-15

Family

ID=75746841

Family Applications (1)

Application Number Title Priority Date Filing Date
FR2101771A Active FR3120127B1 (fr) 2021-02-24 2021-02-24 Procede et dispositif d’analyse d’un liquide susceptible de contenir un analyte

Country Status (9)

Country Link
US (1) US20240125685A1 (fr)
EP (1) EP4298425A1 (fr)
JP (1) JP2024509775A (fr)
KR (1) KR20230156346A (fr)
CN (1) CN117043577A (fr)
BR (1) BR112023017068A2 (fr)
CA (1) CA3205139A1 (fr)
FR (1) FR3120127B1 (fr)
WO (1) WO2022180334A1 (fr)

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9557326B2 (en) * 2010-06-09 2017-01-31 Hitachi High-Technologies Corporation Sample analyzing device and sample analyzing method
FR3001038B1 (fr) * 2013-01-17 2018-02-09 Centre National De La Recherche Scientifique (Cnrs) Procede de capture, procede de detection et kit de capture d'une molecule dans un echantillon
US12339233B2 (en) * 2015-12-24 2025-06-24 Siemens Healthineers Nederland B.V. Optical detection of a substance in fluid
DE102016112024A1 (de) * 2016-06-30 2018-01-04 Zendia Gmbh Schnelltest für den Erreger- und Zellnachweis und Verfahren
JP7249281B2 (ja) * 2016-12-23 2023-03-30 クアンタム ダイヤモンド テクノロジーズ インク． 磁気式多ビーズアッセイのための方法および装置
CN110832301B (zh) * 2018-05-30 2022-05-27 务实诊断有限公司 用于检测生物及化学物质的光学磁光方法
FR3100338B1 (fr) * 2019-08-30 2022-09-02 Centre Nat Rech Scient Kit et méthode de capture d’une molécule

Also Published As

Publication number Publication date
CA3205139A1 (fr) 2022-09-01
FR3120127A1 (fr) 2022-08-26
CN117043577A (zh) 2023-11-10
WO2022180334A1 (fr) 2022-09-01
EP4298425A1 (fr) 2024-01-03
US20240125685A1 (en) 2024-04-18
JP2024509775A (ja) 2024-03-05
BR112023017068A2 (pt) 2023-11-21
KR20230156346A (ko) 2023-11-14

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