FR3340M - Nouveaux médicaments anti-inflammatoires a base de dérivés des acides α(1-aralkylidene ou hétéroaralkylidene-3-indényle) aliphatiques inférieurs. - Google Patents

Nouveaux médicaments anti-inflammatoires a base de dérivés des acides α(1-aralkylidene ou hétéroaralkylidene-3-indényle) aliphatiques inférieurs.

Info

Publication number
FR3340M
FR3340M FR946340A FR946340A FR3340M FR 3340 M FR3340 M FR 3340M FR 946340 A FR946340 A FR 946340A FR 946340 A FR946340 A FR 946340A FR 3340 M FR3340 M FR 3340M
Authority
FR
France
Prior art keywords
heteroaralkylidene
aralkylidene
indenyl
derivatives
acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
FR946340A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US278390A external-priority patent/US3325358A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of FR3340M publication Critical patent/FR3340M/fr
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/36—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by hydrogenation of carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/52—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen
    • C07C57/62—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing halogen containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C07C59/56—Unsaturated compounds containing hydroxy or O-metal groups containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/72—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings and other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
    • C07C63/74—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
    • C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Chemical Kinetics & Catalysis (AREA)
FR946340A 1962-06-06 1963-09-02 Nouveaux médicaments anti-inflammatoires a base de dérivés des acides α(1-aralkylidene ou hétéroaralkylidene-3-indényle) aliphatiques inférieurs. Expired FR3340M (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20035062A 1962-06-06 1962-06-06
US278390A US3325358A (en) 1962-06-06 1963-05-06 Method of treating inflammation

Publications (1)

Publication Number Publication Date
FR3340M true FR3340M (fr) 1965-05-31

Family

ID=39514005

Family Applications (1)

Application Number Title Priority Date Filing Date
FR946340A Expired FR3340M (fr) 1962-06-06 1963-09-02 Nouveaux médicaments anti-inflammatoires a base de dérivés des acides α(1-aralkylidene ou hétéroaralkylidene-3-indényle) aliphatiques inférieurs.

Country Status (2)

Country Link
BE (1) BE633314A (fr)
FR (1) FR3340M (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0015231A1 (fr) * 1979-01-30 1980-09-03 Ciba-Geigy Ag Acides indénone carboxyliques, leurs esters ainsi que procédé pour leur préparation

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3622623A (en) * 1968-08-28 1971-11-23 Merck & Co Inc 1-substituted indenyl-3-aliphatic acids and esters

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0015231A1 (fr) * 1979-01-30 1980-09-03 Ciba-Geigy Ag Acides indénone carboxyliques, leurs esters ainsi que procédé pour leur préparation

Also Published As

Publication number Publication date
BE633314A (fr) 1963-12-06

Similar Documents

Publication Publication Date Title
FR3103M (fr) Médicaments a base de dérivés alkéniques.
FR3340M (fr) Nouveaux médicaments anti-inflammatoires a base de dérivés des acides α(1-aralkylidene ou hétéroaralkylidene-3-indényle) aliphatiques inférieurs.
FR3215M (fr) Nouveaux médicaments a base de dérivés de dibenzocycloheptene.
FR2886M (fr) Médicament a base de dérivés de l'acide anthranilique.
FR3347M (fr) Médicament a activité vitaminique c a base de nouveaux 2,6-diesters d'acide ascorbique.
FR3040M (fr) Médicament a base de dérivés basiques du dibenzo-cycloheptane.
FR3403M (fr) Médicament a base de nouveaux dérivés du 4-aza-thiaxanthene.
FR3586M (fr) Médicament a base de dérivé de diméthyl xanthine.
FR3058M (fr) Gamma-lactones d'acides beta-hydroxy-21-carboxyliques.
FR2869M (fr) Médicament a base d'un dérivé de la cymarine.
FR3766M (fr) Médicament a base de dérivés de naphtamidines.
FR3480M (fr) Nouveaux médicaments a base de dérivés spiro de l'oxazolidinone-2.
FR3173M (fr) Dérivés thérapeutiques d'aralcoyl-2-mercapto-benzazoles.
FR1323062A (fr) Dérivés d'acides fluorène-sulfoniques
FR1349281A (fr) Préparation d'acides omega-aminoalcanoïques
FR3435M (fr) Médicament a base de nouveaux dérivés de l'acide 6-amino-pénicillanique.
FR2975M (fr) Nouveaux médicaments a base de dérivés alcaloides de l'acide théophylline-acétique.
FR3228M (fr) Médicament a base de dérivés d'acide mandélique.
FR2352M (fr) Nouveaux médicaments a base de dérivés du 5-nitrofurane.
FR3072M (fr) Nouveaux médicaments a base de dérivés des 5h-dibenzo [a,d] cycloheptenes.
FR2997M (fr) Médicament nouveaux constitués par des dérivés de succinamide.
FR3751M (fr) Médicaments a base de nouveaux dérivés de la sulfanilyl-aminopyridazinone.
FR2248M (fr) Médicament a base de nouveaux acides octahydrophénanthroiques.
FR2540M (fr) Médicament a base de dérivés de la 4-phényl-6-amino-hexanone-(3).
FR2005M (fr) Médicaments antibiotiques a base de dérivés hydrosolubles de tétracyclines.