GB2134792A - Bioactive composite dressing - Google Patents
Bioactive composite dressing Download PDFInfo
- Publication number
- GB2134792A GB2134792A GB08403620A GB8403620A GB2134792A GB 2134792 A GB2134792 A GB 2134792A GB 08403620 A GB08403620 A GB 08403620A GB 8403620 A GB8403620 A GB 8403620A GB 2134792 A GB2134792 A GB 2134792A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alginate
- dressing
- moss
- sphagnum
- film
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002131 composite material Substances 0.000 title claims abstract description 10
- 230000000975 bioactive effect Effects 0.000 title claims abstract description 4
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical class O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims abstract description 33
- 235000013311 vegetables Nutrition 0.000 claims abstract description 21
- 241000736285 Sphagnum Species 0.000 claims abstract description 18
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 13
- 239000000648 calcium alginate Substances 0.000 claims abstract description 13
- 235000010413 sodium alginate Nutrition 0.000 claims abstract description 5
- 239000000661 sodium alginate Substances 0.000 claims abstract description 5
- 229940005550 sodium alginate Drugs 0.000 claims abstract description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims abstract description 3
- 238000000034 method Methods 0.000 claims description 23
- 229940072056 alginate Drugs 0.000 claims description 17
- 235000010443 alginic acid Nutrition 0.000 claims description 17
- 229920000615 alginic acid Polymers 0.000 claims description 17
- 206010052428 Wound Diseases 0.000 claims description 16
- 208000027418 Wounds and injury Diseases 0.000 claims description 16
- 229960002681 calcium alginate Drugs 0.000 claims description 12
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 239000012528 membrane Substances 0.000 claims description 10
- 238000002156 mixing Methods 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 7
- 239000000203 mixture Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 241000602285 Sphagnum imbricatum Species 0.000 claims description 4
- 241000612788 Sphagnum magellanicum Species 0.000 claims description 4
- 241000736286 Sphagnum palustre Species 0.000 claims description 4
- 241000602188 Sphagnum papillosum Species 0.000 claims description 4
- 230000009286 beneficial effect Effects 0.000 claims description 4
- 241000894007 species Species 0.000 claims description 4
- 241000894006 Bacteria Species 0.000 claims description 2
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 claims description 2
- 206010053567 Coagulopathies Diseases 0.000 claims description 2
- 229920000544 Gore-Tex Polymers 0.000 claims description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000008280 blood Substances 0.000 claims description 2
- 210000004369 blood Anatomy 0.000 claims description 2
- 150000001669 calcium Chemical class 0.000 claims description 2
- 229910001424 calcium ion Inorganic materials 0.000 claims description 2
- 230000015556 catabolic process Effects 0.000 claims description 2
- 230000035602 clotting Effects 0.000 claims description 2
- 230000000295 complement effect Effects 0.000 claims description 2
- 239000000470 constituent Substances 0.000 claims description 2
- 238000002788 crimping Methods 0.000 claims description 2
- 238000006731 degradation reaction Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000005342 ion exchange Methods 0.000 claims description 2
- 230000001766 physiological effect Effects 0.000 claims description 2
- 229920000136 polysorbate Polymers 0.000 claims description 2
- -1 polytetrafluoroethylene Polymers 0.000 claims description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 claims description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 claims description 2
- 229920002635 polyurethane Polymers 0.000 claims description 2
- 239000004814 polyurethane Substances 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 229910052708 sodium Inorganic materials 0.000 claims description 2
- 239000004753 textile Substances 0.000 claims description 2
- 230000029663 wound healing Effects 0.000 claims description 2
- 238000010348 incorporation Methods 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/40—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing ingredients of undetermined constitution or reaction products thereof, e.g. plant or animal extracts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Materials For Medical Uses (AREA)
Abstract
A bioactive dressing comprises a composite containing vegetable matter derived from Sphagnum moss and an alginate salt, such as calcium or sodium alginate.
Description
SPECIFICATION
Bioactive composite dressing
This invention relates to surgical dressings incorporating Sphagnum moss.
Sphagnum mosses have long been used for surgical dressings on account of their absorptive properties. Moss consists of multicellular leaves connected to thin stalks. Liquid can enter the cells through capillary action in the stalks, the cells being capable of retaining twenty to twenty five times their weight of liquid. In addition the cells are reinforced by spiraliy arranged structures which prevent collapse of the cells.
Moss is efficacious in wound healing because red blood constituents can be transmitted to the leaf cells and also because a concentration of leucocytes occurs at the interface tween the moss and the wound. Moss also serves to maintain gaseous interchange at the wound surface.
According to a first aspect of the present invention a surgical dressing comprises a composite containing vegetable matter derived from Sphagnum moss and an alginate salt. The alginate salt may be calcium alginate, sodium alginate, a mixture thereof or any other suitable alginate salt.
Calcium alginate exhibits beneficial physiological properties, possibly due to presence of calcium ions at the wound interface.
Furthermore ion exchange with the insoluble calcium derivatives leads to a slow release of the alginate. Alginate complexes exhibit the advantageous properties of high absorbency, rapid liquid uptake and an enhancement of clotting.
Degradation of alginate complexes lead to products which are soluble in the wound.
The combination of calcium alginate and moss in a dressing in accordance with this invention produces a particularly effective wound management system, the beneficial effects of both components cooperating in a complementary manner.
The calcium alginate is preferably in the form of fibres or of a film.
The Sphagnum moss preferably comprises one or more pure species selected from: Sphagnum papillosum, Sphagnum palustre, Sphagnum magellanicum and Sphagnum imbricatum.
The moss is preferably dried and crimped, to break up any large stalks or otherwise fragmented for example by sieving prior to combination with the alginate.
A membrane permeable to air and vapour but impermeable to water may be incorporated in the dressing. Such a membrane may serve to exclude bacteria from the wound. Examples of such membranes are those manufactured by Smith and
Nephew under the trade mark "Op-Site", and that manufactured by W. L. Gore and Associates under the trade mark "Goretex". Other membranes composed of polyurethane or polytetrafluoroethylene may be used.
Dressings in accordance with this invention may be manufactured by a variety of methods.
According to a second aspect of the present invention a method of manufacture of a surgical dressing comprises the step of blending vegetable matter derived from Sphagnum moss with alginate fibres. The blending may be performed by any suitable means selected from those known from textile technology, including air laying. The method may also comprise the step of forming the blend into pads or portions suitable for surgical use.
According to a third aspect of the present invention a method of manufacture of a surgical dressing comprises the step of causing fragmented vegetable matter derived from
Sphagnum moss to adhere to a film of an alginate.
The film may be sprayed with water to form a sticky surface to which the vegetable matter may adhere. The resultant composite may then be cut into portions and packaged.
A dressing comprising a layer of alginate film may be used with the alginate surface in contact with the wound - this being particularly applicable to shallow or partial thickness wounds.
A dressing may comprise a layer of the vegetable matter sandwiched between two layers of alginate film and may be prepared by a similar method to the second preferred aspect of this invention.
The vegatable matter may be moistened with water prior to formation of the dressing.
The aforementioned methods may include the step of incorporating a water impermeable film as described above.
1. A surgical dressing comprising a composite containing vegetable matter derived from
Sphagnum moss and an alginate salt.
2. A dressing as claimed in claim 1, comprising sodium or calcium alginate or a mixture thereof.
3. A dressing as claimed in claim 2, comprising calcium alginate in the form of fibres or of a film.
4. A dressing as claimed in any preceding claim, wherein the moss comprises one or more pure species selected from: Sphagnum papillosum, Sphagnum palustre, Sphagnum magellanicum and Sphagnum imbricatum.
5. A dressirg as claimed in any preceding claim, wherein the vegetable matter is derived by drying and crimping said moss.
6. A dressing as claimed in any preceding claim, comprising a membrane permeable to air but impermeable to water.
7. A dressing as claimed in any preceding claim comprising a layer of vegetable matter, sandwiched between layers of alginate film.
8. A method of manufacture of a surgical dressing comprising the steps of blending vegetable matter derived from Sphagnum moss with fibres of an alginate salt.
9. A method as claimed in Claim 8, wherein the blending is performed by air laying.
10. A method as claimed in any of claims 8 or 9, comprising the step of forming the blended
**WARNING** end of DESC field may overlap start of CLMS **.
Claims (14)
1. A surgical dressing comprising a composite containing vegetable matter derived from
Sphagnum moss and an alginate salt.
2. A dressing as claimed in claim 1, comprising sodium or calcium alginate or a mixture thereof.
3. A dressing as claimed in claim 2, comprising calcium alginate in the form of fibres or of a film.
4. A dressing as claimed in any preceding claim, wherein the moss comprises one or more pure species selected from: Sphagnum papillosum, Sphagnum palustre, Sphagnum magellanicum and Sphagnum imbricatum.
5. A dressirg as claimed in any preceding claim, wherein the vegetable matter is derived by drying and crimping said moss.
6. A dressing as claimed in any preceding claim, comprising a membrane permeable to air but impermeable to water.
7. A dressing as claimed in any preceding claim comprising a layer of vegetable matter, sandwiched between layers of alginate film.
8. A method of manufacture of a surgical dressing comprising the steps of blending vegetable matter derived from Sphagnum moss with fibres of an alginate salt.
9. A method as claimed in Claim 8, wherein the blending is performed by air laying.
10. A method as claimed in any of claims 8 or 9, comprising the step of forming the blended mixture into pads or portions suitable for surgical use.
11. A method of manufacture of a surgical dressing comprising the steps of causing fragmented vegetable matter derived from
Sphagnum moss to adhere to a film of an alginate salt.
12. A method as claimed in claim 1 wherein the film is sprayed with water to form a surface to which the vegetable matter will adhere.
13. A method as claimed in any of claims 8 to 12, wherein the moss is moistened prior to combination with the alginate.
14. A method as claimed in any of claims 8 to 13, comprising the step of incorporation of a film permeable to air but impermeable to water.
1 5. A dressing substantially as hereinbefore described.
1 6. A method substantially as hereinbefore described.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB08403620A GB2134792B (en) | 1983-02-11 | 1984-02-10 | Bioactive composite dressing |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838303840A GB8303840D0 (en) | 1983-02-11 | 1983-02-11 | Bioactive composite dressing |
| GB08403620A GB2134792B (en) | 1983-02-11 | 1984-02-10 | Bioactive composite dressing |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| GB8403620D0 GB8403620D0 (en) | 1984-03-14 |
| GB2134792A true GB2134792A (en) | 1984-08-22 |
| GB2134792B GB2134792B (en) | 1986-08-13 |
Family
ID=26285207
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB08403620A Expired GB2134792B (en) | 1983-02-11 | 1984-02-10 | Bioactive composite dressing |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB2134792B (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0220422A3 (en) * | 1985-08-29 | 1987-09-30 | Johnson & Johnson | Air laid peat moss board |
| GB2221620A (en) * | 1988-07-29 | 1990-02-14 | Johnson & Johnson Patient Care | Haemostatic wound dressing material |
| WO1993011804A1 (en) * | 1990-06-07 | 1993-06-24 | Killingbeck Bernard R | Improved herbal wound dressing |
| EP0643955A1 (en) * | 1993-09-21 | 1995-03-22 | JOHNSON & JOHNSON INC. | Sphagnum moss composition for the production of sheeted absorbent and method for evaluating the potential of sphagnum moss material for absorbing liquid |
| ES2070077A1 (en) * | 1993-04-30 | 1995-05-16 | Lopez Julian Hermoso | Hygienic/therapeutic article, such as a sanitary towel, nappy, tampon or the like |
| WO1998017328A1 (en) * | 1996-10-22 | 1998-04-30 | Smith & Nephew Plc | Absorbent dressing |
| US5914125A (en) * | 1991-02-07 | 1999-06-22 | Ultra Laboratories Limited | Wound dressing |
| GB2333711A (en) * | 1996-10-22 | 1999-08-04 | Smith & Nephew | Absorbant dressing |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB696309A (en) * | 1950-03-17 | 1953-08-26 | Johnson & Johnson | Surgical dressings |
-
1984
- 1984-02-10 GB GB08403620A patent/GB2134792B/en not_active Expired
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB696309A (en) * | 1950-03-17 | 1953-08-26 | Johnson & Johnson | Surgical dressings |
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0220422A3 (en) * | 1985-08-29 | 1987-09-30 | Johnson & Johnson | Air laid peat moss board |
| GB2221620A (en) * | 1988-07-29 | 1990-02-14 | Johnson & Johnson Patient Care | Haemostatic wound dressing material |
| NL8901936A (en) * | 1988-07-29 | 1990-02-16 | Johnson & Johnson Patient Care | HEMOSTATIC Woven Dressing Material. |
| GB2221620B (en) * | 1988-07-29 | 1991-09-04 | Johnson & Johnson Patient Care | Haemostatic wound dressing material |
| WO1993011804A1 (en) * | 1990-06-07 | 1993-06-24 | Killingbeck Bernard R | Improved herbal wound dressing |
| US5914125A (en) * | 1991-02-07 | 1999-06-22 | Ultra Laboratories Limited | Wound dressing |
| ES2070077A1 (en) * | 1993-04-30 | 1995-05-16 | Lopez Julian Hermoso | Hygienic/therapeutic article, such as a sanitary towel, nappy, tampon or the like |
| US5531726A (en) * | 1993-09-21 | 1996-07-02 | Johnson & Johnson, Inc. | Sphagnum moss composition for the production of sheeted absorbent and method for evaluating the potential of sphagnum moss material for absorbing liquid |
| AU677419B2 (en) * | 1993-09-21 | 1997-04-24 | Johnson & Johnson Inc. | Sphagnum moss composition for the production of sheeted absorbent and method for evaluating the potential of sphagnum moss material for absorbing liquid |
| EP0862905A1 (en) * | 1993-09-21 | 1998-09-09 | JOHNSON & JOHNSON INC. | Sphagnum moss composition for the production of sheeted absorbent and method for evaluating the potential of sphagnum moss material for absorbing liquid |
| EP0872174A1 (en) * | 1993-09-21 | 1998-10-21 | JOHNSON & JOHNSON INC. | Method for harvesting sphagnum moss aggregates |
| EP0874239A1 (en) * | 1993-09-21 | 1998-10-28 | JOHNSON & JOHNSON INC. | Sphagnum moss composition for the production of sheeted absorbent and method for evaluating the potential of sphagnum moss material for absorbing liquid |
| EP0643955A1 (en) * | 1993-09-21 | 1995-03-22 | JOHNSON & JOHNSON INC. | Sphagnum moss composition for the production of sheeted absorbent and method for evaluating the potential of sphagnum moss material for absorbing liquid |
| WO1998017328A1 (en) * | 1996-10-22 | 1998-04-30 | Smith & Nephew Plc | Absorbent dressing |
| GB2333711A (en) * | 1996-10-22 | 1999-08-04 | Smith & Nephew | Absorbant dressing |
Also Published As
| Publication number | Publication date |
|---|---|
| GB8403620D0 (en) | 1984-03-14 |
| GB2134792B (en) | 1986-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |
Effective date: 19940210 |