GB2425309A - C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers - Google Patents

C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers

Info

Publication number
GB2425309A
GB2425309A GB0614749A GB0614749A GB2425309A GB 2425309 A GB2425309 A GB 2425309A GB 0614749 A GB0614749 A GB 0614749A GB 0614749 A GB0614749 A GB 0614749A GB 2425309 A GB2425309 A GB 2425309A
Authority
GB
United Kingdom
Prior art keywords
benzodiazepine dimers
pyrrolo
fluoro
fluoro pyrrolo
benzodiazepine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0614749A
Other versions
GB0614749D0 (en
GB2425309B (en
Inventor
Ahmed Kamal
Peram Surakattula Murali Reddy
Depatla Rajasekhar Reddy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Council of Scientific and Industrial Research CSIR
Original Assignee
Council of Scientific and Industrial Research CSIR
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Council of Scientific and Industrial Research CSIR filed Critical Council of Scientific and Industrial Research CSIR
Publication of GB0614749D0 publication Critical patent/GB0614749D0/en
Publication of GB2425309A publication Critical patent/GB2425309A/en
Application granted granted Critical
Publication of GB2425309B publication Critical patent/GB2425309B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel 2-fluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimers of formula (IX) where n is 3 to 10 useful as antitumour agents and to a process for the preparation thereof.
GB0614749A 2003-12-31 2003-12-31 C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers Expired - Fee Related GB2425309B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/IN2003/000448 WO2005063758A1 (en) 2003-12-31 2003-12-31 C2-FLUORO PYRROLO[2,1-c][1,4]BENZODIAZEPINE DIMERS

Publications (3)

Publication Number Publication Date
GB0614749D0 GB0614749D0 (en) 2006-09-06
GB2425309A true GB2425309A (en) 2006-10-25
GB2425309B GB2425309B (en) 2008-07-09

Family

ID=34717565

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0614749A Expired - Fee Related GB2425309B (en) 2003-12-31 2003-12-31 C2-fluoro pyrrolo[2,1-c][1,4]benzodiazepine dimers

Country Status (4)

Country Link
JP (1) JP4833663B2 (en)
AU (1) AU2003300705A1 (en)
GB (1) GB2425309B (en)
WO (1) WO2005063758A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007093873A1 (en) * 2006-02-13 2007-08-23 Council Of Scientific And Industrial Research Bis-pyrr0l0[2,l-c] [1, 4] benzodiazepine- anthraquinone conjugates as antitumour agents and a process for the preparation thereof
CA2645350C (en) * 2006-03-10 2014-09-09 Council Of Scientific And Industrial Research Novel bis-2-difluoro-pyrrolo[2,1-c][1,4]benzodiazepine dimmers
US8383618B2 (en) 2008-03-11 2013-02-26 Council Of Scientific & Industrial Research C2-fluoro substituted piperazine linked pyrrolo[2,1-C][1,4] benzodiazepine dimers and a process for the preparation thereof
RU2018124319A (en) * 2015-12-04 2020-01-09 ЭББВИ СТЕМСЕНТРКС ЭлЭлСи NEW ANTIBODIES TO CLAUDIN AND WAYS OF THEIR APPLICATION
NZ762505A (en) 2017-09-29 2026-03-27 Daiichi Sankyo Co Ltd Antibody-pyrrolobenzodiazepine derivative conjugate
WO2024213113A2 (en) * 2023-04-13 2024-10-17 Beigene Switzerland Gmbh Targeted pyrrolobenzodiazapine conjugates

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018045A1 (en) * 1992-03-09 1993-09-16 Cancer Research Campaign Technology Limited Anti-cancer pyrrolobenzodiazepine derivatives

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018045A1 (en) * 1992-03-09 1993-09-16 Cancer Research Campaign Technology Limited Anti-cancer pyrrolobenzodiazepine derivatives

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Journal of Medicinal Chemistry Vol. 45, 2002, pages 4679-4688 *
Journal of Medicinal Chemsitry Vol. 44, No. 5, 2001, pages 737-748 *
Journal of Organic Chemistry Vol. 61, No. 23, 1996, pages 8141-8147 *

Also Published As

Publication number Publication date
GB0614749D0 (en) 2006-09-06
JP4833663B2 (en) 2011-12-07
JP2007518671A (en) 2007-07-12
GB2425309B (en) 2008-07-09
AU2003300705A1 (en) 2005-07-21
WO2005063758A1 (en) 2005-07-14

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Legal Events

Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20171231