GB856493A - Therapeutic compositions comprising tetracycline antibiotics - Google Patents
Therapeutic compositions comprising tetracycline antibioticsInfo
- Publication number
- GB856493A GB856493A GB30645/58A GB3064558A GB856493A GB 856493 A GB856493 A GB 856493A GB 30645/58 A GB30645/58 A GB 30645/58A GB 3064558 A GB3064558 A GB 3064558A GB 856493 A GB856493 A GB 856493A
- Authority
- GB
- United Kingdom
- Prior art keywords
- glucosamine
- salts
- acyl
- tetracycline
- demethyltetracycline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000000203 mixture Substances 0.000 title 1
- 229940072172 tetracycline antibiotic Drugs 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000004098 Tetracycline Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 239000003242 anti bacterial agent Substances 0.000 abstract 2
- 229940088710 antibiotic agent Drugs 0.000 abstract 2
- MSWZFWKMSRAUBD-UHFFFAOYSA-N beta-D-galactosamine Natural products NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 abstract 2
- 230000003115 biocidal effect Effects 0.000 abstract 2
- -1 bromtetracycline Chemical compound 0.000 abstract 2
- 229960002442 glucosamine Drugs 0.000 abstract 2
- 150000002302 glucosamines Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229960002180 tetracycline Drugs 0.000 abstract 2
- 235000019364 tetracycline Nutrition 0.000 abstract 2
- 229930101283 tetracycline Natural products 0.000 abstract 2
- 150000003522 tetracyclines Chemical class 0.000 abstract 2
- RMVMLZHPWMTQGK-SOUFLCLCSA-N (4s,4as,5as,6s,12ar)-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=CC=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O RMVMLZHPWMTQGK-SOUFLCLCSA-N 0.000 abstract 1
- GUXHBMASAHGULD-SEYHBJAFSA-N (4s,4as,5as,6s,12ar)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 abstract 1
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 abstract 1
- 239000004099 Chlortetracycline Substances 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 abstract 1
- 239000004100 Oxytetracycline Substances 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 125000004063 butyryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- CYDMQBQPVICBEU-UHFFFAOYSA-N chlorotetracycline Natural products C1=CC(Cl)=C2C(O)(C)C3CC4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-UHFFFAOYSA-N 0.000 abstract 1
- 229960004475 chlortetracycline Drugs 0.000 abstract 1
- CYDMQBQPVICBEU-XRNKAMNCSA-N chlortetracycline Chemical compound C1=CC(Cl)=C2[C@](O)(C)[C@H]3C[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O CYDMQBQPVICBEU-XRNKAMNCSA-N 0.000 abstract 1
- 235000019365 chlortetracycline Nutrition 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- JCSGAUKCDAVARS-UHFFFAOYSA-N demethyltetracycline Natural products CN(C1C(=C(C(C2(C(=C3C(C4=C(C=CC=C4C(C3CC12)O)O)=O)O)O)=O)C(=O)N)O)C JCSGAUKCDAVARS-UHFFFAOYSA-N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000002736 metal compounds Chemical class 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000007524 organic acids Chemical class 0.000 abstract 1
- 229960000625 oxytetracycline Drugs 0.000 abstract 1
- IWVCMVBTMGNXQD-PXOLEDIWSA-N oxytetracycline Chemical compound C1=CC=C2[C@](O)(C)[C@H]3[C@H](O)[C@H]4[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-PXOLEDIWSA-N 0.000 abstract 1
- 235000019366 oxytetracycline Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
- 229940095064 tartrate Drugs 0.000 abstract 1
- IWVCMVBTMGNXQD-UHFFFAOYSA-N terramycin dehydrate Natural products C1=CC=C2C(O)(C)C3C(O)C4C(N(C)C)C(O)=C(C(N)=O)C(=O)C4(O)C(O)=C3C(=O)C2=C1O IWVCMVBTMGNXQD-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Veterinary and pharmaceutical compositions for oral use comprise at least one tetracycline type antibiotic and at least one of the compounds; glucosamine, glucosamine salts, N-acyl glucosamines. Specified antibiotics are tetracycline, oxytetracycline; chlortetracycline, bromtetracycline, 6 - demethyl-chlortetracycline, 6 - demethyltetracycline, 6-deoxy-6-demethyltetracycline in their amphoteric forms and as salts with acids and bases, as complexes with polyvalent metal compounds and as derivatives such as esters which have similar biological activity as the parent antibiotics. Specified glucosamine salts are those non-toxic salts formed from the base and organic or inorganic acids e.g. the phosphate, sulphate, hydrochloride, hydrobromide, citrate, tartrate, succinate and ralicylate. The N-acyl glucosamines may be those in which the acyl group is a lower (C1 to 6) aliphatic acyl group e.g. acetyl, propionyl, butyryl. The ratio by weight of antibiotic to glucosamine compound may be from about 3:1 to 1:3 and is preferably about 1:1.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US856493XA | 1957-10-04 | 1957-10-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB856493A true GB856493A (en) | 1960-12-21 |
Family
ID=22193041
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB30645/58A Expired GB856493A (en) | 1957-10-04 | 1958-09-25 | Therapeutic compositions comprising tetracycline antibiotics |
Country Status (1)
| Country | Link |
|---|---|
| GB (1) | GB856493A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3328258A (en) * | 1962-09-10 | 1967-06-27 | Lipha | Anti-microbial therapeutics consisting of nitrofurantoin, tetracycline, and d-glucosamine |
| EP1083929A4 (en) * | 1998-06-05 | 2002-11-27 | Nutramax Lab Inc | USE OF ANABOLICS, ANTI-CATABOLIC AGENTS, ANTIOXIDANTS AND ANALGETICS FOR THE PROTECTION, TREATMENT AND REPAIR OF TISSUE TISSUE IN HUMAN AND ANIMALS |
| EP1053000A4 (en) * | 1998-02-13 | 2003-01-29 | Nutramax Lab Inc | Agents and methods for protection, treatment and repair of connective tissue |
| EP1461045A4 (en) * | 2001-12-07 | 2005-10-19 | Cargill Inc | Glucosamine organic acid adducts |
-
1958
- 1958-09-25 GB GB30645/58A patent/GB856493A/en not_active Expired
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3328258A (en) * | 1962-09-10 | 1967-06-27 | Lipha | Anti-microbial therapeutics consisting of nitrofurantoin, tetracycline, and d-glucosamine |
| EP1053000A4 (en) * | 1998-02-13 | 2003-01-29 | Nutramax Lab Inc | Agents and methods for protection, treatment and repair of connective tissue |
| EP1917966A1 (en) * | 1998-02-13 | 2008-05-07 | Nutramax Laboratories, Inc. | Agents and methods for protection treatment and repair of connective tissue |
| EP1083929A4 (en) * | 1998-06-05 | 2002-11-27 | Nutramax Lab Inc | USE OF ANABOLICS, ANTI-CATABOLIC AGENTS, ANTIOXIDANTS AND ANALGETICS FOR THE PROTECTION, TREATMENT AND REPAIR OF TISSUE TISSUE IN HUMAN AND ANIMALS |
| AU770010B2 (en) * | 1998-06-05 | 2004-02-12 | Nutramax Laboratories, Inc. | Agents and methods for protection, treatment and repair of connective tissue |
| EP1461045A4 (en) * | 2001-12-07 | 2005-10-19 | Cargill Inc | Glucosamine organic acid adducts |
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