GB921237A - New iminodibenzyl derivatives - Google Patents
New iminodibenzyl derivativesInfo
- Publication number
- GB921237A GB921237A GB39351/59A GB3935159A GB921237A GB 921237 A GB921237 A GB 921237A GB 39351/59 A GB39351/59 A GB 39351/59A GB 3935159 A GB3935159 A GB 3935159A GB 921237 A GB921237 A GB 921237A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- compound
- acid addition
- iminodibenzyl
- bases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZSMRRZONCYIFNB-UHFFFAOYSA-N 6,11-dihydro-5h-benzo[b][1]benzazepine Chemical class C1CC2=CC=CC=C2NC2=CC=CC=C12 ZSMRRZONCYIFNB-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 2
- 150000003242 quaternary ammonium salts Chemical class 0.000 abstract 2
- GDYSMASMPYFROC-UHFFFAOYSA-N (1-benzyl-2,3-dihydrobenzo[d][1]benzazepin-1-yl)-phenylmethanimine Chemical class N=C(C1=CC=CC=C1)C1(CCC=C2C1=C1C(=CC=N2)C=CC=C1)CC1=CC=CC=C1 GDYSMASMPYFROC-UHFFFAOYSA-N 0.000 abstract 1
- HSKBGALULOFBAM-UHFFFAOYSA-N 2,3-dihydroxy-4-methylidene-3h-naphthalene-1-carboxylic acid Chemical class C1=CC=C2C(=C)C(O)C(O)=C(C(O)=O)C2=C1 HSKBGALULOFBAM-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910002092 carbon dioxide Inorganic materials 0.000 abstract 1
- 239000001569 carbon dioxide Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003873 salicylate salts Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
The invention comprises: iminodibenzyl (dihydrodibenzazepine) derivatives of the general formula <FORM:0921237/IV(a)/1> (wherein A represents a straight or branched alkylene chain of 2-6 carbon atoms) and their acid addition and quaternary ammonium salts; the preparation of the bases by reacting a compound of the general formula <FORM:0921237/IV(a)/2> (wherein Z represents the acid residue of a reactive ester) with azetidine, or by reacting iminodibenzyl with a compound of the general formula <FORM:0921237/IV(a)/3> or by heating a compound of the general formula <FORM:0921237/IV(a)/4> above 100 DEG C. until evolution of carbon dioxide ceases; and pharmaceutical compositions containing at least one of the bases, or an acid addition or quaternary ammonium salt thereof, and a pharmaceutical carrier. The pharmaceutical compositions, which have neurotonic activity, may be in forms suitable for oral or parenteral administration, e.g. tablets, pills, dispersible powders, granules, capsules, emulsions, solutions, suspensions, syrups or elixirs. Specified acid addition salts include theophyllineacetates, phenolphthalinates, salicylates and methylene-bis-hydroxynaphthoates.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB39351/59A GB921237A (en) | 1959-11-19 | 1959-11-19 | New iminodibenzyl derivatives |
| FR839869A FR1268813A (en) | 1959-11-19 | 1960-09-29 | New iminodibenzyl derivatives and their preparation processes |
| FR839870A FR764M (en) | 1959-11-19 | 1960-09-29 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB39351/59A GB921237A (en) | 1959-11-19 | 1959-11-19 | New iminodibenzyl derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB921237A true GB921237A (en) | 1963-03-20 |
Family
ID=10409080
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB39351/59A Expired GB921237A (en) | 1959-11-19 | 1959-11-19 | New iminodibenzyl derivatives |
Country Status (2)
| Country | Link |
|---|---|
| FR (1) | FR764M (en) |
| GB (1) | GB921237A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10639313B2 (en) | 2017-09-01 | 2020-05-05 | Ndsu Research Foundation | Compound for inhibition of delta-5-desaturase (D5D) and treatment of cancer and inflammation |
-
1959
- 1959-11-19 GB GB39351/59A patent/GB921237A/en not_active Expired
-
1960
- 1960-09-29 FR FR839870A patent/FR764M/fr active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10639313B2 (en) | 2017-09-01 | 2020-05-05 | Ndsu Research Foundation | Compound for inhibition of delta-5-desaturase (D5D) and treatment of cancer and inflammation |
Also Published As
| Publication number | Publication date |
|---|---|
| FR764M (en) | 1961-08-28 |
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