GEP20002244B - Osteoprotegerin - Google Patents

Osteoprotegerin

Info

Publication number
GEP20002244B
GEP20002244B GEAP19963840A GEAP1996003840A GEP20002244B GE P20002244 B GEP20002244 B GE P20002244B GE AP19963840 A GEAP19963840 A GE AP19963840A GE AP1996003840 A GEAP1996003840 A GE AP1996003840A GE P20002244 B GEP20002244 B GE P20002244B
Authority
GE
Georgia
Prior art keywords
opg
bone diseases
osteoprotegerin
disclosed
treatment
Prior art date
Application number
GEAP19963840A
Inventor
Frank J Calzone
William J Boyle
Ming-Shi Chang
David L Lacey
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/577,788 external-priority patent/US6613544B1/en
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of GEP20002244B publication Critical patent/GEP20002244B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. Technical Result Increase in treatment efficiency of bone diseases. 2. Essence Disclosed is a new member of the tumor-osteoprotegerin (OPG) necrosis factor receptor superfamily. Also disclosed are nucleic acids encoding OPG, polypeptides, recombinant vectors and host cells for OPG expression, antibodies which bind OPG, and pharmaceutical compositions. The method for treatment of bone diseases are developed. 3. Field of Application Medicine, therapy. Figures: 28
GEAP19963840A 1995-12-22 1996-12-20 Osteoprotegerin GEP20002244B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70694595A 1995-12-22 1995-12-22
US08/577,788 US6613544B1 (en) 1995-12-22 1995-12-22 Osteoprotegerin

Publications (1)

Publication Number Publication Date
GEP20002244B true GEP20002244B (en) 2000-09-25

Family

ID=82493846

Family Applications (1)

Application Number Title Priority Date Filing Date
GEAP19963840A GEP20002244B (en) 1995-12-22 1996-12-20 Osteoprotegerin

Country Status (1)

Country Link
GE (1) GEP20002244B (en)

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