GR1000433B - Device and method for a medicine iontophbore release - Google Patents

Device and method for a medicine iontophbore release

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Publication number
GR1000433B
GR1000433B GR900100311A GR900100311A GR1000433B GR 1000433 B GR1000433 B GR 1000433B GR 900100311 A GR900100311 A GR 900100311A GR 900100311 A GR900100311 A GR 900100311A GR 1000433 B GR1000433 B GR 1000433B
Authority
GR
Greece
Prior art keywords
agent
ions
molecular weight
reservoir
electrolyte
Prior art date
Application number
GR900100311A
Other languages
Greek (el)
Inventor
J Richard Gyory
Ronald P Haak
Felix Theeuwes
Original Assignee
Alza Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Alza Corp filed Critical Alza Corp
Publication of GR1000433B publication Critical patent/GR1000433B/en

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Abstract

Μια ηλεκτρικώς περατή μεμβράνη (14) είναι τοποθετημένη μεταξύ της αποθήκης (15) παράγοντα και του ηλεκτροδίου (11) μιας διάταξης (8) ηλεκτροδίου δότη σε μια ιοντοφορητική συσκευή (10) απελευθέρωσης. Προαιρετικά, μια αποθήκη (13) ηλεκτρολύτου είναι τοποθετημένη ενδιαμέσως του ηλεκτροδίου (11) και της αποθήκης (15) παράγοντα. Σε ορισμένες πραγματοποιήσεις η μεμβράνη (14) είναι περατή σε είδος μικρότερο από ένα προσδιορισμένο από πριν μοριακό βάρος και ουσιαστικά λιγότερο περατή σε είδος μεγαλύτερο από το προσδιορισμένο από πριν μοριακό βάρος. Ο παράγων είναι ικανός διάστασης σε ιόντα παράγοντα και αντίθετα ιόντα. Η εκλεκτικότητα μεγέθους της μεμβράνης (14), το μοριακό των ιόντων παράγοντα, το μοριακό βάρος αντιθέτων ιόντων και προαιρετικώς το μοριακό βάρος των ιόντων ηλεκτρολύτου, επιλέγονται ώστε να (Α) παρεμποδίζουν τα ιόντα παράγοντα από αλληλεπίδραση με το ηλεκτρόδιο (11) και από το να διαπερνούν μέσα στην αποθήκη (13) ηλεκτρολύτου,όπου μπορούν αυτά αλλιώς να αποικοδομούνται και (Β) παρεμποδίζουν ιόντα ηλεκτρολύτου που έχουν φορτίο παρόμοιο προς εκείνο των ιόντων παράγοντα, από το να διαπερνούν εντός της αποθήκης (15) παράγοντα και να ανταγωνίζονται τα ιόντα παράγοντα για ιοντοφορητική απελευθέρωση εντός του ασθενούς. ωAn electrically permeable membrane (14) is positioned between the agent reservoir (15) and the electrode (11) of a donor electrode assembly (8) in an iontophoretic release device (10). Optionally, an electrolyte reservoir (13) is positioned between the electrode (11) and the agent reservoir (15). In some embodiments the membrane (14) is permeable to a species less than a predetermined molecular weight and substantially less permeable to a species greater than the predetermined molecular weight. The agent is capable of dissociating into agent ions and counter ions. The size selectivity of the membrane (14), the molecular weight of the agent ions, the molecular weight of the counterions, and optionally the molecular weight of the electrolyte ions, are selected to (A) prevent the agent ions from interacting with the electrode (11) and from permeate into the electrolyte reservoir (13), where they may otherwise be degraded, and (B) prevent electrolyte ions having a charge similar to that of the agent ions from penetrating into the agent reservoir (15) and competing with the agent ions for iontophoretic delivery within the patient. oh

GR900100311A 1990-04-24 1990-04-24 Device and method for a medicine iontophbore release GR1000433B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR90100311 1990-04-24

Publications (1)

Publication Number Publication Date
GR1000433B true GR1000433B (en) 1992-07-30

Family

ID=10940124

Family Applications (1)

Application Number Title Priority Date Filing Date
GR900100311A GR1000433B (en) 1990-04-24 1990-04-24 Device and method for a medicine iontophbore release

Country Status (1)

Country Link
GR (1) GR1000433B (en)

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007269A1 (en) * 1985-06-10 1986-12-18 Drug Delivery Systems Inc. Programmable control and mounting system for transdermal drug applicator
US4702732A (en) * 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
WO1990003825A1 (en) * 1988-10-03 1990-04-19 Alza Corporation Control membrane for electrotransport drug delivery

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4702732A (en) * 1984-12-24 1987-10-27 Trustees Of Boston University Electrodes, electrode assemblies, methods, and systems for tissue stimulation and transdermal delivery of pharmacologically active ligands
WO1986007269A1 (en) * 1985-06-10 1986-12-18 Drug Delivery Systems Inc. Programmable control and mounting system for transdermal drug applicator
US4722726A (en) * 1986-02-12 1988-02-02 Key Pharmaceuticals, Inc. Method and apparatus for iontophoretic drug delivery
US4731049A (en) * 1987-01-30 1988-03-15 Ionics, Incorporated Cell for electrically controlled transdermal drug delivery
WO1990003825A1 (en) * 1988-10-03 1990-04-19 Alza Corporation Control membrane for electrotransport drug delivery

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CLAIMS SEARCHED: ALL *

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