GR1003359B - Liposomic niflumic acid-new transdermal anti-inflammatory medicine - Google Patents
Liposomic niflumic acid-new transdermal anti-inflammatory medicineInfo
- Publication number
- GR1003359B GR1003359B GR980100469A GR980100469A GR1003359B GR 1003359 B GR1003359 B GR 1003359B GR 980100469 A GR980100469 A GR 980100469A GR 980100469 A GR980100469 A GR 980100469A GR 1003359 B GR1003359 B GR 1003359B
- Authority
- GR
- Greece
- Prior art keywords
- encapsulated
- medecine
- liposomes
- niflumic acid
- encapsulation
- Prior art date
Links
- 230000003110 anti-inflammatory effect Effects 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 150000002632 lipids Chemical class 0.000 abstract 3
- 239000002502 liposome Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- JZFPYUNJRRFVQU-UHFFFAOYSA-N Niflumic acid Chemical compound OC(=O)C1=CC=CN=C1NC1=CC=CC(C(F)(F)F)=C1 JZFPYUNJRRFVQU-UHFFFAOYSA-N 0.000 abstract 2
- 238000005538 encapsulation Methods 0.000 abstract 2
- 229960000916 niflumic acid Drugs 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- 239000000725 suspension Substances 0.000 abstract 2
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 238000010276 construction Methods 0.000 abstract 1
- 239000006071 cream Substances 0.000 abstract 1
- 238000005516 engineering process Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000012467 final product Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000035699 permeability Effects 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 238000004321 preservation Methods 0.000 abstract 1
- 238000007493 shaping process Methods 0.000 abstract 1
- 150000003431 steroids Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1277—Preparation processes; Proliposomes
- A61K9/1278—Post-loading, e.g. by ion or pH gradient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Organic Chemistry (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to the encapsulation of the niflumic acid in liposomes for creating a new transdermal non steroid anti-inflamatory preparation. Various pharmaceutical molecules are encapsulated in liposomes (spherical lipid constructions), by techniques such as the active transfer or the encapsulation of the medecine in lipid double-layers. The aim of this technology is to improve the pharmacokinetic properties of said molecules, and increase the selectivity of the medecines concerning the tissues as well as their absorption by the skin. The niflumic acid and its esters are encapsulated in liposomes of different lipid composition by the aforementioned techniques with the purpose of improving the efficiency of the drastic substance. Furthermore, the physico-chemical characteristics of the liposomal suspension with or without the encapsulated medecine, such as size, stability in diverse preservation conditions as to the temperature and the moisture, are measured. The process continues with the shaping in cream of the liposomal suspension with or without the encapsulated medecine as well as with the stability study of the final pharmacoceutical form. The final product is, finally, tested for its permeability, in vitro, on the human skin and, in vivo, for its efficienfy, following precise protocols.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GR98100469 | 1998-12-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GR1003359B true GR1003359B (en) | 2000-04-10 |
Family
ID=10943556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GR980100469A GR1003359B (en) | 1998-12-24 | 1998-12-24 | Liposomic niflumic acid-new transdermal anti-inflammatory medicine |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP1140089A1 (en) |
| JP (1) | JP2002533394A (en) |
| KR (1) | KR20010089889A (en) |
| CN (1) | CN1331592A (en) |
| AU (1) | AU1673400A (en) |
| BR (1) | BR9917006A (en) |
| CA (1) | CA2357765A1 (en) |
| CZ (1) | CZ20012240A3 (en) |
| GR (1) | GR1003359B (en) |
| HU (1) | HUP0104853A3 (en) |
| IL (1) | IL143499A0 (en) |
| IS (1) | IS5964A (en) |
| MX (1) | MXPA01006462A (en) |
| NO (1) | NO20013015D0 (en) |
| PL (1) | PL349344A1 (en) |
| SK (1) | SK7962001A3 (en) |
| WO (1) | WO2000038681A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004047800A2 (en) * | 2002-11-26 | 2004-06-10 | Gilead Sciences, Inc. | Method of drug loading in liposomes by gradient |
| JP5107573B2 (en) | 2003-04-25 | 2012-12-26 | ザ ペン ステイト リサーチ ファウンデーション | Systemic delivery methods and systems for growth-inhibiting lipid-derived bioactive compounds |
| US20050255154A1 (en) | 2004-05-11 | 2005-11-17 | Lena Pereswetoff-Morath | Method and composition for treating rhinitis |
| JP4791082B2 (en) * | 2005-05-30 | 2011-10-12 | 株式会社クラレ | Liposomes and topical skin preparations containing the same |
| JP4931369B2 (en) * | 2005-05-31 | 2012-05-16 | ポーラ化成工業株式会社 | Liposomes and therapeutic compositions containing the same |
| JP5846711B2 (en) | 2005-06-09 | 2016-01-20 | メダ アーベー | Methods and compositions for the treatment of inflammatory diseases |
| US9144575B2 (en) | 2010-07-28 | 2015-09-29 | Life Technologies Corporation | Anti-viral azide containing compounds |
| US20120028335A1 (en) | 2010-07-28 | 2012-02-02 | Life Technologies Corporation | Anti-viral azide-containing compounds |
| SG11201404361UA (en) | 2012-01-26 | 2014-09-26 | Life Technologies Corp | Methods for increasing the infectivity of viruses |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4528193A (en) * | 1978-12-27 | 1985-07-09 | A. Natterman & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
| EP0225162A2 (en) * | 1985-11-27 | 1987-06-10 | Ethicon, Inc. | Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug |
| EP0249561A2 (en) * | 1986-06-12 | 1987-12-16 | The Liposome Company, Inc. | Compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| WO1996032930A1 (en) * | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
-
1998
- 1998-12-24 GR GR980100469A patent/GR1003359B/en not_active IP Right Cessation
-
1999
- 1999-12-22 CZ CZ20012240A patent/CZ20012240A3/en unknown
- 1999-12-22 KR KR1020017008144A patent/KR20010089889A/en not_active Withdrawn
- 1999-12-22 HU HU0104853A patent/HUP0104853A3/en unknown
- 1999-12-22 WO PCT/GR1999/000048 patent/WO2000038681A1/en not_active Ceased
- 1999-12-22 CA CA002357765A patent/CA2357765A1/en not_active Abandoned
- 1999-12-22 SK SK796-2001A patent/SK7962001A3/en unknown
- 1999-12-22 BR BR9917006-0A patent/BR9917006A/en not_active Application Discontinuation
- 1999-12-22 JP JP2000590635A patent/JP2002533394A/en active Pending
- 1999-12-22 AU AU16734/00A patent/AU1673400A/en not_active Abandoned
- 1999-12-22 PL PL99349344A patent/PL349344A1/en not_active Application Discontinuation
- 1999-12-22 IL IL14349999A patent/IL143499A0/en unknown
- 1999-12-22 MX MXPA01006462A patent/MXPA01006462A/en unknown
- 1999-12-22 CN CN99814948A patent/CN1331592A/en active Pending
- 1999-12-22 EP EP99959605A patent/EP1140089A1/en not_active Withdrawn
-
2001
- 2001-06-08 IS IS5964A patent/IS5964A/en unknown
- 2001-06-18 NO NO20013015A patent/NO20013015D0/en not_active Application Discontinuation
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4528193A (en) * | 1978-12-27 | 1985-07-09 | A. Natterman & Cie. Gmbh | Inflammation-preventing pharmaceutical composition of oral administration |
| EP0225162A2 (en) * | 1985-11-27 | 1987-06-10 | Ethicon, Inc. | Inhibition of post-surgical adhesion formation by the topical administration of non-steroidal anti-inflammatory drug |
| EP0249561A2 (en) * | 1986-06-12 | 1987-12-16 | The Liposome Company, Inc. | Compositions using liposome-encapsulated non-steroidal anti-inflammatory drugs |
| WO1996032930A1 (en) * | 1995-04-18 | 1996-10-24 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Liposome drug-loading method and composition |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1140089A1 (en) | 2001-10-10 |
| HUP0104853A3 (en) | 2003-05-28 |
| HUP0104853A2 (en) | 2002-05-29 |
| MXPA01006462A (en) | 2002-06-04 |
| AU1673400A (en) | 2000-07-31 |
| CN1331592A (en) | 2002-01-16 |
| PL349344A1 (en) | 2002-07-15 |
| BR9917006A (en) | 2001-10-30 |
| KR20010089889A (en) | 2001-10-12 |
| NO20013015L (en) | 2001-06-18 |
| JP2002533394A (en) | 2002-10-08 |
| IS5964A (en) | 2001-06-08 |
| CZ20012240A3 (en) | 2001-11-14 |
| WO2000038681A1 (en) | 2000-07-06 |
| CA2357765A1 (en) | 2000-07-06 |
| IL143499A0 (en) | 2002-04-21 |
| SK7962001A3 (en) | 2002-02-05 |
| NO20013015D0 (en) | 2001-06-18 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Kumar et al. | A review on phytosomes: novel approach for herbal phytochemicals | |
| Marianecci et al. | Anti-inflammatory activity of novel ammonium glycyrrhizinate/niosomes delivery system: human and murine models | |
| US8569247B2 (en) | Hydrolysate of crocin | |
| JP2848827B2 (en) | Composite compound of flavonoid and phospholipid, method for producing the same, and pharmaceutical and cosmetic composition containing the composite compound | |
| Rathore et al. | Planterosomes: A potential phyto-phospholipid carriers for the bioavailability enhancement of herbal extracts | |
| Kumar et al. | Phytosomes as emerging nanotechnology for herbal drug delivery | |
| Udapurkar et al. | Phyto-phospholipid complex vesicles for phytoconstituents and herbal extracts: A promising drug delivery system | |
| Nimbalkar et al. | Phytosomes-novel drug delivery system | |
| Varde et al. | Phytosomes: a potential phospholipid nanoparticulate carrier for the bioavailability enhancement of herbal extracts | |
| Ravi et al. | Phytosomes: a novel molecular nano complex between phytomolecule and phospholipid as a value added herbal drug delivery system | |
| KR20010089889A (en) | Liposomic niflumic acid-new transdermal anti-inflammatory medicine | |
| ES2673627T3 (en) | Liposomes containing di-homo-gamma linolenic acid (DGLA), formulations containing them and use thereof | |
| Vrushabh et al. | Review on phytosome for topical drug delivery | |
| AU2016250068B2 (en) | One-step method for production of Ultra-small Lipid Structures | |
| Singh et al. | Herbal bioactive: A booster dose for advanced pharmaceutical nanoscience | |
| Kamireddy et al. | Phytosomal drug delivery system: A detailed study | |
| KR20110114068A (en) | Vitamin complex, method for producing same and cosmetic composition comprising same | |
| BRPI1105312B1 (en) | PHARMACEUTICAL COMPOSITIONS UNDERSTANDING EXTRACT OF ARRABIDAEA CHICA, VERLOT IN MICRO AND NANOPARTICULATED AND LIPOSOMAL RELEASE SYSTEMS, MANUFACTURING PROCESSES AND USE OF THE SAME | |
| CN114681346A (en) | Amygdalin liposome, preparation method thereof and application thereof in cosmetics | |
| JPH0624999A (en) | Liposomal formulation | |
| CN113785975B (en) | Application of spermine and spermidine liposome in anti-oxidation and anti-aging | |
| JP2002212071A (en) | Oral ameliorant for epidermal permeable barrier function | |
| Dwivedi et al. | PHYTOSOMES AS A DRUG DELIVERY SYSTEM: A REVIEW | |
| JPH0482837A (en) | Neolignan deriuative and phospholipid composite, method of its use and pharmaceutical and cosmetic preparation containing said composite | |
| Joshi et al. | Novel Approach on Herbal Drug Delivery System: Phytosome A Brief Overview |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ML | Lapse due to non-payment of fees |