GR1004178B - Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια - Google Patents

Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια

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Publication number
GR1004178B
GR1004178B GR20010100550A GR2001100550A GR1004178B GR 1004178 B GR1004178 B GR 1004178B GR 20010100550 A GR20010100550 A GR 20010100550A GR 2001100550 A GR2001100550 A GR 2001100550A GR 1004178 B GR1004178 B GR 1004178B
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GR
Greece
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detector
integrated
biomolecules
light source
chip
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GR20010100550A
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English (en)
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Priority to GR20010100550A priority Critical patent/GR1004178B/el
Priority to PCT/GR2002/000061 priority patent/WO2003046527A1/en
Priority to EP02793256A priority patent/EP1448978B1/en
Priority to AU2002358915A priority patent/AU2002358915A1/en
Priority to AT02793256T priority patent/ATE420345T1/de
Priority to DE60230801T priority patent/DE60230801D1/de
Priority to US10/496,099 priority patent/US7319046B2/en
Publication of GR1004178B publication Critical patent/GR1004178B/el

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
    • G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides

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  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plasma & Fusion (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Silicon Compounds (AREA)

Abstract

εφεύρεση αφορά σε ολοκληρωμένο οπτοηλεκτρονικό βιοαισθητήρα πυριτίου που είναι σε θέση να ανιχνεύει βιομόρια από την αλλαγή της οπτικής ζεύξης μεταξύ της ολοκληρωμένης πηγής φωτός και του ολοκληρωμένου ανιχνευτή που προκαλείται από την πρόσδεση των κατάλληλα επισημασμένων προς ανάλυση βιομορίων στα μόρια-αναγνώρισης που έχουν προηγουμένως ακινητοποιηθεί στην ολοκληρωμένη οπτική ίνα που συνδέειτην οπτική πηγή με τον ανιχνευτή. Η διάταξη περιλαμβάνει την οπτοηλεκτρονική ψηφίδα πυριτίου και την βιολογική της ενεργοποίηση. Η οπτοηλεκτρονική ψηφίδα κατασκευάζεται με μεθόδους κατασκευής ολοκληρωμένων κυκλωμάτων έτσι ώστε στο ίδιο υπόστρωμα πυριτίου να ολοκληρώνεται μονολιθικά η πηγή φωτός, ο ανιχνευτής και η οπτική ίνα που πραγματοποιεί την οπτική ζεύξη πηγής-ανιχνευτή. Η βιολογική της ενεργοποίηση γίνεται με την φυσικοχημική τροποποίηση της επιφάνειας της ψηφίδας έτσι ώστε να είναι δυνατή η πρόσδεση των βιομορίων αναγνώρισης στην επιφάνεια της οπτικής ίνας. Τα προς ανίχνευση βιομόρια (πρωτείνες η ολιγονουκλεοτίδια) επισημαίνονται με χρωμοφόρες ομάδες ή με νανοσωματίδια ή με ένζυμα και μετά την πρόσδεσή τους στα βιομόρια αναγνώρισης μειώνουν την οπτική ζεύξη οπτικής πηγής-ανιχνευτή παρέχοντας ένα μέτρο για τη συγκέντρωσή τους. ΰ
GR20010100550A 2001-11-29 2001-11-29 Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια GR1004178B (el)

Priority Applications (7)

Application Number Priority Date Filing Date Title
GR20010100550A GR1004178B (el) 2001-11-29 2001-11-29 Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια
PCT/GR2002/000061 WO2003046527A1 (en) 2001-11-29 2002-11-29 Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
EP02793256A EP1448978B1 (en) 2001-11-29 2002-11-29 Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
AU2002358915A AU2002358915A1 (en) 2001-11-29 2002-11-29 Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles
AT02793256T ATE420345T1 (de) 2001-11-29 2002-11-29 Integrierter optoelektronischer silizium- biosensor zum nachweis von mit chromophoren gruppen oder nanopartikeln markierten biomolekülen
DE60230801T DE60230801D1 (de) 2001-11-29 2002-11-29 Integrierter optoelektronischer silizium-biosensor zum nachweis von mit chromophoren gruppen oder nanopartikeln markierten biomolekülen
US10/496,099 US7319046B2 (en) 2001-11-29 2002-11-29 Integrated optoelectronic silicon biosensor for the detection of biomolecules labeled with chromophore groups or nanoparticles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20010100550A GR1004178B (el) 2001-11-29 2001-11-29 Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια

Publications (1)

Publication Number Publication Date
GR1004178B true GR1004178B (el) 2003-03-05

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GR20010100550A GR1004178B (el) 2001-11-29 2001-11-29 Ολοκληρωμενος οπτοηλεκτρονικος βιοαισθητηρας πυριτιου για ανιχνευση βιομοριων επισημασμενων με χρωμοφορες ομαδες ή νανοσωματιδια

Country Status (7)

Country Link
US (1) US7319046B2 (el)
EP (1) EP1448978B1 (el)
AT (1) ATE420345T1 (el)
AU (1) AU2002358915A1 (el)
DE (1) DE60230801D1 (el)
GR (1) GR1004178B (el)
WO (1) WO2003046527A1 (el)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070009198A1 (en) * 2004-07-02 2007-01-11 Robert Petcavich Fiber optic bio-sensor
US7274458B2 (en) 2005-03-07 2007-09-25 3M Innovative Properties Company Thermoplastic film having metallic nanoparticle coating
US7889347B2 (en) * 2005-11-21 2011-02-15 Plexera Llc Surface plasmon resonance spectrometer with an actuator driven angle scanning mechanism
US7463358B2 (en) * 2005-12-06 2008-12-09 Lumera Corporation Highly stable surface plasmon resonance plates, microarrays, and methods
GR20050100623A (el) * 2005-12-27 2007-07-23 Εθνικο Κεντρο Ερευνας Φυσικων Επιστημων "Δημοκριτος" Βιοαισθητηρες ταυτοχρονης ανιχνευσης πολλαπλων αναλυτων που βασιζονται σε μονολιθικα ολοκληρωμενουσοπτοηλεκτρονικους μεταλλακτες σηματος
PT103561A (pt) * 2006-09-08 2008-03-31 Univ Nova De Lisboa Sistema de detecção e quantificação de matéria biológica constituído por um ou mais sensores ópticos e uma ou mais fontes luminosas, processo associado e respectivas utilizações
US7933022B2 (en) 2006-12-01 2011-04-26 3M Innovative Properties Company Integrated optical disk resonator
US7486855B2 (en) * 2006-12-27 2009-02-03 3M Innovative Properties Company Optical microresonator
US7512298B2 (en) * 2006-12-01 2009-03-31 3M Innovative Properties Company Optical sensing methods
US7903906B2 (en) * 2006-12-01 2011-03-08 3M Innovative Properties Company Optical sensing devices and methods
US7903240B2 (en) * 2006-12-01 2011-03-08 3M Innovative Properties Company Optical sensing device
US7702202B2 (en) * 2006-12-01 2010-04-20 3M Innovative Properties Company Optical microresonator
JP5276655B2 (ja) * 2007-06-01 2013-08-28 アトノミックス アクティーゼルスカブ 標的検体の検出用のナノ粒子を用いた生体表面弾性波（ｓａｗ）共振器増幅
US20090060786A1 (en) * 2007-08-29 2009-03-05 Gibum Kim Microfluidic apparatus for wide area microarrays
US8004669B1 (en) 2007-12-18 2011-08-23 Plexera Llc SPR apparatus with a high performance fluid delivery system
US20100081916A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware. Histological facilitation systems and methods
US20100081915A1 (en) * 2008-09-29 2010-04-01 Searete Llc, Alimited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081924A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081927A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
US20100081928A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological Facilitation systems and methods
US20100081926A1 (en) * 2008-09-29 2010-04-01 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Histological facilitation systems and methods
KR20120016297A (ko) 2009-06-01 2012-02-23 코넬 유니버시티 미소구를 이용한 통합 광학유체 시스템
KR101242138B1 (ko) * 2009-11-27 2013-03-12 한국전자통신연구원 광 바이오 센서, 광 바이오 센서 어레이 및 이를 이용한 바이오 물질의 검출 방법
US8137981B2 (en) 2010-02-02 2012-03-20 Nokia Corporation Apparatus and associated methods
US20170058310A1 (en) * 2014-02-19 2017-03-02 Empire Technology Development Llc Biosensing devices and methods of using and preparing the same
US9588289B1 (en) 2016-01-20 2017-03-07 International Business Machines Corporation Cointegration of optical waveguides, microfluidics, and electronics on sapphire substrates
US9643181B1 (en) 2016-02-08 2017-05-09 International Business Machines Corporation Integrated microfluidics system

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037996A1 (en) * 1998-01-23 1999-07-29 Torsana Biosensor A/S Detection of a substance by refractive index change
WO2001071322A2 (en) * 2000-03-22 2001-09-27 Goh M Cynthia Method and apparatus for multiple-analyte assay

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3679596D1 (de) * 1985-05-22 1991-07-11 Siemens Ag Verfahren zum herstellen von mit bor und phosphor dotierten siliziumoxid-schichten fuer integrierte halbleiterschaltungen.
GB8813307D0 (en) 1988-06-06 1988-07-13 Amersham Int Plc Biological sensors
US6589726B1 (en) * 1991-09-04 2003-07-08 Metrigen, Inc. Method and apparatus for in situ synthesis on a solid support
US5418058A (en) * 1993-10-04 1995-05-23 The Regents Of The University Of California Chemical microsensors
US5494801A (en) * 1993-12-03 1996-02-27 Biostar, Inc. Microorganism antigen extraction methods
US5494798A (en) * 1993-12-09 1996-02-27 Gerdt; David W. Fiber optic evanscent wave sensor for immunoassay
EP0725269A3 (en) * 1995-02-03 1997-12-17 Motorola, Inc. Optical sensor and method therefor
US6586193B2 (en) * 1996-04-25 2003-07-01 Genicon Sciences Corporation Analyte assay using particulate labels
US6342349B1 (en) * 1996-07-08 2002-01-29 Burstein Technologies, Inc. Optical disk-based assay devices and methods
US6750016B2 (en) * 1996-07-29 2004-06-15 Nanosphere, Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor
JP2000012856A (ja) * 1998-06-26 2000-01-14 Sony Corp Ｍｏｓトランジスタの製造方法
US6801677B1 (en) * 1998-09-10 2004-10-05 The Regents Of The Universtiy Of California Waveguide-based optical chemical sensor
US6239017B1 (en) * 1998-09-18 2001-05-29 Industrial Technology Research Institute Dual damascene CMP process with BPSG reflowed contact hole
AU6151699A (en) * 1998-09-21 2000-04-10 Ramot University Authority For Applied Research And Industrial Development Ltd. Method, chip, device and system for effecting and monitoring nucleic acid accumulation
DE60119170T2 (de) * 2000-07-11 2007-05-24 Northwestern University, Evanston Nachweismethode mittels verstärkter silberfärbung
US6608360B2 (en) * 2000-12-15 2003-08-19 University Of Houston One-chip micro-integrated optoelectronic sensor
US20020176464A1 (en) * 2001-03-22 2002-11-28 Smolski Oleg V. InGaP etch stop
WO2002096262A2 (en) * 2001-05-25 2002-12-05 Northwestern University Non-alloying core shell nanoparticles
US20030013218A1 (en) * 2001-07-10 2003-01-16 Motorola, Inc. Structure and method for fabricating semiconductor structures and devices for detecting chemical reactant

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999037996A1 (en) * 1998-01-23 1999-07-29 Torsana Biosensor A/S Detection of a substance by refractive index change
WO2001071322A2 (en) * 2000-03-22 2001-09-27 Goh M Cynthia Method and apparatus for multiple-analyte assay

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
HUANG F S ET AL: "RAPID THERMAL ANNEALING OF THE THROUGH-FILM SILICON IMPLANTATION ON GAAS", NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH, SECTION - B: BEAM INTERACTIONS WITH MATERIALS AND ATOMS, NORTH-HOLLAND PUBLISHING COMPANY. AMSTERDAM, NL, vol. PART 2, no. B59/B60, July 1991 (1991-07-01), pages 1003 - 1006, XP001032198, ISSN: 0168-583X *
MISIAKOS K ET AL: "MONILITHIC SILICON OPTOELECTRIC BIOCHIPS", PROCEEDINGS OF THE 40TH. IEEE CONFERENCE ON DECISION AND CONTROL. (CDC). ORLANDO, FL, DEC. 4 - 7, 2001, IEEE CONFERENCE ON DECISION AND CONTROL, NEW YORK, NY: IEEE, US, vol. 5 OF 5. CONF. 40, 2 December 2001 (2001-12-02), pages 359 - 362, XP001086556, ISBN: 0-7803-7061-9 *
MISIAKOS K ET AL: "MONOLITHIC INTEGRATION OF LIGHT EMITTING DIODES, DETECTORS AND OPTICAL FIBERS ON A SILICON WAFER: A CMOS COMPATIBLE OPTICAL SENSOR", INTERNATIONAL ELECTRON DEVICES MEETING 1998. IEDM TECHNICAL DIGEST. SAN FRANCISCO, CA, DEC. 6 - 9, 1998, NEW YORK, NY: IEEE, US, 6 December 1998 (1998-12-06), pages 25 - 28, XP000859313, ISBN: 0-7803-4775-7 *

Also Published As

Publication number Publication date
AU2002358915A1 (en) 2003-06-10
EP1448978B1 (en) 2009-01-07
DE60230801D1 (de) 2009-02-26
US7319046B2 (en) 2008-01-15
US20050003520A1 (en) 2005-01-06
EP1448978A1 (en) 2004-08-25
WO2003046527A1 (en) 2003-06-05
ATE420345T1 (de) 2009-01-15

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