GR1007722B - Μεθοδος για την παρασκευη της αριπιπραζολης - Google Patents

Μεθοδος για την παρασκευη της αριπιπραζολης

Info

Publication number
GR1007722B
GR1007722B GR20110100478A GR20110100478A GR1007722B GR 1007722 B GR1007722 B GR 1007722B GR 20110100478 A GR20110100478 A GR 20110100478A GR 20110100478 A GR20110100478 A GR 20110100478A GR 1007722 B GR1007722 B GR 1007722B
Authority
GR
Greece
Prior art keywords
preparation
aripirazole
aripiprazole
formula
reaction mixture
Prior art date
Application number
GR20110100478A
Other languages
English (en)
Inventor
Θεοχαρης Βασιλειου Κοφτης
Rohit-Ravikant Bapulal Soni
Hitarth Harsendu Acharya
Kandarpkumar Hasmukhabai Patel
Manoj Devidas Ahirrao
Original Assignee
Φαρματεν Αβεε,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Φαρματεν Αβεε, filed Critical Φαρματεν Αβεε,
Priority to GR20110100478A priority Critical patent/GR1007722B/el
Priority to PCT/EP2012/003284 priority patent/WO2013020672A1/en
Publication of GR1007722B publication Critical patent/GR1007722B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Η παρούσα εφεύρεση αφορά βελτιωμένη διαδικασία παρασκευής υψηλής καθαρότητας κρυσταλλικής Αριπιπραζόλης του χημικού τύπου (I) που να έχει μικρή ποσότητα καταλοίπων αιθυλικής αλκοόλης. Η διαδικασία περιλαμβάνει πολτοποίηση της Αριπιπραζόλης που λαμβάνεται από το μείγμα της αντίδρασης με ύδωρ.
GR20110100478A 2011-08-05 2011-08-05 Μεθοδος για την παρασκευη της αριπιπραζολης GR1007722B (el)

Priority Applications (2)

Application Number Priority Date Filing Date Title
GR20110100478A GR1007722B (el) 2011-08-05 2011-08-05 Μεθοδος για την παρασκευη της αριπιπραζολης
PCT/EP2012/003284 WO2013020672A1 (en) 2011-08-05 2012-08-02 Process for the preparation of aripiprazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20110100478A GR1007722B (el) 2011-08-05 2011-08-05 Μεθοδος για την παρασκευη της αριπιπραζολης

Publications (1)

Publication Number Publication Date
GR1007722B true GR1007722B (el) 2012-10-18

Family

ID=46724311

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20110100478A GR1007722B (el) 2011-08-05 2011-08-05 Μεθοδος για την παρασκευη της αριπιπραζολης

Country Status (2)

Country Link
GR (1) GR1007722B (el)
WO (1) WO2013020672A1 (el)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016181406A1 (en) * 2015-05-08 2016-11-17 Davuluri Ramamohan Rao Improved process for the preparation of aripiprazole with reduced particle size
CN105924393A (zh) * 2016-07-05 2016-09-07 陕西省食品药品检验所 一种阿立哌唑新晶型及其制备方法
CN112479999A (zh) * 2020-12-13 2021-03-12 谢小芬 用于制备精神类药物的医药中间体的合成方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
US20060258869A1 (en) * 2006-04-03 2006-11-16 Alembic Limited Process for the preparation of aripiprazole
WO2007094009A1 (en) * 2006-02-15 2007-08-23 Unichem Laboratories Limited A novel process for preparation of aripiprazole and its intermediates
WO2007118923A1 (en) * 2006-04-13 2007-10-25 Fermion Oy A process for the preparation of aripiprazole and intermediates thereof
WO2007148191A2 (en) * 2006-06-20 2007-12-27 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of aripiprazole

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5006528A (en) 1988-10-31 1991-04-09 Otsuka Pharmaceutical Co., Ltd. Carbostyril derivatives

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060079689A1 (en) * 2004-10-12 2006-04-13 Vladimir Naddaka Processes for preparing and purifying carbostyril compounds such as aripiprazole and 7-(4-halobutoxy)-3,4-dihydro-2(1H)-quinolinones
WO2007094009A1 (en) * 2006-02-15 2007-08-23 Unichem Laboratories Limited A novel process for preparation of aripiprazole and its intermediates
US20060258869A1 (en) * 2006-04-03 2006-11-16 Alembic Limited Process for the preparation of aripiprazole
WO2007118923A1 (en) * 2006-04-13 2007-10-25 Fermion Oy A process for the preparation of aripiprazole and intermediates thereof
WO2007148191A2 (en) * 2006-06-20 2007-12-27 Orchid Chemicals & Pharmaceuticals Limited An improved process for the preparation of aripiprazole

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BONACORSI S J JR ET AL: "Synthesis of multilabeled [14C]aripiprazole", JOURNAL OF LABELLED COMPOUNDS AND RADIOPHARMACEUTICALS, JOHN WILEY, CHICHESTER, GB, vol. 49, 22 December 2005 (2005-12-22), pages 1 - 9, XP002428678, ISSN: 0362-4803, DOI: 10.1002/JLCR.1017 *

Also Published As

Publication number Publication date
WO2013020672A1 (en) 2013-02-14

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Effective date: 20121122