GR1008018B - Λιπιδικα συμπλοκα αποτελουμενα απο ανιονικα λυσο-λιπιδια και η εφαρμογη αυτων - Google Patents

Λιπιδικα συμπλοκα αποτελουμενα απο ανιονικα λυσο-λιπιδια και η εφαρμογη αυτων

Info

Publication number
GR1008018B
GR1008018B GR20120100446A GR20120100446A GR1008018B GR 1008018 B GR1008018 B GR 1008018B GR 20120100446 A GR20120100446 A GR 20120100446A GR 20120100446 A GR20120100446 A GR 20120100446A GR 1008018 B GR1008018 B GR 1008018B
Authority
GR
Greece
Prior art keywords
anionic
lysolipids
lipid assemblies
lipids
lipid
Prior art date
Application number
GR20120100446A
Other languages
English (en)
Inventor
Ευγενιος Νικολαου Σιεπης
Ευαγγελος Θεοδωρου Ανδρεακος
Original Assignee
Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων,
Ευγενιος Νικολαου Σιεπης
Ευαγγελος Θεοδωρου Ανδρεακος
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων,, Ευγενιος Νικολαου Σιεπης, Ευαγγελος Θεοδωρου Ανδρεακος filed Critical Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων,
Priority to GR20120100446A priority Critical patent/GR1008018B/el
Priority to CA2882523A priority patent/CA2882523C/en
Priority to EP13756909.1A priority patent/EP2892505B1/en
Priority to US14/425,830 priority patent/US9730893B2/en
Priority to PCT/EP2013/068359 priority patent/WO2014037436A1/en
Publication of GR1008018B publication Critical patent/GR1008018B/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1274—Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases or cochleates; Sponge phases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Η παρούσα εφαρμογή σχετίζεται με λιπιδικά σύμπλοκα, συστάσεις και λιποσωμικά συστήματα παράδοσης τα οποία αποτελούνται από ανιονικά λιπίδια μονής αλυσίδας, και την χρησιμοποίησή τους σε διαγνωστικές και θεραπευτικές εφαρμογές. Περιλαμβάνει τη χρήση ανιονικών λυσο-λιπιδίων με σκοπό την τροποποίηση του φορτίου μιας κατιονικής λιπιδικής σύστασης η οποία με τη σειρά της αποτελείται από τουλάχιστον ένα είδος κατιονικού λιπιδίου, προαιρετικά σε συνδυασμό με ένα ή περισσότερα ουδέτερα λιπίδια ή και ένα ή περισσότερα ανιονικά λιπίδια.
GR20120100446A 2012-09-06 2012-09-06 Λιπιδικα συμπλοκα αποτελουμενα απο ανιονικα λυσο-λιπιδια και η εφαρμογη αυτων GR1008018B (el)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GR20120100446A GR1008018B (el) 2012-09-06 2012-09-06 Λιπιδικα συμπλοκα αποτελουμενα απο ανιονικα λυσο-λιπιδια και η εφαρμογη αυτων
CA2882523A CA2882523C (en) 2012-09-06 2013-09-05 Lipid assemblies comprising anionic lysolipids and use thereof
EP13756909.1A EP2892505B1 (en) 2012-09-06 2013-09-05 Lipid assemblies comprising anionic lysolipids and use thereof
US14/425,830 US9730893B2 (en) 2012-09-06 2013-09-05 Lipid assemblies comprising anionic lysolipids and use thereof
PCT/EP2013/068359 WO2014037436A1 (en) 2012-09-06 2013-09-05 Lipid assemblies comprising anionic lysolipids and use thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR20120100446A GR1008018B (el) 2012-09-06 2012-09-06 Λιπιδικα συμπλοκα αποτελουμενα απο ανιονικα λυσο-λιπιδια και η εφαρμογη αυτων

Publications (1)

Publication Number Publication Date
GR1008018B true GR1008018B (el) 2013-10-29

Family

ID=49115532

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20120100446A GR1008018B (el) 2012-09-06 2012-09-06 Λιπιδικα συμπλοκα αποτελουμενα απο ανιονικα λυσο-λιπιδια και η εφαρμογη αυτων

Country Status (5)

Country Link
US (1) US9730893B2 (el)
EP (1) EP2892505B1 (el)
CA (1) CA2882523C (el)
GR (1) GR1008018B (el)
WO (1) WO2014037436A1 (el)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9856475B2 (en) 2014-03-25 2018-01-02 Arcturus Therapeutics, Inc. Formulations for treating amyloidosis
AU2015236215B2 (en) 2014-03-25 2020-03-19 Arcturus Therapeutics, Inc. UNA oligomers having reduced off-target effects in gene silencing
JP6771387B2 (ja) 2014-03-25 2020-10-21 アークトゥラス・セラピューティクス・インコーポレイテッドＡｒｃｔｕｒｕｓ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． 遺伝子サイレンシング用トランスサイレチン対立遺伝子選択的ｕｎａオリゴマー
US10519447B2 (en) 2015-04-01 2019-12-31 Arcturus Therapeutics, Inc. Therapeutic UNA oligomers and uses thereof
WO2017015671A1 (en) 2015-07-23 2017-01-26 Arcturus Therapeutics, Inc. Compositions for treating amyloidosis
KR101713118B1 (ko) * 2015-08-28 2017-03-10 서강대학교산학협력단 세포외기질 전달용 리포솜
LT3675826T (lt) 2017-08-31 2023-09-11 Life Technologies Corporation Katijoninės lipidų kompozicijos audiniams-specifiniam įterpimui
JP6399530B1 (ja) * 2017-09-04 2018-10-03 一丸ファルコス株式会社 ｐＨ感受性リポソーム
CN110724734B (zh) * 2019-10-22 2020-06-16 北京恩泽康泰生物科技有限公司 含miRNA mimic的人造脂质体及其制备方法与应用
CN113694040B (zh) * 2020-05-20 2023-05-30 中山大学孙逸仙纪念医院 一种基于dppa的治疗性脂质体纳米粒子及其制备方法及应用
CN113350286B (zh) * 2021-05-22 2022-07-26 南开大学 “水桥”介导超响应的功能协同两性离子脂质及其制备方法和应用
CN118666726A (zh) * 2023-03-17 2024-09-20 尧唐(上海)生物科技有限公司 递送治疗剂的脂质化合物及其制备方法与应用
CN118001254B (zh) * 2024-04-09 2024-07-26 北京悦康科创医药科技股份有限公司 靶向抗原呈递细胞的脂质组合物及其应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006048329A1 (en) 2004-11-05 2006-05-11 Novosom Ag Improvements in or relating to pharmaceutical compositions comprising an oligonucleotide as an active agent
JP2008520600A (ja) 2004-11-19 2008-06-19 ノヴォソム アクチェンゲゼルシャフト 局所投与のための医薬組成物におけるまたはそれに関する改善
PL1957044T3 (pl) 2005-12-01 2013-11-29 Pronai Therapeutics Inc Amfoteryczny preparat liposomowy

Also Published As

Publication number Publication date
EP2892505B1 (en) 2016-11-16
CA2882523A1 (en) 2014-03-13
EP2892505A1 (en) 2015-07-15
US20150216803A1 (en) 2015-08-06
CA2882523C (en) 2021-06-15
WO2014037436A1 (en) 2014-03-13
US9730893B2 (en) 2017-08-15

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Effective date: 20131118