GR24231B - METHOD FOR THE MANUFACTURE OF 1, 4 - BENZODIAZEPINE PRODUCERS. - Google Patents

METHOD FOR THE MANUFACTURE OF 1, 4 - BENZODIAZEPINE PRODUCERS.

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Publication number
GR24231B
GR24231B GR600124231A GR600124231A GR24231B GR 24231 B GR24231 B GR 24231B GR 600124231 A GR600124231 A GR 600124231A GR 600124231 A GR600124231 A GR 600124231A GR 24231 B GR24231 B GR 24231B
Authority
GR
Greece
Prior art keywords
alkyl
benzodiazepine
hydroxy
producers
manufacture
Prior art date
Application number
GR600124231A
Other languages
Greek (el)
Original Assignee
F. Hoffmann - La Roche & Co. A.G.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche & Co. A.G. filed Critical F. Hoffmann - La Roche & Co. A.G.
Priority to GR600124231A priority Critical patent/GR24231B/en
Publication of GR24231B publication Critical patent/GR24231B/en

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  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

έθοδος προς παρασκευήν παραγώγων της 1,4-βενζοδιαζεπίνης, ήτις περιλαμβάνει την αντίδρασιν μιας ενώσεως του γενικού τύπου: [*] ένθα το R παριστά υδρογόνον, αλκύλιον, υδροξυ-αλκύλιον ή αραλκύλιον το R1 παριστά υδρογόνον ή αλκύλιον και το R2 παριστά φαινύλιον ή αλκύλιον, ελκοξυ, τριφθορομεθύλιον ή αλογονομονοϋποκατεστημένον φαινύλιον, του δια 1 σημείουμένου πυρήνος όντος μη υποκατεστημένου, μονοϋποκατεστημένου δια τριφθορομεθυλίου ή μονο- ή δισυποκατεστημένου δι' αλκυλίου, αλκοξυ- αλκυλοθειουδροξυαλκυλοθειο-, αλογόνο-, νιτρο-, αμινο-, αλευλοσουλφινυλ- αλκυλοσουλφονυλ-, υδροξυ-, ή ακυλαμινομάδων, μεθ' ενός αναγωγικού μέσου ή ενός φωσφορολογινιδίου, του οιουδήποτε προϊόντος δυναμένου κατόπιν να νιτρωθή των οιωνδήποτε νιτροομάδων δυναμένωννα ανοχθώσι προς αμινομάδας και των τελευταίων δυναμένων να ακυλιωθώσι και των προϊόντων αντιδράσεως τα οποία είναι βασικού χαρακτήρος δυναμένων να μετατραπώσιν εις τα δια προσθήκης οξέος άλατά των. Process for the preparation of 1,4-benzodiazepine derivatives, including the reaction of a compound of general formula: [*] wherein R represents hydrogen, alkyl, hydroxy-alkyl or aralkyl; R1 represents hydrogen or alkyl and R2 represents phenyl or alkyl, elkoxy, trifluoromethyl or halo disubstituted by alkyl, alkoxy-alkylthiohydroxyalkylthio-, halogen-, nitro-, amino-, alevulsulfinyl- alkylsulfonyl-, hydroxy-, or acylamino groups, by means of a reducing agent or a phosphorolinide, of any product which can then be nitrated of any nitro groups which can be reduced to an amino group and of the latter which can be acylated and of which are basic reaction products which can be converted to

GR600124231A 1960-12-09 1960-12-09 METHOD FOR THE MANUFACTURE OF 1, 4 - BENZODIAZEPINE PRODUCERS. GR24231B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GR600124231A GR24231B (en) 1960-12-09 1960-12-09 METHOD FOR THE MANUFACTURE OF 1, 4 - BENZODIAZEPINE PRODUCERS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GR600124231A GR24231B (en) 1960-12-09 1960-12-09 METHOD FOR THE MANUFACTURE OF 1, 4 - BENZODIAZEPINE PRODUCERS.

Publications (1)

Publication Number Publication Date
GR24231B true GR24231B (en) 1963-02-06

Family

ID=36864815

Family Applications (1)

Application Number Title Priority Date Filing Date
GR600124231A GR24231B (en) 1960-12-09 1960-12-09 METHOD FOR THE MANUFACTURE OF 1, 4 - BENZODIAZEPINE PRODUCERS.

Country Status (1)

Country Link
GR (1) GR24231B (en)

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