GR3002377T3 - Ifosfamide-mesna-lyophilized composition and process to prepare it - Google Patents

Ifosfamide-mesna-lyophilized composition and process to prepare it

Info

Publication number
GR3002377T3
GR3002377T3 GR91401005T GR910401005T GR3002377T3 GR 3002377 T3 GR3002377 T3 GR 3002377T3 GR 91401005 T GR91401005 T GR 91401005T GR 910401005 T GR910401005 T GR 910401005T GR 3002377 T3 GR3002377 T3 GR 3002377T3
Authority
GR
Greece
Prior art keywords
ifosfamide
mesna
prepare
lyophilized composition
weight
Prior art date
Application number
GR91401005T
Other languages
English (en)
Inventor
Dieter Sauerbier
Otto Dr Isaac
Wolfgang Peter Dr Brade
Original Assignee
Asta Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asta Pharma Ag filed Critical Asta Pharma Ag
Publication of GR3002377T3 publication Critical patent/GR3002377T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Control Of El Displays (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
GR91401005T 1988-03-19 1991-07-25 Ifosfamide-mesna-lyophilized composition and process to prepare it GR3002377T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3809337 1988-03-19

Publications (1)

Publication Number Publication Date
GR3002377T3 true GR3002377T3 (en) 1992-12-30

Family

ID=6350216

Family Applications (1)

Application Number Title Priority Date Filing Date
GR91401005T GR3002377T3 (en) 1988-03-19 1991-07-25 Ifosfamide-mesna-lyophilized composition and process to prepare it

Country Status (11)

Country Link
US (1) US4959215A (el)
EP (1) EP0334083B1 (el)
JP (1) JP2865698B2 (el)
AT (1) ATE65402T1 (el)
CA (1) CA1326452C (el)
DE (1) DE58900183D1 (el)
ES (1) ES2040394T3 (el)
FI (1) FI89456C (el)
GR (1) GR3002377T3 (el)
IE (1) IE60721B1 (el)
PT (1) PT90030B (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2063412T3 (es) * 1990-07-16 1995-01-01 Asta Medica Ag Tableta y granulado que contienen como principio activo mesna.
US5252341A (en) * 1990-07-16 1993-10-12 Degussa Aktiengesellschaft Tablets and granulates containing mesna as active substance
US5227373A (en) * 1991-10-23 1993-07-13 Bristol-Myers Squibb Co. Lyophilized ifosfamide compositions
DE4233842A1 (de) * 1992-10-08 1994-04-14 Asta Medica Ag Mesna Injektionslösungen
WO1995007083A1 (en) * 1993-09-10 1995-03-16 F.H. Faulding & Co. Limited Ifosfamide lyophilisate composition
US5789000A (en) * 1994-11-14 1998-08-04 Bionumerik Pharmaceuticals, Inc. Sterile aqueous parenteral formulations of cis-diammine dichloro platinum
DE19529057B4 (de) * 1995-08-08 2007-12-13 Baxter Healthcare S.A. Ifosfamid-Lyophilisat-Zubereitungen
IT1284973B1 (it) * 1996-10-11 1998-05-28 A R D O Associazione Ricerca E Uso del sodio 2-mercaptoetansolfonato (mesna) in chirurgia
US6613927B1 (en) 2002-02-08 2003-09-02 American Pharmaceutical Partners, Inc. Sterile lyophilized ifosfamide and associated methods
MXPA05002453A (es) * 2002-09-05 2005-05-27 Bharat Serums & Vaccines Ltd Composicion estable liquida de oxazafosforina con el 2-mercaptoetansulfonato de sodio.
NZ540484A (en) * 2002-12-02 2008-03-28 Bharat Serums & Vaccines Ltd Stable, clear, aqueous ifosfamide compositions for parenteral administration and a process for their preparation
US20070192947A1 (en) * 2003-07-10 2007-08-23 Cylena Medical Technologies Inc. Protective apparel with improved doffing
JP4886517B2 (ja) * 2003-10-01 2012-02-29 バクスター・インターナショナル・インコーポレイテッド 新たな用途の薬学的調製物およびその調製物を製造するためのプロセス
WO2006030450A2 (en) * 2004-09-13 2006-03-23 Bharat Serums & Vaccines Ltd. Stable emulsion compositions for intravenous administration having antimicrobial preservative efficacy
US8436190B2 (en) 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
AR072777A1 (es) 2008-03-26 2010-09-22 Cephalon Inc Formas solidas de clorhidrato de bendamustina
US20110138888A1 (en) * 2008-07-21 2011-06-16 Amany Elshorbagy Treatment of obesity
AU2010218109B2 (en) * 2009-02-24 2015-04-09 Dekk-Tec, Inc. Complexes of 4-hydroperoxy ifosfamide as anti-tumor agents
US10092312B2 (en) * 2013-05-07 2018-10-09 Auxin Surgery Sa Device for chemically assisted dissection
ES2750749T3 (es) * 2014-01-06 2020-03-27 Auxin Surgery Sa Composiciones de Mesna liofilizadas

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4220660A (en) * 1977-12-14 1980-09-02 Asta-werke Aktiengesellschaft, Chemische Farik Process for the treatment of humans suffering from undesired urotoxic side effects caused by cytostatically active alkylating agents
DE3111428A1 (de) * 1981-03-24 1982-10-07 Asta-Werke Ag, Chemische Fabrik, 4800 Bielefeld Oxazaphosphorin-4-thio-alkansulfonsaeuren und deren neutrale salze, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen
ZA851062B (en) * 1984-03-01 1985-11-27 Asta Werke Ag Chem Fab Salts of oxazaphosphorine derivatives and process for their production
US4797388A (en) * 1984-05-21 1989-01-10 Cetus Corporation Pharmaceutical compositions with galactitol as carrier
US4859452A (en) * 1986-01-17 1989-08-22 Board Of Regents, The University Of Texas System Methods for the reduction of difluoromethylornithine associated toxicity
ES2036553T3 (es) * 1986-10-07 1993-06-01 Boehringer Mannheim Italia S.P.A. Composiciones farmaceuticas que tienen actividad antineoplastica.
NO873860L (no) * 1986-10-31 1988-05-02 Asta Pharma Ag Ifosfamid-lyofilisat og fremgangsmaate til deres fremstilling.

Also Published As

Publication number Publication date
DE58900183D1 (de) 1991-08-29
EP0334083A1 (de) 1989-09-27
JP2865698B2 (ja) 1999-03-08
CA1326452C (en) 1994-01-25
ATE65402T1 (de) 1991-08-15
FI891283L (fi) 1989-09-20
EP0334083B1 (de) 1991-07-24
US4959215A (en) 1990-09-25
FI891283A0 (fi) 1989-03-17
PT90030B (pt) 1994-05-31
IE60721B1 (en) 1994-08-10
ES2040394T3 (es) 1993-10-16
FI89456B (fi) 1993-06-30
JPH024796A (ja) 1990-01-09
FI89456C (fi) 1993-10-11
PT90030A (pt) 1989-11-10
IE890854L (en) 1989-09-19

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