GR3015497T3 - Amino-substituted heterocycles as renin inhibitors. - Google Patents

Amino-substituted heterocycles as renin inhibitors.

Info

Publication number: GR3015497T3
Authority: GR; Greece
Prior art keywords: amino; renin; renin inhibitors; substituted heterocycles; hyperaldosteronism
Prior art date: 1989-05-26

Application number

GR950400628T

Other languages

English (en)

Inventor

Cleo Conolly

Annette Marian Doherty

Harriet Wall Hamilton

William Chester Patt

Ila Sircar

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-26

Filing date

1995-03-20

Publication date

1995-06-30

1995-03-20 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

1995-06-30 Publication of GR3015497T3 publication Critical patent/GR3015497T3/el

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/14—Angiotensins: Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0207—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)4-C(=0), e.g. 'isosters', replacing two amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0227—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the (partial) peptide sequence -Phe-His-NH-(X)2-C(=0)-, e.g. Renin-inhibitors with n = 2 - 6; for n > 6 see C07K5/06 - C07K5/10
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Crystallography & Structural Chemistry (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Endocrinology (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Ophthalmology & Optometry (AREA)
Vascular Medicine (AREA)
Diabetes (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)

GR950400628T 1989-05-26 1995-03-20 Amino-substituted heterocycles as renin inhibitors. GR3015497T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US35756189A	1989-05-26	1989-05-26
US07/511,271 US5238923A (en)	1989-05-26	1990-04-25	Amino-substituted heterocycles as renin inhibitors

Publications (1)

Publication Number	Publication Date
GR3015497T3 true GR3015497T3 (en)	1995-06-30

Family

ID=26999702

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR950400628T GR3015497T3 (en)	1989-05-26	1995-03-20	Amino-substituted heterocycles as renin inhibitors.

Country Status (15)

Country	Link
US (3)	US5238923A (el)
EP (1)	EP0399556B1 (el)
JP (1)	JP2980129B2 (el)
KR (1)	KR900018140A (el)
AT (1)	ATE116331T1 (el)
AU (1)	AU625354B2 (el)
CA (1)	CA2017552A1 (el)
DE (1)	DE69015437T2 (el)
DK (1)	DK0399556T3 (el)
ES (1)	ES2066905T3 (el)
FI (1)	FI902557A7 (el)
GR (1)	GR3015497T3 (el)
NO (1)	NO902318L (el)
NZ (1)	NZ233811A (el)
PT (1)	PT94159A (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE68045B1 (en) *	1990-05-11	1996-05-15	Abbott Lab	Renin inhibitors
US5178877A (en) *	1991-01-04	1993-01-12	Abbott Laboratories	Encapsulated renin inhibitor composition
US5220031A (en) *	1991-04-23	1993-06-15	Warner-Lambert Company	Process for the preparation of [1S-(1R,2S3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide
US5089616A (en) *	1991-04-23	1992-02-18	Warner-Lambert Company	Process for the preparation of [1S-(1R,2S,3R*)]-N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl-N-[(1-cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide
US5516784A (en) *	1991-08-13	1996-05-14	Schering Corporation	Anti-HIV (AIDS) agents
WO1993006127A1 (en) *	1991-09-17	1993-04-01	Warner-Lambert Company	Novel amino acid prodrug renin inhibitors
US6420396B1 (en)	1998-12-16	2002-07-16	Beiersdorf Ag	Biphenyl and biphenyl-analogous compounds as integrin antagonists
US6677360B2 (en) *	1998-12-16	2004-01-13	Bayer Aktiengesellschaft	Biphenyl and biphenyl-analogous compounds as integrin antagonists
AR039156A1 (es) *	2002-03-28	2005-02-09	Novartis Ag	Amidas del acido piperidinilamino sulfamico o piperazinil sulfamico y su uso para la manufactura de un medicamento en enfermedades mediadas por la accion de la sulfatasa esteroide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4845079A (en) *	1985-01-23	1989-07-04	Luly Jay R	Peptidylaminodiols
CA1286846C (en) *	1985-02-12	1991-07-23	Catherine Cazaubon	Peptide derivatives which inhibit renin and acid proteases
WO1987002675A1 (en) *	1985-11-01	1987-05-07	Pfizer Inc.	Difluorocyclostatine containing polypeptides
US4839357A (en) *	1987-10-02	1989-06-13	Merck & Co., Inc.	Renin inhibitors containing phenylalanyl-histidine replacements
US5063207A (en) *	1987-10-26	1991-11-05	Warner-Lambert Company	Renin inhibitors, method for using them, and compositions containing them
US5036053A (en) *	1988-05-27	1991-07-30	Warner-Lambert Company	Diol-containing renin inhibitors
US5178877A (en) *	1991-01-04	1993-01-12	Abbott Laboratories	Encapsulated renin inhibitor composition
US5219851A (en) *	1991-03-05	1993-06-15	Warner-Lambert Company	Tetrahydroisoquinoline-type renin inhibiting peptides
US5178887A (en) *	1991-04-10	1993-01-12	Ameron, Inc.	Compound fluted mold for casting prestressed concrete lamp poles

1990
- 1990-04-25 US US07/511,271 patent/US5238923A/en not_active Expired - Lifetime
- 1990-05-23 FI FI902557A patent/FI902557A7/fi not_active IP Right Cessation
- 1990-05-24 AU AU55908/90A patent/AU625354B2/en not_active Ceased
- 1990-05-24 NZ NZ233811A patent/NZ233811A/en unknown
- 1990-05-25 EP EP90109990A patent/EP0399556B1/en not_active Expired - Lifetime
- 1990-05-25 DE DE69015437T patent/DE69015437T2/de not_active Expired - Fee Related
- 1990-05-25 KR KR1019900007732A patent/KR900018140A/ko not_active Withdrawn
- 1990-05-25 ES ES90109990T patent/ES2066905T3/es not_active Expired - Lifetime
- 1990-05-25 CA CA002017552A patent/CA2017552A1/en not_active Abandoned
- 1990-05-25 AT AT90109990T patent/ATE116331T1/de not_active IP Right Cessation
- 1990-05-25 NO NO90902318A patent/NO902318L/no unknown
- 1990-05-25 DK DK90109990.3T patent/DK0399556T3/da active
- 1990-05-25 JP JP2134257A patent/JP2980129B2/ja not_active Expired - Fee Related
- 1990-05-25 PT PT94159A patent/PT94159A/pt not_active Application Discontinuation
1993
- 1993-03-26 US US08/038,728 patent/US5453488A/en not_active Expired - Fee Related
1995
- 1995-03-20 GR GR950400628T patent/GR3015497T3/el unknown
- 1995-05-15 US US08/440,585 patent/US5643879A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
KR900018140A (ko)	1990-12-20
CA2017552A1 (en)	1990-11-26
US5643879A (en)	1997-07-01
EP0399556B1 (en)	1994-12-28
FI902557A0 (fi)	1990-05-23
ES2066905T3 (es)	1995-03-16
NO902318L (no)	1990-11-27
US5238923A (en)	1993-08-24
NZ233811A (en)	1992-10-28
AU5590890A (en)	1990-11-29
EP0399556A1 (en)	1990-11-28
US5453488A (en)	1995-09-26
PT94159A (pt)	1991-02-08
ATE116331T1 (de)	1995-01-15
JPH0386870A (ja)	1991-04-11
NO902318D0 (no)	1990-05-25
DE69015437T2 (de)	1995-05-04
DK0399556T3 (da)	1995-05-29
AU625354B2 (en)	1992-07-09
FI902557A7 (fi)	1990-11-27
JP2980129B2 (ja)	1999-11-22
DE69015437D1 (de)	1995-02-09

Publication	Publication Date	Title
EP0343654A3 (en)	1991-05-29	Diol-containing renin inhibitors
AU3416584A (en)	1986-09-11	Blood-pressure lowering piperazine derivatives
EP0347252A3 (en)	1991-03-27	Method of treating cachexia and certain new compounds for use in this method
AU625354B2 (en)	1992-07-09	Amino-substituted heterocycles as renin inhibitors
WO1991005538A3 (en)	1991-05-30	Thiazolidine derivatives for the treatment of hypertension
HU910930D0 (en)	1991-10-28	Process for the production of 2,8-dioxa-bicyclo/3.2.1/octane derivatives and medical preparations containing them
DK147588D0 (da)	1988-03-17	Benzoxazinderivat samt fremgangsmaade til fremstilling deraf
EP0271862A3 (en)	1990-11-14	Renin inhibitors iii
EP0245902A3 (en)	1989-02-15	Benzothiazinone derivatives
NO173991C (no)	1994-03-02	Analogifremgangsmaate til fremstilling av terapeutisk aktive 1,2,5-ditiazocin-derivater
PH24636A (en)	1990-08-17	Method of treating heart failure
NO164474C (no)	1990-10-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive heksahydropyrrolo(2,1-a)isokinolin-derivater.
MX9703363A (es)	1998-02-28	Nuevos derivados de pirimidiniloxi- y pirimidinilamino etilfenil-dioxolano.
DE3471654D1 (en)	1988-07-07	Ûbis(hydroxymethyl)-methyl¨-isoquinoline derivatives, process for preparing them and pharmaceutical compositions containing them
AU5977980A (en)	1981-01-15	Aminodeoxyclavulanic acids