GR3017070T3 - Solvent-free synthesis of 1,2:5,6-di-O-isopropylidene-3-O-3' -(N',N'-dimethylamino-n-propyl)-alpha,D-glucofuranose and 1,2:5,6-di-O-isopropylidene-3-O-heptyl-alpha,D-glucofuranose. - Google Patents

Solvent-free synthesis of 1,2:5,6-di-O-isopropylidene-3-O-3' -(N',N'-dimethylamino-n-propyl)-alpha,D-glucofuranose and 1,2:5,6-di-O-isopropylidene-3-O-heptyl-alpha,D-glucofuranose.

Info

Publication number: GR3017070T3
Authority: GR; Greece
Prior art keywords: substituted; glucofuranose; isopropylidene; alpha; mixture
Prior art date: 1991-02-20

Application number

GR950402198T

Other languages

English (en)

Inventor

Sudershan K Arora

Original Assignee

Greenwich Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-02-20

Filing date

1995-08-09

Publication date

1995-11-30

1995-08-09 Application filed by Greenwich Pharma filed Critical Greenwich Pharma

1995-11-30 Publication of GR3017070T3 publication Critical patent/GR3017070T3/el

Links

AVVWPBAENSWJCB-IVMDWMLBSA-N D-glucofuranose Chemical compound OC[C@@H](O)[C@H]1OC(O)[C@H](O)[C@H]1O AVVWPBAENSWJCB-IVMDWMLBSA-N 0.000 title 2
230000015572 biosynthetic process Effects 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
239000000203 mixture Substances 0.000 abstract 5
150000002772 monosaccharides Chemical class 0.000 abstract 5
150000001350 alkyl halides Chemical class 0.000 abstract 2
125000000547 substituted alkyl group Chemical group 0.000 abstract 2
DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 abstract 1
125000002777 acetyl group Chemical class [H]C([H])([H])C(*)=O 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
239000002585 base Substances 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
238000010438 heat treatment Methods 0.000 abstract 1
230000003301 hydrolyzing effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Crystallography & Structural Chemistry (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Protection Of Plants (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

GR950402198T 1991-02-20 1995-08-09 Solvent-free synthesis of 1,2:5,6-di-O-isopropylidene-3-O-3' -(N',N'-dimethylamino-n-propyl)-alpha,D-glucofuranose and 1,2:5,6-di-O-isopropylidene-3-O-heptyl-alpha,D-glucofuranose. GR3017070T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US65831191A	1991-02-20	1991-02-20
PCT/US1992/000761 WO1992014745A1 (en)	1991-02-20	1992-02-07	New and improved solvent-free synthesis of ethereally substituted blocked monosaccharides and the selective hydrolysis thereof

Publications (1)

Publication Number	Publication Date
GR3017070T3 true GR3017070T3 (en)	1995-11-30

Family

ID=24640726

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR950402198T GR3017070T3 (en)	1991-02-20	1995-08-09	Solvent-free synthesis of 1,2:5,6-di-O-isopropylidene-3-O-3' -(N',N'-dimethylamino-n-propyl)-alpha,D-glucofuranose and 1,2:5,6-di-O-isopropylidene-3-O-heptyl-alpha,D-glucofuranose.

Country Status (17)

Country	Link
US (1)	US5344924A (el)
EP (2)	EP0572521B1 (el)
JP (1)	JP3170280B2 (el)
KR (1)	KR100211750B1 (el)
CN (1)	CN1034866C (el)
AT (1)	ATE125264T1 (el)
AU (1)	AU659446B2 (el)
CA (1)	CA2104476A1 (el)
DE (1)	DE69203597T2 (el)
DK (1)	DK0572521T3 (el)
ES (1)	ES2078739T3 (el)
FI (1)	FI105553B (el)
GR (1)	GR3017070T3 (el)
IE (1)	IE920527A1 (el)
IL (1)	IL100833A0 (el)
NO (1)	NO300638B1 (el)
WO (1)	WO1992014745A1 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5360792A (en) *	1991-12-20	1994-11-01	Greenwich Pharmaceuticals Incorporated	Anti-proliferative and anti-inflammatory compounds: 5- or 6-deoxy hexose monosaccharides having a saturated nitrogen-containing heterocycle at the 5- or 6-position bound through the nitrogen atom
US5432163A (en) *	1992-11-13	1995-07-11	Greenwich Pharmaceuticals Incorporated	Anti-proliferative and anti-inflammatory compounds: derivatives of pentose monosaccharides
AU7101994A (en) *	1993-06-11	1995-01-03	Boston Life Sciences, Inc.	Immunomodulatory, anti-inflammatory, and anti-proliferative compounds: 5,6-dideoxy, 5-amino derivatives of idose and 6-deoxy, 6-amino derivatives of glucose
DE69738416T2 (de) *	1996-06-18	2008-12-11	Kyowa Hakko Kogyo Co., Ltd.	Liposomale zubereitungen von indolocarbazol-derivaten
US6329344B1 (en) *	1998-10-22	2001-12-11	Ranbaxy Laboratories Limited	Derivatives of monosaccharides as cell adhesion inhibitors
TWI345569B (en) *	2007-10-18	2011-07-21	Nat Univ Tsing Hua	Method for preparing hexose derivatives

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US1488355A (en) *	1921-04-25	1924-03-25	Lilienfeld Leon	Production of ethers of carbohydrates having the empirical formula n(c6h10o5), their conversion products and derivatives
US2715121A (en) *	1950-09-09	1955-08-09	American Home Prod	Alkyl sugar derivatives and their preparation
US3939145A (en) *	1973-03-01	1976-02-17	Strategic Medical Research Corporation	Novel ethereally monosubstituted monosaccharides
US4016261A (en) *	1973-03-01	1977-04-05	Strategic Medical Research Corporation	Therapeutic composition and method of therapeutically treating warm blooded animals therewith
USRE32268E (en) *	1973-03-01	1986-10-21	Strategic Medical Research Corp.	Therapeutic composition and method of therapeutically treating warm blooded animals therewith
US3939146A (en) *	1973-03-01	1976-02-17	Strategic Medical Research Corporation	Novel ethereal monosubstitutions of monosaccharide derivatives
USRE30379E (en) *	1973-03-01	1980-08-19	Strategic Medical Research Corp.	Ethereal monosubstitutions of monosaccharide derivatives
US3965262A (en) *	1973-03-01	1976-06-22	Strategic Medical Research Corporation	Method of enhancing learning and/or memory in warm blooded animals
US4056322A (en) *	1973-12-14	1977-11-01	Strategic Medical Research Corporation	Preparation of ethers of monosaccharides
US4017608A (en) *	1973-12-14	1977-04-12	Strategic Medical Research Corporation	Therapeutic composition and method of therapeutically treating warm blooded animals therewith
GB1589916A (en) *	1976-11-16	1981-05-20	Prodotti Antibiotici Spa	Glucofuranose derivatives
USRE30354E (en) *	1978-02-17	1980-07-29	Strategic Medical Research Corp.	Novel ethereally monosubstituted monosaccharides
US4738953A (en) *	1981-02-17	1988-04-19	Greenwich Pharmaceuticals Incorporated	Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease and a synergistic composition therefor
US4735934A (en) *	1981-02-17	1988-04-05	Greenwich Pharmaceuticals Incorporated	Method of therapeutically treating a warm blooded animal afflicted with an autoimmune disease
US4996195A (en) *	1989-01-09	1991-02-26	Greenwich Pharmaceuticals Inc.	Derivatives of α,D-glucofuranose or α,D-allofuranose and intermediates for preparing these derivatives
US5010058A (en) *	1989-06-22	1991-04-23	501 Greenwich Pharmaceuticals Incorporated	3,5,6-substituted derivatives of 1,2-O-isopropylidene-α,D-glucofuranose and intermediates for preparing these derivatives

1992
- 1992-01-31 IL IL100833A patent/IL100833A0/xx unknown
- 1992-02-07 AT AT92907010T patent/ATE125264T1/de not_active IP Right Cessation
- 1992-02-07 EP EP92907010A patent/EP0572521B1/en not_active Expired - Lifetime
- 1992-02-07 WO PCT/US1992/000761 patent/WO1992014745A1/en not_active Ceased
- 1992-02-07 KR KR1019930702494A patent/KR100211750B1/ko not_active Expired - Fee Related
- 1992-02-07 EP EP92102073A patent/EP0499904A1/en active Pending
- 1992-02-07 AU AU14264/92A patent/AU659446B2/en not_active Ceased
- 1992-02-07 DK DK92907010.0T patent/DK0572521T3/da active
- 1992-02-07 CA CA002104476A patent/CA2104476A1/en not_active Abandoned
- 1992-02-07 JP JP50662392A patent/JP3170280B2/ja not_active Expired - Fee Related
- 1992-02-07 ES ES92907010T patent/ES2078739T3/es not_active Expired - Lifetime
- 1992-02-07 DE DE69203597T patent/DE69203597T2/de not_active Expired - Fee Related
- 1992-02-19 CN CN92101427A patent/CN1034866C/zh not_active Expired - Fee Related
- 1992-02-19 IE IE052792A patent/IE920527A1/en not_active IP Right Cessation
1993
- 1993-04-06 US US08/044,085 patent/US5344924A/en not_active Expired - Lifetime
- 1993-08-19 NO NO932958A patent/NO300638B1/no not_active IP Right Cessation
- 1993-08-19 FI FI933653A patent/FI105553B/fi active
1995
- 1995-08-09 GR GR950402198T patent/GR3017070T3/el unknown

Also Published As

Publication number	Publication date
EP0572521B1 (en)	1995-07-19
DK0572521T3 (da)	1995-10-02
CN1065068A (zh)	1992-10-07
JP3170280B2 (ja)	2001-05-28
NO932958L (no)	1993-08-19
IE920527A1 (en)	1992-08-26
DE69203597T2 (de)	1996-01-04
EP0572521A1 (en)	1993-12-08
EP0499904A1 (en)	1992-08-26
FI933653L (fi)	1993-08-19
CA2104476A1 (en)	1992-08-21
WO1992014745A1 (en)	1992-09-03
IL100833A0 (en)	1992-09-06
DE69203597D1 (de)	1995-08-24
ATE125264T1 (de)	1995-08-15
NO932958D0 (no)	1993-08-19
JPH06508107A (ja)	1994-09-14
KR100211750B1 (ko)	1999-08-02
FI933653A0 (fi)	1993-08-19
AU1426492A (en)	1992-09-15
NO300638B1 (no)	1997-06-30
AU659446B2 (en)	1995-05-18
ES2078739T3 (es)	1995-12-16
FI105553B (fi)	2000-09-15
US5344924A (en)	1994-09-06
CN1034866C (zh)	1997-05-14

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GR3017070T3 (en)	1995-11-30	Solvent-free synthesis of 1,2:5,6-di-O-isopropylidene-3-O-3' -(N',N'-dimethylamino-n-propyl)-alpha,D-glucofuranose and 1,2:5,6-di-O-isopropylidene-3-O-heptyl-alpha,D-glucofuranose.
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