GR3017369T3 - Use of heterocyclic derivatives in the treatment of cognitive disorders. - Google Patents

Use of heterocyclic derivatives in the treatment of cognitive disorders.

Info

Publication number: GR3017369T3
Authority: GR; Greece
Prior art keywords: treatment; cognitive disorders; heterocyclic derivatives; attentional; hydroxytryptamine
Prior art date: 1986-12-17

Application number

GR950402486T

Other languages

English (en)

Inventor

Michael Brian Tyers

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1986-12-17

Filing date

1995-09-13

Publication date

1995-12-31

1986-12-17 Priority claimed from GB868630077A external-priority patent/GB8630077D0/en

1986-12-17 Priority claimed from GB868630074A external-priority patent/GB8630074D0/en

1986-12-17 Priority claimed from GB868630076A external-priority patent/GB8630076D0/en

1987-03-25 Priority claimed from GB878707175A external-priority patent/GB8707175D0/en

1995-09-13 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1995-12-31 Publication of GR3017369T3 publication Critical patent/GR3017369T3/el

Links

208000010877 cognitive disease Diseases 0.000 title abstract 2
125000000623 heterocyclic group Chemical group 0.000 title 1
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 4
102000035037 5-HT3 receptors Human genes 0.000 abstract 1
108091005477 5-HT3 receptors Proteins 0.000 abstract 1
206010012289 Dementia Diseases 0.000 abstract 1
208000026139 Memory disease Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Emergency Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

GR950402486T 1986-12-17 1995-09-13 Use of heterocyclic derivatives in the treatment of cognitive disorders. GR3017369T3 (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB868630077A GB8630077D0 (en)	1986-12-17	1986-12-17	Medicaments
GB868630074A GB8630074D0 (en)	1986-12-17	1986-12-17	Medicaments
GB868630076A GB8630076D0 (en)	1986-12-17	1986-12-17	Medicaments
GB878707175A GB8707175D0 (en)	1987-03-25	1987-03-25	Medicaments

Publications (1)

Publication Number	Publication Date
GR3017369T3 true GR3017369T3 (en)	1995-12-31

Family

ID=27449858

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR950402486T GR3017369T3 (en)	1986-12-17	1995-09-13	Use of heterocyclic derivatives in the treatment of cognitive disorders.

Country Status (7)

Country	Link
US (1)	US4985437A (el)
EP (3)	EP0279990B1 (el)
JP (1)	JP2608079B2 (el)
AT (2)	ATE152623T1 (el)
DE (2)	DE3751404T2 (el)
ES (1)	ES2074981T3 (el)
GR (1)	GR3017369T3 (el)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4948803A (en) *	1986-11-21	1990-08-14	Glaxo Group Limited	Medicaments for treatment on prevention of withdrawal syndrome
US5198447A (en) *	1986-11-21	1993-03-30	Glaxo Group Limited	Medicaments
GB8820651D0 (en) *	1988-09-01	1988-10-05	Glaxo Group Ltd	Medicaments
WO1990014347A1 (fr) *	1989-05-24	1990-11-29	Nippon Shinyaku Co., Ltd.	Derives d'indole et medicament
US5171745A (en) *	1990-07-13	1992-12-15	Du Pont Merck Pharmaceutical Company	Method of treating neurological dysfunction using neutrotransmitter enhancers
AU8405891A (en) *	1990-08-31	1992-03-30	Nippon Shinyaku Co. Ltd.	Indole derivative and medicine
HU211081B (en) *	1990-12-18	1995-10-30	Sandoz Ag	Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
EP0492020A1 (en) *	1990-12-21	1992-07-01	Merrell Dow Pharmaceuticals Inc.	Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and related compounds for treating cognitive disorders
IT1250629B (it) *	1991-07-04	1995-04-21	Boehringer Ingelheim Italia	Uso dei derivati dell'acido benzimidazolin-2-oxo-1-carbossilico.
US5607938A (en) *	1993-03-08	1997-03-04	Fujisawa Pharmaceutical Co., Ltd.	Medicament for treating or preventing cerebrovascular infarction
GB9412995D0 (en) *	1994-06-28	1994-10-26	Prendergast Kenneth F	Safety enhancing pharmaceutical compositions of an active indazole
AR036041A1 (es) *	2001-06-12	2004-08-04	Upjohn Co	Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen
AR036040A1 (es)	2001-06-12	2004-08-04	Upjohn Co	Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen
DE60218493D1 (de) *	2001-09-12	2007-04-12	Pharmacia & Upjohn Co Llc	Substituierte 7-aza-ä2.2.1übicycloheptane für die behandlung von krankheiten
CA2462453C (en)	2001-10-02	2009-07-28	Pharmacia & Upjohn Company	Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease
US6849620B2 (en)	2001-10-26	2005-02-01	Pfizer Inc	N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease
CA2476624A1 (en) *	2002-02-19	2003-08-28	Pharmacia & Upjohn Company	Azabicyclic compounds for the treatment of disease
CA2476681A1 (en) *	2002-02-19	2003-08-28	Bruce N. Rogers	Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease
WO2003072578A1 (en) *	2002-02-20	2003-09-04	Pharmacia & Upjohn Company	Azabicyclic compounds with alfa7 nicotinic acetylcholine receptor activity
WO2004039815A2 (en) *	2002-11-01	2004-05-13	Pharmacia & Upjohn Company Llc	Compounds having both alpha7 nachr agonist and 5ht antagonist activity for treatment of cns diseases
GB201421161D0 (en) *	2014-11-28	2015-01-14	Ge Healthcare As	Metal complex formulations

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2531083B1 (fr) *	1982-06-29	1986-11-28	Sandoz Sa	Nouveaux derives de la piperidine, leur preparation et leur utilisation comme medicaments
JPS5936675A (ja) *	1982-07-13	1984-02-28	サンド・アクチエンゲゼルシヤフト	二環性複素環式カルボン酸アザビシクロアルキルエステルまたはアミド
FR2557110B1 (fr) *	1983-12-23	1989-11-24	Sandoz Sa	Nouveaux derives d'amines cycliques, leur preparation et leur utilisation comme medicaments
DE3587151T2 (de) *	1984-12-20	1993-07-15	Sandoz Ag	Behandlung von gastrointestinalkrankheiten durch anwendung von 5-ht3-antagonisten.
CH667657A5 (de) *	1985-01-07	1988-10-31	Sandoz Ag	Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
US4605652A (en) *	1985-02-04	1986-08-12	A. H. Robins Company, Inc.	Method of enhancing memory or correcting memory deficiency with arylamido (and arylthioamido)-azabicycloalkanes
EP0201165B1 (en) *	1985-03-14	1994-07-20	Beecham Group Plc	Medicaments for the treatment of emesis
US4624961A (en) *	1985-04-17	1986-11-25	A. H. Robins Company, Incorporated	Method for enhancing memory or correcting memory deficiency with arylamidopyrazolidines and arylamidodiazabicycloalkanes
DE3650772T2 (de) *	1985-04-27	2003-04-03	F. Hoffmann-La Roche Ag, Basel	Derivate von Indazole-3-carboxamide und -3-carboxylsäure
DE3687980T2 (de) *	1986-01-07	1993-06-17	Beecham Group Plc	Indolderivate mit einer azabicyclischen seitenkette, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zusammensetzungen.
HU895334D0 (en) *	1986-07-30	1990-01-28	Sandoz Ag	Process for the preparation of nasal pharmaceutical compositions
DE3801659A1 (de) *	1988-01-21	1989-07-27	Boehringer Ingelheim Kg	Tetrahydropyridin - derivate
CA1332151C (en) *	1988-01-28	1994-09-27	Roman Amrein	Use of a benzamide to treat cognitive disorder
DE68912822T2 (de) *	1988-05-16	1994-06-09	Searle & Co	2-Amino-4,5-methylenadipinsäure-Verbindungen für die Behandlung von CNS-Erkrankungen.
YU150489A (sh) *	1989-08-10	1992-12-21	W.L. Gore & Co. Gmbh.	Uređaj za ispitivanje odevnih predmeta na nepromočivost
EP0495831B1 (en) *	1989-10-16	1997-01-15	Hem Pharmaceuticals Corp.	Diagnosis and treatment of neuro-cognitive disorders associated with systemic immunological malfunction
DE69102816T2 (de) *	1990-05-11	1995-03-16	Sankyo Co	Piperdinyloxy- und Chinindidinyloxy- isoxazol- Derivate, ihre Herstellung und ihre therapeutische Verwendung.

1987
- 1987-12-16 DE DE3751404T patent/DE3751404T2/de not_active Expired - Lifetime
- 1987-12-16 ES ES87311079T patent/ES2074981T3/es not_active Expired - Lifetime
- 1987-12-16 EP EP87311079A patent/EP0279990B1/en not_active Expired - Lifetime
- 1987-12-16 AT AT93201171T patent/ATE152623T1/de not_active IP Right Cessation
- 1987-12-16 EP EP93201171A patent/EP0559297B1/en not_active Expired - Lifetime
- 1987-12-16 DE DE3752062T patent/DE3752062T2/de not_active Expired - Lifetime
- 1987-12-16 JP JP62318458A patent/JP2608079B2/ja not_active Expired - Lifetime
- 1987-12-16 EP EP19930200775 patent/EP0551963A3/en not_active Withdrawn
- 1987-12-16 US US07/133,885 patent/US4985437A/en not_active Expired - Lifetime
- 1987-12-16 AT AT87311079T patent/ATE124865T1/de not_active IP Right Cessation
1995
- 1995-09-13 GR GR950402486T patent/GR3017369T3/el unknown

Also Published As

Publication number	Publication date
ATE152623T1 (de)	1997-05-15
DE3751404D1 (de)	1995-08-17
JP2608079B2 (ja)	1997-05-07
JPS63277623A (ja)	1988-11-15
EP0559297A1 (en)	1993-09-08
DE3751404T2 (de)	1995-12-21
US4985437A (en)	1991-01-15
ATE124865T1 (de)	1995-07-15
ES2074981T3 (es)	1995-10-01
EP0279990B1 (en)	1995-07-12
EP0279990A3 (en)	1990-11-28
EP0551963A3 (en)	1993-09-01
DE3752062D1 (de)	1997-06-12
EP0279990A2 (en)	1988-08-31
DE3752062T2 (de)	1997-09-11
EP0559297B1 (en)	1997-05-07
EP0551963A2 (en)	1993-07-21

Publication	Publication Date	Title
EP0279990A3 (en)	1990-11-28	Use of heterocyclic derivatives in the treatment of cognitive disorders
MY132229A (en)	2007-09-28	Indole derivatives as 5-ht receptor antagonist
CA2118704A1 (en)	1993-04-01	Fused Tricyclic Nitrogen Containing Heterocycles as Substance P Receptor Antagonists
GR3026231T3 (en)	1998-05-29	3-aminopiperidine derivatives and related nitrogen containing heterocycles.
GR3015144T3 (en)	1995-05-31	Quinuclidine derivatives.
CA2123403A1 (en)	1993-05-27	Acyclic ethylenediamine derivatives as substance p receptor antagonists
ZA917744B (en)	1993-03-29	Fused ring analogs of nitrogen containing nonaromatic heterocycles.
NZ329627A (en)	1999-11-29	8-Heterocyclically substituted 1,3,8-triaza-spiro[4.5]decan-4-ones
GB8518658D0 (en)	1985-08-29	Medicaments
GR3019490T3 (en)	1996-07-31	Substituted piperazines as central nervous system agents
IE873414L (en)	1988-06-17	Medicament for dementia
DE69524623D1 (de)	2002-01-24	Verwendung von cck-b rezeptor antagonisten zur behandlung von schlafstörungen
DE3578063D1 (de)	1990-07-12	1-substituierte tetralinderivate, ihre herstellung und verwendung.
GR3031514T3 (en)	2000-01-31	USE OF ANTAGONISTS OR PARTIAL AGONISTS ON THE 5-HT 1a RECEPTOR FOR THE TREATMENT AND PREVENTION OF COGNITIVE DISORDERS
ATE95704T1 (de)	1993-10-15	Anwendung heterozyklischer derivate zur herstellung von arzneimitteln.
MY107354A (en)	1995-11-30	Substituted cyclohexenes as central nervous system agents
BG103089A (en)	1999-09-30	Indoline derivatives useful as 5-ht-2c-receptor antagonists
GR3002829T3 (en)	1993-01-25	4-nitrogen substituted isoquinolinol compounds having cardiotonic, phosphodiesterase fraction iii inhibiting properties and/or renal vasodilating properties
NO20012538D0 (no)	2001-05-23	Anvendelse av N-substituerte azabicycloalkanderivater for behandling av forstyrrelser i sentralnervesystemet
EP0330468A3 (en)	1991-04-03	Use of heterocyclic derivatives as kappa-opioid receptor agonists in the treatment of cerebral ischaemia
TW367320B (en)	1999-08-21	Novel aryl compounds having CNS activity, process for their preparation and their use as medicaments