GR3017547T3 - Tablet with improved bioavailability containing dichloromethylenedephosphonic acid as active ingredient. - Google Patents

Tablet with improved bioavailability containing dichloromethylenedephosphonic acid as active ingredient.

Info

Publication number: GR3017547T3
Authority: GR; Greece
Prior art keywords: tablet; active ingredient; improved bioavailability; acid; dichloromethylenedephosphonic
Prior art date: 1993-05-15

Application number

GR950402574T

Other languages

English (en)

Inventor

Walter Preis

Bernd Muesel

Guenter Dr Neugebauer

Rolf-Dieter Dr Gabel

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-05-15

Filing date

1995-09-28

Publication date

1995-12-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25927331&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=GR3017547(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1993-05-15 Priority claimed from DE9307393U external-priority patent/DE9307393U1/de

1993-07-02 Priority claimed from DE19934322057 external-priority patent/DE4322057A1/de

1995-09-28 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1995-12-31 Publication of GR3017547T3 publication Critical patent/GR3017547T3/el

Links

239000004480 active ingredient Substances 0.000 title abstract 3
239000002253 acid Substances 0.000 title 1
229920000168 Microcrystalline cellulose Polymers 0.000 abstract 2
ACSIXWWBWUQEHA-UHFFFAOYSA-N clodronic acid Chemical compound OP(O)(=O)C(Cl)(Cl)P(O)(O)=O ACSIXWWBWUQEHA-UHFFFAOYSA-N 0.000 abstract 2
229960002286 clodronic acid Drugs 0.000 abstract 2
235000019813 microcrystalline cellulose Nutrition 0.000 abstract 2
239000008108 microcrystalline cellulose Substances 0.000 abstract 2
229940016286 microcrystalline cellulose Drugs 0.000 abstract 2
239000000654 additive Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Diabetes (AREA)
Rheumatology (AREA)
Inorganic Chemistry (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

GR950402574T 1993-05-15 1995-09-28 Tablet with improved bioavailability containing dichloromethylenedephosphonic acid as active ingredient. GR3017547T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE9307393U DE9307393U1 (de)	1993-05-15	1993-05-15	Tablette mit verbesserter Bioverfügbarkeit, enthaltend Dichlormethylendiphosphonsäure als Wirkstoff
DE19934322057 DE4322057A1 (de)	1993-07-02	1993-07-02	Tablette mit verbesserter Bioverfügbarkeit enthaltend Dichlormethylendiphosphonsäure als Wirkstoff

Publications (1)

Publication Number	Publication Date
GR3017547T3 true GR3017547T3 (en)	1995-12-31

Family

ID=25927331

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
GR940300095T GR940300095T1 (en)	1993-05-15	1995-01-31	Tablet with improved bioavailability containing dichloromethylenedephosphonic acid as active ingredient.
GR950402574T GR3017547T3 (en)	1993-05-15	1995-09-28	Tablet with improved bioavailability containing dichloromethylenedephosphonic acid as active ingredient.

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
GR940300095T GR940300095T1 (en)	1993-05-15	1995-01-31	Tablet with improved bioavailability containing dichloromethylenedephosphonic acid as active ingredient.

Country Status (25)

Country	Link
US (1)	US5650168A (el)
EP (2)	EP0697890A1 (el)
JP (1)	JP3699110B2 (el)
KR (1)	KR100263284B1 (el)
CN (1)	CN1041797C (el)
AT (2)	ATE128363T1 (el)
AU (1)	AU687744B2 (el)
BR (1)	BR9307859A (el)
CA (1)	CA2162470C (el)
CZ (1)	CZ287984B6 (el)
DE (1)	DE59300688D1 (el)
DK (1)	DK0625355T5 (el)
ES (1)	ES2065313T5 (el)
FI (1)	FI111519B (el)
GR (2)	GR940300095T1 (el)
HU (1)	HU220872B1 (el)
IL (1)	IL106743A (el)
NO (1)	NO307548B1 (el)
NZ (1)	NZ254765A (el)
PL (1)	PL173026B1 (el)
RU (1)	RU2134103C1 (el)
SK (1)	SK281193B6 (el)
TW (1)	TW350772B (el)
UA (1)	UA39884C2 (el)
WO (1)	WO1994026310A1 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI94926C (fi) *	1993-11-12	1995-11-27	Leiras Oy	Menetelmä klodronaattivalmisteen valmistamiseksi
DE19615812A1 (de) *	1996-04-20	1997-10-23	Boehringer Mannheim Gmbh	Pharmazeutische Zubereitung enthaltend Diphosphonsäuren zur oralen Applikation
DE19719680A1 (de)	1997-05-09	1998-11-19	Boehringer Mannheim Gmbh	Verwendung von Diphosphonsäuren zur präventiven Behandlung von Spätfolgen bei Harnblasenerweiterung oder Harnblasenersatz
FI109088B (fi) *	1997-09-19	2002-05-31	Leiras Oy	Tabletti ja menetelmä sen valmistamiseksi
EP0998932A1 (de)	1998-10-09	2000-05-10	Boehringer Mannheim Gmbh	Feste pharmazeutische Darreichungsform enthaltend Diphosphonsäure oder deren Salze und Verfahren zu ihrer Herstellung
SE9901272D0 (sv) *	1999-04-09	1999-04-09	Astra Ab	New improved formulation
CZ289261B6 (cs) *	2000-07-11	2001-12-12	Léčiva, A.S.	Tableta vyrobitelná přímým tabletováním, obsahující aktivní látku kyselinu 4-amino-1-hydroxybutyliden-1,1-bisfosfonovou, a způsob její výroby
RU2192848C1 (ru) *	2001-10-30	2002-11-20	Закрытое акционерное общество "ВЕРОФАРМ"	Противорвотное средство
EP1663175B1 (en) *	2003-09-19	2012-03-28	Sun Pharma Advanced Research Company Limited	Oral drug delivery system
US10213387B2 (en)	2003-09-19	2019-02-26	Sun Pharma Advanced Research Company Ltd.	Oral drug delivery system
US10226428B2 (en)	2003-09-19	2019-03-12	Sun Pharma Advanced Research Company Ltd.	Oral drug delivery system
US7151400B2 (en) *	2004-07-13	2006-12-19	Taiwan Semiconductor Manufacturing Company, Ltd.	Boost-biased level shifter
CN100370972C (zh) *	2006-01-10	2008-02-27	北京申科联华科技有限公司	一种具有益气养阴、活血复脉功效的片剂及制备方法
CN101808640A (zh) *	2007-08-02	2010-08-18	帝人制药株式会社	骨代谢异常所引起的疾病的预防药或治疗药
CN102026628A (zh) *	2008-02-15	2011-04-20	太阳医药高级研发有限公司	具有降低崩裂效果的口服控释片剂
CN118370733B (zh) *	2024-06-21	2024-10-01	山东新时代药业有限公司	一种钙代谢调节药物氯膦酸二钠片及其制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PH9776A (en) *	1967-12-11	1976-03-17	M Francis	Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue and method of use
DE2813121A1 (de) *	1977-03-29	1978-10-12	Procter & Gamble	Verwendung von dichlormethan-diphosphonatverbindungen bei der bekaempfung von collagen-erkrankungen und zur wundheilung
US4634691A (en) *	1980-10-07	1987-01-06	The Procter & Gamble Company	Method for inhibiting tumor metastasis
US4517179A (en) *	1983-04-29	1985-05-14	Pennwalt Corporation	Rapid dissolving, uniform drug compositions and their preparation
SU1437023A1 (ru) *	1986-01-02	1988-11-15	Всесоюзный научно-исследовательский институт химии и технологии лекарственных средств	Антацидное средство "Кальмагин
SE457326B (sv) *	1986-02-14	1988-12-19	Lejus Medical Ab	Foerfarande foer framstaellning av en snabbt soenderfallande kaerna innehaallande bl a mikrokristallin cellulosa
DE3767998D1 (de) *	1986-12-20	1991-03-14	Boehringer Mannheim Gmbh	Clodronat-haltige arzneimittel und verfahren zur herstellung derselben.
DE3804686A1 (de) *	1988-02-15	1989-08-24	Henkel Kgaa	Arzneimittel mit einer kombination von cytostatika bzw. hormontherapeutika und phosphonoderivaten
FR2629716B1 (fr) *	1988-04-07	1991-07-19	Sanofi Sa	Composition pharmaceutique pour administration orale a base d'un derive d'acide diphosphonique
FI83421C (fi) †	1989-06-21	1991-07-10	Huhtamaeki Oy	Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
SK90093A3 (en) *	1991-02-26	1994-09-07	Norwich Eaton Pharma	Mixture of phosphonite and estrogene for treatment of osteoporosis
SE501389C2 (sv) †	1992-04-24	1995-01-30	Leiras Oy	Farmaceutiskt preparat och förfarande för dess framställning
CA2151240A1 (en) *	1992-12-23	1994-07-07	Donna T. Whiteford	Biophosphonate/estrogen therapy for treating and preventing bone loss

1993
- 1993-07-24 BR BR9307859A patent/BR9307859A/pt not_active Application Discontinuation
- 1993-07-24 EP EP93917636A patent/EP0697890A1/de not_active Withdrawn
- 1993-07-24 AT AT93111827T patent/ATE128363T1/de active
- 1993-07-24 UA UA95114854A patent/UA39884C2/uk unknown
- 1993-07-24 EP EP93111827A patent/EP0625355B2/de not_active Expired - Lifetime
- 1993-07-24 CZ CZ1995100A patent/CZ287984B6/cs not_active IP Right Cessation
- 1993-07-24 KR KR1019950705094A patent/KR100263284B1/ko not_active Expired - Lifetime
- 1993-07-24 PL PL93307133A patent/PL173026B1/pl unknown
- 1993-07-24 AU AU47020/93A patent/AU687744B2/en not_active Expired
- 1993-07-24 RU RU95121748A patent/RU2134103C1/ru active
- 1993-07-24 HU HU9403160A patent/HU220872B1/hu unknown
- 1993-07-24 WO PCT/EP1993/001967 patent/WO1994026310A1/de not_active Ceased
- 1993-07-24 NZ NZ254765A patent/NZ254765A/en not_active IP Right Cessation
- 1993-07-24 US US08/537,853 patent/US5650168A/en not_active Expired - Lifetime
- 1993-07-24 JP JP51843194A patent/JP3699110B2/ja not_active Expired - Fee Related
- 1993-07-24 CA CA002162470A patent/CA2162470C/en not_active Expired - Lifetime
- 1993-07-24 SK SK48-95A patent/SK281193B6/sk not_active IP Right Cessation
- 1993-07-24 DE DE59300688T patent/DE59300688D1/de not_active Expired - Lifetime
- 1993-07-24 ES ES93111827T patent/ES2065313T5/es not_active Expired - Lifetime
- 1993-07-24 DK DK93111827T patent/DK0625355T5/da active
- 1993-08-19 IL IL10674393A patent/IL106743A/en not_active IP Right Cessation
- 1993-09-10 TW TW082106635A patent/TW350772B/zh not_active IP Right Cessation
- 1993-09-23 CN CN93118149A patent/CN1041797C/zh not_active Expired - Lifetime
1994
- 1994-05-13 AT AT0007494U patent/AT128U1/de not_active IP Right Cessation
- 1994-11-11 FI FI945313A patent/FI111519B/fi not_active IP Right Cessation
- 1994-11-17 NO NO944405A patent/NO307548B1/no not_active IP Right Cessation
1995
- 1995-01-31 GR GR940300095T patent/GR940300095T1/el unknown
- 1995-09-28 GR GR950402574T patent/GR3017547T3/el unknown

Also Published As

Publication number	Publication date
NO944405L (no)	1994-11-24
AT128U1 (de)	1995-03-27
SK281193B6 (sk)	2001-01-18
PL173026B1 (pl)	1998-01-30
DE59300688D1 (de)	1995-11-02
UA39884C2 (uk)	2001-07-16
EP0625355B1 (de)	1995-09-27
CZ10095A3 (en)	1995-10-18
ATE128363T1 (de)	1995-10-15
FI945313L (fi)	1994-12-13
IL106743A (en)	1999-11-30
TW350772B (en)	1999-01-21
DK0625355T4 (da)	2003-10-06
FI945313A0 (fi)	1994-11-11
EP0625355B2 (de)	2003-06-25
AU687744B2 (en)	1998-03-05
KR960702322A (ko)	1996-04-27
JPH08509697A (ja)	1996-10-15
ES2065313T3 (es)	1995-12-01
CN1041797C (zh)	1999-01-27
PL307133A1 (en)	1995-05-02
SK4895A3 (en)	1997-01-08
IL106743A0 (en)	1993-12-08
NZ254765A (en)	1997-02-24
FI111519B (fi)	2003-08-15
CZ287984B6 (cs)	2001-03-14
NO944405D0 (no)	1994-11-17
CA2162470A1 (en)	1994-11-24
HU220872B1 (en)	2002-06-29
KR100263284B1 (ko)	2000-08-01
HUT70214A (en)	1995-09-28
DK0625355T3 (da)	1995-12-27
ES2065313T5 (es)	2004-01-01
EP0697890A1 (de)	1996-02-28
RU2134103C1 (ru)	1999-08-10
CA2162470C (en)	1998-06-16
ES2065313T1 (es)	1995-02-16
CN1095267A (zh)	1994-11-23
GR940300095T1 (en)	1995-01-31
BR9307859A (pt)	1996-01-09
JP3699110B2 (ja)	2005-09-28
EP0625355A1 (de)	1994-11-23
AU4702093A (en)	1994-12-12
DK0625355T5 (da)	2003-12-01
WO1994026310A1 (de)	1994-11-24
HU9403160D0 (en)	1995-02-28
NO307548B1 (no)	2000-04-25
US5650168A (en)	1997-07-22

Publication	Publication Date	Title
FI945313A0 (fi)	1994-11-11	Parannetun biokäytettävyyden omaavat tabletit, jotka sisältävät dikloorimetyleenifosfonihappoa vaikuttavana aineena
MXPA03007712A (es)	2004-03-16	Sales farmaceuticas.
NO841518L (no)	1984-10-19	Delbare tabletter med forsinket frigjoering av virkestoff, og fremgangsmaate for fremstilling derav
WO2003011204A3 (en)	2003-07-03	Drug delivery systems
GR3019324T3 (en)	1996-06-30	Pharmaceutical chewing-gum containing acetylsalicylic acid
PL304860A1 (en)	1995-03-06	Drug of prolonged active substance release containing a tramadol salt
HUT43843A (en)	1987-12-28	Process for production of derivatives of benzimidasole and medical compounds containing thereof
ATE122668T1 (de)	1995-06-15	Diarylsubstituierte heterocyclische verbindung, ihre herstellung und arzneimittel und kosmetika daraus.
GR3007202T3 (el)	1993-07-30
DK0673245T3 (da)	1998-04-27	Farmaceutisk brusepræparat indeholdende ibuprofen og fremgangsmåde til dets fremstilling.
AU2793989A (en)	1989-06-14	Method for preparing a solid sustained release form of a functionally active composition and the dosage form so obtained
ES2010466A6 (es)	1989-11-01	Formas de administracion solidas, de rapida desintegracion.
HUT50334A (en)	1990-01-29	Process for producing arylpiperazinyl-alkilenephenyl-p-heterocycluc compounds, pharmaceutically acceptable acid addition salts thereof and pharmaceutical compositions comprising the compounds as active ingredient
UA19156A (uk)	1997-12-25	Спосіб одержаhhя амідіhів або їх фармацевтичhо прийhятhих солей
HUT57204A (en)	1991-11-28	Process for producing 4-fluoro-2-///4-methoxy-2-pyridinyl/-methyl/-sulfinyl/-1h-benzimidazol with gastric acid secration-diminishing activity and pharmaceutical compositions containing them
CA2047027A1 (en)	1992-01-17	Tablet and granulate containing mesna as active substance
HU893631D0 (en)	1990-11-28	Process for producing 1,1-dioxo-cephem-4-carbothiolic acid derivatives and pharmaceutical prepartives containing them as active substance
HUT48797A (en)	1989-07-28	Insecticides, acarycides and nematocides containing as active substance derivatives of aryl-pirrol and process for production of the active substances
DE3064773D1 (en)	1983-10-13	Novel quinazoline derivatives, a pharmaceutical composition containing such derivatives as active ingredient and a process for producing the quinazoline derivatives
UA32583C2 (uk)	2001-02-15	Похідні арилтіоалкілтіопіридину
AU1487988A (en)	1988-10-10	Package, for instance for tablets for pharmaceutical use
HUP0302928A3 (en)	2005-03-29	Novel crystals of n-hydroxy-2(s)-methyl-5-ethoxymethoxy-4(s)-[n-(4-phenoxyphenyl-carbonyl)amino] pentanamide, process for their production and medicines containing the crystals as the active ingredient
JPS5661357A (en)	1981-05-26	Benzazepin derivative* its manufacture and medicinal composition containing it
AU2273088A (en)	1989-03-23	Pharmaceutical products containing a 7-diphenylmethylene- bicycloheptane or 7-diphenylmethylenebicycloheptene derivative, the use of these compounds as medicaments, and new 7-diphenylmethylenebicycloheptanes and 7-diphenylmethylene-bicycloheptenes and processes for the preparation thereof
ES2004693A6 (es)	1989-02-01	Un procedimiento para la preparacion de una composicion farmaceutica solida administrable por via oral, que contiene vinburnina como principio activo.