GR3019898T3 - Process for the preparation of fused pyridine compounds - Google Patents

Process for the preparation of fused pyridine compounds

Info

Publication number
GR3019898T3
GR3019898T3 GR960401280T GR960401280T GR3019898T3 GR 3019898 T3 GR3019898 T3 GR 3019898T3 GR 960401280 T GR960401280 T GR 960401280T GR 960401280 T GR960401280 T GR 960401280T GR 3019898 T3 GR3019898 T3 GR 3019898T3
Authority
GR
Greece
Prior art keywords
preparation
pyridine compounds
fused pyridine
ch2ch2coor
pyrimidone
Prior art date
Application number
GR960401280T
Other languages
English (en)
Inventor
Edward C Taylor
Philip M Harrington
Original Assignee
Univ Princeton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Princeton filed Critical Univ Princeton
Publication of GR3019898T3 publication Critical patent/GR3019898T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR960401280T 1987-10-26 1996-05-13 Process for the preparation of fused pyridine compounds GR3019898T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11403087A 1987-10-26 1987-10-26
US07/186,015 US4895946A (en) 1987-10-26 1988-04-25 Process for the preparation of fused pyridine compounds

Publications (1)

Publication Number Publication Date
GR3019898T3 true GR3019898T3 (en) 1996-08-31

Family

ID=26811764

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960401280T GR3019898T3 (en) 1987-10-26 1996-05-13 Process for the preparation of fused pyridine compounds

Country Status (7)

Country Link
US (2) US4895946A (el)
EP (1) EP0314280B1 (el)
JP (1) JPH01113389A (el)
AT (1) ATE134374T1 (el)
DE (1) DE3855017T2 (el)
ES (1) ES2083954T3 (el)
GR (1) GR3019898T3 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
JPH03173890A (ja) * 1989-09-21 1991-07-29 Takeda Chem Ind Ltd ピロロ［２，３―ｄ］ピリミジン誘導体，その製造法，用途及び中間体
US5028608A (en) * 1989-12-11 1991-07-02 The Trustees Of Princeton University N-(6-Amino-(pyrrolo(2,3-d)pyrimidin-3-ylacyl) )-glutamic acid derivatives
DE69216509T2 (de) * 1991-08-12 1997-05-28 Takeda Chemical Industries Ltd Kondensierte Pyrimidinderivate, ihre Herstellung und ihre Verwendung als Antitumormittel
US5254687A (en) 1991-12-04 1993-10-19 The Trustees Of Princeton University Process for the preparation of pyrrolo[2,3-d]pyrimidines
US5594139A (en) * 1993-01-29 1997-01-14 Agouron Pharmaceuticals, Inc. Processes for preparing antiproliferative garft-inhibiting compounds
US5608082A (en) * 1994-07-28 1997-03-04 Agouron Pharmaceuticals, Inc. Compounds useful as antiproliferative agents and GARFT inhibitors
US5831100A (en) * 1995-06-07 1998-11-03 Agouron Pharmaceuticals, Inc. Syntheses of optically pure compounds useful as GARFT inhibitors and their intermediates
US5786358A (en) * 1995-09-08 1998-07-28 The Trustees Of Princeton University Pyridopyrimidines as nonclassical antifolates
EP0904271A4 (en) * 1996-05-01 2002-01-23 Univ Princeton 5,6,7,8-tetrahydro-pyrido [2,3-d] pyrimidines
US6066639A (en) * 1996-05-01 2000-05-23 The Trustees Of Princeton University 5,6,7,8-tetrahydropyrido[2,3-D]pyrimidines
CN1246295C (zh) * 1997-09-26 2006-03-22 伊莱利利公司 用于制造抗叶酸剂的方法和中间体
EP1054859A4 (en) * 1998-02-11 2003-03-05 Lilly Co Eli PROCESSES AND INTERMEDIATES USEFUL FOR THE MANUFACTURE OF ANTIFOLICS
GB2358799A (en) * 2000-02-04 2001-08-08 Lilley Forschung Gmbh A pharmaceutical composition comprising pemetrexed and an antioxidant
US20040092739A1 (en) * 2002-11-13 2004-05-13 Zejun Xiao Process for synthesizing antifolates
CN103030640B (zh) * 2012-06-11 2015-04-22 江苏豪森医药集团连云港宏创医药有限公司 一种培美曲塞或其盐的制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3288792A (en) * 1962-07-05 1966-11-29 Burroughs Wellcome Co Method of preparing 2, 4-diamino-6-alkylpyrido (2, 3-d) pyrimidines
ZA803539B (en) * 1979-06-14 1982-01-27 Wellcome Found Alkoxybenzylrimidines method for their preparation formulation thereof and their use in medicine
ZA861235B (en) * 1985-03-08 1986-10-29 Univ Princeton Pyrido(2,3-d)pyrimidine derivatives
US4684653A (en) * 1985-03-08 1987-08-04 The Trustees Of Princeton University Pyrido(2,3-d)pyrimidine derivatives
FR2582802B1 (el) * 1985-05-28 1989-07-28 Sfena
NZ219971A (en) * 1986-06-06 1989-08-29 Univ Princeton Tetrahydropyrido (2,3-d pyrimidine derivatives and pharmaceutical compositions
JP2830008B2 (ja) * 1988-04-01 1998-12-02 武田薬品工業株式会社 縮合ピリミジン誘導体
US5223620A (en) * 1988-04-01 1993-06-29 Takeda Chemical Industries, Ltd. Pyrido[2,3-d]pyrimidine compounds useful as intermediates

Also Published As

Publication number Publication date
US5473071A (en) 1995-12-05
EP0314280A3 (en) 1989-11-02
ES2083954T3 (es) 1996-05-01
US4895946A (en) 1990-01-23
JPH01113389A (ja) 1989-05-02
ATE134374T1 (de) 1996-03-15
EP0314280B1 (en) 1996-02-21
DE3855017T2 (de) 1996-08-01
DE3855017D1 (de) 1996-03-28
EP0314280A2 (en) 1989-05-03

Similar Documents

Publication Publication Date Title
EP0314280A3 (en) Process for the preparation of fused pyridine compounds
HUT53368A (en) Process for producing pyrazolo-pyridine derivatives and pharmaceutical compositions containing them
NZ329374A (en) Tricyclic amide and urea derivatives, preparation thereof
UA32546C2 (uk) 1,2-заміщені 1н-імідазо[4,5-с]хінолін-4-аміни, проміжні сполуки для їх синтезу, антивірусна фармацевтична композиція, спосіб лікування інфікованих ссавців, спосіб індукування біосинтезу інтерферону у ссавців, спосіб уповільнення росту бластом
CA2175372A1 (en) Novel 9-hydroxy-pyrido[1,2-a]pyrimidin-4-one ether derivatives
CA2148671A1 (en) Stable Crystalline (6S)-and (6R)-Tetrahydrofolic Acid
ES2000368A6 (es) Un procedimiento para preparar di-t-butilfenoles sustituidos
PT83104A (en) Novel guanidinomethylbenzoic acid derivatives
IE872658L (en) Tetrahydroquinoline derivatives, a process for their preparation, their use and pharmaceutical formulations containing them
AU576449B2 (en) Nicotinic acid derivatives
ES2001703A6 (es) Procedimiento para la preparracion de derrrivados de acidos 2-(2-imidazolin -2-il)- piridin -3- carboxilicos.
PT80809A (en) Process for the preparation of 1,6-naphthyridin-2(1h)-ones useful as cardiotonics
JPS6425774A (en) Manufacture of 6-substituted 2-(imidazoline-2- yl)nicotinic acid derivative, intermediate and manufacture
NZ225659A (en) Pharmaceutical compositions containing pyrrolidin-1-yl-6-fluoro-1,4-dihydro-4-oxo-1,8 naphthyridine-3-carboxylic acid derivatives
NO901171L (no) Fremgangsmaate til fremstilling av substituerte azetidinylpyridonkarboksylsyrederivater.
EP0403301A3 (en) Aerosols of pyrido[1,2-a]pyrimidine compounds
IE820239L (en) Carbapenem derivatives
JPS5742690A (en) Thieno 3,2-b pyridinecarboxylic acid derivative
CA2154668A1 (en) Condensed heterocyclic glutamic acid derivatives as antiproliferative agents
IL82946A (en) 1-t-butyl-6-methylergoline-8-methanol derivatives,their preparation and pharmaceutical compositions containing them
EP0367671A3 (en) Novel beta-d-phenylthioxylosides, their method of preparation and their use as pharmaceuticals
EP0539987A3 (en) Process for the purification of crude alkalinic earth metal salts of n(5)-methyl-5,6,7,8-tetrahydrofolic acid
IE872311L (en) Preparation of dicarboxylic acid derivatives.
DE69026638D1 (de) Verfahren zur Herstellung von Pyrido[1,2-a]pyrimidinderivaten
DE69127238D1 (de) Verfahren zur Herstellung von Pyrido[1,2-a]pyrimidinderivaten