GR3025455T3 - Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them - Google Patents

Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them

Info

Publication number: GR3025455T3
Authority: GR; Greece
Prior art keywords: substituted; alkyl; independent; another; phenyl
Prior art date: 1990-07-10

Application number

GR970403100T

Other languages

English (en)

Inventor

Takahiro Haga

Hideo Sugi

Itaru Shigehara

Shinji Odawara

Syuichi Yotsuya

Hirohiko Kimura

Kazuhiro Yamamoto

Original Assignee

Ishihara Sangyo Kaisha

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-07-10

Filing date

1997-11-24

Publication date

1998-02-27

1991-05-24 Priority claimed from JP3222530A external-priority patent/JPH05170742A/ja

1997-11-24 Application filed by Ishihara Sangyo Kaisha filed Critical Ishihara Sangyo Kaisha

1998-02-27 Publication of GR3025455T3 publication Critical patent/GR3025455T3/el

Links

MEHAREFZRGNRJP-UHFFFAOYSA-N 2-(trifluoromethyl)pyrimidine-4,6-diamine Chemical class NC1=CC(N)=NC(C(F)(F)F)=N1 MEHAREFZRGNRJP-UHFFFAOYSA-N 0.000 title 1
108010014865 PLIalpha Proteins 0.000 title 1
229940123898 Phospholipase A2 inhibitor Drugs 0.000 title 1
239000003358 phospholipase A2 inhibitor Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 7
125000001183 hydrocarbyl group Chemical group 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000001188 haloalkyl group Chemical group 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
UVPXDGMMAFWHMJ-UHFFFAOYSA-N 2-(trifluoromethyl)pyridine-3,4-diamine Chemical class NC1=CC=NC(C(F)(F)F)=C1N UVPXDGMMAFWHMJ-UHFFFAOYSA-N 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004448 alkyl carbonyl group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
125000002950 monocyclic group Chemical group 0.000 abstract 1
125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
125000004430 oxygen atom Chemical group O* 0.000 abstract 1
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 abstract 1
125000003367 polycyclic group Chemical group 0.000 abstract 1
125000004585 polycyclic heterocycle group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/76—Nitrogen atoms to which a second hetero atom is attached
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

GR970403100T 1990-07-10 1997-11-24 Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them GR3025455T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP18199990		1990-07-10
JP3222530A JPH05170742A (ja)	1991-05-24	1991-05-24	ジアミノトリフルオロメチルピリジン誘導体、それらの製造方法及びそれらを含有するホスホリパーゼ▲ａ２▼阻害剤

Publications (1)

Publication Number	Publication Date
GR3025455T3 true GR3025455T3 (en)	1998-02-27

Family

ID=26500966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR970403100T GR3025455T3 (en)	1990-07-10	1997-11-24	Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them

Country Status (13)

Country	Link
EP (1)	EP0465913B1 (el)
JP (3)	JP3078896B2 (el)
KR (1)	KR0173311B1 (el)
CN (1)	CN1032534C (el)
AT (1)	ATE157969T1 (el)
AU (1)	AU642267B2 (el)
CA (1)	CA2045857C (el)
DE (1)	DE69127595T2 (el)
DK (1)	DK0465913T3 (el)
ES (1)	ES2107434T3 (el)
GR (1)	GR3025455T3 (el)
IL (1)	IL98762A (el)
NZ (1)	NZ238752A (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0465913B1 (en) *	1990-07-10	1997-09-10	Ishihara Sangyo Kaisha, Ltd.	Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them
GB9403333D0 (en) *	1994-02-22	1994-04-13	Zeneca Ltd	Compound and use
FR2720396B1 (fr) *	1994-05-27	1996-06-28	Adir	Nouveaux N-pyridyl carboxamides et dérivés leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.
ID18983A (id) *	1996-12-04	1998-05-28	Lilly Co Eli	Pirazola sebagai inhibitor sekresi fosfolipase a2 non-pankreas pada manusia
TW415843B (en) *	1997-02-28	2000-12-21	Ishihara Sangyo Kaisha	Anti-cancer pharmaceutical compositions comprising a diaminotrifluoromethylpyridine derivatives or the pharmaceutically acceptable salts thereof
JP4848091B2 (ja) *	2000-01-31	2011-12-28	石原産業株式会社	ジアミノトリフルオロメチルピリジン誘導体を含有する消化器疾患治療剤又は予防剤
JP4848092B2 (ja) *	2000-02-01	2011-12-28	石原産業株式会社	ジアミノトリフルオロメチルピリジン誘導体を含有する肺不全の治療剤又は予防剤
JP2001288089A (ja) *	2000-02-01	2001-10-16	Ishihara Sangyo Kaisha Ltd	ジアミノトリフルオロメチルピリジン誘導体を含有する肝疾患の治療剤又は予防剤
EP1252891B1 (en) *	2000-02-01	2005-10-05	Ishihara Sangyo Kaisha, Ltd.	Use of DIAMINOTRIFLUOROMETHYLPYRIDINE DERIVATIVES FOR the prevention and treatment of LIVER DISEASES
EP1557670A4 (en) *	2002-10-30	2007-03-07	Ishihara Sangyo Kaisha	REGULATION OF INTERACTIONS BETWEEN RAPL AND RAP1
JP5584518B2 (ja)	2009-05-28	2014-09-03	石原産業株式会社	ジアミノトリフルオロメチルピリジン誘導体を含有する抗ショック剤
EP2923710A1 (en)	2014-03-27	2015-09-30	Universitätsklinikum Heidelberg	Bacterial phospholipase inhibitors as modulator of colonic bacterial flora
MX2020004250A (es)	2017-11-02	2020-10-22	Ishihara Sangyo Kaisha	Composicion farmaceutica de liberacion sostenida.
EP3760200A4 (en) *	2018-03-01	2021-12-15	Ishihara Sangyo Kaisha, Ltd.	PHARMACEUTICAL COMPOSITION WITH EXCELLENT STORAGE STABILITY
US12473259B2 (en)	2019-05-15	2025-11-18	Ishihara Sangyo Kaisha, Ltd.	Anhydrous crystal of monosodium n-(2-ethylsulfonylamino-5-trifluoromethyl-3-pyridyl)cyclohexane carboxamide
KR102188659B1 (ko)	2019-12-10	2020-12-08	박영식	핸드 파렛트 트럭용 전도방지장치
AU2021354445A1 (en) *	2020-09-29	2023-05-18	Ishihara Sangyo Kaisha, Ltd.	Liquid pharmaceutical composition demonstrating excellent preservation efficacy

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3962263A (en)	1970-03-20	1976-06-08	Eli Lilly And Company	N-(2,2-difluoroalkanoyl)-2,3-pyridinediamine compounds
FR2124163A1 (en) *	1971-02-10	1972-09-22	Ferlux	2-amino-3-hydroxypyridine derivs - cardiovascular active
US3963660A (en) *	1973-10-04	1976-06-15	The Upjohn Company	Pyridine dioxamic acids and esters
US3961063A (en)	1975-04-03	1976-06-01	Smithkline Corporation	2,3-Bis-(3-acyl-2-thioureido)-pyridines
EP0465913B1 (en)	1990-07-10	1997-09-10	Ishihara Sangyo Kaisha, Ltd.	Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them

1991
- 1991-06-24 EP EP91110421A patent/EP0465913B1/en not_active Expired - Lifetime
- 1991-06-24 DE DE69127595T patent/DE69127595T2/de not_active Expired - Lifetime
- 1991-06-24 AT AT91110421T patent/ATE157969T1/de not_active IP Right Cessation
- 1991-06-24 ES ES91110421T patent/ES2107434T3/es not_active Expired - Lifetime
- 1991-06-24 DK DK91110421.4T patent/DK0465913T3/da active
- 1991-06-27 CA CA002045857A patent/CA2045857C/en not_active Expired - Lifetime
- 1991-06-27 NZ NZ238752A patent/NZ238752A/xx not_active IP Right Cessation
- 1991-06-29 CN CN91104523A patent/CN1032534C/zh not_active Expired - Lifetime
- 1991-07-02 AU AU79497/91A patent/AU642267B2/en not_active Expired
- 1991-07-08 IL IL9876291A patent/IL98762A/en not_active IP Right Cessation
- 1991-07-09 KR KR1019910011613A patent/KR0173311B1/ko not_active Expired - Lifetime
- 1991-07-10 JP JP03264234A patent/JP3078896B2/ja not_active Expired - Lifetime
- 1991-07-10 JP JP3264235A patent/JP2762323B2/ja not_active Expired - Lifetime
1997
- 1997-11-24 GR GR970403100T patent/GR3025455T3/el unknown
1998
- 1998-01-05 JP JP10010019A patent/JP3048344B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ES2107434T3 (es)	1997-12-01
AU7949791A (en)	1992-01-16
NZ238752A (en)	1993-06-25
CN1032534C (zh)	1996-08-14
JP3078896B2 (ja)	2000-08-21
EP0465913A2 (en)	1992-01-15
DE69127595T2 (de)	1998-01-22
EP0465913A3 (en)	1992-04-15
JPH06263735A (ja)	1994-09-20
CN1058396A (zh)	1992-02-05
EP0465913B1 (en)	1997-09-10
JPH06247934A (ja)	1994-09-06
AU642267B2 (en)	1993-10-14
CA2045857C (en)	1997-09-23
KR0173311B1 (ko)	1999-02-01
JP2762323B2 (ja)	1998-06-04
IL98762A (en)	1995-05-26
DE69127595D1 (de)	1997-10-16
HK1001839A1 (en)	1998-07-10
JPH10152473A (ja)	1998-06-09
JP3048344B2 (ja)	2000-06-05
ATE157969T1 (de)	1997-09-15
KR920002546A (ko)	1992-02-28
IL98762A0 (en)	1992-07-15
DK0465913T3 (da)	1997-10-20
CA2045857A1 (en)	1992-01-11

Publication	Publication Date	Title
GR3025455T3 (en)	1998-02-27	Diaminotrifluoromethylpyrimidine derivatives, process for their production and phospholipase A2 inhibitor containing them
ES2085118T3 (es)	1996-05-16	Amidas de piridinas y sus sales, procedimiento para su preparacion y composiciones que las contienen
MXPA03011782A (es)	2004-04-02	Piridinas sustituidas herbicidas, su preparacion y su uso como herbicidas y reguladores del crecimiento de las plantas.
GB8800827D0 (en)	1988-02-17	Fungicides
EP0275132A3 (en)	1989-08-23	Method of combating termites
DE69705480D1 (de)	2001-08-09	Verwendung von Oestrogenagonisten und -antagonisten zur Herstellung eines Medikaments zur Behandlung von Atherosklerose, unabhängig von Lipidsenkung
GB8913888D0 (en)	1989-08-02	New compositions of matter
PT86832A (pt)	1988-03-01	Process for preparing glycine compounds
MX9304249A (es)	1994-02-28	Derivados de n-acildihidroquinolina, metodo para su produccion y composiciones herbicidas que los contienen.
ES8507102A1 (es)	1985-02-01	Procedimiento de preparacion de derivados de acidos fenoxibenzoicos