GR3030211T3 - Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate. - Google Patents

Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate.

Info

Publication number
GR3030211T3
GR3030211T3 GR990401296T GR990401296T GR3030211T3 GR 3030211 T3 GR3030211 T3 GR 3030211T3 GR 990401296 T GR990401296 T GR 990401296T GR 990401296 T GR990401296 T GR 990401296T GR 3030211 T3 GR3030211 T3 GR 3030211T3
Authority
GR
Greece
Prior art keywords
loracarbef
isopropanolate
converting
monohydrate
crystalline
Prior art date
Application number
GR990401296T
Other languages
English (en)
Inventor
William Carl Henning
Michael Eugene O'dea
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of GR3030211T3 publication Critical patent/GR3030211T3/el

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D463/00Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16Nitrogen atoms
    • C07D463/18Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GR990401296T 1993-06-04 1999-05-13 Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate. GR3030211T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/072,204 US5399686A (en) 1993-06-04 1993-06-04 Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate

Publications (1)

Publication Number Publication Date
GR3030211T3 true GR3030211T3 (en) 1999-08-31

Family

ID=22106211

Family Applications (1)

Application Number Title Priority Date Filing Date
GR990401296T GR3030211T3 (en) 1993-06-04 1999-05-13 Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate.

Country Status (16)

Country Link
US (2) US5399686A (el)
EP (1) EP0627429B1 (el)
JP (1) JP3442861B2 (el)
KR (1) KR100308746B1 (el)
AT (1) ATE178328T1 (el)
BR (1) BR9402148A (el)
CA (1) CA2124999C (el)
DE (1) DE69417472T2 (el)
DK (1) DK0627429T3 (el)
ES (1) ES2129106T3 (el)
FI (1) FI108133B (el)
GR (1) GR3030211T3 (el)
HU (1) HUT67911A (el)
IL (1) IL109869A (el)
SI (1) SI0627429T1 (el)
TW (1) TW492968B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
GB9717629D0 (en) 1997-08-21 1997-10-22 Johnson Matthey Plc Removal of residual organic solvents
KR100519650B1 (ko) * 1999-02-05 2005-10-07 제일모직주식회사 점도가 균일한 폴리아믹산의 제조방법
EP1565462A1 (en) * 2002-11-21 2005-08-24 Ranbaxy Laboratories, Ltd. Monohydrate solvates of loracarbef

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3502663A (en) * 1969-04-21 1970-03-24 Lilly Co Eli Crystalline cephalosporin,method for its manufacture
US3531481A (en) * 1969-04-21 1970-09-29 Lilly Co Eli Method for manufacture of crystalline cephalosporin
US4775751A (en) * 1985-06-03 1988-10-04 Eli Lilly & Company Process for cephalexin hydrochloride alcoholates
CA1334970C (en) * 1987-10-06 1995-03-28 Carol Elaine Pasini Crystalline .beta.-lactam hydrate
US4977257A (en) * 1988-11-14 1990-12-11 Eli Lilly And Company DMF solvates of a β-lactam antibiotic
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5352782A (en) * 1993-06-04 1994-10-04 Eli Lilly And Company Process for preparing crystalline β-lactam monohydrate

Also Published As

Publication number Publication date
EP0627429B1 (en) 1999-03-31
FI942631A0 (fi) 1994-06-03
US5672700A (en) 1997-09-30
IL109869A0 (en) 1994-10-07
JP3442861B2 (ja) 2003-09-02
KR100308746B1 (ko) 2001-11-30
FI942631L (fi) 1994-12-05
CA2124999A1 (en) 1994-12-05
JPH06345762A (ja) 1994-12-20
BR9402148A (pt) 1994-12-27
DE69417472D1 (de) 1999-05-06
KR950000703A (ko) 1995-01-03
DE69417472T2 (de) 1999-08-19
EP0627429A1 (en) 1994-12-07
ATE178328T1 (de) 1999-04-15
HU9401673D0 (en) 1994-09-28
CA2124999C (en) 2004-08-10
ES2129106T3 (es) 1999-06-01
SI0627429T1 (en) 1999-10-31
HUT67911A (en) 1995-05-29
IL109869A (en) 1998-06-15
TW492968B (en) 2002-07-01
DK0627429T3 (da) 1999-10-11
FI108133B (fi) 2001-11-30
US5399686A (en) 1995-03-21

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