GR3032253T3 - Novel 4-piperidinyl substituted lactames as neurokinin 2 receptor antagonists for the treatment of asthma - Google Patents

Novel 4-piperidinyl substituted lactames as neurokinin 2 receptor antagonists for the treatment of asthma

Info

Publication number: GR3032253T3
Authority: GR; Greece
Prior art keywords: neurokinin; asthma; treatment; lactames; novel
Prior art date: 1993-11-03

Application number

GR990403208T

Other languages

English (en)

Inventor

Scott Carson Miller

Original Assignee

Zeneca Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-11-03

Filing date

1999-12-23

Publication date

2000-04-27

1999-12-23 Application filed by Zeneca Ltd filed Critical Zeneca Ltd

2000-04-27 Publication of GR3032253T3 publication Critical patent/GR3032253T3/el

Links

208000006673 asthma Diseases 0.000 title abstract 2
239000002746 neurokinin 2 receptor antagonist Substances 0.000 title 1
125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
150000001204 N-oxides Chemical class 0.000 abstract 1
HEAUFJZALFKPBA-YRVBCFNBSA-N Neurokinin A Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)CC=1NC=NC=1)C(C)O)C1=CC=CC=C1 HEAUFJZALFKPBA-YRVBCFNBSA-N 0.000 abstract 1
102400000097 Neurokinin A Human genes 0.000 abstract 1
101800000399 Neurokinin A Proteins 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D211/74—Oxygen atoms
- C07D211/76—Oxygen atoms attached in position 2 or 6
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Peptides Or Proteins (AREA)

GR990403208T 1993-11-03 1999-12-23 Novel 4-piperidinyl substituted lactames as neurokinin 2 receptor antagonists for the treatment of asthma GR3032253T3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB939322643A GB9322643D0 (en)	1993-11-03	1993-11-03	Lactam derivatives
PCT/GB1994/002382 WO1995012577A1 (en)	1993-11-03	1994-10-31	Novel 4-piperidinyl substituted lactames as neurokinin 2 receptor antagonists for the treatment of asthma

Publications (1)

Publication Number	Publication Date
GR3032253T3 true GR3032253T3 (en)	2000-04-27

Family

ID=10744560

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR990403208T GR3032253T3 (en)	1993-11-03	1999-12-23	Novel 4-piperidinyl substituted lactames as neurokinin 2 receptor antagonists for the treatment of asthma

Country Status (12)

Country	Link
US (2)	US5534525A (el)
EP (1)	EP0726893B1 (el)
JP (1)	JP3534765B2 (el)
AT (1)	ATE187963T1 (el)
AU (1)	AU8000594A (el)
CA (1)	CA2172377A1 (el)
DE (1)	DE69422303T2 (el)
DK (1)	DK0726893T3 (el)
ES (1)	ES2139760T3 (el)
GB (1)	GB9322643D0 (el)
GR (1)	GR3032253T3 (el)
WO (1)	WO1995012577A1 (el)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9325074D0 (en) *	1993-12-07	1994-02-02	Zeneca Ltd	Bicyclic heterocycles
US5589489A (en) *	1993-12-15	1996-12-31	Zeneca Limited	Cyclic amide derivatives for treating asthma
GB9408872D0 (en) *	1994-05-03	1994-06-22	Zeneca Ltd	Heterocyclic compounds
TW432061B (en) *	1994-08-09	2001-05-01	Pfizer Res & Dev	Lactams
DE69534213T2 (de) *	1994-10-25	2006-01-12	Astrazeneca Ab	Therapeutisch wirksame Heterocyclen
US5998444A (en) *	1995-10-24	1999-12-07	Zeneca Ltd.	Piperidinyl compounds as NK1 or NK2 antagonists
US6008223A (en) *	1994-10-27	1999-12-28	Zeneca Limited	Therapeutic compounds
GB9421709D0 (en) *	1994-10-27	1994-12-14	Zeneca Ltd	Therapeutic compounds
GB9508786D0 (en)	1995-04-29	1995-06-21	Zeneca Ltd	Substituted heterocycles
US5688960A (en) *	1995-05-02	1997-11-18	Schering Corporation	Substituted oximes, hydrazones and olefins useful as neurokinin antagonists
US5696267A (en) *	1995-05-02	1997-12-09	Schering Corporation	Substituted oximes, hydrazones and olefins as neurokinin antagonists
FR2738245B1 (fr) *	1995-08-28	1997-11-21	Sanofi Sa	Nouveaux derives de piperidine, procede pour leur obtention et compositions pharmaceutiques les contenant
GB9523526D0 (en) *	1995-11-17	1996-01-17	Zeneca Ltd	Therapeutic compounds
GB9601697D0 (en) *	1996-01-27	1996-03-27	Pfizer Ltd	Therapeutic agents
US5998439A (en) *	1996-02-21	1999-12-07	Hoescht Marion Roussel, Inc.	Substituted N-methyl-N-(4-(piperidin-1-yl)-2-(aryl)butyl)benzamides useful for the treatment of allergic diseases
US5932571A (en) *	1996-02-21	1999-08-03	Hoechst Marion Roussel, Inc.	Substituted N-methyl-N-(4-(4-(1H-benzimidazol-2-yl) {1,4}diazepan-1-yl)-2-(aryl) butyl) benzamides useful for the treatment of allergic diseases
US5789422A (en) *	1996-10-28	1998-08-04	Schering Corporation	Substituted arylalkylamines as neurokinin antagonists
CA2309558C (en) *	1997-11-21	2005-05-03	Schering Corporation	Substituted oximes as neurokinin antagonists
GB9924141D0 (en) *	1998-10-30	1999-12-15	Zeneca Ltd	Treatment of gastric asthma
US6063926A (en) *	1998-11-18	2000-05-16	Schering Corporation	Substituted oximes as neurokinin antagonists
AR021968A1 (es) *	1998-12-23	2002-09-04	Schering Corp	Oximas e hidrazonas sustituidas como antagonistas de neuroquinina
GB0015246D0 (en) *	2000-06-22	2000-08-16	Astrazeneca Ab	Method for the treatment of urinary incontinence
SE0103795D0 (sv) *	2001-11-02	2001-11-02	Astrazeneca Ab	Compounds and method for the treatment of överactive bladder
TW200508221A (en)	2003-06-13	2005-03-01	Astrazeneca Ab	New azetidine compounds
GB0326407D0 (en) *	2003-11-12	2003-12-17	Glaxo Group Ltd	Chemical compounds
GB0412865D0 (en) *	2004-06-09	2004-07-14	Glaxo Group Ltd	Chemical compounds
AR057828A1 (es)	2005-09-29	2007-12-19	Astrazeneca Ab	Compuestos derivados de azetidina, su preparacion y composicion farmaceuutica
US20070219214A1 (en) *	2006-02-01	2007-09-20	Solvay Pharmaceuticals Gmbh	Dual NK2/NK3-antagonists, pharmaceutical compositions comprising them, and processes for their preparation
US8106208B2 (en)	2006-05-18	2012-01-31	Albireo Ab	Benzamide compounds that act as NK receptor antagonists

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE903957A1 (en) *	1989-11-06	1991-05-08	Sanofi Sa	Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present
IL99320A (en) *	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676055B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676053B1 (fr) *	1991-05-03	1993-08-27	Sanofi Elf	Nouveaux composes dialkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2676054B1 (fr) *	1991-05-03	1993-09-03	Sanofi Elf	Nouveaux composes n-alkylenepiperidino et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr) *	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
GB9321557D0 (en) *	1992-11-03	1993-12-08	Zeneca Ltd	Carboxamide derivatives
GB9310066D0 (en) *	1993-05-17	1993-06-30	Zeneca Ltd	Alkyl substituted heterocycles
GB9310713D0 (en) *	1993-05-24	1993-07-07	Zeneca Ltd	Aryl substituted heterocycles
GB9317104D0 (en) *	1993-08-17	1993-09-29	Zeneca Ltd	Therapeutic heterocycles
GB9325074D0 (en) *	1993-12-07	1994-02-02	Zeneca Ltd	Bicyclic heterocycles
US5589489A (en) *	1993-12-15	1996-12-31	Zeneca Limited	Cyclic amide derivatives for treating asthma
US5434158A (en) *	1994-04-26	1995-07-18	Merck & Co., Inc.	Spiro-substituted azacycles as neurokinin-3 antagonists
GB9408872D0 (en) *	1994-05-03	1994-06-22	Zeneca Ltd	Heterocyclic compounds

1993
- 1993-11-03 GB GB939322643A patent/GB9322643D0/en active Pending
1994
- 1994-10-31 AU AU80005/94A patent/AU8000594A/en not_active Abandoned
- 1994-10-31 WO PCT/GB1994/002382 patent/WO1995012577A1/en not_active Ceased
- 1994-10-31 CA CA002172377A patent/CA2172377A1/en not_active Abandoned
- 1994-10-31 DE DE69422303T patent/DE69422303T2/de not_active Expired - Fee Related
- 1994-10-31 US US08/332,290 patent/US5534525A/en not_active Expired - Lifetime
- 1994-10-31 AT AT94931126T patent/ATE187963T1/de not_active IP Right Cessation
- 1994-10-31 JP JP51307195A patent/JP3534765B2/ja not_active Expired - Fee Related
- 1994-10-31 DK DK94931126T patent/DK0726893T3/da active
- 1994-10-31 EP EP94931126A patent/EP0726893B1/en not_active Expired - Lifetime
- 1994-10-31 ES ES94931126T patent/ES2139760T3/es not_active Expired - Lifetime
1996
- 1996-04-08 US US08/629,299 patent/US5677317A/en not_active Expired - Fee Related
1999
- 1999-12-23 GR GR990403208T patent/GR3032253T3/el unknown

Also Published As

Publication number	Publication date
WO1995012577A1 (en)	1995-05-11
US5534525A (en)	1996-07-09
CA2172377A1 (en)	1995-05-11
GB9322643D0 (en)	1993-12-22
DE69422303D1 (de)	2000-01-27
EP0726893A1 (en)	1996-08-21
DK0726893T3 (da)	2000-05-29
JP3534765B2 (ja)	2004-06-07
DE69422303T2 (de)	2000-05-18
AU8000594A (en)	1995-05-23
JPH09505036A (ja)	1997-05-20
EP0726893B1 (en)	1999-12-22
US5677317A (en)	1997-10-14
ATE187963T1 (de)	2000-01-15
ES2139760T3 (es)	2000-02-16

Publication	Publication Date	Title
AU8000594A (en)	1995-05-23	Novel 4-piperidinyl substituted lactames as neurokinin 2 receptor antagonists for the treatment of asthma
CA2166800A1 (en)	1995-02-23	4-substituted piperidine derivatives useful as neurokinin antagonists
HU9601568D0 (en)	1996-08-28	Cyclic amide derivatives as neurokinin antagonists
CA2067877A1 (en)	1992-11-04	Polycyclic amine compounds and their enantiomers, their method of preparation and pharmaceutical compositions in which they are present
AU2337197A (en)	1997-10-22	Cinnamic acid derivatives and their use as integrin antagonists
MX9803726A (es)	1998-11-29	Carbamatos de 3-(piperidinil-1-sustituido en la posicion 4)-1-(3,4,diclorofenil)propilo y ureas y derivados como antagonistas de la neurocinina novedosos.
GR3036639T3 (en)	2001-12-31	5-(4-subst.-piperidinyl-1)-3-aryl-pentanoic acid derivatives as tachykinin receptor antagonist
GR3033528T3 (en)	2000-09-29	Novel piperidine derivatives with paf antagonist activity
MX9701955A (es)	1997-06-28	Antagonistas de neuroquinina.
GR3031215T3 (en)	1999-12-31	Bicyclic heterocycles as neurokinin a antagonists
AU3860893A (en)	1993-11-25	New benzimidazole compounds, a process for their preparation and pharmaceutical compositions containing them
GR3021303T3 (en)	1997-01-31	Benzimidazoles, pharmaceutical compositions containing them and process for their preparation
CA2426221A1 (en)	2003-04-17	New neurokinin antagonists, processes for preparing them and pharmaceutical compositions containing these compounds