GR3033762T3 - Tetracyclic 1,4-oxazine derivatives, process for their preparation and pharmaceutical compositions containing them - Google Patents

Tetracyclic 1,4-oxazine derivatives, process for their preparation and pharmaceutical compositions containing them

Info

Publication number: GR3033762T3
Authority: GR; Greece
Prior art keywords: tetracyclic; preparation; pharmaceutical compositions; compositions containing; oxazine derivatives
Prior art date: 1994-06-08

Application number

GR20000401458T

Other languages

English (en)

Inventor

Jean-Louis Peglion

Joel Vian

Bertrand Goument

Mark Millan

Valerie Audinot

Jean-Charles Schwartz

Pierre Sokoloff

Original Assignee

Adir

Inst Nat Sante Rech Med

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-06-08

Filing date

2000-06-23

Publication date

2000-10-31

2000-06-23 Application filed by Adir, Inst Nat Sante Rech Med filed Critical Adir

2000-10-31 Publication of GR3033762T3 publication Critical patent/GR3033762T3/el

Links

150000004896 1,4-oxazines Chemical class 0.000 title 1
239000008194 pharmaceutical composition Substances 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
YHWMFDLNZGIJSD-UHFFFAOYSA-N 2h-1,4-oxazine Chemical compound C1OC=CN=C1 YHWMFDLNZGIJSD-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
125000003342 alkenyl group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000304 alkynyl group Chemical group 0.000 abstract 1
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004076 pyridyl group Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001544 thienyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Addiction (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Hydrogenated Pyridines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

GR20000401458T 1994-06-08 2000-06-23 Tetracyclic 1,4-oxazine derivatives, process for their preparation and pharmaceutical compositions containing them GR3033762T3 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9406985A FR2721027B1 (fr)	1994-06-08	1994-06-08	Nouveaux dérivés tétracycliques de la 1,4-oxazine, leur procédé de préparation et les compositions pharmaceutiques les contenant.

Publications (1)

Publication Number	Publication Date
GR3033762T3 true GR3033762T3 (en)	2000-10-31

Family

ID=9463983

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR20000401458T GR3033762T3 (en)	1994-06-08	2000-06-23	Tetracyclic 1,4-oxazine derivatives, process for their preparation and pharmaceutical compositions containing them

Country Status (17)

Country	Link
US (2)	US5593989A (el)
EP (1)	EP0686637B1 (el)
JP (1)	JP3157418B2 (el)
CN (1)	CN1050358C (el)
AT (1)	ATE192155T1 (el)
AU (1)	AU681780B2 (el)
CA (1)	CA2151096C (el)
DE (1)	DE69516457T2 (el)
DK (1)	DK0686637T3 (el)
ES (1)	ES2147825T3 (el)
FI (1)	FI111948B (el)
FR (1)	FR2721027B1 (el)
GR (1)	GR3033762T3 (el)
NO (1)	NO304741B1 (el)
NZ (1)	NZ272298A (el)
PT (1)	PT686637E (el)
ZA (1)	ZA954738B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2741074B1 (fr) *	1995-11-09	1997-12-19	Adir	Nouveaux composes tetracycliques de la 1,4-oxazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
EP0988289A2 (en) *	1997-06-05	2000-03-29	Takeda Pharmaceutical Company Limited	Heterocyclic compounds, their production and use
WO2004092154A1 (en) *	2003-04-03	2004-10-28	Vertex Pharmaceuticals Incorporated	Compositions useful as inhibitors of protein kinases
FR2906249B1 (fr)	2006-09-26	2008-12-19	Servier Lab	Composes tetracycliques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA1204745A (en) *	1981-11-20	1986-05-20	Merck Co.	Hexahydronaphth (1,2-b) -1,4 -oxazines
US4420480A (en) *	1981-11-20	1983-12-13	Merck & Co., Inc.	Hexahydronaphth[1,2-b]-1,4-oxazines
US4435231A (en) *	1982-03-31	1984-03-06	The United States Of America As Represented By The United States Department Of Energy	Cold worked ferritic alloys and components
DE3583307D1 (en) *	1984-05-10	1991-08-01	Ciba Geigy Ag	Benzo-(pyrano und thiopyrano)-pyridine.
US4774243A (en) *	1985-12-24	1988-09-27	Merck & Co., Inc.	Dopamine agonists for treating elevated intraocular pressure
US4792548A (en) *	1986-05-21	1988-12-20	Warner-Lambert Company	Trans-benzopyran-(4,3-b)-1,4-oxazine derivatives, intermediates and pharmaceutical use
US5294618A (en) *	1989-07-28	1994-03-15	Merck Sharp & Dohme Limited	Octahydrobenzisoquinoline derivatives as antipsychotic agents
WO1993024471A1 (en)	1992-06-02	1993-12-09	Whitby Research, Inc.	Substituted naphthoxazines useful as dopaminergics

1994
- 1994-06-08 FR FR9406985A patent/FR2721027B1/fr not_active Expired - Lifetime
1995
- 1995-06-01 US US08/456,504 patent/US5593989A/en not_active Expired - Fee Related
- 1995-06-06 CA CA002151096A patent/CA2151096C/fr not_active Expired - Fee Related
- 1995-06-06 AU AU20523/95A patent/AU681780B2/en not_active Ceased
- 1995-06-07 CN CN95107344A patent/CN1050358C/zh not_active Expired - Fee Related
- 1995-06-07 ES ES95401311T patent/ES2147825T3/es not_active Expired - Lifetime
- 1995-06-07 FI FI952802A patent/FI111948B/fi not_active IP Right Cessation
- 1995-06-07 NO NO952249A patent/NO304741B1/no not_active IP Right Cessation
- 1995-06-07 DK DK95401311T patent/DK0686637T3/da active
- 1995-06-07 AT AT95401311T patent/ATE192155T1/de not_active IP Right Cessation
- 1995-06-07 DE DE69516457T patent/DE69516457T2/de not_active Expired - Fee Related
- 1995-06-07 EP EP95401311A patent/EP0686637B1/fr not_active Expired - Lifetime
- 1995-06-07 PT PT95401311T patent/PT686637E/pt unknown
- 1995-06-07 NZ NZ272298A patent/NZ272298A/en unknown
- 1995-06-08 JP JP14177295A patent/JP3157418B2/ja not_active Expired - Fee Related
- 1995-06-08 ZA ZA954738A patent/ZA954738B/xx unknown
1996
- 1996-06-06 US US08/659,267 patent/US5668142A/en not_active Expired - Fee Related
2000
- 2000-06-23 GR GR20000401458T patent/GR3033762T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
CN1120541A (zh)	1996-04-17
JP3157418B2 (ja)	2001-04-16
ES2147825T3 (es)	2000-10-01
FI111948B (fi)	2003-10-15
CA2151096C (fr)	2003-07-08
NO304741B1 (no)	1999-02-08
FI952802A0 (fi)	1995-06-07
ZA954738B (en)	1996-01-26
US5668142A (en)	1997-09-16
AU2052395A (en)	1995-12-14
US5593989A (en)	1997-01-14
DE69516457T2 (de)	2001-01-18
NO952249D0 (no)	1995-06-07
CA2151096A1 (fr)	1995-12-09
CN1050358C (zh)	2000-03-15
PT686637E (pt)	2000-08-31
FR2721027B1 (fr)	1996-07-19
FR2721027A1 (fr)	1995-12-15
DE69516457D1 (de)	2000-05-31
JPH07330778A (ja)	1995-12-19
AU681780B2 (en)	1997-09-04
ATE192155T1 (de)	2000-05-15
NO952249L (no)	1995-12-11
NZ272298A (en)	1996-05-28
DK0686637T3 (da)	2000-09-18
EP0686637B1 (fr)	2000-04-26
EP0686637A1 (fr)	1995-12-13
FI952802L (fi)	1995-12-09

Legal Events

Date	Code	Title	Description
2006-01-03	ML	Lapse due to non-payment of fees

Publication	Publication Date	Title
FR2692264B1 (fr)	1994-08-05	Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
ATE233559T1 (de)	2003-03-15	Verwendung von benzothiophene zur behandlung von hypercholesterolämie
ES8105299A1 (es)	1981-06-01	Procedimiento para preparar aroilimidazol-2-onas
FR2674855B1 (fr)	1994-01-14	Derives de piperidine, leur preparation et leur application en therapeutique.
FI901325A0 (fi)	1990-03-16	Menetelmä uusien, farmaseuttisesti aktiivisten 1H,3H-pyrrolo/1,2-c/tiatsoli-7-karboksamidijohdannaisten valmistamiseksi
EP0436734A4 (en)	1992-01-02	New aminopiperazine derivatives
ZA954738B (en)	1996-01-26	Tetracyclic piperidine and 1,4-oxazine compounds a process for their preparation and pharmaceutical compositions containing them
AU572690B2 (en)	1988-05-12	Tricyclic or tetracyclic compounds, process for their preparation, and medicinal composition containing them
EP0446921A3 (en)	1992-01-29	Optically active alkylene-dioxybenzene derivatives and their use in therapy
GR3035432T3 (en)	2001-05-31	Tetracyclic 1,4-oxazine compounds, process for their preparation and pharmaceutical compositions containing them
HUT39741A (en)	1986-10-29	Process for preparing pyridine derivatives and pharmaceutical compositions containing such compounds as active ingredients
HUT48818A (en)	1989-07-28	Process for production of analgetic medical preparatives containing as active substance derivatives of pirido-pirimidin or pirimido-pirimidin
IL61911A0 (en)	1981-02-27	2,3-dihydro-imidazo(1,2-b)pyridazine derivatives,their preparation and pharmaceutical compositions containing them
DE3867563D1 (en)	1992-02-20	2-amino-5-hydroxy-4-pyrimidone.
ES8401055A1 (es)	1983-12-01	"metodo para la fabricacion de derivados de la quinolina".
GR3036191T3 (en)	2001-10-31	Aminoalkyl benzothiazolinones, process for their preparation and pharmaceutical compositions containing them.
GR3015212T3 (en)	1995-05-31	Ethanolaminebenzoate derivative, process for their preparation and pharmaceutical compositions containing them.