GR3034592T3 - Tumour therapy - Google Patents

Tumour therapy

Info

Publication number
GR3034592T3
GR3034592T3 GR20000402281T GR20000402281T GR3034592T3 GR 3034592 T3 GR3034592 T3 GR 3034592T3 GR 20000402281 T GR20000402281 T GR 20000402281T GR 20000402281 T GR20000402281 T GR 20000402281T GR 3034592 T3 GR3034592 T3 GR 3034592T3
Authority
GR
Greece
Prior art keywords
compound
vascular compartment
tumour
mammal
following administration
Prior art date
Application number
GR20000402281T
Other languages
English (en)
Inventor
Kenneth Dawson Bagshawe
Original Assignee
Enzacta R & D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Enzacta R & D Ltd filed Critical Enzacta R & D Ltd
Publication of GR3034592T3 publication Critical patent/GR3034592T3/el

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6895—Rescue therapy; Agonist-antagonist; Antidotes; Targeted rescue or protection, e.g. by folic acid-folinic acid or conjugated to antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GR20000402281T 1996-11-30 2000-10-11 Tumour therapy GR3034592T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9624993.3A GB9624993D0 (en) 1996-11-30 1996-11-30 Tumour therapy
PCT/GB1997/003284 WO1998024478A2 (en) 1996-11-30 1997-11-28 Tumour therapy

Publications (1)

Publication Number Publication Date
GR3034592T3 true GR3034592T3 (en) 2001-01-31

Family

ID=10803777

Family Applications (1)

Application Number Title Priority Date Filing Date
GR20000402281T GR3034592T3 (en) 1996-11-30 2000-10-11 Tumour therapy

Country Status (11)

Country Link
EP (1) EP0918545B1 (el)
JP (1) JP2001505220A (el)
AT (1) ATE194499T1 (el)
CA (1) CA2273218A1 (el)
DE (1) DE69702527T2 (el)
DK (1) DK0918545T3 (el)
ES (1) ES2150286T3 (el)
GB (1) GB9624993D0 (el)
GR (1) GR3034592T3 (el)
PT (1) PT918545E (el)
WO (1) WO1998024478A2 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9712370D0 (en) 1997-06-14 1997-08-13 Aepact Ltd Therapeutic systems
GB9812550D0 (en) * 1998-06-11 1998-08-05 Aepact Ltd Tumour therapy and imaging
CA2471645A1 (en) * 2002-01-03 2003-07-10 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Immunoconjugates useful for treatment of tumours
GB0916749D0 (en) * 2009-09-23 2009-11-04 Mologic Ltd Peptide cleaning agents
CN103561771B (zh) 2011-03-17 2019-01-04 伯明翰大学 重新定向的免疫治疗
GB201203442D0 (en) 2012-02-28 2012-04-11 Univ Birmingham Immunotherapeutic molecules and uses
GB201308363D0 (en) 2013-05-09 2013-06-19 Bagshawe Kenneth D Tumour therapy
US10441649B2 (en) 2015-02-02 2019-10-15 The University Of Birmingham Targeting moiety peptide epitope complexes having a plurality of T-cell epitopes
FI3377103T4 (fi) 2015-11-19 2025-04-16 Revitope Limited Funktionaalinen vasta-ainefragmenttikomplementointi kaksikomponenttiselle järjestelmälle epätoivottujen solujen uudelleenohjattua tappamista varten

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8809616D0 (en) * 1988-04-22 1988-05-25 Cancer Res Campaign Tech Further improvements relating to drug delivery systems
GB9200415D0 (en) * 1992-01-09 1992-02-26 Bagshawe Kenneth D Inactivation of cytotoxic drugs
EP0869818A1 (en) * 1995-12-29 1998-10-14 AEPACT Limited Cytotoxic agents

Also Published As

Publication number Publication date
ATE194499T1 (de) 2000-07-15
WO1998024478A2 (en) 1998-06-11
DE69702527T2 (de) 2001-03-08
PT918545E (pt) 2000-12-29
CA2273218A1 (en) 1998-06-11
WO1998024478A3 (en) 1998-07-30
DK0918545T3 (da) 2000-11-27
ES2150286T3 (es) 2000-11-16
EP0918545B1 (en) 2000-07-12
EP0918545A2 (en) 1999-06-02
JP2001505220A (ja) 2001-04-17
GB9624993D0 (en) 1997-01-15
DE69702527D1 (de) 2000-08-17

Similar Documents

Publication Publication Date Title
MY122383A (en) Cyclic boroproline compounds
EP0935415A4 (en) METHOD FOR MAKING CONNECTIONS INTO A CELL
AU527371B2 (en) Amidine
DK0654078T3 (da) Thrombinblodfraktion til anvendelse i en medicinsk procedure
AU2970584A (en) Hydroxy substituted peptides
DE69427706D1 (en) Cryptophycine
CA2145093A1 (en) Therapeutic inhibitor of vascular smooth muscle cells
NZ334691A (en) Compositions of anti-4-1BB antibody effective for immunomodulation and treatment of T-cell autoimmune disease
MY129973A (en) Sulphonylbenzyl-substituted pyridones.
AU2058692A (en) Catalytic reduction of nox using methane in the presence of oxygen
ZA981936B (en) Novel benzimidazole inhibitors of fructose 1,6-bisphosphatase.
GR3034592T3 (en) Tumour therapy
MY104992A (en) Composition inducing a binding.
PL330910A1 (en) Mode of administering inhibitors of h+, k+ - atpase
TWI256892B (en) Plasminogen activator inhibitor and external preparation for skin comprising the same
TR200001486T2 (tr) Hiperkeratozlu deri hastalıklarının tedavisi için diol ve alfa-hidroksi asitten oluşan bir karışımın kullanılması
EP1093816A3 (en) Use of ST1435 in hormonal therapy by transdermal application
IL131478A0 (en) Methods for treatment of scar tissue
WO1997034627A3 (en) Protection of hemopoietic cells during chemotherapy or radiotherapy
AU4280689A (en) Cogel catalyzed conversion of methane to higher hydrocarbons
AU6858691A (en) High activity vanadium-based catalyst
EP0340933A3 (en) Heparin-containing formulations
WO1996007421A3 (en) An antiulcer medicine comprising a protein possessing all growth factor activity and a proton pump inhibitor
DE59712247D1 (de) Mammakarzinom-assoziiertes gen
ZA977895B (en) Transdermal therapeutic system having an active compound combination comprising oestriol.

Legal Events

Date Code Title Description
ML Lapse due to non-payment of fees