GR33806B - Μεθοδος δια την παρασκευην παραγωγων της βενζοδιαζεπινης. - Google Patents

Μεθοδος δια την παρασκευην παραγωγων της βενζοδιαζεπινης.

Info

Publication number
GR33806B
GR33806B GR670133806A GR670133806A GR33806B GR 33806 B GR33806 B GR 33806B GR 670133806 A GR670133806 A GR 670133806A GR 670133806 A GR670133806 A GR 670133806A GR 33806 B GR33806 B GR 33806B
Authority
GR
Greece
Prior art keywords
alkyl
preparation
benzodiazepine
producers
lower alkylene
Prior art date
Application number
GR670133806A
Other languages
English (en)
Original Assignee
F. Hoffmann - La Roche & Co. Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F. Hoffmann - La Roche & Co. Aktiengesellschaft filed Critical F. Hoffmann - La Roche & Co. Aktiengesellschaft
Publication of GR33806B publication Critical patent/GR33806B/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/74—Quinazolines; Hydrogenated quinazolines with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to ring carbon atoms of the hetero ring
    • C07D239/76—N-oxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

έθοδος δια την παρασκευή παραγώγων της βενζοδιαζεπίνης χαρακτηριζόμενη εκ του ότι θερμαίνομε μιαν οξίμην του γενικού τύπου (1) εις τον οποίον τα R1 και R2 σημαίνουν έκαστο κατώτερο αλκύλιο ή ομού κατώτερο αλκυλένιο, άζα- κατώτερο αλκυλένιον, Ν-κατώτερο αλκυλο-άζα- κατώτερο αλκυλένιο, όξα- κατώτερο αλκυλένιο ή θεία-κατώτερο αλκυλένιο, τα R3 και R4και R5 σημαίνουν υδρογόνο, αλογόνο, κατώτερο αλκύλιο κατώτερο αλκόξυ, κυάνιο, τριφθορομεθύλιο ή νίτρο, τα R6 και R7σημιάνουν υδρογόνο ή κατώτερο αλκύλιο και το R10 σημαίνει κατώτερο αλκύλιο ή αραλκύλιον.
GR670133806A 1966-01-19 1967-01-17 Μεθοδος δια την παρασκευην παραγωγων της βενζοδιαζεπινης. GR33806B (el)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52155166A 1966-01-19 1966-01-19

Publications (1)

Publication Number Publication Date
GR33806B true GR33806B (el) 1968-02-06

Family

ID=24077176

Family Applications (2)

Application Number Title Priority Date Filing Date
GR670135752A GR35752B (el) 1966-01-19 1967-01-17 Μεθοδος δια την παρασκευην παραγωγων της βενζοδιαζεπινης.
GR670133806A GR33806B (el) 1966-01-19 1967-01-17 Μεθοδος δια την παρασκευην παραγωγων της βενζοδιαζεπινης.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GR670135752A GR35752B (el) 1966-01-19 1967-01-17 Μεθοδος δια την παρασκευην παραγωγων της βενζοδιαζεπινης.

Country Status (16)

Country Link
US (1) US3446806A (el)
JP (1) JPS4938814B1 (el)
BE (2) BE692378A (el)
CH (3) CH560692A5 (el)
DE (2) DE1695176A1 (el)
DK (4) DK120347B (el)
ES (2) ES335789A1 (el)
FI (1) FI47576C (el)
FR (2) FR1507878A (el)
GB (2) GB1144516A (el)
GR (2) GR35752B (el)
IL (2) IL27189A (el)
MY (2) MY6900383A (el)
NL (3) NL6700785A (el)
OA (1) OA02391A (el)
SE (4) SE321233B (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310429A (en) * 1978-06-19 1982-01-12 The B. F. Goodrich Company Stabilized polymers, novel stabilizers, and synthesis thereof
US4601839A (en) * 1978-06-19 1986-07-22 The B. F. Goodrich Company Stabilized polymers, novel stabilizers, and synthesis thereof
US4472435A (en) * 1980-07-31 1984-09-18 Hoffman-La Roche Inc. Benzophenone derivatives useful in treating heart failure
EP0749426A1 (en) * 1994-03-08 1996-12-27 Takeda Chemical Industries, Ltd. Quinoline or quinazoline derivatives as anti-inflammatory agents, in particular for treating arthritis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3267110A (en) * 1960-06-03 1966-08-16 Smith Kline French Lab Trifluoromethyl substituted o-aminophenyl ketones
US3321467A (en) * 1963-11-27 1967-05-23 Hoffmann La Roche 3-halo-1, 4-benzodiazepin-2-ones

Also Published As

Publication number Publication date
US3446806A (en) 1969-05-27
ES335788A1 (es) 1968-03-16
NL6700786A (el) 1967-07-20
NL131198C (el)
GB1144515A (en) 1969-03-05
BE692378A (el) 1967-07-10
CH553193A (en) 1974-08-30
MY6900383A (en) 1969-12-31
DE1618486A1 (de) 1971-04-01
BE692558A (el) 1967-07-13
FR1507878A (fr) 1967-12-29
NL6700785A (el) 1967-07-20
FI47576C (fi) 1974-01-10
DK120347B (da) 1971-05-17
DK120392B (da) 1971-05-24
CH461517A (de) 1968-08-31
JPS4938814B1 (el) 1974-10-21
SE386168B (sv) 1976-08-02
DK114556B (da) 1969-07-14
CH560692A5 (el) 1975-04-15
IL27189A (en) 1971-01-28
SE321233B (el) 1970-03-02
DE1695176A1 (de) 1970-04-16
ES335789A1 (es) 1967-12-16
IL27212A (en) 1971-04-28
MY6900384A (en) 1969-12-31
FR1508490A (fr) 1968-01-05
FI47576B (el) 1973-10-01
SE353717B (el) 1973-02-12
DK119656B (da) 1971-02-08
GB1144516A (en) 1969-03-05
OA02391A (fr) 1970-05-05
GR35752B (el) 1968-10-25
SE335858B (el) 1971-06-14

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