GR34948B - METHOD FOR THE MANUFACTURE OF CALM - HYPNOTICS. - Google Patents

METHOD FOR THE MANUFACTURE OF CALM - HYPNOTICS.

Info

Publication number
GR34948B
GR34948B GR670134948A GR670134948A GR34948B GR 34948 B GR34948 B GR 34948B GR 670134948 A GR670134948 A GR 670134948A GR 670134948 A GR670134948 A GR 670134948A GR 34948 B GR34948 B GR 34948B
Authority
GR
Greece
Prior art keywords
chlorine
formula
bromine
iodine
compound
Prior art date
Application number
GR670134948A
Other languages
Greek (el)
Original Assignee
Bristol - Myers Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol - Myers Company filed Critical Bristol - Myers Company
Publication of GR34948B publication Critical patent/GR34948B/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

ία μέθοδος δια την παρασκευήν γλυκινικών τριαλογονωμένων αιθυλίων του τύπου: [*] εις τον οποίον το Χ αντιπροσωπεύει βρώμιον ή χλώριον, και των μη τοξικών φαρμακευτικώς αποδεκτών αλάτων τούτων η οποίαμέθοδος περιλαμβάνει την ακυλίωσιν μιας 2,2,2-τριαλογονωμένης αιθανόλης του τύπου: X3C-CHOH εις τονοποίον το Χ είναι ως ανωτέρω περιγράφεται, με εν ισομοριακόν βάρος μιας ενώσεως του τύπου: [*] εις τον οποίον το Υ είναι (κατώτερον) αλκοξυ, χλώριο, βρώμιον, ιώδιον ή υδροξύλιον, και το Ζ είναι αμίνη, χλώριον, βρώμιον, και ιώδιον ή με εν ενεργειακόνισοδύναμον του [*] ως μιας ακυλιωτικής ουσίας διαμίαν πρωτοταγή αλκοόλην προς παραγωγήν μιας ενώσεως εχούσης τον τύπον: [*] και όπου το Ζ είναι χλώριον, βρώμιον, ή ιώδιον, περαιτέρω αντίδρασιν του ενδιαμέσου προϊόντος μετά υγράς αμμωνίας ή πυκνής ΝΗ4ΟΗ δια την παραγωγήν του ζητουμένου προϊόντος. A process for the preparation of glycated trihalogenated ethyl of the formula: [*] wherein X represents bromine or chlorine, and non-toxic pharmaceutically acceptable salts thereof which method comprises acylating a 2,2,2-trialogenated ethanol of the formula: X3C-CHOH where X is as described above, with an equimolar weight of a compound of the formula: [*] wherein Y is (lower) alkoxy, chlorine, bromine, iodine or hydroxyl, and Z is amine, chlorine, bromine, and iodine or with an energy equivalent of [*] as an acylating substance for the primary alcohol to produce a compound having the formula: [*] and wherein Z is chlorine, bromine, or iodine, further reacting the intermediate with liquid ammonia or concentrated NH 4 OH to produce the desired product.

GR670134948A 1966-12-28 1967-12-22 METHOD FOR THE MANUFACTURE OF CALM - HYPNOTICS. GR34948B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US60515666A 1966-12-28 1966-12-28

Publications (1)

Publication Number Publication Date
GR34948B true GR34948B (en) 1968-07-24

Family

ID=24422490

Family Applications (1)

Application Number Title Priority Date Filing Date
GR670134948A GR34948B (en) 1966-12-28 1967-12-22 METHOD FOR THE MANUFACTURE OF CALM - HYPNOTICS.

Country Status (11)

Country Link
AT (1) AT277186B (en)
BE (1) BE708555A (en)
CH (1) CH495333A (en)
DE (1) DE1643267B2 (en)
FR (2) FR1571342A (en)
GB (1) GB1210520A (en)
GR (1) GR34948B (en)
IL (1) IL29190A (en)
NL (1) NL6717739A (en)
NO (1) NO122702B (en)
SE (1) SE347254B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374765A (en) * 1990-09-03 1994-12-20 Mitsui Toatsu Chemicals, Incorporated Method for extracting an amino acid ester from a hydrous solution of a mineral acid salt thereof
JP2923009B2 (en) * 1990-09-03 1999-07-26 三井化学株式会社 Extraction method of amino acid ester

Also Published As

Publication number Publication date
SE347254B (en) 1972-07-31
FR7556M (en) 1969-12-29
NO122702B (en) 1971-08-02
CH495333A (en) 1970-08-31
IL29190A (en) 1972-03-28
FR1571342A (en) 1969-06-20
DE1643267C3 (en) 1975-02-13
AT277186B (en) 1969-12-10
BE708555A (en) 1968-06-27
GB1210520A (en) 1970-10-28
DE1643267B2 (en) 1974-06-20
NL6717739A (en) 1968-07-01
DE1643267A1 (en) 1972-02-24

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