GR75544B - - Google Patents

Info

Publication number: GR75544B
Authority: GR; Greece
Prior art keywords: loweralkyl; benzyl; loweralkoxy; substituent; halogen
Prior art date: 1981-04-13

Application number

GR67845A

Other languages

English (en)

Inventor

Roger M Freidinger

Daniel F Veber

Original Assignee

Merck & Co Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1981-04-13

Filing date

1982-04-07

Publication date

1984-07-27

1982-04-07 Application filed by Merck & Co Inc filed Critical Merck & Co Inc

1984-07-27 Publication of GR75544B publication Critical patent/GR75544B/el

Links

125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 6
229910052736 halogen Inorganic materials 0.000 abstract 4
150000002367 halogens Chemical class 0.000 abstract 4
-1 hydroxy, amino Chemical group 0.000 abstract 4
125000001424 substituent group Chemical group 0.000 abstract 4
125000000217 alkyl group Chemical group 0.000 abstract 3
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 2
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
229910052717 sulfur Inorganic materials 0.000 abstract 2
239000011593 sulfur Substances 0.000 abstract 2
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 abstract 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
- C07K14/6555—Somatostatins at least 1 amino acid in D-form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/16—Somatostatin; related peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Endocrinology (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Obesity (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Hematology (AREA)
Biophysics (AREA)
Emergency Medicine (AREA)
Molecular Biology (AREA)
Ophthalmology & Optometry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)

GR67845A 1981-04-13 1982-04-07 GR75544B (el)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US06/254,010 US4360516A (en)	1981-04-13	1981-04-13	Modified D-retro cyclic hexapeptide somatostatin analogs

Publications (1)

Publication Number	Publication Date
GR75544B true GR75544B (el)	1984-07-27

Family

ID=22962578

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR67845A GR75544B (el)	1981-04-13	1982-04-07

Country Status (9)

Country	Link
US (1)	US4360516A (el)
EP (1)	EP0063308B1 (el)
JP (1)	JPS57179142A (el)
AT (1)	ATE14439T1 (el)
DE (1)	DE3264861D1 (el)
DK (1)	DK159382A (el)
ES (1)	ES511335A0 (el)
GR (1)	GR75544B (el)
PT (1)	PT74720B (el)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4427661A (en) *	1982-07-30	1984-01-24	Merck & Co., Inc.	Fluorinated cyclic hexapeptide somatostatin analogs
CH655505B (el) *	1982-08-24	1986-04-30
DE3303345A1 (de) *	1983-02-02	1984-08-02	Hoechst Ag, 6230 Frankfurt	Cyclische peptide mit somatostatin-wirkung
US4508711A (en) *	1983-04-18	1985-04-02	American Cyanamid Company	Cyclic pentapeptide displaying somatostatin antagonism and method of treatment of mammals therewith
US4522813A (en) *	1983-10-27	1985-06-11	Merck & Co., Inc.	Cyclic hexapeptide somatostatin analogs
US4612302A (en) *	1983-11-14	1986-09-16	Brigham And Women's Hospital	Clinical use of somatostatin analogues
US4612366A (en) *	1985-06-17	1986-09-16	Merck & Co., Inc.	Cyclic hexapeptide somatostatin analogs
AU1194092A (en) *	1991-02-06	1992-09-07	Georgetown University	Receptor blocking peptides of fibroblast growth factor receptor
CA2079896A1 (en) *	1991-02-08	1992-08-09	Arthur E. Bogden	Method of treating benign and malignant proliferative skin disease
US5811512A (en) *	1991-08-22	1998-09-22	The Trustees Of The University Of Pennsylvania	Non-peptide peptidomimetics and related cyclic hexapeptides
US5504069A (en) *	1993-02-11	1996-04-02	Biomeasure, Inc.	Inhibition of trauma-induced tumor growth
US5597894A (en) *	1995-06-05	1997-01-28	The Louisiana State University Medical Center Foundation	Multi-tyrosinated somatostatin analogs
US5770687A (en) *	1995-06-07	1998-06-23	Peptor Limited	Comformationally constrained backbone cyclized somatostatin analogs
EP0981364B1 (en) *	1997-05-13	2006-03-01	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Method and compositions for treating hyperlipidemia
AU7655098A (en) *	1997-05-13	1998-12-08	Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.)	Somatostatin and somatostatin agonists for decreasing body weight
PT980253E (pt) *	1997-05-13	2004-08-31	Conseils De Rec Appl Scient S	Somatostatina e agonistas de somatostatina para tratar a insensibilidade a insulina e a sindrome x
US6004928A (en) *	1997-05-13	1999-12-21	Biomeasure, Incorporated	Method of treating hyperlipidemia
US5968903A (en) *	1998-05-07	1999-10-19	Biomeasure, Incorporated	Inhibition of H. pylori proliferation
AU2002305845B2 (en)	2001-06-08	2006-03-30	Ipsen Pharma S.A.S.	Somatostatin-dopamine chimeric analogs
US8709998B2 (en)	2003-04-22	2014-04-29	Ipsen Pharma S.A.S.	Peptide vectors
BRPI0915142A8 (pt)	2008-06-12	2018-01-02	Syntaxin Ltd	Polipeptídeos, ácido nucleico e usos dos mesmos
JP5728380B2 (ja)	2008-06-12	2015-06-03	シンタクシンリミテッドＳｙｎｔａｘｉｎＬｉｍｉｔｅｄ	神経内分泌疾患の抑制
GB0820970D0 (en)	2008-11-17	2008-12-24	Syntaxin Ltd	Suppression of cancer
DK3007704T3 (da)	2013-06-13	2021-03-29	Antisense Therapeutics Ltd	Kombinationsterapi til akromegali

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE7708136L (sv) *	1976-08-02	1978-02-03	Merck & Co Inc	Cykliska hexapeptider
US4162248A (en) *	1976-10-14	1979-07-24	Merck & Co., Inc.	Somatostatin analogs
LU78191A1 (de) *	1977-09-28	1979-05-25	Ciba Geigy Ag	Verfahren zur herstellung von neuen cyclopeptiden
US4190648A (en) *	1979-03-13	1980-02-26	Merck & Co., Inc.	Peptides having somatostatin activity
NZ195303A (en) *	1979-10-31	1984-10-19	Merck & Co Inc	Cyclic hexapeptide somatostatin analogues,and pharmaceutical compositions
US4235886A (en) *	1979-10-31	1980-11-25	Merck & Co., Inc.	Cyclic hexapeptide somatostatin analogs

1981
- 1981-04-13 US US06/254,010 patent/US4360516A/en not_active Expired - Fee Related
1982
- 1982-04-06 EP EP82102924A patent/EP0063308B1/en not_active Expired
- 1982-04-06 DE DE8282102924T patent/DE3264861D1/de not_active Expired
- 1982-04-06 AT AT82102924T patent/ATE14439T1/de not_active IP Right Cessation
- 1982-04-07 PT PT74720A patent/PT74720B/pt unknown
- 1982-04-07 GR GR67845A patent/GR75544B/el unknown
- 1982-04-07 DK DK159382A patent/DK159382A/da not_active Application Discontinuation
- 1982-04-08 ES ES511335A patent/ES511335A0/es active Granted
- 1982-04-10 JP JP57059001A patent/JPS57179142A/ja active Granted

Also Published As

Publication number	Publication date
ATE14439T1 (de)	1985-08-15
ES8304068A1 (es)	1983-02-16
DK159382A (da)	1982-10-14
EP0063308A1 (en)	1982-10-27
JPS57179142A (en)	1982-11-04
US4360516A (en)	1982-11-23
JPH0360839B2 (el)	1991-09-17
PT74720B (en)	1985-01-08
PT74720A (en)	1982-05-01
DE3264861D1 (en)	1985-08-29
ES511335A0 (es)	1983-02-16
EP0063308B1 (en)	1985-07-24

Publication	Publication Date	Title
DK159382A (da)	1982-10-14	Fremgangsmaade til fremstilling af somatostatinforbindelser
AU537414B2 (en)	1984-06-21	Pyroglutamic acid derivatives
ES8401019A1 (es)	1983-11-16	"un compuesto".
ES8205771A1 (es)	1982-06-16	Un procedimiento para la obtencion de un derivado acilado sustituido de acido octahidro-1h-indol-2-carboxilico
ATE50559T1 (de)	1990-03-15	Substituierte p,p'-methylen-bis-aniline.
IL80216A0 (en)	1987-01-30	3-vinyl-and 3-ethinyl-beta-carboline derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
DE3266708D1 (en)	1985-11-07	Pyridazinone derivatives, process for their preparation and their use as fungicides
SE8503415D0 (sv)	1985-07-09	Novel isoindolinyl-alkyl-piperazines
FI870090A0 (fi)	1987-01-12	Laongkedjade alkylresorcinolfosfiter.
DK149270C (da)	1986-08-25	Analogifremgangsmaade til fremstilling af beta-carbolin-3-carboxylsyrederivater
GB2015521A (en)	1979-09-12	Pyrrolidin-2-one derivatives
DE69106386D1 (en)	1995-02-09	Oxysulfonylcarbamate.
GR3004165T3 (el)	1993-03-31
KR860009011A (ko)	1986-12-19	치환된 이속사졸 유도체의 제조방법
KR830010101A (ko)	1983-12-26	티에닐과 벤조티에닐-t-부틸아미노페녹시프로파놀의 제조방법
AU579416B2 (en)	1988-11-24	3-Amino-2,3-dihydro-1-benzoxepine-compounds and methods for their preparation and pharmaceutical preparations containing these compounds
DE3680725D1 (en)	1991-09-12	Propanolabkoemmlinge.
DE3660546D1 (en)	1988-09-22	Phosphoroimidates
JPS5439028A (en)	1979-03-24	Acetanilide derivatives and bactericides containing the same for agricultural and horticultural, uses
IE830758L (en)	1983-10-06	Benzothiophene s-oxide and s, s-dioxide derivatives