GR862010B - Method for preparing novel phenylpiperazine derivatives - Google Patents

Method for preparing novel phenylpiperazine derivatives

Info

Publication number: GR862010B
Authority: GR; Greece
Prior art keywords: phenylpiperazine; formula; alkyl; group; see diagramm
Prior art date: 1985-07-31

Application number

GR862010A

Other languages

English (en)

Inventor

Lafon Louis

Original Assignee

Lafon Labor

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-07-31

Filing date

1986-07-29

Publication date

1986-12-23

1986-07-29 Application filed by Lafon Labor filed Critical Lafon Labor

1986-12-23 Publication of GR862010B publication Critical patent/GR862010B/el

Links

238000000034 method Methods 0.000 title abstract 3
YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 5
150000001875 compounds Chemical class 0.000 abstract 4
229910052801 chlorine Inorganic materials 0.000 abstract 2
229910052731 fluorine Inorganic materials 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
DLCHHOUUUHBPTB-UHFFFAOYSA-N 1,2,4-trimethyl-3-phenylpiperazine Chemical compound CN1CCN(C)C(C)C1C1=CC=CC=C1 DLCHHOUUUHBPTB-UHFFFAOYSA-N 0.000 abstract 1
ITYRNNPBHAPPDY-UHFFFAOYSA-N 1-ethyl-2-methyl-3-phenylpiperazine Chemical compound CC1N(CC)CCNC1C1=CC=CC=C1 ITYRNNPBHAPPDY-UHFFFAOYSA-N 0.000 abstract 1
WISXSZAVLBTQKR-UHFFFAOYSA-N 2-methyl-3-phenyl-1-propan-2-ylpiperazine Chemical compound CC1N(C(C)C)CCNC1C1=CC=CC=C1 WISXSZAVLBTQKR-UHFFFAOYSA-N 0.000 abstract 1
FGMBXZFXOUIKOT-UHFFFAOYSA-N 2-methyl-3-phenylpiperazine Chemical compound CC1NCCNC1C1=CC=CC=C1 FGMBXZFXOUIKOT-UHFFFAOYSA-N 0.000 abstract 1
REMUSKKHPCZIGD-UHFFFAOYSA-N 2-phenyl-1,2-dihydropyrazine Chemical compound N1C=CN=CC1C1=CC=CC=C1 REMUSKKHPCZIGD-UHFFFAOYSA-N 0.000 abstract 1
RIMRLBGNCLMSNH-UHFFFAOYSA-N 2-phenylpiperazine Chemical compound C1NCCNC1C1=CC=CC=C1 RIMRLBGNCLMSNH-UHFFFAOYSA-N 0.000 abstract 1
GFQHZHMRYXWCBK-UHFFFAOYSA-N 3-phenyl-1-propan-2-ylpiperazine Chemical compound C1N(C(C)C)CCNC1C1=CC=CC=C1 GFQHZHMRYXWCBK-UHFFFAOYSA-N 0.000 abstract 1
PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 1
229910010084 LiAlH4 Inorganic materials 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
229910052794 bromium Inorganic materials 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
239000012280 lithium aluminium hydride Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
125000004193 piperazinyl group Chemical group 0.000 abstract 1
238000006722 reduction reaction Methods 0.000 abstract 1
239000012279 sodium borohydride Substances 0.000 abstract 1
229910000033 sodium borohydride Inorganic materials 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Neurology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Biomedical Technology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Anesthesiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Luminescent Compositions (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

GR862010A 1985-07-31 1986-07-29 Method for preparing novel phenylpiperazine derivatives GR862010B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8511684A FR2585702B1 (fr)	1985-07-31	1985-07-31	Derives de phenyl-piperazine, procede de preparation et utilisation en therapeutique

Publications (1)

Publication Number	Publication Date
GR862010B true GR862010B (en)	1986-12-23

Family

ID=9321805

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
GR862010A GR862010B (en)	1985-07-31	1986-07-29	Method for preparing novel phenylpiperazine derivatives

Country Status (13)

Country	Link
US (1)	US4912110A (el)
EP (1)	EP0211746B1 (el)
JP (1)	JPH0730047B2 (el)
AT (1)	ATE53026T1 (el)
AU (1)	AU580179B2 (el)
CA (1)	CA1263392A (el)
DE (1)	DE3671445D1 (el)
DK (1)	DK165876C (el)
FR (1)	FR2585702B1 (el)
GR (1)	GR862010B (el)
IE (1)	IE59320B1 (el)
PT (1)	PT83109B (el)
ZA (1)	ZA865685B (el)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2699533A1 (fr) *	1992-12-21	1994-06-24	Mouhtaram Mohamed	Dérivés de N-((1,4-dialkyl-6-arylpipérazine-2-yl)méthyl)benzamides. (Isomères cis et trans) Propriétés pharmacologiques et applications.
TR200103035T2 (tr) *	1999-04-19	2002-01-21	Teva Pharmaceutical Industries Ltd.	Yeni piperazin halkası sentezi.
ES2190305B1 (es) *	2000-05-24	2004-07-01	Medichem S.A.	Compuestos intermedios para la preparacion de mirtazapina y sus procedimientos de obtencion.
IN190478B (el)	2000-11-07	2003-08-02	Sun Pharmaceutical Ind Ltd
ATE392410T1 (de)	2001-09-14	2008-05-15	Medichem Sa	Zwischenprodukte für die herstellung von mirtazapin und verfahren zu deren herstellung

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CA919590A (en) *	1967-05-24	1973-01-23	Neher Robert	Process for the manufacture of thyrocalcitonin
GB1181322A (en) *	1967-06-29	1970-02-11	Chugai Pharmaceutical Co Ltd	Piperazine Derivatives and processes for preparing the same
JPS52139085A (en) *	1976-05-13	1977-11-19	Hokuriku Pharmaceutical	22allylpiperazine derivative and method for its preparation
DE3420782A1 (de) *	1984-06-04	1985-12-05	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von 2-cyclohexylpiperazinen

1985
- 1985-07-31 FR FR8511684A patent/FR2585702B1/fr not_active Expired
1986
- 1986-07-23 AT AT86401644T patent/ATE53026T1/de not_active IP Right Cessation
- 1986-07-23 DE DE8686401644T patent/DE3671445D1/de not_active Expired - Lifetime
- 1986-07-23 EP EP86401644A patent/EP0211746B1/fr not_active Expired - Lifetime
- 1986-07-29 DK DK360286A patent/DK165876C/da active
- 1986-07-29 GR GR862010A patent/GR862010B/el unknown
- 1986-07-30 AU AU60691/86A patent/AU580179B2/en not_active Ceased
- 1986-07-30 PT PT83109A patent/PT83109B/pt not_active IP Right Cessation
- 1986-07-30 IE IE203286A patent/IE59320B1/en not_active IP Right Cessation
- 1986-07-30 ZA ZA865685A patent/ZA865685B/xx unknown
- 1986-07-31 JP JP61181806A patent/JPH0730047B2/ja not_active Expired - Lifetime
- 1986-07-31 CA CA000515056A patent/CA1263392A/fr not_active Expired
1988
- 1988-12-13 US US07/283,736 patent/US4912110A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PT83109A (fr)	1986-08-01
FR2585702A1 (fr)	1987-02-06
DK360286D0 (da)	1986-07-29
DK360286A (da)	1987-02-01
US4912110A (en)	1990-03-27
DK165876C (da)	1993-06-21
JPH0730047B2 (ja)	1995-04-05
AU6069186A (en)	1987-02-05
DK165876B (da)	1993-02-01
ZA865685B (en)	1987-03-25
CA1263392A (fr)	1989-11-28
JPS6229576A (ja)	1987-02-07
ATE53026T1 (de)	1990-06-15
AU580179B2 (en)	1989-01-05
IE862032L (en)	1987-01-31
IE59320B1 (en)	1994-02-09
DE3671445D1 (de)	1990-06-28
EP0211746A1 (fr)	1987-02-25
EP0211746B1 (fr)	1990-05-23
PT83109B (pt)	1989-02-28
FR2585702B1 (fr)	1989-03-03

Publication	Publication Date	Title
ES537677A0 (es)	1985-12-16	Procedimiento para preparar una 1h-imidazo (4, 5-c) quinolin-4-amina
ES8403445A1 (es)	1984-03-16	"procedimiento de preparacion de un nuevo derivado de la benzhidrilsulfinilacetamida"
SE8404712D0 (sv)	1984-09-20	Azole derivatives, process for their production compositions containing them and their use
YU42355B (en)	1988-08-31	Process for preparing diphenylethers
ATE19066T1 (de)	1986-04-15	1,3-dihydro 4-(1-hydroxy-2-aminoethyl)2-h-indol-2-on-deriva e, ihre saelze, verfahren zu ihrer herstellung, verwendung als heilmittel und zusammenstellungen die sie enthalten.
ATE75737T1 (de)	1992-05-15	Indenothiazolderivate und verfahren zu ihrer herstellung.
GR862010B (en)	1986-12-23	Method for preparing novel phenylpiperazine derivatives
KR840001555A (ko)	1984-05-07	치환된 2-페닐-2-(피리딜욕시)-에틸아민과 그의 등 배전자화합물 및 그들의 산부가염을 제조하는 방법
ATE30718T1 (de)	1987-11-15	Herstellung von 1-benzyl azetidin-3-ol und von dem entsprechenden halid acid.
GB1507414A (en)	1978-04-12	Hydantoin derivatives
DE68926016D1 (de)	1996-04-25	Halogeno-4-Methylpyrazole und Verfahren zu ihrer Herstellung
ES423746A1 (es)	1976-05-01	Procedimiento para preparar derivados de 2-aminoindano.
ES423745A1 (es)	1976-04-16	Procedimiento para preparar derivados de 2-aminoindano.
ES421929A1 (es)	1976-05-01	Procedimiento para la preparacion de sulfonanilidas susti- tuidas.
RO85311B1 (ro)	1984-10-30	Procedeu pentru obtinerea unui agent de blocare beta-adrenergica
PL68345B1 (el)	1973-02-28
ES437408A1 (es)	1977-08-01	Un procedimiento para la preparacion de nuevos derivados de indan 1, 3-diona.
ES486629A1 (es)	1980-07-01	Procedimiento para la obtencion de derivados tiadiazolicos
ES349158A1 (es)	1969-04-01	Procedimiento para la preparacion de nuevas 4 - arilsulfo- nilsemicarbacidas 1 - sustituidas.
ES289533A1 (es)	1964-03-01	Procedimiento de preparaciën de nuevos compuestos biciclicos