GR890100736A - Μεθοδοι για την παρασκευη υποκατεστημενων παραγωγων αλλυλαμινης και χρηση αυτων. - Google Patents

Μεθοδοι για την παρασκευη υποκατεστημενων παραγωγων αλλυλαμινης και χρηση αυτων.

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Publication number
GR890100736A
GR890100736A GR890100736A GR890100736A GR890100736A GR 890100736 A GR890100736 A GR 890100736A GR 890100736 A GR890100736 A GR 890100736A GR 890100736 A GR890100736 A GR 890100736A GR 890100736 A GR890100736 A GR 890100736A
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Greece
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identically
alkyl
differently
representing
represent
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GR890100736A
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English (en)
Inventor
Masahiro Hayashi
Masahiro Horie
Masaaki Hosoi
Yoshiaki Iida
Yoshikazu Iwasawa
Toshio Kamei
Hiroshi Takezawa
Yoshimi Tsuchiya
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Banyu Pharma Co Ltd
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Publication of GR890100736A publication Critical patent/GR890100736A/el

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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07D207/325—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
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    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D263/32—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Ενα υποκαταστημένο παράγωγο αλλυλαμίνης του γενικού τύπου (Ι) όπου Α1 και Α2, ταυτόσημα ή διαφορετικά, παριστάνουν το καθένα CH, N., O, ή S. Q1 και Q2, ταυτόσημα ή διαφορετικά, μπορεί να παρέχουν 1 ή 2 από Ο, N, S και σχηματίζουν ένα 5- ή 6- αρωματικό δακτύλιο μαζί με τους παρακείμενους C και τα Α1 ή Α2.Χ και Υ, ταυτόσημα ή διαφορετικά, το καθένα παριστάνει Ο ή S, =CO, -- CHRa--, --NR86-, (Ra, Rb παριστώντας Η ή κατώτερο αλκύλιο ή μαζί Χκαι Υ σχηματίζουν --CH=CH-- ή --C--C--. R1 παριστάνει μια 5- ή 6- ετεροκυκλική ομάδα με 1 ως 4 από Ν, Ο και S ετεροάτομα R2 παριστάνει κατώτερο αλκύλιο, CH2=CH--CH2--, HC--C--CH2--ή --CC C. R3 και R4, ταυτόσημα ή διαφορετικά, παριστάνουν το καθένα κατώτερο αλκύλιο ή μαζί σχηματίζουν κυκλοαλκύλιο με τον παρακείμενο C:R5 παριστάνει Η, κατώτερο -αλκύλιο ή -αλκοξυ και R6 και R7, ταυτόσημα ή διαφορετικά, παριστάνουν το καθένα Η, αλογόνο, ΟΗ, CN, κατώτερο -αλκύλιο ή -αλκοξυ με τον όρο όταν ένα από Χ και Υ είναι Ο, S, ή --NRb-- το άλλο είναι =CO ή --CHRa-- και το τοξικό του αλάτι, χρήσιμα για την αναστολή θηλαστικής σκουάλιας εποξειδάσης και θεραπεία υπερχολιστεριναιμίας, υπερλιπαιμίας και αρτηριοσκλήρυνσης. Μέθοδοι για την παρασκευή τους. ω
GR890100736A 1988-11-11 1989-11-07 Μεθοδοι για την παρασκευη υποκατεστημενων παραγωγων αλλυλαμινης και χρηση αυτων. GR890100736A (el)

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JP28538188 1988-11-11

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EP (1) EP0395768A4 (el)
KR (1) KR900701751A (el)
AU (1) AU3732889A (el)
DK (1) DK166590A (el)
GR (1) GR890100736A (el)
WO (1) WO1990005132A1 (el)
ZA (1) ZA898464B (el)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU634871B2 (en) * 1990-03-20 1993-03-04 Banyu Pharmaceutical Co., Ltd. Substituted amine derivatives having anti-hyperlipemia activity
EP0609448A4 (en) * 1992-06-01 1994-10-19 Banyu Pharma Co Ltd SUBSTITUTED HETEROCYCLIC DERIVATIVES WITH SQUALEN EPOXIDASE INHIBITING EFFECT AND THEIR USE.
US5405873A (en) * 1992-09-10 1995-04-11 Banyu Pharmaceutical Co., Ltd. Substituted acetamide derivatives
FR2745572A1 (fr) * 1996-02-29 1997-09-05 Pf Medicament Nouveaux sulfonamides derives de benzylamines, leurs sels, ainsi que leurs procedes de fabrication, les compositions pharmaceutiques et leur utilisation comme medicaments
US7741317B2 (en) 2005-10-21 2010-06-22 Bristol-Myers Squibb Company LXR modulators
US7888376B2 (en) 2005-11-23 2011-02-15 Bristol-Myers Squibb Company Heterocyclic CETP inhibitors
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EP0395768A1 (en) 1990-11-07
KR900701751A (ko) 1990-12-04
DK166590A (da) 1990-09-07
ZA898464B (en) 1991-01-30
EP0395768A4 (en) 1991-05-15
AU3732889A (en) 1990-05-28
WO1990005132A1 (fr) 1990-05-17

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