HK1056830A1 - Mannose as intranasal vaccine adjuvant - Google Patents

Mannose as intranasal vaccine adjuvant Download PDF

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Publication number
HK1056830A1
HK1056830A1 HK03107477.4A HK03107477A HK1056830A1 HK 1056830 A1 HK1056830 A1 HK 1056830A1 HK 03107477 A HK03107477 A HK 03107477A HK 1056830 A1 HK1056830 A1 HK 1056830A1
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HK
Hong Kong
Prior art keywords
antigen
mice
llo
mannan
iga
Prior art date
Application number
HK03107477.4A
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English (en)
French (fr)
Chinese (zh)
Other versions
HK1056830B (en
Inventor
Ian Farquhar Campbell Mckenzie
Geoffrey Allan Pietersz
Christina Cheers
John Stambas
Charles Eric Reynolds
Neil Martin O'brien-Simpson
Original Assignee
Igavax Pty Ltd.
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Filing date
Publication date
Application filed by Igavax Pty Ltd. filed Critical Igavax Pty Ltd.
Publication of HK1056830A1 publication Critical patent/HK1056830A1/en
Publication of HK1056830B publication Critical patent/HK1056830B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0208—Specific bacteria not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Claims (10)

  1. Verwendung einer Zusammensetzung, umfassend ein Antigen und ein Kohlenhydrat-Polymer-Adjuvans, umfassend Mannose, wobei das Polymer
    a) Monomere umfasst, die unter Bildung von Aldehydgruppen oxidiert sind, und
    b) kovalent an das Antigen gebunden ist;
    zur Herstellung eines Impfstoffs zur intranasalen Verabreichung zur Erzeugung einer Immunantwort auf das Antigen, umfassend eine sekretorische Immunantwort.
  2. Verwendung gemäß Anspruch 1, wobei die Immunantwort eine humorale Immunantwort umfasst.
  3. Verwendung gemäß Anspruch 1 oder 2, wobei die Immunantwort eine IgA-Antwort umfasst.
  4. Verwendung gemäß einem beliebigen der Ansprüche 1 bis 3, wobei die Immunantwort erhöhte Antikörperlevel an Stellen in der Mukosa umfasst.
  5. Verwendung gemäß einem beliebigen der Ansprüche 1 bis 4, wobei die Immunantwort erhöhte Antikörperlevel im Serum umfasst.
  6. Verwendung gemäß einem beliebigen der Ansprüche 1 bis 5, wobei die Immunantwort die Stimulation von Mediatoren von Th1- und/oder Th2-Zellimmunität umfasst.
  7. Verwendung gemäß einem beliebigen der Ansprüche 1 bis 6, wobei die IgE-Produktion reduziert oder unverändert ist.
  8. Verwendung gemäß einem beliebigen der Ansprüche 1 bis 7, wobei das Antigen ausgewählt ist aus der Gruppe, bestehend aus den Folgenden oder immunogenen Teilen davon: Pollen, Allergene, Bakterien, Viren, Hefen, Pilzen, Protozoen oder anderen Mikroorganismen, umfassend Pathogene von Menschen, Tieren und Pflanzen.
  9. Verwendung gemäß Anspruch 8, wobei das Antigen ausgewählt ist aus der Gruppe, bestehend aus Influenza-Virus, Influenza-Haemagglutinin, Porphyromona gingivalis, Proteinase- und Adhesinepitope von Porphyromona gingivalis, Helicobacter pylori, Helicobacter pylori-Urease, Rotavirus, rekombinantes VP5-Protein von Rotavirus, HIV, HIV-gp120, RSV, Oberflächenproteinen von RSV und Ovalbuminpeptide und Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium avium, BCG, Influenza Nucleoprotein, Respiratory-Syncyticial-Virus (RSV) F- oder G-Proteine, Candida albicans und Chlamydia trachomatis oder äußere Membranproteine davon, Neisseria meningitidis Klasse 1 äußeres Protein, Herpes simplex Virus Typ I Glycoprotein G oder gp D oder CP27, menschliches Papilloma-Virus, Murray-Valley-Encephalitis-Virus E-Glycoprotein, antigene Teile davon und Derivate davon.
  10. Verwendung gemäß Anspruch 8 oder 9, wobei das Antigen ausgewählt ist aus der Gruppe, bestehend aus HIV-Antigenen, Malaria-Antigenen, Antigenen von Mikroorganismen, welche Geschlechtskrankheiten, herkömmliche Erkältung oder Influenza verursachen, und Antigenen, die Asthma induzieren.
HK03107477.4A 2000-06-06 2001-06-06 Mannose as intranasal vaccine adjuvant HK1056830B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPQ7977 2000-06-06
AUPQ7977A AUPQ797700A0 (en) 2000-06-06 2000-06-06 Vaccine
PCT/AU2001/000669 WO2001093912A1 (en) 2000-06-06 2001-06-06 Vaccine

Publications (2)

Publication Number Publication Date
HK1056830A1 true HK1056830A1 (en) 2004-03-05
HK1056830B HK1056830B (en) 2010-10-22

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Also Published As

Publication number Publication date
AU6365301A (en) 2001-12-17
US8182821B2 (en) 2012-05-22
ATE456958T1 (de) 2010-02-15
AU2007302633A1 (en) 2008-04-03
AU2006222717A1 (en) 2006-10-19
EP1301208B1 (de) 2010-02-03
EP2066332A1 (de) 2009-06-10
EP1301208A4 (de) 2004-11-17
WO2001093912A1 (en) 2001-12-13
US20040043032A1 (en) 2004-03-04
EP1301208A1 (de) 2003-04-16
US20110033493A1 (en) 2011-02-10
US20100008951A1 (en) 2010-01-14
AUPQ797700A0 (en) 2000-06-29
DE60141243D1 (de) 2010-03-25
EP2066332A4 (de) 2012-01-18

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