HK1056830A1 - Mannose as intranasal vaccine adjuvant - Google Patents

Mannose as intranasal vaccine adjuvant Download PDF

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Publication number
HK1056830A1
HK1056830A1 HK03107477.4A HK03107477A HK1056830A1 HK 1056830 A1 HK1056830 A1 HK 1056830A1 HK 03107477 A HK03107477 A HK 03107477A HK 1056830 A1 HK1056830 A1 HK 1056830A1
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HK
Hong Kong
Prior art keywords
antigen
mice
llo
mannan
iga
Prior art date
Application number
HK03107477.4A
Other languages
German (de)
English (en)
Chinese (zh)
Other versions
HK1056830B (en
Inventor
Ian Farquhar Campbell Mckenzie
Geoffrey Allan Pietersz
Christina Cheers
John Stambas
Charles Eric Reynolds
Neil Martin O'brien-Simpson
Original Assignee
Igavax Pty Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Igavax Pty Ltd. filed Critical Igavax Pty Ltd.
Publication of HK1056830A1 publication Critical patent/HK1056830A1/en
Publication of HK1056830B publication Critical patent/HK1056830B/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/0208—Specific bacteria not otherwise provided for
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/04—Mycobacterium, e.g. Mycobacterium tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/15—Reoviridae, e.g. calf diarrhea virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55544—Bacterial toxins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/20011—Papillomaviridae
    • C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C12N2720/12311—Rotavirus, e.g. rotavirus A
    • C12N2720/12334—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Claims (10)

  1. Utilisation d'une composition comprenant un antigène et un adjuvant à base de polymère de glucide comprenant du mannose, où ledit polymère
    a) comprend des monomères de mannose oxydés pour produire des groupes aldéhydes, et
    b) est lié de manière covalente à l'antigène ;
    pour la préparation d'un vaccin destiné à une administration intranasale pour générer une réponse immunitaire contre l'antigène comprenant une réponse immunitaire sécrétoire.
  2. Utilisation selon la revendication 1, où la réponse immunitaire comprend une réponse immunitaire humorale.
  3. Utilisation selon la revendication 1 ou la revendication 2, où la réponse immunitaire comprend une réponse d'IgA.
  4. Utilisation selon l'une quelconque des revendications 1 à 3, où la réponse immunitaire comprend une augmentation des taux d'anticorps au niveau de sites mucosaux.
  5. Utilisation selon l'une quelconque des revendications 1 à 4, où la réponse immunitaire comprend une augmentation des taux d'anticorps dans le sérum.
  6. Utilisation selon l'une quelconque des revendications 1 à 5, où la réponse immunitaire comprend une stimulation de médiateurs de l'immunité cellulaire Th1 et/ou Th2.
  7. Utilisation selon l'une quelconque des revendications 1 à 6, où la production d'IgE est réduite ou inchangée.
  8. Utilisation selon l'une quelconque des revendications 1 à 7, où l'antigène est choisi dans le groupe constitué des suivants ou de parties immunogéniques de ceux-ci : pollens, allergènes, bactéries, virus, levures, champignons, protozoaires ou d'autres micro-organismes y compris des agents pathogènes des êtres humains, des animaux et des végétaux.
  9. Utilisation selon la revendication 8, où l'antigène est choisi dans le groupe constitué par le virus de la grippe, l'hémagglutinine de la grippe, Porphyromona gingivalis, des épitopes de protéinases et d'adhésines de Porphyromona gingivalis, Helicobacter pylori, l'uréase de Helicobacter pylori, des rotavirus, la protéine VP5 recombinante de rotavirus, le VIH, la gp120 du VIH, le RSV, des protéines de surface du RSV et des peptides de l'ovalbumine et Listeria monocytogenes, Mycobacterium tuberculosis, Mycobacterium avium, le BCG, la nucléoprotéine de la grippe, des protéines F ou G du virus respiratoire syncytial (RSV), Candida albicans et Chlamydia trachomatis ou la protéine de la membrane externe de celles-ci, la protéine externe de classe 1 de Neisseria meningitidis, la glycoprotéine G de type 1 ou la gp D ou CP27 du virus Herpes simplex, le virus du papillome humain, la glycoprotéine E du virus de l'encéphalite de la vallée de la Murray, des parties antigéniques de ceux-ci et des dérivés de ceux-ci.
  10. Utilisation selon la revendication 8 ou la revendication 9, où l'antigène est choisi dans le groupe constitué d'antigènes du VIH, d'antigènes du paludisme, d'antigènes provenant de micro-organismes qui provoquent des maladies vénériennes, un rhume banal ou la grippe et d'antigènes qui induisent l'asthme.
HK03107477.4A 2000-06-06 2001-06-06 Mannose as intranasal vaccine adjuvant HK1056830B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPQ7977A AUPQ797700A0 (en) 2000-06-06 2000-06-06 Vaccine
AUPQ7977 2000-06-06
PCT/AU2001/000669 WO2001093912A1 (fr) 2000-06-06 2001-06-06 Vaccin

Publications (2)

Publication Number Publication Date
HK1056830A1 true HK1056830A1 (en) 2004-03-05
HK1056830B HK1056830B (en) 2010-10-22

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Also Published As

Publication number Publication date
EP1301208A4 (fr) 2004-11-17
DE60141243D1 (de) 2010-03-25
EP2066332A4 (fr) 2012-01-18
US20100008951A1 (en) 2010-01-14
US20040043032A1 (en) 2004-03-04
EP1301208A1 (fr) 2003-04-16
US20110033493A1 (en) 2011-02-10
AU2007302633A1 (en) 2008-04-03
ATE456958T1 (de) 2010-02-15
US8182821B2 (en) 2012-05-22
EP2066332A1 (fr) 2009-06-10
EP1301208B1 (fr) 2010-02-03
WO2001093912A1 (fr) 2001-12-13
AU2006222717A1 (en) 2006-10-19
AUPQ797700A0 (en) 2000-06-29
AU6365301A (en) 2001-12-17

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Owner name: JOHN STAMBAS

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Owner name: JOHN STAMBAS TO CHRISTINA CHEERS

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Effective date: 20140606