HK1199462A1 - Silk-based bioactive oligopeptide compositions and manufacturing process therefor - Google Patents

Silk-based bioactive oligopeptide compositions and manufacturing process therefor Download PDF

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Publication number
HK1199462A1
HK1199462A1 HK14113091.5A HK14113091A HK1199462A1 HK 1199462 A1 HK1199462 A1 HK 1199462A1 HK 14113091 A HK14113091 A HK 14113091A HK 1199462 A1 HK1199462 A1 HK 1199462A1
Authority
HK
Hong Kong
Prior art keywords
properties
silk
oligopeptides
improvement
activity
Prior art date
Application number
HK14113091.5A
Other languages
Chinese (zh)
Inventor
Manote SUTHEERAWATTANANONDA
Nanteetip LIMPEANCHOB
Chainarong TOCHARUS
Waree TIYABOONCHAI
Duangkamol KANTHALERT
Pomnarin TAEPAVARAPRUK
Jiraporn TOCHARUS
Rossukon KHOTCHARRAT
Supasit PANNARUNOTHAI
Original Assignee
Agricultural Research Development Agency (Public Organization)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agricultural Research Development Agency (Public Organization) filed Critical Agricultural Research Development Agency (Public Organization)
Publication of HK1199462A1 publication Critical patent/HK1199462A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/145—Extraction; Separation; Purification by extraction or solubilisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43586—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from silkworms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/18—Peptides; Protein hydrolysates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Biophysics (AREA)
  • Insects & Arthropods (AREA)
  • Wood Science & Technology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Mycology (AREA)

Abstract

A process for preparing or manufacturing target molecular weight silk-derived oligopeptides with bioactive properties includes providing silk cocoon, extracting proteins or peptides from the silk cocoon, introducing an enzyme solution to obtain oligopeptides, and separating target oligopeptides from other peptides. Silk-derived oligopeptides in accordance with the present disclosure possess one or more of antioxidant properties, cholesterol lowering activity, lipid oxidation prevention properties, blood sugar lowering properties, blood pressure lowering properties, natural killer cell enhancement activity, insulin production enhancement activity, body weight regulatory activity, central nervous system stimulant properties, and neuroprotective, cognitive function protective, memory protective, and/or neural function improvement properties (e.g., memory deficit alleviation, spatial memory improvement, recognition memory improvement, learning improvement, synaptic transmission facilitation, and anti -neurodegenerative properties).
HK14113091.5A 2011-08-26 2011-08-26 Silk-based bioactive oligopeptide compositions and manufacturing process therefor HK1199462A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/TH2011/000037 WO2013032411A1 (en) 2011-08-26 2011-08-26 Silk-based bioactive oligopeptide compositions and manufacturing process therefor

Publications (1)

Publication Number Publication Date
HK1199462A1 true HK1199462A1 (en) 2015-07-03

Family

ID=47756655

Family Applications (1)

Application Number Title Priority Date Filing Date
HK14113091.5A HK1199462A1 (en) 2011-08-26 2011-08-26 Silk-based bioactive oligopeptide compositions and manufacturing process therefor

Country Status (6)

Country Link
EP (1) EP2748177A4 (en)
JP (1) JP5866015B2 (en)
KR (1) KR101638034B1 (en)
CN (1) CN103842371A (en)
HK (1) HK1199462A1 (en)
WO (1) WO2013032411A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020014888A1 (en) * 2018-07-18 2020-01-23 岱妮国际生技有限公司 Application of sericin peptide in inhibiting browning of fruits and vegetables
CN110499350B (en) * 2019-03-15 2021-02-02 辽东学院 Sericin hydrolysis method, product and application thereof
KR20240059675A (en) * 2022-10-25 2024-05-08 대한민국(농촌진흥청장) Composition for Increasing Bone Function Comprising Sericin and Uses Thereof

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH064679B2 (en) * 1985-02-06 1994-01-19 鐘紡株式会社 Powdered silk fibroin peptide and method for producing the same
JPH06292595A (en) * 1993-04-05 1994-10-21 Kiyoshi Hirabayashi Production of low-molecular weight fibroin
JPH0767687A (en) * 1993-08-27 1995-03-14 Yamaguchi Kaken Kk Production of water-soluble silk fibroin
JPH0767686A (en) * 1993-09-06 1995-03-14 Shinano Kenshi Co Ltd Production of silk fibroin peptide having low molecular weight
KR100431659B1 (en) * 1997-06-18 2004-05-17 독립행정법인농업생물자원연구소 Wound dressing material containing silk fibroin and sericin as a main component and method for preparing same
KR19980081941A (en) * 1998-08-06 1998-11-25 조병남 Method for producing functional silk amino acid and peptide material using silkworm cocoon by enzymatic digestion
KR100335702B1 (en) * 1999-04-15 2002-05-08 김원동 Silk peptide and process for the preparation thereof
KR20010100728A (en) * 2000-05-06 2001-11-14 김정수 Manufacturing method of foods in silk with enzyme
KR20010105931A (en) * 2000-05-19 2001-11-29 권혁윤 A manufacturing method of silk peptide
JP2002128691A (en) * 2000-10-24 2002-05-09 National Institute Of Agrobiological Sciences Sericin-containing material, its production method and its use
KR20020074746A (en) * 2001-03-21 2002-10-04 주식회사 아미노젠 Anticancer agents containing antigenotoxic and immunostimulation peptides produced from the hydrolyate of silkworm cocoon
KR100600695B1 (en) * 2003-02-13 2006-07-14 주식회사 바이오그랜드 Method for producing silk peptide having neuronal cell protective activity
US7193038B2 (en) * 2003-02-28 2007-03-20 National Institute Of Agrobiological Sciences Extraction and utilization of cell growth-promoting peptides from silk protein
JP3906924B2 (en) * 2003-02-28 2007-04-18 独立行政法人農業生物資源研究所 Extraction and utilization of cell growth peptides from silk proteins
JP3906927B2 (en) * 2003-03-14 2007-04-18 独立行政法人農業生物資源研究所 Production and utilization of functional protein derived from silk protein
US7115388B2 (en) * 2003-03-14 2006-10-03 National Institute Of Agrobiological Sciences Production of functional polypeptides originating from silk protein and use thereof
KR100494229B1 (en) * 2003-03-24 2005-06-13 김정호 manufacturing process of sericin and sericin mask pack
JP2004305175A (en) * 2003-04-10 2004-11-04 Kao Corp Alkaline protease
US20050170023A1 (en) * 2004-01-29 2005-08-04 L'oreal Composition, process for making using pressurized fluid, and uses thereof
EP1773864A4 (en) * 2004-07-31 2009-02-18 Biogrand Co Ltd Silk peptide improving neuroprotective and neurofunctional effects and a method of its preparation
CN101972278A (en) * 2010-10-26 2011-02-16 自贡市荣成实业有限责任公司 Method for preparing silk peptide compound capsule for treating hypertension
CN101965982A (en) * 2010-10-26 2011-02-09 曹新志 Method for preparing beverage from silk peptide

Also Published As

Publication number Publication date
KR20140063725A (en) 2014-05-27
JP5866015B2 (en) 2016-02-17
WO2013032411A1 (en) 2013-03-07
EP2748177A4 (en) 2015-04-08
CN103842371A (en) 2014-06-04
EP2748177A1 (en) 2014-07-02
JP2014525265A (en) 2014-09-29
KR101638034B1 (en) 2016-07-11

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