HK16092A - Adinazolam methanesulfonate - Google Patents

Adinazolam methanesulfonate Download PDF

Info

Publication number
HK16092A
HK16092A HK160/92A HK16092A HK16092A HK 16092 A HK16092 A HK 16092A HK 160/92 A HK160/92 A HK 160/92A HK 16092 A HK16092 A HK 16092A HK 16092 A HK16092 A HK 16092A
Authority
HK
Hong Kong
Prior art keywords
adinazolam
mixture
methanesulfonate
methanesulfonic acid
hygroscopic
Prior art date
Application number
HK160/92A
Other languages
German (de)
English (en)
Inventor
Steve Nichols
Paul Allen Meulman
Burris Dwight Tiffany
Original Assignee
The Upjohn Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Upjohn Company filed Critical The Upjohn Company
Publication of HK16092A publication Critical patent/HK16092A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (3)

1. Méthanesulfonate d'adinazolam cristallin, qui est pratiquement non hygroscopique.
2. Procédé de préparation de méthanesulfonate d'adinazolam cristallin, pratiquement non hygroscopique, qui consiste:
(i) à préparer un mélange d'adinazolam sous forme de base libre, d'acide méthanesulfonique, d'un alcanol en C1 ou C2 et d'un acétate d'alkyle en C4 à C6, dans lequel le rapport molaire de l'acide méthanesulfonique à l'adinazolam est non supérieur à 1;
(ii) à chauffer le mélange à une température suffisante pour dissoudre au moins une certaine quantité de l'adinazolam sous forme de base libre et pendant un temps suffisant pour éliminer pratiquement la totalité de l'alcanol et toute quantité d'eau; et
(iii) à refroidir le mélange et à séparer le méthanesulfonate d'adinazolam cristallin précipité.
3. Procédé suivant la revendication 2, dans lequel le mélange est préparé par addition d'acide méthanesulfonique à l'adinazolam sous forme de base libre, l'alcanol et l'acétate.
HK160/92A 1983-12-19 1992-02-27 Adinazolam methanesulfonate HK16092A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56268583A 1983-12-19 1983-12-19

Publications (1)

Publication Number Publication Date
HK16092A true HK16092A (en) 1992-03-06

Family

ID=24247327

Family Applications (1)

Application Number Title Priority Date Filing Date
HK160/92A HK16092A (en) 1983-12-19 1992-02-27 Adinazolam methanesulfonate

Country Status (10)

Country Link
EP (1) EP0146306B1 (fr)
JP (1) JPS60166685A (fr)
KR (1) KR890005303B1 (fr)
AU (1) AU571024B2 (fr)
CA (1) CA1234810A (fr)
DE (1) DE3477196D1 (fr)
ES (1) ES8603714A1 (fr)
HK (1) HK16092A (fr)
PH (1) PH21251A (fr)
ZA (1) ZA848791B (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4684725A (en) * 1983-12-19 1987-08-04 The Upjohn Company Non-hygroscopic adinazolam methanesulfonate salt and process therefor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH544764A (de) * 1971-01-21 1974-01-15 Ciba Geigy Ag Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten
US4250094A (en) * 1971-04-28 1981-02-10 The Upjohn Company 1-(Aminoalkyl) substituted-6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines
FI53821C (fi) * 1971-11-15 1978-08-10 Ciba Geigy Ag Foerfarande foer framstaellning av farmakologiskt vaerdefull 6-fenyl-8-klor-4h-s-triazolo(4 3-a)(1 4)bensodiazepin-1-metanol
US3910944A (en) * 1974-11-20 1975-10-07 Upjohn Co Spiro(cyclopropane-1,4{40 -(4H)-s-triazolo-(4,3-a)(1,4)benzodiazepines)
US4009175A (en) * 1976-03-15 1977-02-22 The Upjohn Company 1-[(Aminooxy)-methyl]-6-substituted-4H-s-triazolo[4,3-a][1,4] benzodiazepines

Also Published As

Publication number Publication date
EP0146306A1 (fr) 1985-06-26
JPS60166685A (ja) 1985-08-29
ES8603714A1 (es) 1986-01-16
AU3537184A (en) 1985-06-27
DE3477196D1 (de) 1989-04-20
JPH0481994B2 (fr) 1992-12-25
KR890005303B1 (ko) 1989-12-20
AU571024B2 (en) 1988-03-31
ZA848791B (en) 1985-06-26
KR850004761A (ko) 1985-07-27
CA1234810A (fr) 1988-04-05
PH21251A (en) 1987-08-31
EP0146306B1 (fr) 1989-03-15
ES538455A0 (es) 1986-01-16

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Legal Events

Date Code Title Description
NR Patent deemed never to have been added to the register under section 13(7) of patents (transitional arrangements) rules