HK17088A - Water-soluble salts of 2,4-diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl) quinazoline, compositions containing such salts and the production of such salts - Google Patents

Water-soluble salts of 2,4-diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl) quinazoline, compositions containing such salts and the production of such salts Download PDF

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Publication number
HK17088A
HK17088A HK170/88A HK17088A HK17088A HK 17088 A HK17088 A HK 17088A HK 170/88 A HK170/88 A HK 170/88A HK 17088 A HK17088 A HK 17088A HK 17088 A HK17088 A HK 17088A
Authority
HK
Hong Kong
Prior art keywords
methyl
salts
quinazoline
diamino
trimethoxyanilino
Prior art date
Application number
HK170/88A
Other languages
English (en)
French (fr)
Inventor
Norman Lloyd Colbry
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of HK17088A publication Critical patent/HK17088A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Claims (5)

1. Verfahren zur Herstellung einer Verbindung mit der folgenden Formel I worin Z 2-Hydroxyäthansulfonsäure oder Glucuronsäure bedeutet, welches Verfahren dadurch gekennzeichnet ist, daß eine Verbindung der folgenden Formelmit 2-Hydroxyäthansulfonsäure oder mit Glucuronsäure umgesetzt wird.
2. Verfahren nach Anspruch 1 zur Herstellung der Verbindung 2,4-Diamino-5-methyi-6-[(3,4,5-Trimethoxyanilino)-methyl]-chinazolin-monoisethionat.
3. Verfahren nach Anspruch 1 zur Herstellung der Verbindung 2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)-methyl]-chinazolin-glucuronat.
4. Verfahren zur Herstellung einer pharmazeutischen Zusammensetung umfassend eine therapeutisch akzeptable Menge einer Verbindung der Formel I, wie in Anspruch 1 gezeigt, dadurch gekennzeichnet, daß diese Verbindung in einen pharmazeutisch akzeptablen Träger inkorporiert wird.
HK170/88A 1980-10-31 1988-03-03 Water-soluble salts of 2,4-diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl) quinazoline, compositions containing such salts and the production of such salts HK17088A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US20251280A 1980-10-31 1980-10-31

Publications (1)

Publication Number Publication Date
HK17088A true HK17088A (en) 1988-03-11

Family

ID=22750192

Family Applications (1)

Application Number Title Priority Date Filing Date
HK170/88A HK17088A (en) 1980-10-31 1988-03-03 Water-soluble salts of 2,4-diamino-5-methyl-6-((3,4,5-trimethoxyanilino)methyl) quinazoline, compositions containing such salts and the production of such salts

Country Status (8)

Country Link
EP (1) EP0051415B1 (de)
JP (1) JPS5799574A (de)
CY (1) CY1416A (de)
DE (1) DE3167224D1 (de)
HK (1) HK17088A (de)
LU (1) LU88603I2 (de)
NL (1) NL950003I2 (de)
SG (1) SG92087G (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670013A (en) * 1982-12-27 1987-06-02 Miles Laboratories, Inc. Container for blood and blood components
DE3374140D1 (en) * 1983-10-26 1987-11-26 Schlotter Gmbh & Co Kg Max Dr Stripping bath and process for the electrolytical stripping of metals from titanium as a base metal
US5716960A (en) * 1995-01-13 1998-02-10 U.S. Bioscience Inc. And Individuals Crystalline trimetrexate salts and the process for making the same
US6017922A (en) 1998-05-18 2000-01-25 U.S. Bioscience, Inc. Thermally stable trimetrexates and processes for producing the same

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1345502A (en) * 1972-07-06 1974-01-30 Parke Davis & Co Quinazoline compounds and processes for their production

Also Published As

Publication number Publication date
CY1416A (en) 1988-04-22
NL950003I1 (nl) 1995-05-01
EP0051415B1 (de) 1984-11-14
NL950003I2 (nl) 1998-10-01
EP0051415A1 (de) 1982-05-12
JPH0438750B2 (de) 1992-06-25
DE3167224D1 (en) 1984-12-20
LU88603I2 (fr) 1995-07-10
JPS5799574A (en) 1982-06-21
SG92087G (en) 1988-05-06

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Legal Events

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PE Patent expired