HK56690A - Naphthoquinone derivatives - Google Patents

Naphthoquinone derivatives

Info

Publication number
HK56690A
HK56690A HK566/90A HK56690A HK56690A HK 56690 A HK56690 A HK 56690A HK 566/90 A HK566/90 A HK 566/90A HK 56690 A HK56690 A HK 56690A HK 56690 A HK56690 A HK 56690A
Authority
HK
Hong Kong
Prior art keywords
formula
compounds
compound
group
alkyl
Prior art date
Application number
HK566/90A
Other languages
German (de)
English (en)
Inventor
Alan Thomas Hudson
Anthony Winchester Randall
Original Assignee
The Wellcome Foundation Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Wellcome Foundation Limited filed Critical The Wellcome Foundation Limited
Publication of HK56690A publication Critical patent/HK56690A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/30—Unsaturated compounds
    • C07C62/34—Unsaturated compounds containing ether groups, groups, groups, or groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C46/00—Preparation of quinones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C50/00—Quinones
    • C07C50/26—Quinones containing groups having oxygen atoms singly bound to carbon atoms
    • C07C50/32—Quinones containing groups having oxygen atoms singly bound to carbon atoms the quinoid structure being part of a condensed ring system having two rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/08—Saturated compounds having a carboxyl group bound to a six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/15—Saturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/39—Unsaturated compounds containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C61/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C61/16—Unsaturated compounds
    • C07C61/40—Unsaturated compounds containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C62/00—Compounds having carboxyl groups bound to carbon atoms of rings other than six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C62/08—Saturated compounds containing ether groups, groups, groups, or groups
    • C07C62/10—Saturated compounds containing ether groups, groups, groups, or groups with a six-membered ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (10)

1. Composés de formule (I) et leurs sels physiologiquement acceptables
où soit R1 représente hydrogène et R2 est choisi parmi C1-6alcoxy, aralcoxy, C1-6alcoyl-C1-6alcoxy, phényle substitué par un ou deux radicaux choisis entre halogéno et C1-6alcoyle, halogèno et perhaloC1-6alcoyle, soit R1 et R2 représentent tous deux C1-6alcoyle ou phényle, et
n représente 0 ou 1.
2. Composés suivant la revendication 1, dans lesquels n représente 0.
3. Composés suivant la revendication 1, dans lesquels n représente 1.
4. Composés suivant l'une quelconque des revendications précédentes, dans lesquels R1 représente hydrogène et R2 représente t-butoxy ou un radical phényle substitué par un ou deux radicaux choisis entre chloro et méthyle aux positions 3 et/ou 4.
5. Composés suivant l'une quelconque des revendications 1 à 3, dans lesquels R1 représente hydrogène et R2 représente un radical phényl-C1-6alcoyle éventuellement substitué par un ou deux atomes d'halogène.
6. Procédé de préparation des composés de formule (I) et de leurs sels physiologiquement acceptables, qui comprend:
a) l'hydrolyse du composé 3-X-substitué correspondant (où X représente un radical qui est hydrolysable en un radical hydroxyle) ou du 2,3-époxyde correspondant;
b) l'oxydation d'un composé de formule (II): (où n, R1 et R2 sont tels que définis ci-dessus);
c) la réaction d'un composé de formule (III): (où Y représente un radical hydroxyle ou un radical hydrolysable en celui-ci) avec un composé donneur apportant le radical cyclohexyle ou cyclohexylméthyle R1- et R2-substitué (où R1 et R2 sont tels que définis ci-dessus) et (lorsque Y représente un radical hydrolysable), l'hydrolyse de ce radical en un radical hydroxyle;
d) la conversion d'un composé de formule (I) (où n représente 1) en un composé correspondant de formule (I) (où n représente 0) par une oxydation de Hooker et, éventuellement, la conversion d'un composé résultant de formule (I) en un sel physiologiquement acceptable de celui-ci;
e) la conversion d'un composé de formule (IV): (où R1 et R2 sont tels que définis ci-dessus) en un composé de formule (I) où n représente 1 par réduction du radical oxométhyle.
7. Compositions thérapeutiques comprenant au moins un composé de formule (I) ou un sel physiologiquement acceptable suivant l'une quelconque des revendications 1 à 5, conjointement avec un ou plusieurs excipients physiologiquement acceptables.
8. Composés de formule (I) suivant l'une quelconque des revendications 1 à 5, à utiliser comme agents thérapeutiques.
9. Composés suivant la revendication 8, à utiliser pour le traitement ou la prophylaxie d'une affection par protozoaires.
10. Composés suivant la revendication 9, à utiliser pour le traitement ou la prophylaxie du paludisme chez l'être humain.
HK566/90A 1983-04-14 1990-07-26 Naphthoquinone derivatives HK56690A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB838310141A GB8310141D0 (en) 1983-04-14 1983-04-14 Naphthoquinone derivatives

Publications (1)

Publication Number Publication Date
HK56690A true HK56690A (en) 1990-08-03

Family

ID=10541105

Family Applications (1)

Application Number Title Priority Date Filing Date
HK566/90A HK56690A (en) 1983-04-14 1990-07-26 Naphthoquinone derivatives

Country Status (17)

Country Link
EP (1) EP0123238B1 (fr)
JP (1) JPS59205341A (fr)
AT (1) ATE27696T1 (fr)
AU (1) AU574353B2 (fr)
CY (1) CY1549A (fr)
DE (2) DE19475021I2 (fr)
DK (1) DK172273B1 (fr)
GB (1) GB8310141D0 (fr)
HK (1) HK56690A (fr)
IL (1) IL71545A (fr)
LU (1) LU88579I2 (fr)
MX (1) MX9202993A (fr)
MY (1) MY102117A (fr)
NL (1) NL950002I2 (fr)
PH (1) PH22018A (fr)
SG (1) SG39390G (fr)
ZA (1) ZA842797B (fr)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8310140D0 (en) * 1983-04-14 1983-05-18 Wellcome Found Antiprotozoal agents
US5175319A (en) * 1983-04-14 1992-12-29 Burroughs Wellcome Co. Naphthoquinone derivatives
EP0253501A3 (fr) * 1986-07-16 1990-04-04 Imperial Chemical Industries Plc Cycloalcoylméthylamines N-disubstituées utiles comme fongicides
DE3801743A1 (de) * 1987-07-03 1989-01-19 Bayer Ag Schaedlingsbekaempfungsmittel auf basis von substituierten 1,4-naphthochinonen und neue substituierte 1,4-naphthochinone
CA1329621C (fr) * 1988-08-16 1994-05-17 Victoria Susan Latter Naphtoquinones pour le traitement ou la prophylaxie des infections a pneumocystis carinii
GB8819477D0 (en) * 1988-08-16 1988-09-21 Wellcome Found Medicaments
US5225184A (en) * 1988-08-16 1993-07-06 Burroughs Wellcome Co. Medicaments
US5206268A (en) * 1988-08-16 1993-04-27 Burroughs Wellcome Co. Medicaments
GB8921516D0 (en) * 1989-09-22 1989-11-08 Wellcome Found Medicaments
EP0567162A1 (fr) * 1989-09-22 1993-10-27 The Wellcome Foundation Limited Médicaments pour le traitement de la toxoplasmose
GB8923254D0 (en) * 1989-10-16 1989-12-06 Wellcome Found Medicaments
GB9126874D0 (en) * 1991-12-18 1992-02-19 Wellcome Found Medicaments
GB9207517D0 (en) * 1992-04-06 1992-05-20 Wellcome Found Heterocyclic compounds
GB9216859D0 (en) * 1992-08-07 1992-09-23 Wellcome Found Medicaments
GB9224739D0 (en) * 1992-11-26 1993-01-13 Wellcome Found Medicaments
GB9226905D0 (en) * 1992-12-24 1993-02-17 Wellcome Found Pharmaceutical preparation
US5856362A (en) * 1994-09-02 1999-01-05 Glaxo Wellcome Inc. Medicaments for the treatment of toxoplasmosis
WO2006008752A1 (fr) * 2004-07-16 2006-01-26 Usv Limited Nouvelles formes polymorphes d'atovaquone, et leur procede de preparation
WO2006011394A1 (fr) * 2004-07-30 2006-02-02 Japan Health Sciences Foundation Agent anti-protozoaire
ITMI20070941A1 (it) * 2007-05-09 2008-11-10 Chimico Internazi0Nale S P A L Procedimento per la preparazione di naftochinoni trans2,3-disostituiti
CN101774901B (zh) * 2009-01-09 2012-10-03 武汉泰祥通生物技术有限公司 一种制备阿托伐醌的方法
ES2517366T3 (es) 2009-08-20 2014-11-03 Ipca Laboratories Limited Nuevo complejo para el tratamiento y/o profilaxis de infecciones parasitarias
GB2476644B (en) * 2009-12-23 2012-11-14 Haomamedica Ltd 1,4-Dihydro-1,4-dioxonaphtalene derivatives for the treatment of osteoporosis
US8598387B2 (en) 2010-12-15 2013-12-03 Glaxo Group Limited Process for the preparation of atovaquone
EP2845588A1 (fr) * 2013-09-09 2015-03-11 Centre National de la Recherche Scientifique (C.N.R.S.) Inhibiteurs PIN1 destiné à être utilisé dans la prévention et/ou le traitement de theileriosis et applications associées

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2553647A (en) * 1946-03-20 1951-05-22 Research Corp Naphthoquinone antimalarials
IL56013A (en) * 1977-11-22 1983-06-15 Wellcome Found 2-cycloalkyl-3-hydroxy-1,4-naphthoquinone derivatives,their preparation and therapeutic compositions containing them

Also Published As

Publication number Publication date
DK193584A (da) 1984-10-15
JPH0533212B2 (fr) 1993-05-19
EP0123238A2 (fr) 1984-10-31
EP0123238B1 (fr) 1987-06-10
DK172273B1 (da) 1998-02-16
DE3464132D1 (de) 1987-07-16
GB8310141D0 (en) 1983-05-18
NL950002I1 (nl) 1995-03-01
EP0123238A3 (en) 1985-10-30
IL71545A (en) 1987-12-20
PH22018A (en) 1988-05-13
MY102117A (en) 1992-03-31
DK193584D0 (da) 1984-04-13
MX9202993A (es) 1992-07-01
LU88579I2 (fr) 1995-03-01
DE19475021I2 (de) 2001-08-02
IL71545A0 (en) 1984-07-31
NL950002I2 (nl) 1998-04-01
AU2679684A (en) 1984-10-18
ZA842797B (en) 1985-11-27
SG39390G (en) 1990-11-23
ATE27696T1 (de) 1987-06-15
JPS59205341A (ja) 1984-11-20
AU574353B2 (en) 1988-07-07
CY1549A (en) 1991-03-22

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Legal Events

Date Code Title Description
PE Patent expired