HK79097A - Pharmaceutical aerosol formulation - Google Patents

Pharmaceutical aerosol formulation Download PDF

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Publication number
HK79097A
HK79097A HK79097A HK79097A HK79097A HK 79097 A HK79097 A HK 79097A HK 79097 A HK79097 A HK 79097A HK 79097 A HK79097 A HK 79097A HK 79097 A HK79097 A HK 79097A
Authority
HK
Hong Kong
Prior art keywords
formulation
medicament
propellant
particulate
ethanol
Prior art date
Application number
HK79097A
Other languages
German (de)
English (en)
Inventor
Ann Akehurst Rachel
James Taylor Anthony
Andrew Wyatt David
Original Assignee
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26299998&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK79097(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB919126444A external-priority patent/GB9126444D0/en
Priority claimed from GB929202522A external-priority patent/GB9202522D0/en
Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited
Publication of HK79097A publication Critical patent/HK79097A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4402—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 2, e.g. pheniramine, bisacodyl
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Rheumatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Thermistors And Varistors (AREA)

Claims (18)

  1. Composition d'aérosol pharmaceutique, caractérisée en ce qu'elle comprend un médicament particulaire, un propulseur du type fluorocarbone ou chlorofluorocarbone contenant de l'hydrogène et 0,01 à 5% p/p, sur base du propulseur, d'un cosolvant polaire, laquelle composition est essentiellement dépourvue de surfactif.
  2. Composition d'aérosol pharmaceutique essentiellement constituée d'un ou plusieurs médicaments particulaires, d'un ou plusieurs propulseurs du type fluorocarbone ou chlorofluorocarbone contenant de l'hydrogène et 0,01 à 5% p/p, sur base du propulseur, d'un cosolvant polaire.
  3. Composition suivant la revendication 1 ou la revendication 2, caractérisée en ce que le médicament est une substance anti-allergique, un bronchodilatateur, ou un stéroïde anti-inflammatoire.
  4. Composition suivant la revendication 3, caractérisée en ce que le médicament est un bronchodilatateur.
  5. Composition suivant la revendication 4, caractérisée en ce que le médicament est l'éphédrine, l'adrénaline, le phénotérol, le formotérol, l'isoprénaline, le métaprotérénol, la phényléphrine, la phénylpropanolamine, le pirbutérol, le réprotérol, le rimitérol, la terbutaline, l'isoétharine, le tulobutérol, l'orciprénaline ou le (-)-4-amino-3,5-dichloro-α-[[[6-[2-(2-pyridinyl)éthoxy]hexyl]amino]méthyl]benzèneméthanol ou un sel d'un de ces composés physiologiquement acceptable.
  6. Composition suivant la revendication 5, caractérisée en ce que le médicament est le pirbutérol.
  7. Composition suivant l'une quelconque des revendications 1 à 3, caractérisée en ce que l'on choisit le médicament parmi le salmétérol, le salbutamol, le propionate de fluticasone, le dipropionate de béclométhasone et les sels et solvates physiologiquement acceptables de ces produits.
  8. Composition suivant l'une quelconque des revendications 1 à 7, caractérisée en ce qu'elle contient deux ou plus de deux médicaments particulaires.
  9. Composition suivant l'une quelconque des revendications 1 à 8, caractérisée en ce qu'elle comprend un médicament bronchodilatateur particulaire et un médicament anti-inflammatoire particulaire.
  10. Composition suivant l'une quelconque des revendications 1 à 9, caractérisée en ce qu'elle comprend du salmétérol ou un sel physiologiquement acceptable de ce produit, en combinaison avec du propionate de fluticasone.
  11. Composition suivant l'une quelconque des revendications 1 à 10, caractérisée en ce qu'elle comprend du xinafoate de salmétérol en combinaison avec du propionate de fluticasone.
  12. Composition suivant l'une quelconque des revendications 1 à 11, caractérisée en ce que le propulseur est constitué de 1,1,1,2-tétrafluoréthane ou de 1,1,1,2,3,3,3-heptafluoro-n-propane.
  13. Composition suivant l'une quelconque des revendications 1 à 12, caractérisée en ce que le cosolvant polaire est l'éthanol.
  14. Composition suivant l'une quelconque des revendications 1 à 13, caractérisée en ce que le médicament y est présent en une proportion de 0,005 à 10% p/p sur base du poids total de la composition.
  15. Composition suivant l'une quelconque des revendications 1 à 14, caractérisée en ce qu'elle possède une fraction respirable de 20% ou de plus de 20% en poids du médicament.
  16. Composition suivant l'une quelconque des revendications 1 à 15, caractérisée en ce que le médicament particulaire est modifié en surface.
  17. Boîte convenant pour débiter une composition d'aérosol pharmaceutique, caractérisée en ce qu'elle est constituée d'un récipient capable de résister à la pression de vapeur du propulseur utilisé, lequel récipient est fermé à l'aide d'une valve doseuse et contient une composition d'aérosol pharmaceutique qui comprend un médicament particulaire, un propulseur du type fluorocarbone ou chlorofluorocarbone contenant de l'hydrogène et 0,01 à 5% p/p, sur base du propulseur, d'un cosolvant polaire, laquelle composition est essentiellement dépourvue de surfactif.
  18. Inhalateur à dose mesurée, caractérisé en ce qu'il est constitué par une boite suivant la revendication 17, équipée d'un dispositif de canalisation approprié.
HK79097A 1991-12-12 1997-06-12 Pharmaceutical aerosol formulation HK79097A (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB919126444A GB9126444D0 (en) 1991-12-12 1991-12-12 Medicaments
GB929202522A GB9202522D0 (en) 1992-02-06 1992-02-06 Medicaments
PCT/EP1992/002810 WO1993011745A1 (fr) 1991-12-12 1992-12-04 Medicaments

Publications (1)

Publication Number Publication Date
HK79097A true HK79097A (en) 1997-06-20

Family

ID=26299998

Family Applications (1)

Application Number Title Priority Date Filing Date
HK79097A HK79097A (en) 1991-12-12 1997-06-12 Pharmaceutical aerosol formulation

Country Status (16)

Country Link
US (1) US5817293A (fr)
EP (1) EP0616525B1 (fr)
JP (1) JP3280974B2 (fr)
AT (1) ATE128350T1 (fr)
AU (1) AU663906B2 (fr)
CA (1) CA2125665C (fr)
CY (1) CY2008A (fr)
DE (1) DE69205177T2 (fr)
DK (1) DK0616525T3 (fr)
ES (1) ES2079210T3 (fr)
GR (1) GR3018168T3 (fr)
HK (1) HK79097A (fr)
MX (1) MX9207200A (fr)
NZ (1) NZ246046A (fr)
TW (1) TW229159B (fr)
WO (1) WO1993011745A1 (fr)

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AU663906B2 (en) 1995-10-26
JP3280974B2 (ja) 2002-05-13
NZ246046A (en) 1995-12-21
CA2125665C (fr) 2001-06-12
JPH07501811A (ja) 1995-02-23
GR3018168T3 (en) 1996-02-29
AU663906C (en) 1993-07-19
ATE128350T1 (de) 1995-10-15
AU3085292A (en) 1993-07-19
US5817293A (en) 1998-10-06
CA2125665A1 (fr) 1993-06-24
CY2008A (en) 1998-02-20
EP0616525A1 (fr) 1994-09-28
EP0616525B1 (fr) 1995-09-27
DE69205177T2 (de) 1996-03-21
DE69205177D1 (de) 1995-11-02
WO1993011745A1 (fr) 1993-06-24
TW229159B (fr) 1994-09-01
ES2079210T3 (es) 1996-01-01
MX9207200A (es) 1993-07-01
DK0616525T3 (da) 1996-01-08

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