HK7997A - Controlled release combination of carbidopa/levodopa - Google Patents

Controlled release combination of carbidopa/levodopa Download PDF

Info

Publication number
HK7997A
HK7997A HK7997A HK7997A HK7997A HK 7997 A HK7997 A HK 7997A HK 7997 A HK7997 A HK 7997A HK 7997 A HK7997 A HK 7997A HK 7997 A HK7997 A HK 7997A
Authority
HK
Hong Kong
Prior art keywords
levodopa
carbidopa
polymer
water soluble
formulation
Prior art date
Application number
HK7997A
Other languages
English (en)
French (fr)
Inventor
Robert E. Dempski
Scott A. Reines
Edward C. Scholtz
Donald W. Nibbelink
Original Assignee
Merck & Co. Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26829626&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK7997(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.
Publication of HK7997A publication Critical patent/HK7997A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)

Claims (4)

1. Formulierung für die gesteuerte Freigabe einer oralen Dosierung umfassend eine gleichmäßige Dispersion von 5 - 300 mg Carbidopa, 20 - 1200 mg Levodopa, 0 - 25 mg eines Tabletten-Gleitmittels und gegebenenfalls einen pharmazeutisch annehmbaren Farbstoff, in einem Polymer-Vehikel umfassend 0 - 120 mg wasserlösliches Kydroxypropylcellulosepolymer und 0 - 120 mg eines weniger wasserlöslichen Polyvinylacetat-CrotonsäureCopolymers, wobei bei folgender Verabreichung Carbidopa und Levodopa langsam und gleichzeitig aus der Formulierung freigegeben werden; dadurch gekennzeichnet, daß das wasserlösliche Hydroxypropylcellulosepolymer Klucel LF® ist, und daß das weniger wasserlösliche Polyvinylacetat-CrotonsäureCopolymer Vinac ASB-516® ist, mit der Maßgabe, daß kein Polymer 0 mg beträgt.
2. Formulierung nach Anspruch 1 umfassend 200 mg Levodopa und 50 mg Carbidopa oder 100 mg Levodopa und 25 mg Carbidopa.
3. Formulierung für die gesteuerte Freigabe einer oralen Dosierung nach Anspruch 1, umfassend eine gleichmäßige Dispersion von 25 - 100 mg Carbidopa, 100 - 400 mg Levodopa, 1 - 10 mg eines Tabletten-Gleitmittels und gegebenenfalls einen pharmazeutisch annehmbaren Farbstoff, in einem Polymer-Vehikel umfassend 5 - 25 mg wasserlösliches Hydroxypropylcellulosepolymer und 2 - 50 mg eines weniger wasserlöslichen Polyvinylacetat-Crotonsäure-Copolymer, wobei bei folgender Verabreichung von Carbidopa und Levodopa langsam und gleichzeitig aus der Formulierung freigegeben werden; dadurch gekennzeichnet, daß das wasserlösliche Kydroxypropylcellulosepolymer Klucel LF® ist, und daß das weniger wasserlösliche Polyvinylacetat-Crotonsäure-Copolymer Vinac ASB-516® ist.
4. Formulierung nach Anspruch 3 umfassend 200 mg Levodopa und 50 mg Carbidopa oder 100 mg Levodopa und 25 mg Carbidopa.
HK7997A 1987-12-11 1997-01-16 Controlled release combination of carbidopa/levodopa HK7997A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13160187A 1987-12-11 1987-12-11
US07/223,861 US4832957A (en) 1987-12-11 1988-07-25 Controlled release combination of carbidopa/levodopa

Publications (1)

Publication Number Publication Date
HK7997A true HK7997A (en) 1997-01-24

Family

ID=26829626

Family Applications (1)

Application Number Title Priority Date Filing Date
HK7997A HK7997A (en) 1987-12-11 1997-01-16 Controlled release combination of carbidopa/levodopa

Country Status (15)

Country Link
US (1) US4832957A (de)
EP (1) EP0320051B1 (de)
JP (1) JPH0667830B2 (de)
KR (1) KR890009377A (de)
AT (1) ATE81970T1 (de)
AU (1) AU616449B2 (de)
CA (1) CA1318602C (de)
DE (1) DE3875705T2 (de)
DK (1) DK170515B1 (de)
ES (1) ES2052691T3 (de)
GR (1) GR3006220T3 (de)
HK (1) HK7997A (de)
IE (1) IE61547B1 (de)
IL (1) IL88563A0 (de)
PT (1) PT89157B (de)

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Also Published As

Publication number Publication date
GR3006220T3 (de) 1993-06-21
DK685888D0 (da) 1988-12-09
PT89157A (pt) 1989-12-29
JPH02209A (ja) 1990-01-05
KR890009377A (ko) 1989-08-01
IE883679L (en) 1989-06-11
DE3875705T2 (de) 1993-05-13
ES2052691T3 (es) 1994-07-16
IL88563A0 (en) 1989-07-31
US4832957A (en) 1989-05-23
AU616449B2 (en) 1991-10-31
CA1318602C (en) 1993-06-01
AU2673388A (en) 1989-06-15
IE61547B1 (en) 1994-11-16
ATE81970T1 (de) 1992-11-15
DK170515B1 (da) 1995-10-09
DE3875705D1 (de) 1992-12-10
PT89157B (pt) 1993-06-30
EP0320051B1 (de) 1992-11-04
DK685888A (da) 1989-07-25
JPH0667830B2 (ja) 1994-08-31
EP0320051A1 (de) 1989-06-14

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