HN2003000080A - Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso - Google Patents

Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso

Info

Publication number
HN2003000080A
HN2003000080A HN2003000080A HN2003000080A HN2003000080A HN 2003000080 A HN2003000080 A HN 2003000080A HN 2003000080 A HN2003000080 A HN 2003000080A HN 2003000080 A HN2003000080 A HN 2003000080A HN 2003000080 A HN2003000080 A HN 2003000080A
Authority
HN
Honduras
Prior art keywords
useful
tienopiridins
antiangiogen
indolil
procedures
Prior art date
Application number
HN2003000080A
Other languages
English (en)
Inventor
Robert Steven Kania
William Henry Romines Iii
Stephan James Cripps
Mingying He
Jihong Lou
Ru Zhou
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of HN2003000080A publication Critical patent/HN2003000080A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A NUEVAS TIENOPIRIDINAS Y DERIVADOS DE TIENOPIRIDINA QUE SON UTILES EN EL TRATAMIENTO DE ENFERMEDADES HIPERPROLIFERATIVAS TALES COMO CANCERES, EN MAMIFEROS.
HN2003000080A 2002-03-01 2003-02-27 Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso HN2003000080A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US36095202P 2002-03-01 2002-03-01

Publications (1)

Publication Number Publication Date
HN2003000080A true HN2003000080A (es) 2004-05-05

Family

ID=27789048

Family Applications (1)

Application Number Title Priority Date Filing Date
HN2003000080A HN2003000080A (es) 2002-03-01 2003-02-27 Indolil-urea derivados de tienopiridinas utiles como agentes antiangiogenicos y procedimientos para su uso

Country Status (15)

Country Link
US (1) US6833456B2 (es)
EP (1) EP1483268A2 (es)
JP (1) JP2005527511A (es)
AR (1) AR040398A1 (es)
AU (1) AU2003206068A1 (es)
BR (1) BR0308162A (es)
CA (1) CA2478050A1 (es)
GT (1) GT200300046A (es)
HN (1) HN2003000080A (es)
MX (1) MXPA04008403A (es)
PA (1) PA8568101A1 (es)
PE (1) PE20030944A1 (es)
TW (1) TW200306193A (es)
UY (1) UY27685A1 (es)
WO (1) WO2003074529A2 (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA77303C2 (en) 2002-06-14 2006-11-15 Pfizer Derivatives of thienopyridines substituted by benzocondensed heteroarylamide useful as therapeutic agents, pharmaceutical compositions and methods for their use
TW200503994A (en) * 2003-01-24 2005-02-01 Novartis Ag Organic compounds
AU2008202205B2 (en) * 2003-12-23 2009-09-10 Pfizer Inc. Novel quinoline derivatives
JP4503022B2 (ja) * 2003-12-23 2010-07-14 ファイザー・インク 新規キノリン誘導体
EP1698621A4 (en) * 2003-12-26 2008-11-19 Daiichi Seiyaku Co PROCESS FOR PREPARING A PYRROLIDINE DERIVATIVE
GB0412467D0 (en) * 2004-06-04 2004-07-07 Astrazeneca Ab Chemical compounds
CA2573538C (en) 2004-07-30 2014-11-25 Methylgene Inc. Inhibitors of vegf receptor and hgf receptor signaling
JP5148499B2 (ja) 2005-05-20 2013-02-20 メチルジーン インコーポレイテッド Ｖｅｇｆ受容体およびｈｇｆ受容体シグナル伝達の阻害剤
ES2473341T3 (es) 2005-05-20 2014-07-04 Methylgene Inc Inhibidores de la se�alizaci�n del receptor del VEGF y del receptor del HGF
AU2006277742B2 (en) * 2005-08-08 2010-08-26 Pfizer Inc. Salts and polymorphs of a VEGF-R inhibitor
AR059246A1 (es) * 2006-01-30 2008-03-19 Array Biopharma Inc Compuestos heterobiciclicos de tiofeno y metodos de uso
WO2007107005A1 (en) * 2006-03-22 2007-09-27 Methylgene, Inc. Inhibitors of protein tyrosine kinase activity
US20110053931A1 (en) * 2006-06-08 2011-03-03 John Gaudino Quinoline compounds and methods of use
WO2009109035A1 (en) 2008-03-05 2009-09-11 Methylgene Inc. Inhibitors of protein tyrosine kinase activity
KR101126736B1 (ko) * 2008-11-27 2012-04-12 주식회사 레고켐 바이오사이언스 티로신 키나아제 저해 화합물, 이의 이성질체 또는 이의 약학적으로 허용가능한 염 및 이를 포함하는 약학적 조성물
CN103140478A (zh) 2010-07-29 2013-06-05 比亚尔-珀特拉和Ca股份公司 取代的脲化合物的合成方法
US9056877B2 (en) 2011-07-19 2015-06-16 Infinity Pharmaceuticals, Inc. Heterocyclic compounds and uses thereof
AU2014359456B2 (en) 2013-12-04 2019-01-24 Evotec International Gmbh Sulfoximine substituted quinazolines for pharmaceutical compositions
WO2015162515A1 (en) 2014-04-25 2015-10-29 Pfizer Inc. Heteroaromatic compounds and their use as dopamine d1 ligands
CN115746017B (zh) * 2022-11-30 2024-06-07 英维沃化工科技(广州)有限公司 一种噻吩并嘧啶类化合物及其制备方法和应用
CN116082214A (zh) * 2023-02-24 2023-05-09 常州大学 一种2-芳基-3-叔丁基吲哚类化合物、制备方法及其应用

Family Cites Families (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8827305D0 (en) 1988-11-23 1988-12-29 British Bio Technology Compounds
US6177401B1 (en) 1992-11-13 2001-01-23 Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis
PL315941A1 (en) 1994-02-23 1996-12-09 Pfizer 4-heterocyclic substituted derivatives of quinazoline, methods of obtaining them and their application as anticarcinogenic agents
US5863949A (en) 1995-03-08 1999-01-26 Pfizer Inc Arylsulfonylamino hydroxamic acid derivatives
DE69536015D1 (de) 1995-03-30 2009-12-10 Pfizer Prod Inc Chinazolinone Derivate
JP3053222B2 (ja) 1995-04-20 2000-06-19 ファイザー・インコーポレーテッド Ｍｍｐおよびｔｎｆ抑制剤としてのアリールスルホニルヒドロキサム酸誘導体
EP0831829B1 (en) 1995-06-07 2003-08-20 Pfizer Inc. Heterocyclic ring-fused pyrimidine derivatives
US5880141A (en) * 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
AR004010A1 (es) 1995-10-11 1998-09-30 Glaxo Group Ltd Compuestos heterociclicos
GB9624482D0 (en) 1995-12-18 1997-01-15 Zeneca Phaema S A Chemical compounds
ES2169355T3 (es) 1996-03-05 2002-07-01 Astrazeneca Ab Derivados de 4-anilinoquinazolina.
EP0907642B1 (en) 1996-06-24 2005-11-02 Pfizer Inc. Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
AU2710597A (en) * 1996-06-27 1998-01-14 Pfizer Inc. Derivatives of 2-(2-oxo-ethylidene)-imidazolidin-4-one and their use as farnesyl protein transferase inhibitors
HRP970371A2 (en) 1996-07-13 1998-08-31 Kathryn Jane Smith Heterocyclic compounds
EA199900021A1 (ru) 1996-07-13 1999-08-26 Глаксо, Груп Лимитед Бициклические гетероароматические соединения в качестве ингибиторов протеинтирозинкиназы
CA2260898C (en) 1996-07-18 2002-05-14 Pfizer Limited Phosphinate based inhibitors of matrix metalloproteases
PL331895A1 (en) 1996-08-23 1999-08-16 Pfizer Arylosulphonylamino derivatives of hydroxamic acid
CA2272705C (en) 1996-11-27 2003-03-18 Pfizer Inc. Fused bicyclic pyrimidine derivatives
DE69730151T2 (de) 1997-01-06 2005-08-04 Pfizer Inc. Cyclische sulfonderivate
AU721748B2 (en) 1997-02-03 2000-07-13 Pfizer Products Inc. Arylsulfonylamino hydroxamic acid derivatives
CA2279863A1 (en) 1997-02-07 1998-08-13 Pfizer Inc. N-hydroxy-beta-sulfonyl-propionamide derivatives and their use as inhibitors of matrix metalloproteinases
WO1998034918A1 (en) 1997-02-11 1998-08-13 Pfizer Inc. Arylsulfonyl hydroxamic acid derivatives
JP2002501532A (ja) 1997-05-30 2002-01-15 メルク エンド カンパニー インコーポレーテッド 新規血管形成阻害薬
ATE368665T1 (de) 1997-08-22 2007-08-15 Astrazeneca Ab Oxindolylchinazolinderivate als angiogenesehemmer
JP2001518470A (ja) 1997-09-26 2001-10-16 メルク エンド カムパニー インコーポレーテッド 新規な血管形成阻害剤
PA8469401A1 (es) 1998-04-10 2000-05-24 Pfizer Prod Inc Derivados biciclicos del acido hidroxamico
PA8469501A1 (es) 1998-04-10 2000-09-29 Pfizer Prod Inc Hidroxamidas del acido (4-arilsulfonilamino)-tetrahidropiran-4-carboxilico
IL139934A0 (en) 1998-05-29 2002-02-10 Sugen Inc Pyrrole substituted 2-indolinone derivatives and pharmaceutical compositions containing the same
CN1398189A (zh) 1998-12-23 2003-02-19 G.D.西尔公司 用于治疗肿瘤形成的放疗与cox－2抑制剂的联合治疗
AU2001252463A1 (en) * 2000-06-06 2001-12-17 Pfizer Products Inc. Thiophene derivatives useful as anticancer agents
WO2003000194A2 (en) * 2001-06-21 2003-01-03 Pfizer Inc. Thienopyridine and thienopyrimidine anticancer agents

Also Published As

Publication number Publication date
US6833456B2 (en) 2004-12-21
WO2003074529A2 (en) 2003-09-12
WO2003074529A3 (en) 2003-12-24
GT200300046A (es) 2003-10-10
BR0308162A (pt) 2004-12-07
US20040019065A1 (en) 2004-01-29
JP2005527511A (ja) 2005-09-15
EP1483268A2 (en) 2004-12-08
AU2003206068A8 (en) 2003-09-16
PE20030944A1 (es) 2003-11-08
UY27685A1 (es) 2003-10-31
CA2478050A1 (en) 2003-09-12
PA8568101A1 (es) 2003-11-12
AU2003206068A1 (en) 2003-09-16
MXPA04008403A (es) 2004-11-26
TW200306193A (en) 2003-11-16
AR040398A1 (es) 2005-04-06

Similar Documents

Publication Publication Date Title
HN2003000182A (es) Derivados de heteroarilamida benzocondensada de tienopiridinas utiles como agentes terapeuticos, composiciones farmaceuticas que incluyen a los mismos y metodo para su uso
HN2003000416A (es) Derivados de pirrolopirimidina
HN2007015177A (es) Derivados de triazolopirazina
CR8919A (es) Analogos de tetrapeptidos
HN2000000051A (es) Derivados heterociclicos utiles como agentes anticancerosos
HN1999000080A (es) Derivados de isotiazol utiles como agentes anticancerosos.
PA8600601A1 (es) Ligandos de receptores de cannabinoides y sus usos
CR9014A (es) Novedosos derivados de heteroarilsulfamida benzofusionados como agentes anticonvulsionantes
HN2003000257A (es) Nuevos derivados de benzoimidazol utiles como agentes antiproliferativos.
UY33616A (es) Compuestos con estructura de imidazotriazinona
SV2010003662A (es) Derivados de azetidina y ciclobutano como inhibidores de jak ref. x-19081
HN2003000422A (es) Derivados de pirimidina para el tratamiento del crecimiento celular anormal.
NI201000044A (es) Bromhidrato de bupropión y aplicaciones terapéuticas
ITMI20052171A1 (it) Composti e-amminocarbonil bicicloepten pirimidindiamminici stereoisomericamente arricchiti e loro uso
CR10304A (es) Compuestos de tetrahidropiridotienopirimidina y procedimientos de uso de los mismos
HN2004000146A (es) Dihidroquinazolinas sustituidas
ECSP088821A (es) Derivados de tioxantina y su uso como inhibidores de la mpo
SV2006002283A (es) Formulaciones
CR9223A (es) 18-metil-19-nor-17-pregn-4-en-21, 17-carbolactonas,asi como preparaciones farmaceuticas que las contienen
CL2007002384A1 (es) Uso de compuestos derivados de 2,5-dihidroxibenceno para el tratamiento de la psoriasis.
NI201000015A (es) Bromhidrato de bupropión y aplicaciones terapéuticas
HN1999000124A (es) Derivados de pirazol substituido.
ECSP067120A (es) 3-aminociclopentanocarboxamidas como moduladores de receptores de quimioquinas
HN2002000365A (es) Lactamas como antagonistas de taquiquininas
UY28313A1 (es) Nonadepsipeptidos acilados