HRP20000065A2 - 2-acylaminopropanamines as tachykinin receptor antagonists - Google Patents
2-acylaminopropanamines as tachykinin receptor antagonists Download PDFInfo
- Publication number
- HRP20000065A2 HRP20000065A2 HR20000065A HRP20000065A HRP20000065A2 HR P20000065 A2 HRP20000065 A2 HR P20000065A2 HR 20000065 A HR20000065 A HR 20000065A HR P20000065 A HRP20000065 A HR P20000065A HR P20000065 A2 HRP20000065 A2 HR P20000065A2
- Authority
- HR
- Croatia
- Prior art keywords
- amino
- acetyl
- indol
- propane
- acetylamino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5499797P | 1997-08-06 | 1997-08-06 | |
| PCT/US1998/016333 WO1999007677A1 (en) | 1997-08-06 | 1998-08-06 | 2-acylaminopropanamines as tachykinin receptor antagonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20000065A2 true HRP20000065A2 (en) | 2001-04-30 |
Family
ID=21994906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20000065A HRP20000065A2 (en) | 1997-08-06 | 1998-08-06 | 2-acylaminopropanamines as tachykinin receptor antagonists |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US6358994B1 (tr) |
| EP (1) | EP1005454A4 (tr) |
| JP (1) | JP2001512715A (tr) |
| KR (1) | KR20010022581A (tr) |
| CN (1) | CN1272842A (tr) |
| AU (1) | AU8693398A (tr) |
| BR (1) | BR9811821A (tr) |
| CA (1) | CA2298701A1 (tr) |
| EA (1) | EA200000198A1 (tr) |
| HR (1) | HRP20000065A2 (tr) |
| HU (1) | HUP0002929A3 (tr) |
| ID (1) | ID24468A (tr) |
| IL (1) | IL134301A0 (tr) |
| NO (1) | NO20000519L (tr) |
| PL (1) | PL338453A1 (tr) |
| TR (1) | TR200000291T2 (tr) |
| WO (1) | WO1999007677A1 (tr) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUP0003548A3 (en) * | 1997-08-06 | 2002-04-29 | Lilly Co Eli | 2-acylaminopropanamines as tachykinin receptor antagonists and pharmaceutical compositions containing the same |
| CA2444395C (en) * | 2001-04-23 | 2010-12-21 | F. Hoffmann-La Roche Ag | Use of nk-1 receptor antagonists against benign prostatic hyperplasia |
| AU2003230829B8 (en) | 2002-04-26 | 2008-12-11 | Eli Lilly And Company | Triazole derivatives as tachykinin receptor antagonists |
| ES2307925T3 (es) * | 2002-04-26 | 2008-12-01 | Eli Lilly And Company | Antagonistas de los receptores de la taquiquinina. |
| AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
| AR055343A1 (es) * | 2005-06-30 | 2007-08-22 | Smithkline Beecham Corp | Derivados de indolcarboxamida inhibidores de quinasas ikk2 |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| EP2117538A1 (en) | 2007-01-24 | 2009-11-18 | Glaxo Group Limited | Pharmaceutical compositions comprising 2-methoxy-5- (5-trifluoromethyl-tetrazol-i-yl-benzyl) - (2s-phenyl-piperidin-3s-yl-) |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| WO2010102968A1 (en) | 2009-03-10 | 2010-09-16 | Glaxo Group Limited | Indole derivatives as ikk2 inhibitors |
| WO2011104307A2 (en) * | 2010-02-25 | 2011-09-01 | Graffinity Pharmaceuticals Gmbh | Ligands for antibody purification by affinity chromatography |
| CN105906608B (zh) * | 2016-05-03 | 2018-10-19 | 中山大学 | 8-氨基喹啉-松果体素杂联体及其药物组合物 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1340588C (en) | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
| US5278316A (en) * | 1989-06-29 | 1994-01-11 | Warner-Lambert Company | N-substituted cycloalkyl and polycycloalkyl alpha-substituted Trp-Phe- and phenethylamine derivatives |
| AU687754B2 (en) | 1990-08-31 | 1998-03-05 | Warner-Lambert Company | Tachykinin antagonists |
| DE69231395T3 (de) | 1991-09-20 | 2005-07-21 | Glaxo Group Ltd., Greenford | Neue medizinische Indikation für Tachykinin-Antagonisten |
| US5328927A (en) * | 1992-03-03 | 1994-07-12 | Merck Sharpe & Dohme, Ltd. | Hetercyclic compounds, processes for their preparation and pharmaceutical compositions containing them |
| WO1994001402A1 (en) * | 1992-07-13 | 1994-01-20 | Merck Sharp & Dohme Limited | Heterocyclic amide derivatives as tachykinin derivatives |
| WO1994010167A1 (en) | 1992-10-30 | 1994-05-11 | Merck Sharp & Dohme Limited | Tachykinin antagonists |
| US6403577B1 (en) | 1993-11-17 | 2002-06-11 | Eli Lilly And Company | Hexamethyleneiminyl tachykinin receptor antagonists |
| US5491140A (en) | 1994-06-30 | 1996-02-13 | Eli Lilly And Company | Naphthyl tachykinin receptor antagonists to treat physiological conditions |
| WO1996001819A1 (en) * | 1994-07-12 | 1996-01-25 | Eli Lilly And Company | Heterocyclic tachykinin receptor antagonists |
-
1998
- 1998-08-06 TR TR2000/00291T patent/TR200000291T2/tr unknown
- 1998-08-06 PL PL98338453A patent/PL338453A1/xx unknown
- 1998-08-06 ID IDW20000220A patent/ID24468A/id unknown
- 1998-08-06 WO PCT/US1998/016333 patent/WO1999007677A1/en not_active Ceased
- 1998-08-06 AU AU86933/98A patent/AU8693398A/en not_active Abandoned
- 1998-08-06 EA EA200000198A patent/EA200000198A1/ru unknown
- 1998-08-06 EP EP98938403A patent/EP1005454A4/en not_active Withdrawn
- 1998-08-06 JP JP2000506181A patent/JP2001512715A/ja not_active Withdrawn
- 1998-08-06 HR HR20000065A patent/HRP20000065A2/hr not_active Application Discontinuation
- 1998-08-06 CN CN98809800A patent/CN1272842A/zh active Pending
- 1998-08-06 HU HU0002929A patent/HUP0002929A3/hu unknown
- 1998-08-06 KR KR1020007001172A patent/KR20010022581A/ko not_active Withdrawn
- 1998-08-06 BR BR9811821-8A patent/BR9811821A/pt not_active Application Discontinuation
- 1998-08-06 IL IL13430198A patent/IL134301A0/xx unknown
- 1998-08-06 US US09/463,855 patent/US6358994B1/en not_active Expired - Fee Related
- 1998-08-06 CA CA002298701A patent/CA2298701A1/en not_active Abandoned
-
2000
- 2000-02-01 NO NO20000519A patent/NO20000519L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TR200000291T2 (tr) | 2000-07-21 |
| HUP0002929A2 (hu) | 2001-10-28 |
| EP1005454A1 (en) | 2000-06-07 |
| EA200000198A1 (ru) | 2000-10-30 |
| WO1999007677A1 (en) | 1999-02-18 |
| ID24468A (id) | 2000-07-20 |
| CN1272842A (zh) | 2000-11-08 |
| JP2001512715A (ja) | 2001-08-28 |
| KR20010022581A (ko) | 2001-03-26 |
| AU8693398A (en) | 1999-03-01 |
| NO20000519D0 (no) | 2000-02-01 |
| IL134301A0 (en) | 2001-04-30 |
| NO20000519L (no) | 2000-03-31 |
| BR9811821A (pt) | 2000-08-15 |
| EP1005454A4 (en) | 2003-01-15 |
| HUP0002929A3 (en) | 2002-01-28 |
| US6358994B1 (en) | 2002-03-19 |
| PL338453A1 (en) | 2000-11-06 |
| CA2298701A1 (en) | 1999-02-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A1OB | Publication of a patent application | ||
| OBST | Application withdrawn |